diff --git a/cpematcher/core.py b/cpematcher/core.py
index 96e49d4..8547c7d 100644
--- a/cpematcher/core.py
+++ b/cpematcher/core.py
@@ -77,6 +77,7 @@ def matches(self, other: Self) -> bool:
 
     @staticmethod
     def _glob_equal(value1: str, value2: str) -> bool:
+        value1, value2 = value1.lower(), value2.lower()
         # Depending on the order, fnmatch.fnmatch could return False if wildcard
         # is the first value. As wildcard should always return True in any case,
         # we reorder the arguments based on that.
diff --git a/cpematcher/version.py b/cpematcher/version.py
index b90e03d..bf89e45 100644
--- a/cpematcher/version.py
+++ b/cpematcher/version.py
@@ -2,8 +2,8 @@
 
 
 class Version:
-    def __init__(self, version: str):
-        self.version = version
+    def __init__(self, version: str | None):
+        self.version = version and version.lower()
 
     def __bool__(self):
         return bool(self.version)
diff --git a/tests/test_core.py b/tests/test_core.py
index 9c8e17e..9e0df6a 100644
--- a/tests/test_core.py
+++ b/tests/test_core.py
@@ -50,9 +50,21 @@ def test_matches_with_same_branch(self):
 
     def test_matches_with_exact_version(self):
         version_cpe = CPE("cpe:2.3:a:apache:activemq:4.1.1:*:*:*:*:*:*:*")
-
         assert version_cpe.matches(version_cpe)
 
+    def test_matches_case_insensitive(self):
+        cpe_str = "cpe:2.3:a:apache:activemq:4.1.1:*:*:*:*:*:*:*"
+        cpe = CPE(cpe_str)
+        upper_cpe = CPE(cpe_str.replace("apche", "APACHE"))
+        assert cpe.matches(upper_cpe)
+
+        cpe_alnum_version = (
+            "cpe:2.3:o:microsoft:windows_server_2008:r2:sp1:*:*:*:*:x64:*"
+        )
+        alnum_cpe = CPE(cpe_alnum_version)
+        cpe_alnum_upper = CPE(cpe_alnum_version.replace("r2:sp1", "R2:SP1"))
+        assert alnum_cpe.matches(cpe_alnum_upper)
+
     def test_matches_with_version_start_including(self):
         branch_cpe = CPE(self.template % "4.1.*", version_start_including="4.1.3")