From d91ef95b98575a0ad19931f703d5a853eada9cfa Mon Sep 17 00:00:00 2001 From: zhiz Date: Mon, 11 Mar 2024 17:26:35 +0100 Subject: [PATCH] add _quarto.yml --- .gitignore | 2 + _quarto.yml | 43 + _site/fig/TCGA_adaptiveLasso.png | Bin 0 -> 355433 bytes _site/fig/TCGA_bayesEN.png | Bin 0 -> 132073 bytes _site/fig/TCGA_bayesLassoM.png | Bin 0 -> 131116 bytes _site/fig/TCGA_bayesSpikeSlab.png | Bin 0 -> 75691 bytes _site/fig/TCGA_bayeslasso.png | Bin 0 -> 123261 bytes _site/fig/TCGA_elastic.png | Bin 0 -> 211399 bytes _site/fig/TCGA_lasso.png | Bin 0 -> 202917 bytes _site/fig/TCGA_pca.png | Bin 0 -> 213555 bytes _site/fig/TCGA_surv_auc_lasso.png | Bin 0 -> 38434 bytes _site/fig/TCGA_surv_brier_lasso.png | Bin 0 -> 89835 bytes _site/fig/TCGA_surv_brier_t_lasso.png | Bin 0 -> 55848 bytes _site/fig/TCGA_surv_calibration.png | Bin 0 -> 88255 bytes _site/fig/TCGA_surv_cindex_lasso.png | Bin 0 -> 46967 bytes _site/fig/TCGA_surv_iauc_lasso.png | Bin 0 -> 34251 bytes _site/fig/TCGA_surv_km1.png | Bin 0 -> 191886 bytes _site/fig/TCGA_surv_km2.png | Bin 0 -> 106460 bytes _site/fig/TCGA_surv_km_lasso.png | Bin 0 -> 103667 bytes _site/fig/TCGA_surv_km_lasso2.png | Bin 0 -> 113602 bytes _site/fig/TCGA_surv_nomogram.png | Bin 0 -> 160725 bytes _site/fig/TCGA_surv_roc.png | Bin 0 -> 50183 bytes _site/fig/TCGA_survival.png | Bin 0 -> 129483 bytes _site/fig/TCGA_tsne.png | Bin 0 -> 196712 bytes _site/fig/TCGA_umap.png | Bin 0 -> 118770 bytes _site/fig/mlr3_calibration_BS.png | Bin 0 -> 87787 bytes _site/fig/mlr3_calibration_RCLL.png | Bin 0 -> 61909 bytes _site/fig/mlr3_discrimination_msrs.png | Bin 0 -> 60882 bytes _site/index.html | 8 + _site/search.json | 51 + .../bootstrap/bootstrap-dark.min.css | 10 + .../site_libs}/bootstrap/bootstrap-icons.css | 0 .../site_libs}/bootstrap/bootstrap-icons.woff | Bin _site/site_libs/bootstrap/bootstrap.min.css | 10 + .../site_libs}/bootstrap/bootstrap.min.js | 0 .../site_libs}/clipboard/clipboard.min.js | 0 .../site_libs}/quarto-html/anchor.min.js | 0 .../site_libs}/quarto-html/popper.min.js | 0 .../quarto-syntax-highlighting-dark.css | 189 +++ .../quarto-syntax-highlighting.css | 0 .../site_libs}/quarto-html/quarto.js | 0 .../site_libs}/quarto-html/tippy.css | 0 .../site_libs}/quarto-html/tippy.umd.min.js | 0 _site/site_libs/quarto-nav/headroom.min.js | 7 + _site/site_libs/quarto-nav/quarto-nav.js | 277 ++++ .../quarto-search/autocomplete.umd.js | 3 + _site/site_libs/quarto-search/fuse.min.js | 9 + .../site_libs/quarto-search/quarto-search.js | 1140 +++++++++++++++++ survomics.html => _site/survomics.html | 232 +++- survomics.qmd | 12 +- .../libs/bootstrap/bootstrap.min.css | 10 - theme-dark.scss | 8 + 52 files changed, 1974 insertions(+), 37 deletions(-) create mode 100644 _quarto.yml create mode 100644 _site/fig/TCGA_adaptiveLasso.png create mode 100644 _site/fig/TCGA_bayesEN.png create mode 100644 _site/fig/TCGA_bayesLassoM.png create mode 100644 _site/fig/TCGA_bayesSpikeSlab.png create mode 100644 _site/fig/TCGA_bayeslasso.png create mode 100644 _site/fig/TCGA_elastic.png create mode 100644 _site/fig/TCGA_lasso.png create mode 100644 _site/fig/TCGA_pca.png create mode 100644 _site/fig/TCGA_surv_auc_lasso.png create mode 100644 _site/fig/TCGA_surv_brier_lasso.png create mode 100644 _site/fig/TCGA_surv_brier_t_lasso.png create mode 100644 _site/fig/TCGA_surv_calibration.png create mode 100644 _site/fig/TCGA_surv_cindex_lasso.png create mode 100644 _site/fig/TCGA_surv_iauc_lasso.png create mode 100644 _site/fig/TCGA_surv_km1.png create mode 100644 _site/fig/TCGA_surv_km2.png create mode 100644 _site/fig/TCGA_surv_km_lasso.png create mode 100644 _site/fig/TCGA_surv_km_lasso2.png create mode 100644 _site/fig/TCGA_surv_nomogram.png create mode 100644 _site/fig/TCGA_surv_roc.png create mode 100644 _site/fig/TCGA_survival.png create mode 100644 _site/fig/TCGA_tsne.png create mode 100644 _site/fig/TCGA_umap.png create mode 100644 _site/fig/mlr3_calibration_BS.png create mode 100644 _site/fig/mlr3_calibration_RCLL.png create mode 100644 _site/fig/mlr3_discrimination_msrs.png create mode 100644 _site/index.html create mode 100644 _site/search.json create mode 100644 _site/site_libs/bootstrap/bootstrap-dark.min.css rename {survomics_files/libs => _site/site_libs}/bootstrap/bootstrap-icons.css (100%) rename {survomics_files/libs => _site/site_libs}/bootstrap/bootstrap-icons.woff (100%) create mode 100644 _site/site_libs/bootstrap/bootstrap.min.css rename {survomics_files/libs => _site/site_libs}/bootstrap/bootstrap.min.js (100%) rename {survomics_files/libs => _site/site_libs}/clipboard/clipboard.min.js (100%) rename {survomics_files/libs => _site/site_libs}/quarto-html/anchor.min.js (100%) rename {survomics_files/libs => _site/site_libs}/quarto-html/popper.min.js (100%) create mode 100644 _site/site_libs/quarto-html/quarto-syntax-highlighting-dark.css rename {survomics_files/libs => _site/site_libs}/quarto-html/quarto-syntax-highlighting.css (100%) rename {survomics_files/libs => _site/site_libs}/quarto-html/quarto.js (100%) rename {survomics_files/libs => _site/site_libs}/quarto-html/tippy.css (100%) rename {survomics_files/libs => _site/site_libs}/quarto-html/tippy.umd.min.js (100%) create mode 100644 _site/site_libs/quarto-nav/headroom.min.js create mode 100644 _site/site_libs/quarto-nav/quarto-nav.js create mode 100644 _site/site_libs/quarto-search/autocomplete.umd.js create mode 100644 _site/site_libs/quarto-search/fuse.min.js create mode 100644 _site/site_libs/quarto-search/quarto-search.js rename survomics.html => _site/survomics.html (97%) delete mode 100644 survomics_files/libs/bootstrap/bootstrap.min.css create mode 100644 theme-dark.scss diff --git a/.gitignore b/.gitignore index 0965576..f41e8b2 100644 --- a/.gitignore +++ b/.gitignore @@ -5,3 +5,5 @@ GDCdata/ MANIFEST.txt TCGA_data.rda + +/.quarto/ diff --git a/_quarto.yml b/_quarto.yml new file mode 100644 index 0000000..00e15fb --- /dev/null +++ b/_quarto.yml @@ -0,0 +1,43 @@ +project: + type: website + output-dir: _site + +theme: + light: default + dark: [default, theme-dark.scss] + +website: + page-navigation: true + title: "Survive with Omics" + repo-url: https://github.com/ocbe-uio/survomics + repo-actions: [source, issue] + + navbar: + background: light + search: true + tools: + - icon: github + menu: + - text: Source Code + url: https://github.com/ocbe-uio/survomics + - text: Report a Bug + url: https://github.com/ocbe-uio/survomics/issues/new + + +format: + html: + grid: + # body-width: 2000px + sidebar-width: 350px + margin-width: 350px + toc: true + code-overflow: wrap + + # sidebar: + # title: "Survive with Omics" + # pinned: true + # tools: + # - icon: github + # href: https://github.com/ocbe-uio/survomics + # text: "Survive with Omics repo" + \ No newline at end of file diff --git a/_site/fig/TCGA_adaptiveLasso.png b/_site/fig/TCGA_adaptiveLasso.png new file mode 100644 index 0000000000000000000000000000000000000000..1f4bf6cd224cdb16af98e455ed4db0bb751c204c GIT binary patch literal 355433 zcmeFZcRbha-#)HgN{c9k7G+095n3ucdsFsSviGG@Dap#p3K1bY`x3G@8HFNyWo7d_ zUR>9G-=FUv-^b(k&+qa3<9g<9Hs&^LakIEqRlSl$w-;goI4w)^!;Y zl3l+^NOlbE+>F0r-pU$^-*(-*rTl<|M3{^Ce^b(z3>p%W<0K;2ugKYUjCR_nQM9hk zuf^<)JO0$|>=)8X29_8*g4`zN@WbeU4{PQ|4 zuxPpI-!Di=ZjtX&|L?C}ojsWI-(MYE*Y#28lIoyj-t)*Khmx3lfrNCnI`1aQn(klhli?LE^6i125=RA1?ZM?a5wcRn;bSpPtcC76z6J7uvpj zaUUm+&b7mJ{V0CB&o50BvTGKwa9-fxxL@S9ZE=w=O|P!E%xl|3ZEfw#ySF3b;%-&n zIm^fxnH+uNm#mtanz$xmHkVn8e5&yK-yxUT0(MK@No1j?@0%HFnmLNU#3z(&m_^st zfx2*)`QMSEv0Jxptv6r)Cdt8@>vmyFKH8RYtwr|FcxRPI?tgr%-j1H0-r>)v^z4V~ z>guSQUX2biKYsp{RxIx+eLi${{ofj$xVCPj^;S>z(bblh-|j7Ob#*;(>PG!v$?Es- z-@kh|aw@Q~QHGE3NfK9;r$>l??piCWo!>{gWACxEXU|4#*>Hi=&)4@O;+w^T2M-@U zY!RHRkGwW>V*O)WbvBk_`K`cdi7QBVWMV>!Zo>g?QLfwY<*fJlT^5h)>+7-DCeQVs zB5BmQwQl=4%-r0wCC|u%n{O*A9j2h*vYXQ3o0e$IvzuO;o7nBnZQ9{iu>N+Jdo~=4 zkLCFBhz}pci$#}LRzwC1?hZGS68H z^-q0ueBEzdlRP{glyPdzg$p|211PGZqN37LQ@2XlSXgkLKQ9|aSkBL%Ki%#! zFfg#Ou^Bb5{r*`T5fOn;i(QsdQ3=MI#}F^wG`$-8+2OvPp2l382?mMa-wbvS>B4vH zqrHCpx>}AUBNG$TsZ*zz*I(@Hb>-#dJuahTW8L;6tor);XU@dBlO6qP$u9Cyg#D89 z@_f1XDJpgi@ul$Q=4Lmy&AWH+#!ng>8{^lbM?>JD*}1vAM$Jz-_F+HsIPER6-)IoW zVp$s_7EtmlCrLe*l8#QudQ_>XT+?M`)>lgKefIV<^z^2kIabsCH7O}6m8ZtW#?DB- znQzw*S5{WeKf4U4S4>iSzg*G~b#tP-P}4K>(4j-ywrw-*%3Bz0h>DlIdH($QqXPEn zSy_Zlk2JqO)$jN8=~Ml>FnP9xp6BduqoVx7`$k6it%jSK9(U&2xEP8~6+PUsckf;| zRuOUW^o$I77R_{n1|NE{tx{{#bwaUH;Yl~1g!5S${r*wpc9;B&705B`%#m4m%{HEVgjUe8?XB=`My~loLV{W)Wo2u# zt(qac=8~eKGD9U{0uBXht4jq11u9ZeqS#lpJlp#dUHLfkEVIsob{+)<&UIk|0+%l3 z<>kRBKAY=c10%jv5GFbp;U%=H^n2|O&9P&@EbOja`72O9KwVAEDDHhbGs*UNCcT zZlas&fxVVikC>F#vu6h$x?1MhPp-BksAZjA(A(zJ1tAJL-lf3|>}7 z=H%m>syZQbf{ybYA&V-sbbV&uKXI6}og<5#4+#tu59S)er>hLn@8TJHjHk1+w>N4$ zCm;`Cxe&8J8g^9e}f`ZOC ziwFJH6;)NTLnXg{{W@{Y-Eq2xcZyn7ey}k{Ou*sK^5RHxDGNKxV1@4)oY`n=a(BMN zoTZbi)nI+(O)pxvyJatFn39>@dpj zP^_z~lRC%1&MxJ-kC&BoY;ktP?QZWEPlut^0)O}j0@HY}m(W*H$;sMK{%h`g7KUQO zZHouL_xc6}wZq0spHl_+`57c|WM^luti)wtlaXbCIC3esl>ICXV( z;j95^Y11tUigtWhiEHrX_54;Zz;827@#6lydxKs14y7&*_VymiRu_*Szx*7*`Nc6o zM_WnBm+rGH%Bect1x_7ff8#(TgE)nm$vY`x-o4Ao&K|OtY%MFhS$#6)#EBE}Uma%# zr8x{w)6voOZNg&}KiRjBl(ex&J;2}JX?0=1+1VL!El=OFZ?dAYlA2TJ7Fo=}QzuVu z-$(n#+dHyR`JhSTZq+O^8a~T7h1KnEJ))zdv0K}B?3jLm=O$6v$jkK{2p~vKRC^LG zF)RLxuWD#$zy^O6J(a9kIR5kJbfLJ1;UaGD1Q^d|W?#_>k4@y!5NWm;3(2>gsA!tWk4xNPf=9nXXQENUUSpHx);T6wy&x>{UHN{Y3Xq^hPyzakJ~~0UAukeu@O4kfDvh0Iw^ytfZu5qF`yfC0&1ZxFvvHlX8#m z9bYCy*1ABB-WD$GwnGsSH)yU*+DW-!etg<|->ISEs|*;w(Loe~>iu?Pp10bB&F1Duz6)tgHyd$ocY> zh~Zt4*Pc|;1D#gZ)hTMIA`s%k<0*oJf?CvUxQ&_(%3qy`jEt--zIyd)iIkpz#jmG# zUgYOH!S)mQgWtTlq+ff?J7A=R^KB5eIGV2Mat0+NjHDYjsi~_Ylh4ksbywa%a*_%cB-^*I`{UhW?^8ER zstW|}{czQ~A$tEM;W2j<^!|*t$G>ah8W|=sMpRKyGX+NiU{!aG?fDh^7roD zvmMGtfYDM=&rC~WW@lGSwo6bo5{Zq|TC8blk^dNPUa)XudB^>=RVNMs)If20VQ=0X zqJ<52_OJw$rMrs?U!pj(yAW zdiwOXjH;4SAdq)?M~>CV7jsiA`Z9CdwRKB6vTN5at%KV=;Qw*(H*p^+9hIw-$-*v6 zW4s*RH*VZO&R<=bBhuJ%V^o@c-OCp*Oj_dot@(fd{nr*Zj@?vjjtH#Vio2ZV)H$Yg zg=-D`SY&0JU@)Za&%WQ7gLNYjS85+ScI?fYH}U)cU3^7;`cL-K{F&(1EOd72yL(>0 zc6qXlZreAkCda6SNdpky5m@Mi(lvN(rb+wBz)L*m&MBp6J)Q~;DYbOl8gkmV0=fV7 z>(>nZr)c>s2Q!RYfth1Y>$QEn%WL+1@M~g7AZgUww~}F(D$9bGRpGKYdmVk=+4vONxU|IfLsaInqL-*3~MVF3=H8nMDOQU}G?wzL7tbaKv z;Dmb7VRfm&N*zv3P0gafj~~x*Ra7gs}Yj#bx!{k&{v8obCTS9BgX@SOwmd1!YT4A9# zJgFZ)ew<;_E+d`+#In0Emw=Ns|CD|1JzWVN*wh@G35`x^BovMWwu$z%o8rz%9@q_! zT_M<3)a51Dtw-CW#Wzbu!>x9Gu|=}i9M0A*d+D}&=RjZIAqtAYnYihh84B?PeO=wh zPoC^nu=-Vgpy;rt_S5t8r_Y?( ztsz|fvX>oT{4D@urM8c+uYWUR5d)t7*}^F5s4V?D+9JC#_O`aR(eK%^)r$j&wPHZ=1)&0yk%ruMMZ^8IrX|@2BP=D^G{@6 zw6!S}9qu#sRPYWBW&Py(QJeuT+dA}@zK#x;+4l=Y=Zd6+PMo-MZ?jEnk~;8?T4%$L zA9srMs>1|SV{(t4yW{F}C`|K$n~pH zf5*2({CPly&TdK;gRZ=6(Q9wv+^`smJ-$_afTq2?7l>8-TlDYJdN)w%m$V*_nE|Oj zhN1XJ0`f4|u(kaZD3Y(~yr5g`P9~o-say5>S@?tZ*HK6yZ26a=Kz*8g?^~v6hR*21 z!omtFkV-=gPa1yfon~9_jeox=zt%`# zmdh>ddF$2maVLvxwd#V*%2w5++bP2qIPIyAPD_7KsUV{$>Fi!x7@#XUjHmW~&Z^jt zO0~er!8>=FsR1j6>lloXU%dC@Z^U&CG52uP)(AdReLCjd1vGSY-SP4X!<$R0DdbYS zrV#NsIXV5pyAW!(lTpXn+W_(&c*DIqKiLbg%Y)kFYk?cg?CJ6aM9cw{5JZJOvNWDM zk%=(hZ!cmbQ3*=uCXV4+q7wgoRNO3bw*XiYLo0@J)`7sU^tX`MJ7{cwNmU_>7!5~m#{J- zIMr|6*l8I>Il0rH9Ad=3+gBaBo|Hob|9}8RMEfFAa&q$Bq@-Jm?f;Cv*Vtz{)*+8j zS}k|JM!;qD65sj@3xJI{dTXdDvDf|mTs8rErT^A+75!Jsbr?Ra4!O<;p2)Tp@_1-zyGV+;%)IQ zMzO84^M{WdsR`koK!x9&7azF(3U^s;2d&fDnSavP$lN@6MB?DIp0$NVK?*iLYB1~x6a9EMxYpHBl(6yLdvRVBUNzU*~Czz)y~2q@Op)~J05N(Bxp z!IQ-YNaQ@klY^ZF$f}g0SkB$V;cH;*S6-+RClLL6zB+_gYD|dS?)~@g-@#~sRpU1A z`d(2n1pko`6Km>Zcy=VcCYZbF<72$H8^=cFLAH^|PP6j!FU5$YGL zva0XH(r7Z6Cil<|GATvN{^}rDu4Lf3pJ0mscV2K^2?h8@nx6`UM>4*fL3ysBpz!V& z%e8C8_j|uECI>xAioW%0l7ok*i$KYb-cp0f`U8dv8FdOp)BbQTKRMr$Jt|)MsS!)3W&k@E7LBY(-OfYbru->V@DiCL~I#El!&_k>9{)1Ap)Oc8yn*o{+t%){-cB`?D3_MWArSm@r25i6r({BQ=DIy|bh`PVj3vnOJ*fuIB zZZ0lVdQ}w_cAmT%$r|}8t9(AIy-~5T1K@mr{`3wBIePG5Dk@UgHtXIHFndSN>#5~h zODwx>O3o6|vR`UBZ3&EB&2EXuy-dF0B0~qWyDTK8=jIf{>JRzy*y8iS%mf7m*_+-H z5o!3%hJvzSahTb==+B=&f`Wnw&;(9<_H5U+$;Z3M83@O$5Y4v8zQn~f0}!7)Ke--d zW{@Z!sEdh-6>+s;!NAYAukmVBJ^9N_KoDRT?}QgnJ5KS^y&soR8(CPS_H*Nqpv$a< z2|DFSa*0%jcbulDH*6!}usQLLp4er-uKB&x%Y^lCwnN#^5%KZ3o9z54O$xtRe?Q%Caw+(k)F$ID1C%>~G$&hXkA2UvN`UZGoZFUe=zB*ToCBNMr*oj)yob)#sKz{p@B8n7 z^zq@XK4`D-)I9I+E=^BQ19ogHCTa}lny#6dnU0H`WiO6IIns0@PJ2AdMqKhxGgoHt#aT(7 zyD@E*Eq#scF8h;y5I9C@Ek|s zapLUHURjTxuihfh&ClBor4Lm4GlQBD-CUxxm!M8xzkc_n1?;Ff**Cfa2c%_W-d_4r zU;n#!pAdy+Y`>WQ@L41zn=ZSXcGUopI#(GTA3S)lZ{I%eb<+FJi>VW&wBby_Jf?i$ zlc8yWBa}~2K%!Cm^$b;F<1>a?)RUT;^WjbiU+=6R62;hIZ8I})oHk*nh;#kNs~CN1 z?W@?&hDS3qM5>~GzG1|}#54>dmYPRH+&T|fgW$L{2OjUHG8&tonVy!Vy$2c_&~tFm zfSv=T6E_bJrCli?(5^3F+a4<3l(6lk3rD@?ggO?A02m^_zg6%#|!Va-rjSXx2>p4CD#)|wm+ zaly_mdrB0Z$^%0@QS z*XubYtIX`f`Qe1*l1JG&Ia9`HDIlrezftO0ygYVsYGz2b=%ZvP-?kk)jGeQWmzN0x zW_wQ!ct}H|-szb9P9g+plaAk7+>ZXpkt1t!E^Ar#vqs*g{I|)1473uAd&G$im;Lor&Ak2Fw_KQ(N_G#( zSsF@8hQpNm_ebb#szW{_Ww6xcY=>I;CNvZ=m*ueC(w{L#*>?tg+a<)sw`v1L(g``M zscS^1g1VFvT=;d!i?ry)5_A8^NW!H^RXMrnUxSZ!k?+~FM=qxaMZez};te5I8IOndcm{}a2i88Hu@`GKc&aXr-$)Fh^^jj2GXz!KkuwMe zv*Zz@RIDcreGXJZTBC+jW`_W4D&z%=@t*ae*LQTx#U;S)YKHr5~)FB^6&k= z&366}2);*)kY`BEO-@SB`XQocn0IT~5yCqbrm3RBlv;a;S>chpJE{A7zLB{@gB=;h z#lexbX)+FuB|1{r13=J3qZ+6bZn7z4d-k9ZiSCXjU0hrww3AY`K@=C-UtSQ;{6hTJ zt;5hJ?Co;`jWSa81c}vboL~AVB+Prc*Mr3S2M1wVH%-+ofitw;iG6_za{aoTO**hb zS67!7o1&T;v{(U%%K`7UB0Vc4YmAMKekc_-6V{7HY|YZC@PTGFycw14&*5RFPnkv% zw;QLEAA{Hjy>CCz(cVr3vX(SN?EczN=EK&@^OGnNcAG7!XlSffoC$ZFETwWgWIg`f z4$mOtAbrVYby>OQw&U8Zu}O~e=O0*GQ|{TlcQ28q16vIrBY{f2xgdQGV7dl)Y*E6V zQ0^5J6tviEz`&1p=017yg!$P5Qagk!hN-^qs4JnEO>g+@u??S9xt^5up>!ylGw1`* zby8B2)=7Vjs^S>=wdp%wyh_2O!Pbbq7?0 z@C`PV^zw!Vj^oFVv$2f}8xdOexpVb(b;;nTpc8yud;$O^P!tG!5XNUEDx=*3#VntE zgHLY0a32q^^;&i>Dd})yOw~&oehoekQBhHBM>{wKq=aYLgcXpH8P8e^gGYpbewx7q zjS8^k6<`cnRBP(u3JPD57l7UH3Kw!=Q;JPaPEO)_@Am9j1zI4$nW1#tvFGqPtPG(7 zEWAfzF0wIr>#s@bBfoxe=~nuIJ@C%p5ZGYk^F7x12|nxiHbX;0;Akz%7x_+0nUwk< z3sYxDT3vuO-R|=6@E`;)F1Dw19YwAaRV@qT3T9i@kC&R5?EVZ zEmuJE!Q$e@i-2X7+8})MoR+MM;-QkjHoisO+-Gb&f@p?hxM|DwJj=tE5F2yom6*lW z74nwoIzm>Xqe~tpN;mWTSq0C%&7@@1T!$}OM5Ci5G0_xNog?vD&VDce;!gPMkKW$i ziHSAQ!k7gA;jeE4x>6A+Kc!BCQG=rNEk^5lDO30_Xl)bw;HUy4HoOfQaI4J7&l)hAI%g$p<+R9JRx+f8ZGkB{=5vDDtgYlv{cmA zQi>0He1DPo>C-%DrzEw5hY!cidPf`tB9Nb+Gwn#1<_}@^t=({OHv-HC-v%LAMMEw&C(y!2M{&dt^+}iG7b|m^nfZI$(lkO-j#~#Jlx#s*%mQd zm#n+;>>y_(ujUZy{fnV*S;;S7D)kxX7x;O3dAU=qj3gIcA0Lk2B_>t{kOM+`TEnNm zcN)@Nra?oGJkL9L37yMwiVq2)&m(MuiVIJEClAQdj>iMDXm<}!L1KDh1B;hF+_4W3 zxa7K#&6Z9oyx$oHmUHJmMn_*4aYgUNKB47^QuiZAkK%DOi$%e$>D9h@U#eg=(bWlU z<(vsz){O(XT`tul!|x&=pY>3qaEvUM)S!y0D(C_AWwRQiIL*S<)s>}h8OCJ}BB@?p z5UP>9HQFC)8yV#oHZg!Fq~|zjBIB=lj9}0uvMTHA??LlM8_XqcJgY0^1{Dx}_16rc z;9ElZXP`cZjuQ@M9X%bLW5|7W)l`~}lc?Se6Yd`6F{#(_?xLb(*Z7VGq(m-5`~ZN* zq4QFfcw0B)7J@fq&{Hp@W|C+eL;nYuxqd1dPMvbJHf&Q2miGcR27BMW_gJ}@NRL+? zSS&oGF;|9WQFAjF3(E(-Zr; zPbXKnwoU>#1lOynuIBonk6?z} zq^C#pAsyU<4f!)Q1!+@;HuK)k&%srx&1d}&<`}UwsD;A6mqE!OvUKE!q7Z{LV?EIo z%IhO}Ne~(AB6iC&Y1~*(&w8-_#N_j>x6s@GyfFqMkh>udwutih=U7&E|K0UR-;hI& z??S{aaF|O9EDshNth}C_pYffk0#oEVs0@L|vQ6wzm^__0Le#O`VTfSy`0qV}paXP?3?z zjAJqZmEkz!qwQ%D!CXH*qpx{MfmXpO#fk@=)cb3byeAMMvSqwv>uadS53H>6E&4p* zA(_GYCMK7Fq0xTTQa^lvF!hak$mh6)y;%*xk?LIKJ#%INJdxH(REc&YUs<^oex#?S zlJ4523_Ltfb5eM?DYgzmI|6*f@H5a6*n)8+D@{MNzf`ohD_3WutaRgmf}#euMd+;c z)DRL9;<$?t`WlC4&2Fl%4^<=V_wRd?BD%tesPn&krL?rQ@pp-{lYiX3`+K$VPk^i- z?b+Je8W`{XhGaF~o_6NK1*K|@LcWIRN|g+wzKIDJl(X1VBN?yA$e%BcoJU3`fG)~& z+WlBwg!^DcpM^bfYL_K)(a8j-N83Xfw8TrP;M!2Cg9fxihBHnVLGC47Oh+er>fD0| z(=hkCU~VyAzerm!(yFikB=%BA<=uPsPy{_pCWE@LdCQh-*RDa>5q6^c+JqzT27{BI zmxsf>xual{mzOw$n21Pwp^M9%J3pYu!aC&yIzNB@{O#LP{#@6C`}gf0hR7-F=;+}4 zSO&7u^)M|1gTbC2PIMI^{+f<`AR2rxw^J#t!zmIC0_kDb-5)(7L?0BxAeWFYknvz_ zcp0|Dw*Wb!OikyGlz2g~VFLCufcTS>lSnoYV2GY6LMKl&g@dB&C=}QbQLM1%C6GM8 z&r9?md3aQ!oUW~fR{^)4hZ4ujYlEg2d?3_s=p(vXTAx3~bACa{p`fO=hYkZS6)z+^ z6yYG5aRhiBJ$h7Me?ZV_5p_7akLtC}yLx3$@bb>VK!IcP*3okoS`W~r`M|;gze0ZB zLq>L#%is>mPgEBOyQuzJDu~y6Bv0bqm8zZ)$olIi1Y}aqDhST`_fBRR7KjL*-H2i<` zHIo?rZwvIszTnsYZSp3f$;Rvd-sJuNxzTKNm6QD74nBAHs=p67ekjJiVczc`oKsO! zDzGVkx_5VOywhs@1_*;cfNOG$YFTEX{{Dx;*U6My9${*1vFkm~KQf${o0<}20I6ke z-@aUT3oUfYaHBpS)I<)pwu9e2qu;$lYD^bJSlp+YZcr4vK8oP;dA*7JpB?)D^_;;! z`$ggbjsQJdDEiO|>Fw{2*ro+oftS91Yo@8{wPM8?D^4PZad3d8$8G{TqZ$F}lZO2K z@#B6?5mW&PMC-9A2T>R@3*swE6wnGrNqzWIWX;#x`z|^Q(ZYn6v9ap4R^S*%NTmqp zDBK~)7%vH-!#TsKn%KR+kGh-75`S=AJA)8>`t&a-u==%c?0)~aVs#e~1{$;_;^pKd z8snvVuY!!K2KTPkGc@!*d2NmTq&z|*nqQ!ML1hDKjjkL*?GBCD4jK$lM9gVbJ5Vr0 z4(ZD0hu}XM_x`;hu!PX!U=+b7qA^0%>1;q1aO~1tw+k}O0C2y@CQoW^uyoBtmg($- zJk4F$11%a2O=*Av;Q30UfT)k~m;{E0cjrzNsG=n8q&ZJ4<+kzAzxkL%<69QzW4X7_ zo{3z!Qp9X_LsYbqy>K}d6%SNOe@PRx=Rrt;-k8ux7#Mkjf;Kq$WP>5SZs@hT=%tD=RDLfj-U9R$cu;l!^v@%EiS|J%y;6!4x^p zjjMCWx3{$|0~?}W(8$FIDH3(lE;6!1OkyP#>fR8 z73hJP3MF-YLxZ#qK`#m4yvfhckM3fn;@4=_dW#O9lWAZLST0^{ud6c$kBUk|an=Gx zgyj<0yxb&7oB^$np{VzBbC<*hm`BC~iTLEoOS{fJki_Mqz(-wjaf3*Z7zWr4Oh_;W zQ^VkoCOY&Uv#Ndi2u*%j8Gpt;95`^`kdPTP094kHcA3=qgoL^QSfH#K@vZ{4ETP4m zLh%WuB>*^1t256|c9{_tj#gE4G|6c*%z@zo8`s;@)Aiz?o!a#8(=bTBf!*9ll(PbI zgN_sDl%vLm8r9lAJM*Of>(`ROT#SGkAl1;y&xB60C?8B(?06m(1&F^IgI&Hc`&)s#4iqZzW z1hxUdy>|8L*JMr2PPq<1QBVLIuctyl~}Rps=;2rQ=9q7Cs9djKR?JUcI{4 zQ?iSGHwCY0#|$hTnoVWy_``jI^C)K$_>G{}*#7JKqj$ud*#%mzeW zMInz;;k|8naq+cky>yRV>QMW!W{)*9cqaJo&d$z5Qs5-k(0yAX{)^_qy&n*`y1?+2 zUXzxVmVGDw?Bz>^OI&ytbWtPx}QZM6L0)URH3>xo3mB(alV3`LV1P$nU4<z>ZTFqwuki1bOYz?5%$TU%g`y}x5X_Y)h zd}prcM^_!r2MtofDa*jt!=^=GY|!|MD#cHqh&iwasIS?ULyZBnD~Nar{Ae3=aWv$! zMg{_bT1iBj4^UYV8ciCbD~|H4Z|)DzjRtZOqbR6TO!SETDrtJ2qW+F(#ql`*;!wb^ zLrdG_HH9$X1d`g#8+p;gu80&I7w9v26aSOQBD}m=OpifuA(6-?uc&643}F_d{0BHG zM~FTieP~8U)bZ#;T7`})$3n+r(gqf!13G}M(1Pjh-Ej2$#&PrfW5pTXJ!)vL zn*+{?lM{jI9MX3L;}O>yjY64uoL`lOiYg%BbzQhnp>))ZlgtERq!npDhIbD{+7^vn zhJwbbnkmPEF5QP(KcTM5$jHP~z(rk9MN|%)R74HvHEi)S=feN-$*414_VDB*mr6%5 zm5v(v)5w&{GB&gUER<1M#eEMp77%W?U#ul{-}IzzfuaY|q4F`>;y_r? zB1%2?K?w@^K;dE*y0Ch9lM_GS=zv0;hbTYiaBr+N)A4!i`rKzk=6lc$2-;l9H`xM& z>}PHsII4>I!I-#Po^D4~!qgJU0Cgiv!&4Ifxk*AfDq5wgq>7#o9tQdn7 zEoy!nAAa!qy6R10^d3G>boIh(nL>5-^u7X2!XC+v@_ZmzQiS`yii@*T!T$b!erG8Q zlq!JP@R}EP&bo?$P>lS^pr$=t*EX(2A#_)C>wAH ze6~I2ACS$sxVd9;{Sux%N`m0rNAG=zJcqqzQ^NI@M{L^L30Kyj+Ta~-k9<(g0;wXI zl83bkE&sj-yghVsvZuE<*d}dweCW(^=NkcT4 zmrfykzTvldS^Xv+ZT0bY$q+*2Mft#GE|g)tin~DK$e5F>%?8(O*mdhh2NX#&8_<#j ztX5`lU?9tKNQQ?`z8Gi(13oQ+=oXs5Ps@{H%8qGmaCB6SJ^}-2OiZG_dYai5kN*$D zVMFNlcuaurWF85NAai$!(TFVZPWI@$hdkncwdfHbDw-B$mfk|>V4}C&SkQ0k4c^+d zgZ{*cNKvAb6E$R{hAF_C(2#Ls zYb`hbgDur5d>mVnM_W0rVfMXPO*Y zQN9cBMHwbP^+HvKh?8{iykTQB z!6_#wN{K&4Q&Kn(Hll)c&t%|VmkY_xQoI8O3Hq;1-D5Pv@eiR0{;j! z{n@#>I<(TNq1eRZp}}PeECN&zMU!LsckGzM*#;V7IKS3@vx^f_`t_&pjAQzPk}VXa2J~7swATxbA->hcjptK#1sgPOVLhjJ%7;8Ny{a1z?R`LnaMy z$HOF{w`Xl-!sU>8C0c6n1@IpDW$5+s2Y>YUW5{!;k{;)&iAfaEIfQuy-IbrNt|SzE z`3Imxx?R?s?%at$vsMox0mi;3al!;BYcUO3{9=G|2i>m-Kg~&zcnIL*<+Zll>G`w6 zOOw56?KMs&d!Z=)A~|R#T)#7N=SdHWSN6xXg!h-INQ)+>3thRKen@p>lR}}z&P=Ab zr&=)@f%ne#ef&OmVpsNr_Jc7!uWq_to5H5{SEFV=6{F)L3qQPqDykg?mwu*AtW+1+ z2=?lbp2uAdNUZ2}Gn5L&w0a^sTd*63eAfChI|OXq`96N*4k(9n(hh#Z6q^V_gFt!J)F z+cx~|w=||W+K`%C-nE%ZU%y@wzB&_&^CbEsz8~Db|F_WEv=CQ6obDy90H0yw>4AOE zyu2`uIafH}^Biq$iqA({5?awYz-!V5pX^-*DEH(;s6nwjw4UUCT(Nau2Tb!^Q4K_J zC|n#)K#gs#n+1+h3g?H~k+n-~5e;0J2}r~A=}Q-*zLXDLWqN6taWn5oAA;Ch(2-X} z?a6>{jxR5cfVXmizQQl|AuevdOlUO)iUU*x^|8&Gu}u)r48bKKSTqb-&a7kZ-z*!c zp2Y3=PBbJTQwqQl!HftCKfV!#D+?UJ^kHs1F{=v&dfVbp%pD^L7NDINW#93g;QpZa z9s@mQ)vDfF`A{+6zvxaIIu#KtfhBPfLWRySBpcLaSFe7q;q89&>Q((udgOdPU0nf4Ur zd!J?>N^@dlco;>{iyPXgpK$ZV%JRHF(~rj~VktR{?K@jqTF{FPdIQuw+H$Eq-6ePK z&uvzF#TgS=(~qC?@F3;5gqrf~5!&o}_Z^YBQ;gf`Vh=1$$SIv866YztcqaKpk-5>wFG1U*SJ3bTysKv{2&j> zUt*72MxuAxVHyMdgr}LAM*t;lu3dZRlp7wdX>Y%XSa1o~BR~x>&QP&u_>sN71clqW zx_yAdSe!j7n4TW3s0M>I-@-!T3KX;?6WA-nET1%5%aa~8~x}*v&U;+z$s;(|0 zifJc|SOC1{LtuaV_T*5wC0{3~X_r4~;hh#$tZ0`W9t|JAA4#_F?L8aayq^ccDVBK` z)TB0J3!Km}hk7W{<<5|04sZxI^nK)K_WT*2d@Zb2Hll>Mp`(Ku!inWk*S}+GhplWM zT|yTMqIzhy^eNnwgN1R0)XYfzO|BiFWhMKL;OZqp`Q&3C7-^&C z6@_HIzmc)A%R-eVpU`LY_qU_hIzVv=Bh!kUk*c?EA72WhZ4JU9WVDR@z0)v72{g>m zutXO4odSzKQkp}*Bidq=I{g^SjWUvy)4q7_n$ZIgm6h!kKY;S|R|r3`nKY`f8y#I; z5cRp#$H1)3mLLxfq>bNtN5iT$yOjh-61GEM*h+`r zDO~|mPuv-yx-1K@0kT8@Tsm+*ItKGgoruPNyQyD5USGvPNFJm)TEeEKc=J%SI3wg9 zWYe&f6mJIn2FeUh~mE3M;Z+HEk!c ze1?wI&PiEA*btyiV<*OnsaRDg4j(@IZQA{)*+-ScO2ws6n=bE`XxWK+;{J$UW2*U| z=Pv({(VgWxchwo3=F4RIvu6!36py2A6p&zOg7e{?kbzHyoOKs=JXNQa=G7&IK<0H! ztidP)O#BbH#i5pf9sRAkDk7?wPV4y>+YTjLS6Z?5I3}LxEZtI~s>(PgG71BFVZNGB*6dWAa~r z_6goxPkur1~@5p*b+%O_)5 zYrAQb&pINP7r!qt|bEn=dgxN|IK2QHzBId62q;g88c z`1yt-yE;=-Ifwk5R1$e`*Vu?SLbv-cp?kA@xPDP5mLw%1L2Dy$ zBh8hIX0I-es2jb~4|h_qb|*^VPXjyX9FKRJqSmyuBEsZ2;mI%e`QQevPt&GEn@)RY zJ`#tTLGg%{-A0DdLWZFh0({aX<~|zbU0htsLQ+(~ee&WqwV~H2#5?Ysv(+RQ080-Z z<4+6HfN(9q7FFlh2VNqn_8Nr@+wq{NfrPCD--^a$@g!dbGwL&t0O#2rYu|rcvM~|aDRjB0ZARNpbaEo|VxarXz5u5d{2i*C-R#D1iShzbs0poux8yq&+Rx&ocaZ^S63ucm?YU)b)wJ%>46&0nj zLJ_N_GfQjNQN<$<79Y2M&uY!6z*|bn=dzk-$&Dd(Ztj*AJ={Fz=ge%Ap;|xRzn6&k zPbi|>st^n%>4lGPe zm1RPuhbb4S$5H#91ul|JWlfEBO=n|a5r2K_-le-s0$9+Qq$KEBq0JYNTmuT1b)B5@ zovJXs3Z?RL4jEijYL<`xD!?CxAVjl%_4o6+*lK8mnLO_m$c5Ectp~>s5tWsqL-7vX z?+{Ff;!Sck^A}`qK}2skv5isIqec%?ZLiE4MrPT#b9+}lp+H7%>Jk;`lwX*1uhCmV z&FTI6btXs`h16`f<3uNEkbW4>qz+wzPRp_{?nWjPq5ig?iILxrA3q===2*HPHP4gI zvB&iSWlJfSn$ZUVky1yK1_Oae6_VkbcB&OnD(Y%BqUsH)(L3X{0;HoVboBD5%(Z*B z3EUtjFHf&-Wte1}3#YxMh#+=s4$(ICeISzAP4gXCK;I1j2rZ-#P=+EsFZsvsy{9Pa z{*%p@(|h$O?REO~6;$X1gE@pK3EDaIQgnR05g?h@rK$23=Pd)X;aYokJMEXn<%JaV z4vv!G{UrxFo;0{_+7g{GJ39-H#0gH#yapVb0R1(Z0GNm}-lsEelk4AoyYJ5eMMDk@ za>__ewSbC>2yQz4_j4-tB-Jd*9C~hUE6DjXcY)X`38&WDw$jgA2soOOoWr61SJ9nU zH7VbF1SoOWOH_+dM)LNpTg#cWIfHN~6hJpbE>MK%van-!Z4(|fN;$48iaI~_=GB}M zy)=+*5|l@w$bYJLSCo;mk+;ojz>Plxp*GGK;WImiTMRqUl>^$0Uof|9WZm4>uVNIg zaE|Z)VwKT*0&seE=8>6%M9r3cmyXjs$zSLXNfK1u>1w{6ZQ^+X$PpKei%Br}I#pqy zk7zj=%V^EC@GI5wu90Ne`57sFc{$K;X9-)&wjJxR3FNMseu&BUPtw*)!g_k|dd*Uw z&7wQ0^epCQ7r@a^bYzTR47E|245|-$c&sq#hC$PdjEv9bwhpbJRxlI zh$03cH0_7zhlu_Rh}}-Vi*_jT|3cvg+{TA1kSu%g_%5>vnhj5`jLN7I#!5?Z0#_pG z-j|AMNWZ}RzSp;rO|!tUjK*eWqI-=U*`1hae9){YFF%I)A>3$+@Mbp{`2=eA=iDs_ zBmuG4%TcEh6T3OW$*n>&_1BPUnBT|eGF|Ly!$=Cor+>9kBl2VLxCu2AA`)6oakV5) zFdv41wkmPl(U!ReQHQu=M01IVmk)_>@27q4u#PH5S2~1J8QIzA2KCzUh7J??XPo{r z&zszyk2-Y0LXAjbXdGeblmUGXtP5J#X{zE3piz&L2^kp~P?!V0#^oX>9qi43tJW6k zT;g@QSY6v%=&hzBb}m$(ulv>4CzACYcl@zRX0t5y6D{5d#jB%fbsdh^<4U!_Xlp~B z>lG(b*RaOiC~9f+F=l5)p;5Or@p?vziN{DRsA z@Sm}B3Wbdw0CHluW>iBSSV%NLw5RGmcY+?&i;_mMJ+LzOzZ}~&=~(;LZQHW#50+g+ zAK#_)D<2d_2**xbLlFuZQc4jfULx;#BMn+7BpIaGN;5U`twkn0RsCKEap~$MT-Yo2 znx$drQ{$!-v6%JcUVo$pod~qF&QVw!E=Vh!|`n~VegRA9Eab>s&wlEU!g&63e00A9NUX8H-WR)6KAoju(wc(8S@>iP@c2r{k}>iD5ChYzVc)J4vs!flFJtnm&fSZ=a-hMoG(Dz z#X4~orSP9NMG%+spLes@OOb4*y5C}kB7mGh{GKz+bqRgrp(bn*{RCc-qdkEq#&Fn7 z3AvOKV9g(*?**`sl~yZ51ro*RC-vASfj@29n9O2lWF+K=08Qth&`@~p5c=0qHQhmA zfB7VDs**YJQsA-U)^<*#QxP1$VDerx{QZtR0lQ6YDGymImVP-J?l>hPE$wYtg`TGg zM*&>KLhG`8f9N$_7*y+gdFz* z!pYRSXcP%L8uD`f%AaqwbQU1{jg#}OA-{z!snY#D^6()j3e!_ciC=-_F!(wTyzpv; zk&)35E{t&#R@%UTfPur`8=IPl(OINj+?rIr8jZ**6;9mPi6FfLX=rsZL35?@!9eyV z0xHzHT{75{jRvHnW}kkBuPvXU>i8`Jgc?mIZXc&SIqIsW;JZyyZTdH}tAl*7< z3t5jrr*hXW?|-y6XlG36#cOg&DA_@d2fVBZbNbT`oY^2koR>Ut8pIW($Tg{Be4%Er z7fkeoT)5u@s)&Y8REIMN`+>>P-#$JE`OZC6XWFyZqeUXr^CP5a%uYEY#WWt-ER4>g zZ@4iKm&>)hw0fgtjsc;bU8;;InyN$j=ioO1xarW+!O9BPZ6(;HxwiF%q*SGSd4+pn zFmyN!DErOv20K=GJbr9_g=?!0L&G#S-+vm(gHI2|MWCJ7_xt~Ig}t^}e>E6b_FhVj zO0p(@7>s*W1~F9frv-in(X8p(#tI>5BrB)g$RtKJQB>h33S`yl%F0EwB;u;4C$KFD zLUl+4*24DaYx-uE>#2E!D6|N>ZT`9wl?1$z8WRy9o@mzaxXlQ$Xr{^aKYw_SyD`04 z!9qW-onzqR>j-Lu)2{))NoP*_D{2@T8TG7e)(Y77g>9D03WOce90X(vFCi{#gmDtH z|F8mDYHFr$55Q!AzDQit@`5GrZ?RU?{c;pqL1O^>&d(@N2XC0}_0tEVa^-({{8oVX1>gP znh$dy@3D{lx_zGKuIr3-uC*>~QW{+_?x~LO4CZ9nk{3i_qNR{G%iiH_!Xyll+!-kb z!;4PyfKK5 z!X*v+u)R5I*L>4@wAygDYU0=$-ijV}ekiNpW-axkwVpGKb@_(e2_>a2?g11vfGx?V zsOv94;toxr;O?kH51%AEAU!}4hk;88F~?bH@8F_lQhmF|77x}*XV`C`Ib`HOmK5G# zZ2H{AYX^jx`UWYU@Bml!`(yG~(Oat7*VVPOyYDglq=PkZRew5V^L*b=SC~bo7`oq9d2ARIw48cO!O{5z^BGb}_ z6!0osr(a7W;3MDobE>nKsT>wC6so&0$|?w7579rmUuq1wrdnTgdE?9A45LvCOle_8 z%a22Jb`=M!i$7e`3JV{V(gN+Z*{P7?N6FqHpD?sk?${r|kA{Jsit2u822hmxBEh+l zk*jb43*ukoN!&d)Hsn=s#PY3|L=mWIXvmu0!b3;q%)p$sJHdiH0tV0PAfI2>0aH<= zU##uEP#`OWBts`F>IC4+LJ|O$w%w5mgc#@wR%>?kW(1^Qt_J;sqq|Tu5g^x|x1HU( zh&PfvRx8$<5QU}9L?N&@pr+2u$NiZ(^-GVlInvs>VYULAzQve5TXGMn| zl$Dn9fJC;m)5d!<9y~01+R>6RQF??Lbua?}IA|dTlK#Pd1y4>FRDm&Uy5>bg%Q{F1 zzflQoFa13R^)fcg7f5~sxClz1!WH+L6Hrd;f%4+<bgMM+UDF5(Bawz*$zfc?LuPTiO}40Egy4 zygroXfxx%h)&DUkCo+RA;Yo=$P>!FFWr$0m)#8;`Gv=LuvqT{))CxH{^g%EHU#(n1 zOkfAgz?>w=8p|*?+Yfoc-biTznSeS%@b@0~4B!m_1@{5jDsP1tCMZ2>Y2AZeUEqK8 zRp-(-HvJIYTX+4*0fMoVT`HM@rtzCjl|}qi*vF3y3pg-zK}6F5_$zB`ok)(hK_-bQ zACVi-(zIT6$n*WuCpdKo4jBgL_AGyGd?;Uh>n1NR?=&R{g#t9iANk;h^3ISMKpul9 zAFFVK65~F|tq~*{Cd}N9SVOUnP-}WxT{euhX<{>e_`SV7I&X3N0E|I3u0DM5;FT5F z6HK+A|ELu|g{^hJtfB%b2w@DQ$VtoINkZsOjtog9Wilmipr?X)794P+JCdPj^?sE{ zM@tLgru#FRCy%Y03MyKt2s|!mVAqAP%@%JnFnk^B?fn)2eb?d@B+^VufhXdhvJU$2)-Pa*4EBOt)JrJNEgg)Z8?TefQu0zE%ckPF6eRrv?LCbT4=g_%N3E- z>I!Tphb}Le=?Y)Gi`1QfG-kkU=y{Rn;nL6FK{W#W_;D8BxDvi`VsL-7Yy+NqqG!Tq zSy;MY2VWDb$m#!b{7VEKc-a8u#SR{Q4=aK*Z3Y05Kw)Q-Gg?k>E*%o4M%7HWG(~ih zbpC+A>Sln*(KDP&dykPvKMYng3)$@^4xYZRxSl97Eq13}9wYw7rgqjEKcPNavGIv) z&vt=R2O)b_T44nQ9GTa|;21k{6OX`2SRJE)t@j*B5kTbz}TpD3Sy`3zpH3o%ev z{&~bi76g6d*uG34I4&Fzidu9oxWq<1u61%9*C%_+#^?I*=tnw^sMW|hRp7U6LWqgLbA=l-!mSAVg<~XdsvZ7$aQ&j zuwV)ZzCEnKyiE~0cfGutE)UE?5DHWeE8sE*P<1DYJpca09gquSGSEHWr?^xgYlWm3 zMwKo=3^Q^7cdDFA^58FRlmfrVw(EeV2LJ$Ie}V;tS>)IbCwNc*uW_7_(s|!<`B6$# z5FWjhw6ts)(vlE{H16}9LL~tzan`Xr=Di=oj~lUk*+^`DB=B*;jHedjJ^(C_@4QQ3 z`3Unbq&#DVI!mpAbsO`Ay8p}Cwo7Qfzh^s>*Y24=J$~iye`zS;9YoMe&r_qtVM@?O zaB2m3*Ghi1WyeQY-i%#_b^Gl$=`W#r>j^>2$3j`dbR&CU2)AcFwh<_hoo#In8-D_B zxj%5;ljj|iSi4vtn}|$^ot(ws4J@>|HrF0MKyn%nNiw?T70jgidwcIWSUNd5K|FsF zK*8@AxQhX+gRBald8VNGRwO~elkYd^J?^Wiseu^jNkG0%Svbr=Qg$3QVht1DOoc&( z)Z&~Z;F8C65vEX3K6Lc`nUOz({E(f6M2Yr5K>$yCS=b-OKKfQZA&qxnyfCCR^^!=> z_UY#lTuQ&WPnRprS&%CFX1i%s>YRF3754D+_sSjr_2T;8j4D`^^my79o1Q zZHp#&3g5#?A-utQPecM*EyCVRu@Hn|Utza6P^y5~v{-HmeGkwHSx5MQx7yB$33uWa zQTZ@lRa92edE5;E&Nen9MM&vDuXoL7PyFfAtf>=dNDjnded+UdHRT}Ib6>~+h8N$h5->P{sX#ow>^zg;_$#6BYImQsyn;*w71B_LdJaMj zfR;IGWo>S*%wyO3ADrthPkfkL<~g)h3v=_=_dYKNR3ejCn3WEJ4~LJ>DLi4Y z$3rY?fOXX~1|S8{RTDv#;f@O|KX?8N8MvJFMA;EEZl7 zofm!iEJvt7_T3^Q-fgIAqY3jB0IyS{E+E7EDsGMSRUB%?am`sWnQo&N4O7!>^ZBlu^2F1rl8Q* z)N}=q9NG~`ejRq5(7z&>L+uWd!iioZgX-vngakq#`;iY2b*s3%pUu<2AOi!H2rm*z z75>L0L);DUyzmlGX@e>BmZs=2tn~Umw~J#AokEH0PVylx^TU>+C*~v%X{|#jD?xc@{BoXv;2$=s}z>(mV4Rp9bvaizZPvCQ4Aq=tcM*2=} z@ATqxXu6Ow8DU!+A)&E-alhx!0m&19zD4^QG@DgZi%_P6m-r1J?=}?x+y4*bFc8Vk z7x*5WwI$Vl03t>oO<-YS9spbk{yIy0zwVlnPC{i13b{KrXVW&!*gGJAfDBg7OCbmC z8{l*m;AlRM@2e5c3uryu^2vKEw(+oV!Jeerpy5)p^v+*==WHU|7445jvH|dkDb#Qs z%V4iq50AHWZ|f!+rLCJj3MoclpmowEehp0E1l%4#Ck%BMm=2NQ<4fpY6r@G!a|I@l zxiS{w0WSlU`wb>8(20VAw0^%gP%j?=>;dW$0$0az97<>0s><{z7=j@UK2-70KRa(+ z&s7(I@)WE|CN=5~2y8Bk8axa~P&-663-I|aG`8Qx^D1WJkX#QB-g^2@%>sh2+Dy^` zzDk+^r~_D0g@%MU9DM{+%{stlMNW?#iiYIG&jFhJ7}fs$yB6H;kIHGl)ak3GNC1=< zpy`DeU+K#*D46BO?J+M|1)3&wv@j88^>2pJyAD*_B?Ed!gzjhXFk?n(=?)CtVL&k9 zU6PupkXZ$dR5DN;0BG&mKbK5u^H%Ny&?8SF#P%(1v&Im>PDKD+fBM97mYONU+D)i) zu+fyR6b&T+K%bnP92+~()%6N!kDyHfOFuC1Aia$CETkO#Y&@W)280%d%FrT!$p-Wc z@Hf)aX)39Hai0O9S}$O3#{@fcfgc=rwe0Q!;Rhj8LUcAWW4L(>0rL4}0cBx=zW{#| z4rb=7SFS8TJ_q&_I9yMUJMf~pw!5Z*e+qO;fc`=o1#@K>DnV+6J_7DO`&oYayNTC7 zbTlQ#q%%LCfBx_P6K)z(PZj?Hq!|%j^Eu2ykzj_6rbn?#C-+vg{KBs>V31+Bpn1}a z=AtSJA?kr)32>e6VxWD!`RgVUSJi=~IU8q@#|N`;N(|sQ0G*T=`@FC1WwcvX;PVFB zPnywlf85~*MyuV5%8y|A0Ffk==Nx>0H5z0WH0=Z5UbE#kPxbSZqvy~janJ0zzcc-l~+S1`*{bS$~|>m&0nx-9t`NJWqx}Z^{YHRMKf0KzG?5}mA?j} zf4_1bjps}0#zsJNyVDM<#pNR=?t8V{Y1wg0$#vCgsDAUK@nw;^c5!quv(ImrrE_JH ziBe@>o%Ee#@(I}}EUs$bFXLK#zVjGHLH`~p7sxqLF(wWd#agljCwoX(c$V}XM2fEP zL|0Rl^fmMTmp#m1-_bf%$f~7AuiNgQWWg}1?k+0C{?KZBUF<&uWZ#`T+U*l+$+)po z7q))i&&rxr)lJID9M*iRW|^(tDXXI6bw*_QpEIaA(RIlCVt6CgC)P1QA&nrmF4x|m z-#CmC!>{X!mG^e*oVlyAc}|4Qf4R%W17)WI6ZUH<)(u}(@*?J`^H#I?tqQaf1;0lP zE;YWSFlYB#`n~BQ@O*f2>I`ZB_xDyFSy&6IdMKlku6x06@JeFe(6IP{ead+>Kkc>} zSmP~f_P+c`>LiwX)<4fn_y6+4ZL8TTCh=<5(ZeW1BW?jm$KZ8}CX%=}z>>LUwT*X_ zv@9fBio*lGw_fjI3N?;eQlfXJ7KG)=*_Tt5VQzKW094XT|8$ zrGG{$XJLYSE>UFic&vE~GZ;5kzh=WN^5^$o3hzq~_DF$>3!<@L>#CJfJbKp@UNpWi zDRFAFf5J|nE7~vl$yG>&hd+}~K)*72+i7pd$5eG^z^qvUyV!;zOYz#)Pm){{vFn9Q zii4X~RvQCmJ|iBBHk~%bSMC>Nxf>burv;Tc8Bpis3fKAzI6h1M5yu^3`9EGewU0qt z0`-NhbfT5%jN&G1L~mxm)91@0&yS9{sCvH5JTD=_j-i|DK07HMc`rfL;D%4Q#V{;cbjg|vzA#CU2J=3D4z!3!mTfOP*JtDmowE@wyn-WdES#vi6$ zDxQ*j`oOEQ-1EmPopDRsg`+g;%c0@R>};oLt}f3C3N7^W;VY(}&)Ma+}rpH%m|2A0Vzc;uIzSDjnZT7kpuuT|Q3(G%eaeB;-T9@hfx?W^B zG24JnC|%C}4D+dH)&xsf%EDJ3RajvEXy(sOvHs@He#}KN*OQHYp54xDN4`|DDT))@ zuP-$6J=rk6a*B5l%}CQZRpnjPFN71j`qutTEphf)+jrgOCwT{~YmB>Ukp#TPAulHimrla9z}|dxy$e(e%2k z52(#xeKhK)5um4b^lZ706X_m)?Ng`7Z~jlV^KGj=p4g8OFFxlZ>vOMuE!(ZkBz`7u z%IE24;{xbhYXiJcCoRC_55Y|O?@T$Xg*{6LY8Iz{J+!)-Jvw5Os^K@~TP)WzD8bSR3J?gou zaunWKsoU+(e!Ok9D#By_*^4h{;{_S*;$81L`M7M{yMC0acggyRR+sr9cRP$ zh{zoRef;6Ih>IH~ISRw*@nkP?u;i<$ciipVT>2K+Y|tU_>ijqGqLeJNh1Fu| z*&@P7r!%{Y-2xS+VoCT!QF&%Ozel8vu^b2k!uF@f3!1bJuv^$-!KGr?0-g9)|jdfMe$5V z2z6th*l1GcD3>u@3%$SvJkZMNvwVK@}4QqmFAMl8vkY92MS2OB#hr~JR_rC+tMi!O*Mc;aD0*Ti>*?r-!S$t99*%?Yd3-2Id8-Q zA4TVf6u3$ST_p_3sI49EqXMJVZ&c^cpTB{Jx4>%skJ$d~wv@Aj7+daxx&~lerTs3Y z^j?Vx`Gc?DwwEL~!&g#b0OYsxJqB@g`YjBoD#%^{0mkK9^ghbk%-N-GtcFo16b_TEypj6sbBo4s} z{}wQX>DNUPQECN^9~&DX`fcbC0jyT|&GVndAX+5>@3pCJsdlc$NN(aLD{N*2a-qPs zmCjlCcyBKa8|)S7;u;Sm&frK^L~Yv{k)D3|-!x@Ll&C;->z1C54(MwD>B@`AFX=2B zJt+Rc+S=Y;V(QS)&@htR&P^J&Lw|DV;>9a|kBf#tR00Qdzq#rbV2%L8SFnd9>#RjA z26J-o&~H;w`F)Q8dvde?mFrUyL59>w5(=|&ZMpeU)7ly63Zr6UM>N8ufTrj~-N^(S z9xb==C+5Mpk(XDaQu+D|Xq-hv>R?^~k8N!KsG!fhy|a@j_MK(Lae3AM%C%%o3w(OK!nz};-@b%GoA z-~onLTH=2Tla-7%U(U9gCNn@bQ2dqHox*Oa65^j0;4 zWz(+=13YGTn~5nK#OnY)z~6!)*G{}I+$ZpEOyJ7}kreZ%ZZp`UNT%6Lb<mRH^ml?zXn7Z}xv{aE zmjCZoYkvb%$_29$ZM%n04$<4F;@j!y9CZ_Iw4QX%21B%2rU!m1Fa=%mOM6~e!`ouS zqXDu`d^|jAwt@bBfbG;f5O&)59+37PkWdHz%LO1MCzp$zzy6;p$v50Uu>?FkhI#wp zhB;6J5?pn6qL2~;-jY}o2T8z}07fB-h1(9?O)|A;I!Abib%wZr1&#Ww$+E+kqVuGa zZN#Dee}4?kfw0LoUdE;8Uru~Sc7BvuDvmw`br*m&c0=YRmAvcrqN2WD728!$Ga|lP z&1BWUfB_Ca%Dw%4kUsq+;YU#Ke~%O+_~Y*;x-lJPDXW~o0n+wiw8I{{ipnxXDHN)9pRd=UjmGm07N@%U|JaL z(##LU&_SCT2oUDRolQ+rhxQ>ZSXccX1ANR&1%JKyzdfHLag84Pc#}40#K8hJX+K5> zyi{Tn5?I(ES^_*9-#*(zvh0EdkD|0tM^`to{5mnQYe|Bml~rz|A+AN=0iN6BhRTGBVe}L*xVe_2JkTqhuLmgcXGm)!L+5gToK%0K_^^3+A8}w z^968=m$~@TjNI}6`(>0K?~5U2M$YP#%EEHQ!6A$VG9B=5Hk)D7-jSTR_;`ytynzn0 zyLz>rTBx1P%_91Un?rb&P%Jq5hW}TMJO9AF2H5+Uew0XW9vB|JnqGL9R31!Ejz0{- zwc0Hj(bLk<1ma16dn-7#3qyo~h4kbO36?*+sjyMi2t_{ZTkTqMd7czvQ#S)!WY>!A z-;(f;JD6OIAZ$q|Aa}qpfVcfD#EH`5(rcD>s*cJa_u|D1fYj4Ie^$DV9{C+&oT*Q# zbv)#BFjNEt7g982IEWC8jCP}}V7AM{vtv>G%i4g>?Y+87Svk2b||T@Xf0<1_TjE zI3^Mj=wWB}dZMP#j26-(JFk5sa~4p9s19Kps5KYG;0AUrZSPb>jR5fu{C6QcExQao z1k@LzL#cN_flw+LIr->Ne(&X{mONy+Xc&H!9-_Q9*r0`zF9mj;)$rY+CIBb_F}8u7 z0IY5$B_>+w-{Q36z(i;1rtxvlO_Wlg&l&hlrka7>v40>h2`dqdDHQ)0E_IqlohSg{#7rb}1R#mZSt273o_Uso!{T~)duTmxT;rtbpZ4)fpD z)8o2R*gxS$^I9GJ@vkDt@IOq7{!GXWAshi=C`ipqvNJna>HJ}&+}7HPF7{`06RsBv zoPff^ajsl3xTNe_tiDkQzuT)7x10kFr-tIm?t5K*HF7tbKQ?BjqS${EOYJ)|?qa8tfK<{-xUZGM*SKfay7#>9N@_3P48XZ5(ab}J_4JL*F&4pT8&Gf&a6hft!l ze=l0tyx#X5AkZF@FNqM+((J5>9VC08L$3fO37A5a;5cFO7%UZ(`0Ui5tmmm57Co)` zMW_R7k|)_^WU@#oUJlZ@s@k?nKPx~u= zLE&^arg+G*`26V3uth%5y+$-n{{)CY6XU)ZFP8Q?Z=)Z1nor=$fo>dW4USwg4<>imt^iS+TS^->u5#DfcF4+Mqu9coPMOX8641vW>2AN>F?1#qf>e_GAPrp35LC%C1|ZoJ^;ClZaar_2B9P$*;M@#Oh7^bMpPO z5wg2Js)dRNXh!eger@8>ZCzbR{c+`Lm|BrS?g=BM1p<|d0DRhRZ_ys+a_h7RmBw zf_y00m$u#gV8>J6;bPd64E@WKJIBCL_J)zu$~A?eDj@%XI>W^0Guv5qr5)lbhf1$? z!o{Mq!{6UOcwZKZp+A34tBhNxHsYXngULN~DAlPI$18ZiITe1%OGERmvoqq>NXc+@ zbZM`u1zz=Z$b_w~ZQz9BS{H{^*RRjxJ0i4~n={alC%7D|?{P0BDYRZhSu(%~`FO)b zJl?~c+dG10)ZG;2f1W;y&hetygKG=>?x${~sbMTnrD+`{#lO1e%O&EnRkW8mF?%2V zsaoVZe`V~n$%7bP1mEk|uYU%q6UduHHd?6R<$rUs08(?XUt1h0TLbC{Oj(~Y!(UYB zgQ8uyujJSzs#N$0@8oc2XnsDKZe?rLLlIhLSgYM>&5C7(P%5gat5*zIXFX)G} z`<2BzxMF#DwS6#$zj&Xcrv7=^pU!#nT7DVvW*EV~Jb^TJEWnCl*8$lk+t96mSjuAy-ea*3yEwwzZ z&6i5kNVI}Hnf0MN7RFMhmC%bbR`;ENp z=|2?My>L(J$jN4Y`fVPASb8K79l z)I^h@dSR0KtXx2=o$e4=LnyR9TWJ(R;1APncK3uapur9T59rBO;lIM}3RY@r1pY`C zrnD3640%7l?S4@VUG!YFKG%hIS|d)d)*)zY)V zsO2tau+VV%cj`-l4+~1mfo*nG}aT!i_)^ zeUmOqc^yj7FO;2|aMOaa%Iqi9!>5#bc{4O)N=8=J9bA)QIk=fS# z71hto3@^8T#BPLEeNB>9IL(lpR|}SHcy$`hfuQ1OXdE9MI{4rjj}HM69@6_ySaWMb z(EfluW6gHI4oD$D&JP~G+OQwRm&f(xpgIbw)yo=R9|5+(bvEEIBuYSz1>q4SjumUovVuI{ENrA5?eX_yhL$1 zES9ZxUk8YTrw61YZgHjzcr&JuMSaD7hLa!}Br3{F-P_lv>pWzfHCQ;X6y~F;rYFN>|Z5&u_g~$Bc zbhnnGi!5*6cQN`L-|=CvQo={`#?L1oqnnCfYL(h2CjNf(6gTbV_rB}%d!s(Ht8+Hf z`d_neWXI`cbar;z*5Fd$dbRR4HS0&#esRU(Tx!ibTrHRgn-ojD!E;$Jh$&$~|G!{-s^ z+4({$Lt)|4VOG~%E>ro|Ot?$Xd}6I)U7XkIeFwFN0rL`nz$HVofY@z;RMri|n*9+!az6P)^d>y%77wF`wGiNHd)+poFChidXzb-PFN~^w;G#B(SKVLCPVJwK= zCWiLCQu&Ke+9!e$we#4XehJ=~oA}nZiEt|z=4qb=x?)PJcCWAL%H(lpIoUh*e8TtIIU)ye_unn$z(ERt=f#mqZnrC+XPZlsL zb}E);7A)+Ee!U>MhWb10tH+38(YkT^rwOFaKuoztA$-)UqF4j$%Ty(^y*}#KEwEb~ z(D;)nQ;=vKX>r4-?9%gR2E^p&m0F&S?*+Ht5xXv-9M$?04a`iilu&)hgZFeZh?&OWp?<`Tb)n?oLlGis%*1^>N?zR8jfSbP2W!WV4Jt*6 zJqO>XEHskmySYxaf(r|O+CCTOYgR42v+FnDA$>!Ro{+ z7ipy5qe0wdYmDMHhgPSZ)9eGf=0&@X(97p5NyI=X3#||swUk4D=nhVYLRGL4I0*g2 ztlHq}sz*=6N}X4<9i@@%+QI`^r!g{_Er4LGS17D?Ejh zC)T9ll4Cy8@SqQ$g^sFlo7uGcE`wxgU#w$QUx)ZfIKCZ@c9WAczO74GaPeFBkY@ht zV!NR-M(<g-)`8m&57(8IzX+ z3O?**?+RhpfLT$9PEgfS~7r8WsP|W%rUL ziV2qTy95H+yJaU9$NmB#v3k~tAr2;je}-bUV5ARX_H8hxI)UCzRXb5K4M_N2TVTxO z36eFim3XdxU zo`^sR<*mcxjbxog(p{WW)4b8-)T4LTe!%5g&IIjs*?9J|w-wqmafk-bldKT=JbXlh z&3ms}HrIizq{F+@D>P7Vanz&2%6gq)Nl^cB66c80ok1?nGGa4a_wWOqM$KaG-owbB zWEw=e@7}+)^M`yo^-(n&N}MAiW?GsJM5np$zuX=D6}ZZ%Yu7UOM_SxK1~pNAJl9v2ZH7OY z8q&_K-&y7Q_Tun;uci1higoTA-D|@xL?%OdpW7SWaq(cxn|uVC=q_B?NyO=1#OZ$W zX;5RwU8Cz~Z0a$1fv>VxD?NJT_xGVc0Z#-Cl-=wjcj z4bB&12zj8A*IWk5Ubsgl`L-3fUr0-|Vks?@;+raMQc6!8RF7h5Yb_Wz7#?MMS}UB) zej`W;)#Xxn$Llai@#tplti#dez&kf5OqH@u(}Tk&Dfo+31j% zUU!|oqKqH;#xGf7ouq!9JNa_%DN9J_g%9ij&!$wKU1|5td`)uT=PxRNd-G~>n0cd* zYxt>tv;NFN@(<0DE>!e;>~J&VRX>*l;b_@!r==?^k}+|XVT?iIPgG64s88SMm(ixND_q~c0Ooq0<-Ef5Zv&MqDRUD#)mqjE z+wX&69dX&ptwVHQ;{aQ0B0<*Jt+0(2^gx)18duzYd z(RA>o@9H2V^r-mwD%ivuRE|3kWHe6LZ*;@T1le;f;_?HMR9dMs7#6vv8}!n~;7|32 z7%nQt7~0cz6LEB+NAlKz9)olD<{d(FZ|9*n++JriofRj9{Yu$wjrBO}U&`4Vxpyi%2tJjeYY0kw69- z$(?dxop&B$e$3uYylr?U>NW#$DrH|Jq89CK*vgM~Z+ZmI>+W_RuNuw0ZH>J5aF%`h z5~1yI==u!|akN56k}P`Fd$5~^Fc@Ck0h`k8?3}zxfSM75*Z=v-hOUp1PQJXt5lPaTvJq-UKnla3qk!?5j zg9+L_y}IJZRF4ct3MFp5Jj}qrdyP7(w=SEKBO5<&E%mH_n8X>cJ4g3aGsdA-D&v-2 zE@A4fgHMQHP0ORm9&9=@wJ#YyE`8jX3RLcuGhy@=s}FuNa9`C=c)>$>+S+`O8gLs; z66{SxPSztJ1MGopL?y4ns9+E*gDb%70V#VxG=8?qe6!2|0f(W;x&!Pu!@&Yij^oxt z^ns~$8fHwY%s8+=0%t5c@}3saZmKQYPvfnmkyS(dwfiZZ>x>hwy%X80%s{@+GMV25 z6hNz9&E&!QG$WI+0pn{x<4NlA2M%I;3J=!?g*y-1p)+HPZCh{zQZx~LCr2;SEWkEy zl{45>=2y3C2G@7j@WW8+TZ)N?Q45XzZj57({WJ+SpKmO!37vR`8rI-WIIOJE*hP&y z4J40+R1PZz{xq??-u03lx?hpw1;u=jbONKk#y-2{w5fq$vaQ((*^(zkDRJw&$@pAef zrI+EGC4^K=KMKElQN<3L2Yr-?jeJmECOOadgZI`BU-O`+POHUn8Df9 z;0;IaVXVhmp0_?T1ncGVo@6O8Y&BARRc*P1bLshehNf6Y|7Up}@9GK;z4nWiIuqB1 zxM%Z+*vU=y>#Br(s@4Jpbu&8aTJCW5k;!$TjJ^*n6It7NOGtR=N=I@FR~-tEEFGYd zYQOR*Hk;XYgszKU5l6d#G@q~mWCb`UoPs2ri3{p+D1*vD<0Nu4c@2bF^$bY9Kn^(@ zNEv>wK4GwZE&HiCHZ&e)-R;vdr}QCWe`I>W;C+!1Ah?wx4yjaocf zn)V#pN73Tm+~8|cdGIdqo_d{cj$m?5^$&jfg`lq-R$CS*n6l!XR);A@t}HEu`0zjg zqT?YBy>o@S=gzWt^y!gJvky@afJpCRcoi-R4B+cGW*xc|gf^wuIj+R&^xb$JY$m_1 z#`Gw|{drJT(R?c`*p5KnFEb5~zENOfCs3rlmBxbPX0v-!*|34GWK};TcJc)Y7rLW? zEn&#aOsu|Mfng&8qwJj$f(l#&vP+WtViurGcxivJ2YAV?9=yTFK!@75bMETP`%~A5 z;jAmJQhzN|QSiKxD?V?H<=pnu$&-shNacm|kA>VUXSz|@B$Y30q}M@hQgM6LGjD^+ zft&RA{fFBj=n;!tT($gnv0Jb{u{4(XRZT^tP+%+*RWOvGLLF4`>MmAoVAYMiTcHDA*#FYYZiT}w*;iOx_fMWQ?H zmziXXiDT5^Dmu}L^>_RDOD+weH&3p7v8~hFU_^JRRcg{W7JxTtT3$VE@TSH1FVM`yYvsH#! z^U!2fE(Nj-wB zjbao0N0(ZjWQAYclJZP;Riv0Ct7^EFPmFJ*9NssgIfXJ>IPYK_UHiC)7ei&ETCx}O z1`!7ODoEWYPIk(~^;D?NI&b7eIkF^_q2z#=yS7W85nR}4$Qj?xpNNAydWD)u3Tmjd zqV875@L~H;#b_c^!`g)9Bzg zUybl6(sZ9>y{7-oWhU#$_c8ejnhL(*IS$%RorEloOWe=T)WCWEWZoo3*fopXpL?Dvg~ z3H+0M>z{K*qYPufwi8F1Bcnk-^_&t-7NBE->1mq30-M)pK4kt_Z9$47KTb)AbbbS+b@lxU#P@>wsX3)mm_!_&o{xnP=_%uWvD!pg&V!Je9FA` zn}F}?TlRpD1TYDx?(=ZPvRR~8%duxIy5zM;z4pB(uk)I#;hO>TEPWNU1$>tK|&*Sf*YUDYJ+p7tDy4@C4&kCTm-@`)tjSe1Z4G9@c3302`anY?GjSZ%r zo2Pu+nfkq>sp{B6nzus?=18R1lg%DS8|4$D2L2rG6gja^8y9ka2!AE}ifSW)Fm>+4 ze=hk`g+tTO+dSpO65n{vdA9S99xTY{XRs4z=M~B%zT^_~|IhuAct!U60LgK@9scEX zkwM0pi|iijx|TC6I>8nOOE-=UWaI({NGP(Rb0~feoo|tNL5kd@M*}15NABZ|&xHws zBwe;|d8c|s=xpJ2EBh?%BwgSgWG6LOsUY1v&8amOWS?FCFc4+7x{qpHe4pRJNrB_iJ+>g4o0wg`zkLxH|;AwwKb>C=RHc2N+(1^>q(Hx(1UK^rLc`|Lx>^ELkR&792~r^n``-) zew*T*SKJOTN2)I~TdP*?WIx~*Pd+`(wi)WGT*@C?!&8=SDQVwd4|5B#ef#F>-!SC+ zv}0-=Q0$9S@Fs8=po`fep_Q4K+{o)Oyn}b%P0Nkm^?Yv6`Gh}SpEp&@=wuA zx2UB63jH}EXtZEBGCJm!jN6^{SVIYOsdKy_3Z+ve^5~@VBxRYOHjZpfpi$%2pG0#k zsQ*`MJFj=i^P@Z7Rs-X#buiHUG$9w;_VV>VNyv90U~a#*Ryd-WE6Kl{yct~29nAuB zR3(L>ewFZv{I!fx5%`gLStg*nV?cY}(mQuFn@}DM(kUyxnLTz9^N1OkJC<%=DuhS!SJ|gcckmZ-< z0H#Mgckd#*j3O3;z!wQU2R~1IP3(GQRaG4rp}s)5RKNu?G)8dyleWLk@Z z`ljY-i1NZ7Z@?}z0@(V|6KlMr-8#tl^+OPFoDp3%3@Bkx4h}(GVALdRO9DXw#Pp#A zz%UYhL$kfJgY1*p$?M-&q76i~cW?d6?OjHM^7tWQ%-SsBctlee(1)U~RdBSa=M~{m zl^_?{jcdQ+FwpjM0ML|fJ*>q~r+Kw%NlC^Gw@hRzv@YOkX;EkPPomKhv86uV&;?QU z)3>Q1W=K?&lLfyOK(r5`^FbunK=wZE1v?n9A$@Thx*w$$D?44bScdRQ^a7|~hAgwJ z19Q^H;YN+&<||?;{Ahs=uih;BXm}r$5zYPn7VPa-|AKGP#_Rpl_@n%~d(4MRJ0U8? z)L{>Wl5@!I3O>_VukqQ=#s;9r1a#jQC8C>XB+@@>p^ivdM7D*ie^IegI#R8-R(Cv7 zXTSh|a)2w@4VyA0c09Iq{G#k{01U{{>%0VFDB5jxw)lj_UY)ZNh)VlO*6sJ0UV0g9 z5rI*d-{F(59<5a@RefFc=1SvaWO#Y=i#6@dQk3awezuK$L(ILMz-M#Ac&yRd=_R?u z#^RBK)UT!fr!E7X-=ME+^#!i2( zxc>qEHyQiRh-Kex+e(Z2cxpE7YqG$EtZf~XpJ|x$2WhGLcWq9qmK^pcODe81Z@Jy` zlnDsodJqjL5wbxL5?0V&B@z1rT2$)*&I5*U!zhgaqj%)jWg9Syw41SSb*>U(6hrZC z@1%5g(>OwTQh^NkA`cayL9GxhOfU;U(j3}P@tV4A{UzQ}t?Dhv&oXZ3PXCbmd@we3 z8Kf3D3N{89n%Nfh=-fY%4a*4}4A1IDk_QS++pdCdXlQE*+X~5>!Kqd!x1V#ZQgVJh z@EqT^dS1e))6V6tC*5~Gg>iTA5XLTT5ZXr5R+2MYd=rC3{nnn1qw}p51IhBcw>n6h z2J?SImSNJxEt^d z?}^3=PW^D{{9j!KNjBKz19Q8gf2Ql*K5*%fKeFo~_IoiP}PGFxt5((P#_ z9f+aHeVvMt^AhHt!2^2mGL!bltG@xI%rMgjlEcJFnTShmChCf=d14K~xxc?X zyxVZ^pW6Oag-QE;F&cQRbm(I9tEgm$a#5!GhB=apQ2f-ZM(wfc7iiwG!O7{FWB!?Fpb>n&k~8?&2e z=N<*%hrJGH;S$T|(YLrw#pleNIS$FA7|S~amgL*)&_x!vuO#bqUf zX87r;`k;HnGs`IdMtjW<{yCpmA9=Sa4o=$|47f>XuPT5ys_!~^F%-T+j?dl!712yB z^T;nJfpSiHk^laRx7wZ@raY$mkMD`rL1wQr`~zo^lGw}uJEIas4!T9(h2{^O-|@m9 z$Kr=@X1``|R7EfGPXQ1$naHZzV-f@NTK&H4)vA3nI;HA83fvQ)#fopFCOX!YLZh>R| zk^>c{%z?;*@fpJS&Z5f#1`xjest>n#h zbF)GNV+PHyD8oud+baaFfzQ}Z41Nf1H@l9DuriDZ(@0GAA*^ZybLktz^LEs%tsctZ z(6{OQ#I9N@xFYjAz9wL10YH_Gc=QqyX&!8bT{jE?icI2{2zaRo|3(Lyi;B zFgaLgd=;1V@5aCYlXAb4BYtvr+K@QUaEKJa(Wz{e4`;osq=fDy7pv8~x7ksj<{ovE zYQJr1nxK}xz^ACP_VJC~Ol>JN&+7dQ8V}fzIT|$%l%!~(42l*NJT8+wbIlTtKPF07 zzlEG?S1*&R4As+CH6#%Y?=ldHT-082s%X%ie320-!vEkGofKyTG9w#b6(}5VQcZgL zXz8THbx0{bxG7zXmm4cXauv6>o8H?lU^KO8p|K&pQ|sWA~6XC1@_jKIO2tn`!p9s;Vi0 z`--_gSAfA!H$1lb=3am952VBWOI;y4A|c~JWz%Dq%zT;I(Jm!I--Pm+7tMypmHWNi z-$LEvZhZQV^1egbV6r=g)~e*0Idp$`QfaiHW)NobR3uktH1_14(>_3>kNRp{e&pb! z{Z~2MiQ8N9nx>17X%KpEPR#@2yx=vm1hgr|B3V)o9sviV)fVeTklP zV6|o(6N030qH3^KS#S9w$JY zeni%h*((cY?0u|+ZCI8MKQ}e zUN|<|nGCJ<PQV9hHLz6-=HLI0w!Vg104j?)=#Cj3HG77({k^vj1L566)X4|YwYj{DfilLm zq=b!SSF;vnZ!K-`Go?(Hz_J(8rgcAB@Onh(A{6>=7B z0Ei=@x>wmb*(rV8)I!y>GojQ+RS&y%OiN9T_lr@UVoo)%oGoDb9eTe(MPo}KmV@XY zBFg}DW*2wDHS@qGIk${Cnzi`V$SMs_#(+qA;M|U6fj`6+##AV9CeCibP3K z@jVxkPE%g^515LXgoc*~@LCSqt0seZ$y^o-s;a7{mQ6sG4Cola4dXsZ++dk5C2%C4 zt2ik{0)KtitVyQ;9ut7?30zhw85zxJYbU-$OD+;$VPP3IBCK>S2$V2Kk;rXB?XG(X z_+eStW36?A1K%dBHAc@a`v(lUH+^tQv@kcvzW8*x8~`Ov&BPw#rUE#eJShbkFw&=- z{2#IlZEkLY0o}LKS~QnAkjFp*RicyZZQY+il!+FIMDNBRTpdswe2WA51BPeu#Kss%gDbF@0qNX1I7(Gb(2fS_Dp0kt0Nx$UzJZ!c{fDy{FDeLFyF>094r&6H5*j z;a`BBf=-sq7y{-OzLI*#?*y1(@z{&eVdS`bA zBQ!I}!ruQ_h~GQjA#Ssu@jBXs(RzOAhMJi#Q*-O>=8^=Nv?*{6OfE)Br59NLyNGun zr&u|%UaXo6?t_V6WF3(@6UKrGwfGn2;oS26`x;vy?u8(v50I{m^>o80B!q{wm*US< z|K%J;fZ}r#YWh(8nn3Sxb>tom!~!lf>O7!YPeIVx5ucoAq0kf$_rCZR@lZ}A5RoZ= z1D4U?!00YgJ9Y=#`{}_I_S@~Nr7F!j1%P+4U^TG3B0f_)wzB2iFb+*E2nVOl>bG?- zIpQKpFHU;XPY3+jIf&@MqsY$8gyT>@O2b~o^>HbLl1JxGQ~8*eAovSQE8t{18VGW^ zU32nu5qB|Dxcub502{K6xz-hQEfGz_i+3CErPdFZ%$?uBVejd|4;1xQ zeLq48ym5Lt@_Z&w(&gn0rnvCGX?plEh%0<$yt=gDy~ZEbCf;r~LR*f}`Jz~2Pkq;O&hJb%_bIyT&tQcqvOZJGh4e?3$|0f`q_5$4(k#CkaKI4fs zMR1fWxI(6saEi94rC75z&tD6$M^bA@{TM$d%SZ7(Sdm0(p3&<<<Y6>f=(U7Tu z#n;s-YRmt-PYNP$d&Mi9o1x8^EmoTLllsrgZ!AG19(>TR;dgEAxgxg~X+ZSN7zHD9 zz^@!TOLoPpN;5ycoY=ofRaI4<4xi~l^JRoKsH~i+m=jUF^SU-atsA7HChow*^n?%G zGRBLllf#Y^&}m)d+yLhlNANrdwaZzA0SR{?uOH1m6&M6ZHn_Va*4g=uoD_>P=nm8?BZr41h_vrwp>Ia};nB3WxB>P;Eu{XR5|FE0l@ z?}`d%(*+I=4!TbDph=hrhJn9zR5c2vfX)3hwG)hOAbGn~VNM6;J3-lST_~fg9Hy3mb1d~^l+$bw?*#W0 z4e<2s>+0G7UyH_$@&6qsP0NtUgX!CEFkeQ*(OQ3iiuy9Rnt(=D-8d9IPv)G5D7knA z^YXsXln*HxQv)tQ&1pX*MUkxjX$sjM->3L1Tl}Vjp0W_hYl6j2&gaho9=DvUYbq)# zU^NC!P3@w`*pSJjmb?M61s4KHL#qvFf=VqRzpMuVE3#|KUcb*dRlor1i2So{K+xNE zt_I^9AB3@a!4^(N>-*pv#wO3E6q1mzwB`s@nJK$_AwHt1bt(@KGMFE&{sj}?*>h5F`9d~rhuqgu1YxR5CUj6OzyW@Hmsg;|0Dw) z`0BVszS(5*eneRAXDi=a4mUa)nrFE0z*}QnsGOv^J^I19z|;LS0pT@Wij9-N|Ne-L zckQ{3mn^hhA~P|78B~>g$9-mzKtJ{ z4^0>#>mJNl_JL602$L9;3;DDJ{!1{_jW{oqTCD7JgO(%*94mkC=JGV0h5M4i@}N5b zZ(7@>cCoN69AI};aWT?Ry2-%cYq3RoY%}9>6Suj&PxVTXDVpcNH4gx(t|DveH;#!8 zTqNU`j?sGm-i$m1eu1O4!&NhHe5jWg`lpR0pvPFkwGY&lLnwWH zs2$Fy^Qc=Id@un;L$$H}UWA9f8&h3f4Y`ENpVyZZKPwjiJssfC1Q^43wM*SQI(iK9 z*~??K9w6Hd0pc8CG{}7b$}UcVtP4+Hn!e|3Iz57o=l{2SJaX zx=K9oqjH-(syIbpez5JuP=!b%IvMozLbM2W_VOdhUIJ?6#6y}=F8oO`2WEn&=5|Sj zU!Q&L$yZls>Z+%ort9BnNTOgNvDq$hMcv*Y@)|J*Sd}jhmFABfKBFxBi?`nh(aZ-& zL=ZUu0fGBWOdu{%QAG6qvX>yjXMqF+PH zZN9O4tp~*p6QSbm`6i@~p|)AuUEpA_lKh1-$bgql7H!lnOt}MN2dA)!WO-qW?@f_{ zF@1qfk~Af8Jb$d>0gB z-mgKPi4lzlv+FQ;e?Q+AyfJ)-5B^_g(qq4X?Bc@VL1=DVX%VKR8N3nV#SVP8hi03U zV#a1>3huSUc!H)ALYc+cq z&OAh=tmnM>tw2b9<7~yP=9er8)gKW$CIj`%-QbAucuj^%{q|Up;9Rif3E+c^{HiN+ zda^v%!utO`SDtw_iqo6ivR61x>l-4J?86%>fK=#hiB#wVEICh}@2SVsTBHbZ`gB@>8@a8TQ{HasPB z(uHBGo6?(e;J5;(sUq3*%uK4~RSZg*iL?lXPdvf&wWYRt7t=?vgJ<^O$Za|iB*aNZ z(rVB1kXU*(XggI@RShrMyYP`w%+Jk%tc79@dv1Qt$Z}*P0eTA%ba#hW^mFC!JeMh- zJm$1fVTgp*)nT$X*&q}_=@N0kP*1ikCVQA5S?ahp0l3*P)Ms!|p8`;xY*rvw+kD9u zoFZ&siUeWL-XFO{3IcNl7Dx?c+BSpvGBV4so=KFF8*`tCe(F0QF@ z-~GnT8rQC9(+ehIQ4A_?%=?kYZZr#)97!Nc4x^?K+>jX+H%~fE_|n|iBjdV=0EuuI z!{)s$fTUMn3jh=VJ0fLf1`p^Z8%CWKOKX=w@4pjNm3brUkS7%u+Xq)E9~Z(cm3!F7+G-sF@o z&ZIEC%D1wy=a@L-G`h00!FMN66tLDc22fB2T<0lF!NvC6G+Ph5$gNdQ1*Ug+Y1Lk^$rH^;5FB2asN&;djO5hSv48h^K6> zmB3rjf|dMv^E!OJXF!UujUES>0v5Gs7(F7Bg3n=5SlhxD2Rr+Hl_t6fI%eklFJCM( zt2Ci*lFgd>WkHKqUy$gSy?fRWVrxQ9DzyLBw4^o6Xd0d0>6iy^Q8>tNf1tpSoTRS_{fN79N2}pOBmPYx&ngXSs=7(pYpaSAgs}S(KWo21^ zTn&SDbm{CFiU}@o_|(UX+Bb)k@IwYj^XykMKf_%vJEie`#{(!0mgqpKg;woe$TQv3 zeyn*~QMt-r_zE_VVvd3XK?6&&^fTP^PjC<2Jq)0s1zJKT3$Ox*hK9Tc09{!IP3r6I z7cfMidm?VyZigOAXRB`OL+b=+NW3*5xIGD9fmQdJoCm@f<;p=Z_h?VDGe^q+w#QIy?XnX zqwzTX57#n`b5wzo$tcVkCr4hs_!jt^+;9>U+B?@>AT%AVDu-fj66b@=a7wMhEZ`hM z{FkoxAoGlt2(K*2V^Z}!V|!~Bd&J1gTFkTvZ*Tk4a39vDQvk9`+nbxX*E=@g=|Tn_ zwxu&TG!$Wo9Lx|}`It;N;wmdDrs#oJ5aGCIm^g#J9I1y=Wt8+S_^;*l7SyLX0WIQ$ z_>XA5dnCOWhpB4~@MD6hRI5u&Uv2Rt8{a>!Jf%!likv*~Aif@$jW&BD|0xy#81@L@ z^89Vfv_HcfL?flZr?dK&(9kdw;>r%G!a$Ly90!juUk^bUY(6{RwB_YJT9yUO1Ee<^!y9usx^bLM%Etx z*UG#V_zkgI2Dt5tmmtt&^8vlf&ldpOU+_R@sl)Js5{=sgc;XtO3e>m{B7O7`{GmWF$pPr2xt3uzv?J!;4di0KrSA-aZI)rwX^_4Tbt`}kEJTzk zd3m6sQg1cQ^4_R21BfW~ zjE?60i1~xDz4>qBU`Rt)K}LO;G_rq;JB`k4tnqbhRE@37IPu>Oyp45nQU!FPczKD1 zF0t5E&*Y6wX7kS4>^1^tGEYyL*n}<14wcSIp^D7>+|a<5wU86WYXY~2y`8!z*xrhW zg!;cVAWRpL4Zcyn@1X<-+PcF_S~ighW;{qO6aHM){POZiZ45|}02T}ehwlBLY17wd zfKr7pE}E)ML`{MXSWrz(4G>;GE6B_1a>Q9-2V7!8pRSCTxYS{nm+;S|-zl9Po96p6 zrr|-?9}#|S8eqcizayK%lus?SDeP=*8w~^+g(^=oj!kVAA}|w2)0bLu4Z}W?k$Lc- z653ZSgYuG+L9k`6G&~FK?n6GD-RqFq8SXuBM|#$$pBDz&$V`b&aL%%ul#ud`<|M>JvJ==Ld^KbHy?Op|N7NA48!OG`i#8mBW_T2s_5PNj=a2nYyVf|CheoH@@HM=bVsp{T z?O1Uo`9X1$$RfwlX#|B?#EWhqd51`D*z%mtbv+jFxj-pHc>}T#m`{Q}XsV1@sB$Ez zDvG9tOmYDvNB(>eFmQZ~f51M=qwg(cYVmhSw@QQPZbiM?5;sGMo1%P1Brltn9)Rb7 z&?Cr#^da4Rj$F%I1VpEB6+@1A_(TuR?@m9;tEerXchzB8L&+n#pO$G{Dc^zXd8>>o zGI$FM3*N@BzgZ0ft48M4E#!}0#?}#XApZhqZ&owoeknK3qC;O2wtcf9p2~$i)iw(8 zc4+E9w<{<5mX%gsJ^)D1K3-cPfO4<^{xZ^8j{e6nWMK~|PbrMlp1Cb<{zc0+r2KYE znH+?0BtlUd{W5?o6MW154%)n|s4x9XK7Ce$B$P1evB24dw$|3g`1Uc#!o7WO{7KR) zdHe|9%;!lSzIH!v4DnG;N@|2s0`|{9L~{7c1T_c(>0cP!N0BudP4fEjUA!yTY6Dbr z^;Hz}`*uvm=x>U2&TItEuv?Nm6`maXzN!=fK*r48TRzT0h}Worab?*Ul*&o<5ilu5a#^jhF|V`x=eda7q23@W}ql&gaPI! zBo+#8Xiy7*H3{F-Tt!esds2EUQ1r;Xmd}iZ=slh9XUKKvdUiQ~TS(I4@wgv4Qr?i6 z*45Kf$?b*r6DWGmPlp!o#`(I*HRuEEQf#CSaU>>FS+kuyKEbWVRi@h&Db%m|z6q=K`v>HfDs z=i$A>DI32H#H6lmyNVHW$Zw=Tybdnyx>C!}pFzSD0Cx%F1&Ss}8bFPGVj()dnkAP3 z#CgigG!2IT_uBx=03+-b$=$F(##=B{bfTN}LT#fitZry*+=F;M^GbPWI3TYGFF z9VBu8$_5ru;qT<%Yb$e*zO}U$F{FSRwXBK7?f;_h6-aX0onF>f9)p5OokB4dZ=bUD z+oKf!A3drU#~L3J{=G_8m8Va=Lz4mZxm{Ba$kG+BDWhS%XvI}_P$)w_FLfCOJIMNG zK zG9C%~|GhJ;ERoqgx8_6`od?RcWdxnuF>2eZt*GNEE7NyMF&_IxWfrd8T#Ri*lIRkr z^_aux$r(dWuKx3mo_{WfHr%r2ddkQ1xgqiqS@X8(C*@Fl-W+SiATl#qRRP}#gB;m4 z8GBi&T>8jR>qNhZM)Z1QO5tLleP4)KODJRc=Yqw8SK>FtMsFEE!{(-}8$WYa=xk$8 zW2fV>Vb-;Aif3;~JY8##joEHr`{PZG`KN1arDF*I?*Mofk2PT47d~DKsMtObTQ=S1 zEGjMr1yy$Tp6Q}rQEd+IG*whuM#?@wzS&MU#na>^ z;gDj>Mnf9$9^>c8FIwm&;UM{!C)`%>V@ z=MF^l1;W~ck(KES6);+8ynGRuqorMQy2H|1B^=z#xj&PG%PjbNpLtRFDT6q(vNEkR zXssz37|;kof%?Ux-?Rj-TQ!K=Mrim2b%VGfFXrE(;9$@zbA|V{mRWXIA;Umk)TQMW zzNV=%+O!vOdSJ)J$|_sqh156m{w=!m%gap8aO8rB?Uw;l)X8O*o$HY+nZuxAT-^17 zB7~N`2eV}B_g~!+&m-!r^dv2(qqLsR);PMW zH4$uuhs_Zwt!sEYlJ^jqn;eTR!I#p>_tIwZt zvXT~goiBrVi7OoSx9Zbl>C^&#Uw_&$vK(h_6UgG3`5`+yEG!KEXq8SS5{Ha0nwJL2 ztEAuRs=&&)E-0MZ`GWctYYc~-O{Lu5DX6AYqmTkvoLrJhmOYSE~27?f@SrMF;Jp%(RxDX&e zE<5riMnvG7aSX#h#X_N@)HVi+DgcQqDBP+h75w}5GR5PJb6o|OYlqyrBqY2IvjdC) zA_sv_uLUsQ`u-i$EE2v+Ba#vlMi0!`Zj%xd7Y#wM>(VcZX`hB+j^}BR)o_tWQil!Zf~(M? z{Xt{n`E$y4uE|Ihj?wKc&9gl_Y;!`8_$+&FUCnr7lE2%9*DXTEu2=;C_^m z`UPhulsqW*HAg+QGj0+6hMHGBTf$^$Nz8XE4`3-Inl*>?z6zHQA_b$ z)Vf*T^^4bdUvnU3PQL*BKB$vJS~a%9>@1p!TmO;;nh-#-c^3M~jiqF0sX#fPGl%J{ z26Azamz=2`mvfX7$G%W1MVj8R8gtE`87Wr$_A~i(39UNc|KEr-i)u7t}=qpOKN4_CkhAbtb6nUBc?>>OfPnv@kP0J$*@_&g~8JDS5&( zHcY-tE6!tl?rZsH+P>_zyI3n`WaYIR^7*L1Ck;Pk@bp|=s|;n{3@we8C#}NOd8&dY zCP;?Dhi*W*&G}aG{NM0~(T!`CGMtpB3HoT*gM2%7iJwrc_OD?S_WW6q{M%$?=BB2) zrycJ_+J84HftmJ7EB<(UAtZ)%=$GoP%B&aKc}+Up&YQHSD+y!qYz@X~8I@OXRc0(o zKXIL=L9b*@IX-Erc1HPLwON69E8g_)(=GAU{NHt`KkPW)@u=Lk#5LSSaQQ@jh4e?L zzlK~oixRMi#V`7y^7i4L=j4Omv?z!?G71x7N z94`s6D}Jkf5$q~wdtNRs_t~?`eM2*j~lpx>9VRgMsynTfsfg%SND+8&@*LXZFg!)7XaW| z70Mg8h=~{G=8P;XIx3%segb3xcKy->xUGXiE7nD!m}A6mH8}O1mYO0W6d@oIT0Pngq!e`~?*?t)bjJjw&_Y2B65^_203{~G#eo|;j0sr? zFhzkqIP~5{Fq3IpCnj{@RLtU)pu7PFse{%aw`^gtg1wYIFC~XrP*d|$yXd~F&}lDC z{;8%tu~JxwZA$%6Yv|JJyd96SCDHfSD+B70?AP=uT||ZJULl!HNolErogLr|RqgT$ z8k(A#%F5sMiv)cjT;nB}^e$|PQe4kHkK8#F-1SwvX!{VPtvfs6 z5u|5ic;RMeLzo0Fy1Nz+!&#yr5)fm|4VFD8cDb=Ok6R2K+U{!PW`prD|XnY)Ts zN(vsa&L8R9tjAHb!vDhcGg{IEmD!1%b2Cgdk!_%6HGH}JM6TLlQ+0?)ZIS;9k{e5V zS%@VgnRXGvCA2gv7vuXK7&fx#|&RCs@{dju&3gbHms0%qg zu~89`zdJjVsS+S$;a$N`&?(8tFfcQd5Pt;aFigYs8298Ok6HB&$k~BOMt#aq_6qWz zacphwV71=;%kQ5O&z_r6()2L0+k~vmj9^kVK(=U#YjM_IEJ&`sIX*NYR9#&tI~$%C z0pkyRK`a~`IY{C9hU0HwWlSd9E~35{pO63+Jfbq{k=$1Wcln>3YO)HW<-Gpa4tq`}!#8PP4xyq}$&DBz)) zv`-(^uFvbb%i>jz@#Si$u`@-@-FMN7kp?%~1btw0y~E9!Q*4!*_wG4sm}Z%QXfA{>#oMs?pdNrO1srUkhmN|YtFrCL z7co4-;efg+753Pn=x^@uQVSkvR3DQY=ju9f0X^}tUv^uYxkl(Dq#<>}jPzmCV1Z~p zA9Ww&>-!|8;_ur%-)*@_ucp0vRp3P4Xl-p4mmsjd8#Z3=v-2gjvSZM_nvX?yrI2Xv z49QpQ-x(2hTqM+CS?k0EKjYM(^jG2{QN$C$d>|mOV#~9I-2(ruwzhWNW%wr&aKc&u z=EN5SqiVA_VG7v(`}-B0hQPQhWU!bI+CF!j1S=V%Ke{(ntk$q}XoKU+&{8?EG+OZ> z)OcU)q{D-(f-7QG$(>%MP=guAwbAY28sq#=2!YzM;*h$U4tQlsnP#=xKQ+3Zk89!j zYK>+hSMHaO%`ewidL6eGe_=h3e z_SP1_G?u@v(4E!|FHidA!%a?;OiA`TmF?{HzmoGVoPAx-=HTd9R!|U9cLrnWW<5UI zn3mLqku|sU={8M6-~5^*gCx0dYD>1=`A%wwUwO{#tdDXSf}5sGyQ<5-$P_UQ47N)& z->!Z^dFG>a`G}T%v4AC90T)S7^W>mN(ZFzDU#SUlWm!tI#*|{fPz0n&p$C{Ufug8+ zZ3Tslj0|WWcg;;X-aFmkp4Iv5v<|wWK)bklZ_uOK&)uBc+6|~aT&z%-JG7D)5sOGUT$Jk!ne>?;$362Ij2!N zG}6@-#(T*xJNxR@tL|X5d`?12>JIdD?%VC*AS)5WMTJTxuZfn_YIAt0W-dKl=rGi$ z8WQSyw!S6%6?Gv#j7(C(6#m>_n_OBS(;T%u;|I^-sg)meKM(BqtobW( z-QF)C%y=*fYhiDBTfs_c$V0>P`S1iuMg9h*fm38i)RX05Qbq;_TE7&n7a3heMMWTH zHk_cb)Yv7jpb&=wqHJ1aW#uXvq#EENRA2uFmm;i%0Zb|E?Uy$u1DWTM%l*P>Mufio zZX6!0L#2hzJlCQaR6RjK)4Ab#0}E*()SlI%adV0|tPV7lJ-6@8h?Mk|{OG3QRu2qf zy}rVp^(>E6C8YX&La~fP4WT1CYTVa?^uUA2PnL3y)54)#?{g2nukfa-0z}O%3g|1; zz5J4!Yer}f5vM4WZE$k!{9BN~zW+{HLxbuU)xY|gy{p$D8rsv-#d z^$ZPt>dt(*r0%n?8TjIa&(_NP$XHflWtg-jwB5YeFw3kq*X`@za`>X1EuFG!Xe<=(^}sra?%vJzpbwoO!tY3ERdwfy)|wTJp?$`Kq8pk85nKjaxE zITUHSD&~fU{c{>i^<50DhHNlsVI)%FD@>6fIV0M3fU7lvyl7L1TkfFqe!Mhx4ES={kk{m?QGF^$wTpS6+ukiGO1BQQk&`H_<%v!s!5C7?OfqBZH0-p`mDD= z{eJu!fd2e<%*;*qO7b0(e}TUh3JqHNQEgQ3VBP`1E!CMRNF0lcyE{7z)=Ha}mW-b! z>E9|BY2f7%x6=4ii%hZsh6Ku-HHT>C+SU52z%R#KgRu?5Yqk$#eyp4vuLuC|MZ}@7 zrslW@5Dfn8I~WURHfWQ zIlYW~1T(k;O9YTqIp>;{mWvWyIr^@PyB$}pny#e*BpB7Z+1W7JZHx{ZG#*2F;f7KI zRj2;i@43yz#m_Z?eFt$-sX00Hcvp-@f+6FHm&|}xx{cP*SkKQ#?d#SViz74W@;9fM z)ng_R8IZd<*^L`J)Tbi$n0}aaKVo`5GAarfk3k4o7<3#THmKRzJYQXzNu+AMU<+MO zmUdDyvQfb&Uu)cyE@w=N zNx>cpFCSZ4$*z#Hv9nW%t1L}UPIeVy7Lge})G=X+Zl88@|FRZ=peSGCpbQ~(7+!q;shx@w$TXffTZ%ars zU&&9Jn zi2W^&IXkVX&E%!n@7O%I*Pm>tNjox|w-C;m>yIS9uNEL{A+%7baSzhJbv(jurmBkJ-80G?ddsDB zmD$T(PN5~50bc5HJ#nO&1=nAA;=J?uWzn@by2^E_vh^6KtnULt%D=gz6rQx|E3B1$~M#5 zii&J00~k@hLT?+^GBrFLUjj0U*1VK604ze?;N0`MYmR}>s{+d9i7r!P=MA}n>}*(x z-Hp|qhPHNF?KZe-s;XSSu?9>dWia01Ix+s`86C8P_MbHn(+H37HesKhjNdudUcP+_ zZ+#%1Eh#SM+wOnmFk%pZKHY11WLk@j4T0`w{`=86Nu?SX%_9L}=B3-_?mj%Ue}(U(X%9BS?x@skS7aze;`Y zj`$q`%27p%)r#m7!Uhwp?$K1L8bKemc%i}itm#*Rm^|FCGK?O+@cv!UN6{sSnQP;M zdNWjYGWV3^QEgAZ6tf;iKRIv61@&rYJAHl8+D!JF=Ela*?SLVdm>1tB*T5%Fo-WOz z>l9dwDZNuW=7Da-Kce5OdwZ#EY-MrLl!d4}61aHK(zn+^Dpp_NiHRov{qLm!hXH=i z#%8DlinM67-jeFuI?LH#le*pn+G-{tj56ouO32{3wZr^J5(u!#YVD0~ zB<{pNa#5_^y>r~)v0I1ZE?qW2ShMQI?7rr|e=6F>T)lZCwfa8bLT+2F8+xiu@Qi3& zBoQ3o+ZC6g_#3W|cpio+AL}_%a6WmUe+|bcZvFSLIK^tTqYC>f%G`!QG;1%HI?uUu zCb!cMuk@k7to>|qK0m4TX|}=i-A$%WO@fQGZ=Z4@_h;!CU3sWLH9Xh8mUEEJZOUHs zOehgjc}$BJo0!NHACsAhv=8(0sv^oCWB~ePJq2g^{o14#)DL-hvM*&q3fKMfTi(Pe z)&gv8a2`7R1H~_3Gpt@s2Mc9XsI&H)5+s0PF&%e%boxaGTs@%o?_w0^XN2gA@n==r|+ zxsZ<_jyWv-(0==uccbNUtdI1u>S38-EWLQilemnI`Cen5Qc-c|bwy*8b9tUZ|n$Z6R*qRiZKeXCzI8^lv?-4aNz#9k1*^da{mb
  • Multi-omics integrative modeling
  • -
  • R session info
  • +
  • References
  • - - + + +
    @@ -2162,8 +2225,8 @@

    Multi-omics integrative modeling

    To capture associations between modalities of omics features, including their overlapping or nested and hierarchical relationships, the use of biological network structures can become useful, as for example in the Bayesian Cox model with spike-and-slab and MRF priors (Madjar et al. 2021). There is an increasing knowledge of biological interconnections across various molecular profiles, and systems biology approaches are being developed that try to capture these deep insights when modeling or predicting disease mechanisms (Yan et al. 2018; Karimi et al. 2022). There is a number of review and benchmarking studies of the methodologies for multi-omics integration, although these reviews do not focus specifically on survival applications; for example, Herrmann et al. (2021) for penalized regression-based methods, boosting-based methods and random forest-based methods; Agamah et al. (2022) for network analyses, Ickstadt, Schäfer, and Zucknick (2018) and Chu et al. (2022) for Bayesian approaches; and Kang, Ko, and Mersha (2022) for deep learning methods.

    However, to achieve a comprehensive and biologically meaningful integration of high-dimensional multi-omics data, there is a need for continued development of computational and statistical approaches that consider both technical and biological intricacies of the data and technologies, respectively (Wissel, Rowson, and Boeva 2023). This is currently a very active research field, and we expect to see many improved multi-omics methods for survival prediction in the future.

    -
    -

    R session info

    +
    +

    R session info

    Code @@ -2268,10 +2331,12 @@

    R session info

    [178] htmlwidgets_1.6.2 mlr3data_0.7.0 RColorBrewer_1.1-3 [181] biomaRt_2.56.1 rlang_1.1.1 uuid_1.1-1 [184] fansi_1.0.4 prodlim_2023.03.31 psbcSpeedUp_2.0.4 -
    +
    +

    References

    + -

    References

    +
    Agamah, Francis E., Jumamurat R. Bayjanov, Anna Niehues, Kelechi F. Njoku, Michelle Skelton, Gaston K. Mazandu, Thomas H. A. Ederveen, Nicola Mulder, Emile R. Chimusa, and Peter A. C. ’t Hoen. 2022. “Computational Approaches for Network-Based Integrative Multi-Omics Analysis.” Frontiers in Molecular Biosciences 9 (November): 967205. https://doi.org/10.3389/fmolb.2022.967205.
    @@ -2413,8 +2478,10 @@

    R session info

    Zucknick, Manuela, Maral Saadati, and Axel Benner. 2015. Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models.” Biometrical Journal 57 (6): 959–81. https://doi.org/10.1002/bimj.201400160.
    -
    - + + + +