diff --git a/instrumentation/opentelemetry-instrumentation-openai/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-openai/test-requirements.txt
index 6b3d9ef39d..bca6bfbd0e 100644
--- a/instrumentation/opentelemetry-instrumentation-openai/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-openai/test-requirements.txt
@@ -3,6 +3,8 @@ Deprecated==1.2.14
 importlib-metadata==6.11.0
 packaging==24.0
 pytest==7.4.4
+pytest-vcr==1.0.2
 wrapt==1.16.0
-# -e opentelemetry-instrumentation
-# -e instrumentation/opentelemetry-instrumentation-openai
+
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-openai
diff --git a/tox.ini b/tox.ini
index 600929a6ec..02066afc19 100644
--- a/tox.ini
+++ b/tox.ini
@@ -6,6 +6,11 @@ envlist =
     ; Environments are organized by individual package, allowing
     ; for specifying supported Python versions per package.
 
+    ; instrumentation-openai
+    py3{8,9,10,11,12}-test-instrumentation-openai
+    pypy3-test-instrumentation-openai
+    lint-instrumentation-openai
+
     ; opentelemetry-resource-detector-container
     py3{8,9,10,11,12}-test-resource-detector-container
     pypy3-test-resource-detector-container
@@ -399,6 +404,12 @@ commands_pre =
   opentelemetry-instrumentation: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   opentelemetry-instrumentation: pip install -r {toxinidir}/opentelemetry-instrumentation/test-requirements.txt
 
+  openai: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  openai: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  openai: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  openai: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  openai: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-openai/test-requirements.txt
+
   distro: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   distro: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
   distro: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
@@ -445,6 +456,11 @@ commands_pre =
   kafka-pythonng: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
   kafka-pythonng: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
 
+  openai: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  openai: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  openai: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  openai: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-openai/test-requirements.txt
+
   confluent-kafka: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   confluent-kafka: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
   confluent-kafka: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk