diff --git a/.github/component_owners.yml b/.github/component_owners.yml
index b092d5d2c3..e3ca06b450 100644
--- a/.github/component_owners.yml
+++ b/.github/component_owners.yml
@@ -45,27 +45,13 @@ components:
 
   instrumentation/opentelemetry-instrumentation-urllib:
     - shalevr
-    - ocelotl
 
   instrumentation/opentelemetry-instrumentation-urllib3:
     - shalevr
-    - ocelotl
 
   instrumentation/opentelemetry-instrumentation-sqlalchemy:
     - shalevr
 
-  instrumentation/opentelemetry-instrumentation-flask:
-    - ocelotl
-
-  instrumentation/opentelemetry-instrumentation-jinja2:
-    - ocelotl
-
-  instrumentation/opentelemetry-instrumentation-logging:
-    - ocelotl
-
-  instrumentation/opentelemetry-instrumentation-requests:
-    - ocelotl
-
   instrumentation/opentelemetry-instrumentation-cassandra:
     - mattcontinisio
 
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 3dd53582ec..07510f643c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,11 +7,15 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+## Version 1.27.0/0.48b0 ()
+
 ### Added
 
 - `opentelemetry-instrumentation-kafka-python` Instrument temporary fork, kafka-python-ng
   inside kafka-python's instrumentation
   ([#2537](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2537))
+- `opentelemetry-instrumentation-asgi`, `opentelemetry-instrumentation-fastapi` Add ability to disable internal HTTP send and receive spans
+  ([#2802](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2802))
 
 ### Breaking changes
 
@@ -44,6 +48,10 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#2563](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2563))
 - `opentelemetry-instrumentation` fix `http.host` new http semantic convention mapping to depend on `kind` of span
   ([#2814](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2814))
+- `opentelemetry-instrumentation` Fix the description of `http.server.duration` and `http.server.request.duration`
+  ([#2753](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2753))
+- `opentelemetry-instrumentation-grpc` Fix grpc supported version
+  ([#2845](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2845))
 
 ## Version 1.26.0/0.47b0 (2024-07-23)
 
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index 9072a6a641..61f261f001 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -275,6 +275,7 @@ Below is a checklist of things to be mindful of when implementing a new instrume
 - Isolate sync and async test
   - For synchronous tests, the typical test case class is inherited from `opentelemetry.test.test_base.TestBase`. However, if you want to write asynchronous tests, the test case class should inherit also from `IsolatedAsyncioTestCase`. Adding asynchronous tests to a common test class can lead to tests passing without actually running, which can be misleading.
   - ex. <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/60fb936b7e5371b3e5587074906c49fb873cbd76/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_server_interceptor.py#L84>
+- All instrumentations have the same version. If you are going to develop a new instrumentation it would probably have `X.Y.dev` version and depends on `opentelemetry-instrumentation` and `opentelemetry-semantic-conventions` for the same version. That means that if you want to install your instrumentation you need to install its dependencies from this repo and the core repo also from git.
 
 ## Expectations from contributors
 
diff --git a/_template/version.py b/_template/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/_template/version.py
+++ b/_template/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/eachdist.ini b/eachdist.ini
index 2bcbde9c7c..79c865b334 100644
--- a/eachdist.ini
+++ b/eachdist.ini
@@ -16,7 +16,7 @@ sortfirst=
     ext/*
 
 [stable]
-version=1.27.0.dev
+version=1.28.0.dev
 
 packages=
     opentelemetry-sdk
@@ -34,7 +34,7 @@ packages=
     opentelemetry-api
 
 [prerelease]
-version=0.48b0.dev
+version=0.49b0.dev
 
 packages=
     all
diff --git a/exporter/opentelemetry-exporter-prometheus-remote-write/src/opentelemetry/exporter/prometheus_remote_write/version.py b/exporter/opentelemetry-exporter-prometheus-remote-write/src/opentelemetry/exporter/prometheus_remote_write/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/exporter/opentelemetry-exporter-prometheus-remote-write/src/opentelemetry/exporter/prometheus_remote_write/version.py
+++ b/exporter/opentelemetry-exporter-prometheus-remote-write/src/opentelemetry/exporter/prometheus_remote_write/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt b/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt
index f7e66ddd13..5836dc9764 100644
--- a/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 charset-normalizer==3.3.2
 # We can drop this after bumping baseline to pypy-39
diff --git a/exporter/opentelemetry-exporter-richconsole/pyproject.toml b/exporter/opentelemetry-exporter-richconsole/pyproject.toml
index 6d38226160..eb00eb0437 100644
--- a/exporter/opentelemetry-exporter-richconsole/pyproject.toml
+++ b/exporter/opentelemetry-exporter-richconsole/pyproject.toml
@@ -27,7 +27,7 @@ classifiers = [
 dependencies = [
   "opentelemetry-api ~= 1.12",
   "opentelemetry-sdk ~= 1.12",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "rich>=10.0.0",
 ]
 
diff --git a/exporter/opentelemetry-exporter-richconsole/src/opentelemetry/exporter/richconsole/version.py b/exporter/opentelemetry-exporter-richconsole/src/opentelemetry/exporter/richconsole/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/exporter/opentelemetry-exporter-richconsole/src/opentelemetry/exporter/richconsole/version.py
+++ b/exporter/opentelemetry-exporter-richconsole/src/opentelemetry/exporter/richconsole/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/exporter/opentelemetry-exporter-richconsole/test-requirements.txt b/exporter/opentelemetry-exporter-richconsole/test-requirements.txt
index dee47c7880..0ef562821f 100644
--- a/exporter/opentelemetry-exporter-richconsole/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-richconsole/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 flaky==3.7.0
 importlib-metadata==6.11.0
diff --git a/instrumentation/README.md b/instrumentation/README.md
index 22c4241bab..3558027ea9 100644
--- a/instrumentation/README.md
+++ b/instrumentation/README.md
@@ -21,7 +21,7 @@
 | [opentelemetry-instrumentation-falcon](./opentelemetry-instrumentation-falcon) | falcon >= 1.4.1, < 4.0.0 | Yes | experimental
 | [opentelemetry-instrumentation-fastapi](./opentelemetry-instrumentation-fastapi) | fastapi ~= 0.58 | Yes | migration
 | [opentelemetry-instrumentation-flask](./opentelemetry-instrumentation-flask) | flask >= 1.0 | Yes | migration
-| [opentelemetry-instrumentation-grpc](./opentelemetry-instrumentation-grpc) | grpcio ~= 1.27 | No | experimental
+| [opentelemetry-instrumentation-grpc](./opentelemetry-instrumentation-grpc) | grpcio >= 1.42.0 | No | experimental
 | [opentelemetry-instrumentation-httpx](./opentelemetry-instrumentation-httpx) | httpx >= 0.18.0 | No | migration
 | [opentelemetry-instrumentation-jinja2](./opentelemetry-instrumentation-jinja2) | jinja2 >= 2.7, < 4.0 | No | experimental
 | [opentelemetry-instrumentation-kafka-python](./opentelemetry-instrumentation-kafka-python) | kafka-python >= 2.0, < 3.0,kafka-python-ng >= 2.0, < 3.0 | No | experimental
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
index c8be384fe6..65dfe3c7ac 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
@@ -26,7 +26,7 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.5",
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/src/opentelemetry/instrumentation/aio_pika/version.py b/instrumentation/opentelemetry-instrumentation-aio-pika/src/opentelemetry/instrumentation/aio_pika/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/src/opentelemetry/instrumentation/aio_pika/version.py
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/src/opentelemetry/instrumentation/aio_pika/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
index a08f6427db..de853e16c9 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
@@ -1,6 +1,6 @@
 aio-pika==7.2.0
 aiormq==6.2.3
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
index 99b5fdfd1f..dbfb89fe82 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
@@ -1,6 +1,6 @@
 aio-pika==8.3.0
 aiormq==6.6.4
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
index 7051299461..6a95bd69f0 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
@@ -1,6 +1,6 @@
 aio-pika==9.0.5
 aiormq==6.7.1
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt
index de5e8b310f..82e742a1f4 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt
@@ -1,6 +1,6 @@
 aio-pika==9.4.1
 aiormq==6.8.0
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
index cfc53f723a..fbe663a50b 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/version.py b/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/version.py
index aa0c1a911f..49b83ce95e 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/version.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/src/opentelemetry/instrumentation/aiohttp_client/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
index be0311238f..dee4736133 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
@@ -1,6 +1,6 @@
 aiohttp==3.10.2
 aiosignal==1.3.1
-asgiref==3.7.2
+asgiref==3.8.1
 async-timeout==4.0.3
 blinker==1.7.0
 certifi==2024.7.4
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
index 6d62bd7956..a8e912e68d 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
     "opentelemetry-api ~= 1.12",
-    "opentelemetry-instrumentation == 0.48b0.dev",
-    "opentelemetry-semantic-conventions == 0.48b0.dev",
-    "opentelemetry-util-http == 0.48b0.dev",
+    "opentelemetry-instrumentation == 0.49b0.dev",
+    "opentelemetry-semantic-conventions == 0.49b0.dev",
+    "opentelemetry-util-http == 0.49b0.dev",
     "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py b/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py
index 659ff24af6..6db7719c76 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/__init__.py
@@ -207,7 +207,7 @@ async def middleware(request, handler):
     duration_histogram = meter.create_histogram(
         name=MetricInstruments.HTTP_SERVER_DURATION,
         unit="ms",
-        description="Duration of HTTP server requests.",
+        description="Measures the duration of inbound HTTP requests.",
     )
 
     active_requests_counter = meter.create_up_down_counter(
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/version.py b/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/version.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/src/opentelemetry/instrumentation/aiohttp_server/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
index 9cd6a3c111..e6dff52db9 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
@@ -1,6 +1,6 @@
 aiohttp==3.10.2
 aiosignal==1.3.1
-asgiref==3.7.2
+asgiref==3.8.1
 async-timeout==4.0.3
 Deprecated==1.2.14
 frozenlist==1.4.1
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
index 404bc9c445..3a583db3dd 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/version.py b/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/version.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/src/opentelemetry/instrumentation/aiopg/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
index bc61c3d6fc..1443104081 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
@@ -1,5 +1,5 @@
 aiopg==1.4.0
-asgiref==3.7.2
+asgiref==3.8.1
 async-timeout==4.0.3
 Deprecated==1.2.14
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
index 480ca75df7..45c436aad4 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
@@ -27,9 +27,9 @@ classifiers = [
 dependencies = [
   "asgiref ~= 3.0",
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
index 3356c9eee0..bc45eacaa4 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/__init__.py
@@ -485,7 +485,7 @@ def get_default_span_details(scope: dict) -> Tuple[str, dict]:
 
 
 def _collect_target_attribute(
-    scope: typing.Dict[str, typing.Any]
+    scope: typing.Dict[str, typing.Any],
 ) -> typing.Optional[str]:
     """
     Returns the target path as defined by the Semantic Conventions.
@@ -531,6 +531,7 @@ class OpenTelemetryMiddleware:
             the current globally configured one is used.
         meter_provider: The optional meter provider to use. If omitted
             the current globally configured one is used.
+        exclude_spans: Optionally exclude HTTP `send` and/or `receive` spans from the trace.
     """
 
     # pylint: disable=too-many-branches
@@ -549,6 +550,7 @@ def __init__(
         http_capture_headers_server_request: list[str] | None = None,
         http_capture_headers_server_response: list[str] | None = None,
         http_capture_headers_sanitize_fields: list[str] | None = None,
+        exclude_spans: list[typing.Literal["receive", "send"]] | None = None,
     ):
         # initialize semantic conventions opt-in if needed
         _OpenTelemetrySemanticConventionStability._initialize()
@@ -581,7 +583,7 @@ def __init__(
             self.duration_histogram_old = self.meter.create_histogram(
                 name=MetricInstruments.HTTP_SERVER_DURATION,
                 unit="ms",
-                description="Duration of HTTP server requests.",
+                description="Measures the duration of inbound HTTP requests.",
             )
         self.duration_histogram_new = None
         if _report_new(sem_conv_opt_in_mode):
@@ -655,6 +657,12 @@ def __init__(
             )
             or []
         )
+        self.exclude_receive_span = (
+            "receive" in exclude_spans if exclude_spans else False
+        )
+        self.exclude_send_span = (
+            "send" in exclude_spans if exclude_spans else False
+        )
 
     # pylint: disable=too-many-statements
     async def __call__(
@@ -798,8 +806,10 @@ async def __call__(
                 span.end()
 
     # pylint: enable=too-many-branches
-
     def _get_otel_receive(self, server_span_name, scope, receive):
+        if self.exclude_receive_span:
+            return receive
+
         @wraps(receive)
         async def otel_receive():
             with self.tracer.start_as_current_span(
@@ -823,6 +833,66 @@ async def otel_receive():
 
         return otel_receive
 
+    def _set_send_span(
+        self,
+        server_span_name,
+        scope,
+        send,
+        message,
+        status_code,
+        expecting_trailers,
+    ):
+        """Set send span attributes and status code."""
+        with self.tracer.start_as_current_span(
+            " ".join((server_span_name, scope["type"], "send"))
+        ) as send_span:
+            if callable(self.client_response_hook):
+                self.client_response_hook(send_span, scope, message)
+
+            if send_span.is_recording():
+                if message["type"] == "http.response.start":
+                    expecting_trailers = message.get("trailers", False)
+                send_span.set_attribute("asgi.event.type", message["type"])
+
+            if status_code:
+                set_status_code(
+                    send_span,
+                    status_code,
+                    None,
+                    self._sem_conv_opt_in_mode,
+                )
+        return expecting_trailers
+
+    def _set_server_span(
+        self, server_span, message, status_code, duration_attrs
+    ):
+        """Set server span attributes and status code."""
+        if (
+            server_span.is_recording()
+            and server_span.kind == trace.SpanKind.SERVER
+            and "headers" in message
+        ):
+            custom_response_attributes = (
+                collect_custom_headers_attributes(
+                    message,
+                    self.http_capture_headers_sanitize_fields,
+                    self.http_capture_headers_server_response,
+                    normalise_response_header_name,
+                )
+                if self.http_capture_headers_server_response
+                else {}
+            )
+            if len(custom_response_attributes) > 0:
+                server_span.set_attributes(custom_response_attributes)
+
+        if status_code:
+            set_status_code(
+                server_span,
+                status_code,
+                duration_attrs,
+                self._sem_conv_opt_in_mode,
+            )
+
     def _get_otel_send(
         self,
         server_span,
@@ -836,74 +906,46 @@ def _get_otel_send(
         @wraps(send)
         async def otel_send(message: dict[str, Any]):
             nonlocal expecting_trailers
-            with self.tracer.start_as_current_span(
-                " ".join((server_span_name, scope["type"], "send"))
-            ) as send_span:
-                if callable(self.client_response_hook):
-                    self.client_response_hook(send_span, scope, message)
 
-                status_code = None
-                if message["type"] == "http.response.start":
-                    status_code = message["status"]
-                elif message["type"] == "websocket.send":
-                    status_code = 200
-
-                if send_span.is_recording():
-                    if message["type"] == "http.response.start":
-                        expecting_trailers = message.get("trailers", False)
-                    send_span.set_attribute("asgi.event.type", message["type"])
-                    if (
-                        server_span.is_recording()
-                        and server_span.kind == trace.SpanKind.SERVER
-                        and "headers" in message
-                    ):
-                        custom_response_attributes = (
-                            collect_custom_headers_attributes(
-                                message,
-                                self.http_capture_headers_sanitize_fields,
-                                self.http_capture_headers_server_response,
-                                normalise_response_header_name,
-                            )
-                            if self.http_capture_headers_server_response
-                            else {}
-                        )
-                        if len(custom_response_attributes) > 0:
-                            server_span.set_attributes(
-                                custom_response_attributes
-                            )
-                if status_code:
-                    # We record metrics only once
-                    set_status_code(
-                        server_span,
-                        status_code,
-                        duration_attrs,
-                        self._sem_conv_opt_in_mode,
-                    )
-                    set_status_code(
-                        send_span,
-                        status_code,
-                        None,
-                        self._sem_conv_opt_in_mode,
-                    )
+            status_code = None
+            if message["type"] == "http.response.start":
+                status_code = message["status"]
+            elif message["type"] == "websocket.send":
+                status_code = 200
 
-                propagator = get_global_response_propagator()
-                if propagator:
-                    propagator.inject(
-                        message,
-                        context=set_span_in_context(
-                            server_span, trace.context_api.Context()
-                        ),
-                        setter=asgi_setter,
-                    )
+            if not self.exclude_send_span:
+                expecting_trailers = self._set_send_span(
+                    server_span_name,
+                    scope,
+                    send,
+                    message,
+                    status_code,
+                    expecting_trailers,
+                )
 
-                content_length = asgi_getter.get(message, "content-length")
-                if content_length:
-                    try:
-                        self.content_length_header = int(content_length[0])
-                    except ValueError:
-                        pass
+            self._set_server_span(
+                server_span, message, status_code, duration_attrs
+            )
+
+            propagator = get_global_response_propagator()
+            if propagator:
+                propagator.inject(
+                    message,
+                    context=set_span_in_context(
+                        server_span, trace.context_api.Context()
+                    ),
+                    setter=asgi_setter,
+                )
+
+            content_length = asgi_getter.get(message, "content-length")
+            if content_length:
+                try:
+                    self.content_length_header = int(content_length[0])
+                except ValueError:
+                    pass
+
+            await send(message)
 
-                await send(message)
             # pylint: disable=too-many-boolean-expressions
             if (
                 not expecting_trailers
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/version.py b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/version.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/src/opentelemetry/instrumentation/asgi/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
index ebe439d1d2..18a11500e1 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py b/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py
index a21dd626c8..a9d7897ea6 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/tests/test_asgi_middleware.py
@@ -566,6 +566,30 @@ async def test_background_execution(self):
             _SIMULATED_BACKGROUND_TASK_EXECUTION_TIME_S * 10**9,
         )
 
+    async def test_exclude_internal_spans(self):
+        """Test that internal spans are excluded from the emitted spans when
+        the `exclude_receive_span` or `exclude_send_span` attributes are set.
+        """
+        cases = [
+            (["receive", "send"], ["GET / http receive", "GET / http send"]),
+            (["send"], ["GET / http send"]),
+            (["receive"], ["GET / http receive"]),
+            ([], []),
+        ]
+        for exclude_spans, excluded_spans in cases:
+            self.memory_exporter.clear()
+            app = otel_asgi.OpenTelemetryMiddleware(
+                simple_asgi, exclude_spans=exclude_spans
+            )
+            self.seed_app(app)
+            await self.send_default_request()
+            await self.get_all_output()
+            span_list = self.memory_exporter.get_finished_spans()
+            self.assertTrue(span_list)
+            for span in span_list:
+                for excluded_span in excluded_spans:
+                    self.assertNotEqual(span.name, excluded_span)
+
     async def test_trailers(self):
         """Test that trailers are emitted as expected and that the server span is ended
         BEFORE the background task is finished."""
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
index cda5403ef5..36ed960392 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.14",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py b/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py
index ae10560861..e83f384a8c 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py
@@ -14,7 +14,7 @@
 """
 .. asyncio: https://github.com/python/asyncio
 
-The opentelemetry-instrumentation-asycnio package allows tracing asyncio applications.
+The opentelemetry-instrumentation-asyncio package allows tracing asyncio applications.
 The metric for coroutine, future, is generated even if there is no setting to generate a span.
 
 Run instrumented application
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/version.py b/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/version.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
index a196e8d4e3..7f20d1497c 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml
index 820c86070d..5a6632a028 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/src/opentelemetry/instrumentation/asyncpg/version.py b/instrumentation/opentelemetry-instrumentation-asyncpg/src/opentelemetry/instrumentation/asyncpg/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/src/opentelemetry/instrumentation/asyncpg/version.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/src/opentelemetry/instrumentation/asyncpg/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
index badc61cde8..60cef50a7a 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 async-timeout==4.0.3
 asyncpg==0.29.0
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml
index b512faa3eb..debc3ce033 100644
--- a/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "opentelemetry-propagator-aws-xray ~= 1.0.1",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-aws-lambda/src/opentelemetry/instrumentation/aws_lambda/version.py b/instrumentation/opentelemetry-instrumentation-aws-lambda/src/opentelemetry/instrumentation/aws_lambda/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-aws-lambda/src/opentelemetry/instrumentation/aws_lambda/version.py
+++ b/instrumentation/opentelemetry-instrumentation-aws-lambda/src/opentelemetry/instrumentation/aws_lambda/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt
index 6540349a2e..8d9fe19483 100644
--- a/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml b/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml
index 3abda7b175..a2bdba302f 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-boto/src/opentelemetry/instrumentation/boto/version.py b/instrumentation/opentelemetry-instrumentation-boto/src/opentelemetry/instrumentation/boto/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/src/opentelemetry/instrumentation/boto/version.py
+++ b/instrumentation/opentelemetry-instrumentation-boto/src/opentelemetry/instrumentation/boto/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
index ab4819b538..fe6467d1c4 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 boto==2.49.0
 boto3==1.34.44
 botocore==1.34.44
diff --git a/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml b/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml
index cbbf9cd679..72dc38cbec 100644
--- a/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-boto3sqs/src/opentelemetry/instrumentation/boto3sqs/version.py b/instrumentation/opentelemetry-instrumentation-boto3sqs/src/opentelemetry/instrumentation/boto3sqs/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-boto3sqs/src/opentelemetry/instrumentation/boto3sqs/version.py
+++ b/instrumentation/opentelemetry-instrumentation-boto3sqs/src/opentelemetry/instrumentation/boto3sqs/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt
index c5942b6a72..d8a9c38315 100644
--- a/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 boto3==1.34.44
 botocore==1.34.44
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml b/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml
index f286e7fc7b..797145b728 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "opentelemetry-propagator-aws-xray ~= 1.0.1",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/version.py b/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/version.py
+++ b/instrumentation/opentelemetry-instrumentation-botocore/src/opentelemetry/instrumentation/botocore/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
index e45fa6ba44..a89fdf2e30 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 aws-xray-sdk==2.12.1
 boto3==1.28.80
 botocore==1.31.80
diff --git a/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml b/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml
index b2ee19bdd2..3e785d1e8b 100644
--- a/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-cassandra/src/opentelemetry/instrumentation/cassandra/version.py b/instrumentation/opentelemetry-instrumentation-cassandra/src/opentelemetry/instrumentation/cassandra/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-cassandra/src/opentelemetry/instrumentation/cassandra/version.py
+++ b/instrumentation/opentelemetry-instrumentation-cassandra/src/opentelemetry/instrumentation/cassandra/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
index dc2090627d..189b2f65d0 100644
--- a/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 cassandra-driver==3.29.0
 click==8.1.7
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml b/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml
index 0d302a4206..9f0f594581 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/version.py b/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/version.py
+++ b/instrumentation/opentelemetry-instrumentation-celery/src/opentelemetry/instrumentation/celery/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt
index 401921f5e4..fcf838fc32 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt
@@ -1,5 +1,5 @@
 amqp==5.2.0
-asgiref==3.7.2
+asgiref==3.8.1
 backports.zoneinfo==0.2.1
 billiard==4.2.0
 celery==5.3.6
diff --git a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt
index 1c5aad2c07..76b2f03d12 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt
@@ -1,5 +1,5 @@
 amqp==5.2.0
-asgiref==3.7.2
+asgiref==3.8.1
 billiard==4.2.0
 celery==5.3.6
 click==8.1.7
diff --git a/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml b/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml
index 13433ba9e2..2edfdeb038 100644
--- a/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml
@@ -25,7 +25,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "opentelemetry-api ~= 1.12",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-confluent-kafka/src/opentelemetry/instrumentation/confluent_kafka/version.py b/instrumentation/opentelemetry-instrumentation-confluent-kafka/src/opentelemetry/instrumentation/confluent_kafka/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-confluent-kafka/src/opentelemetry/instrumentation/confluent_kafka/version.py
+++ b/instrumentation/opentelemetry-instrumentation-confluent-kafka/src/opentelemetry/instrumentation/confluent_kafka/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt
index 5400e507f5..f78f498620 100644
--- a/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 confluent-kafka==2.4.0
 Deprecated==1.2.14
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml
index 991c7bb8af..bfa63dbcad 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/version.py b/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/version.py
index e0bef4b1e3..79e27849a4 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/version.py
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/version.py
@@ -12,6 +12,6 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
 
 _instruments = tuple()
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
index 0d98d28069..f76b488d90 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/pyproject.toml b/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
index a8b53820bc..27cdf157c4 100644
--- a/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
@@ -26,15 +26,15 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-wsgi == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
 asgi = [
-  "opentelemetry-instrumentation-asgi == 0.48b0.dev",
+  "opentelemetry-instrumentation-asgi == 0.49b0.dev",
 ]
 instruments = [
   "django >= 1.10",
diff --git a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py
index 651df12043..d37c45993c 100644
--- a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/__init__.py
@@ -344,7 +344,7 @@ def _instrument(self, **kwargs):
             _DjangoMiddleware._duration_histogram_old = meter.create_histogram(
                 name=MetricInstruments.HTTP_SERVER_DURATION,
                 unit="ms",
-                description="Duration of HTTP server requests.",
+                description="Measures the duration of inbound HTTP requests.",
             )
         _DjangoMiddleware._duration_histogram_new = None
         if _report_new(sem_conv_opt_in_mode):
diff --git a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/version.py b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/version.py
+++ b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
index 5f22f2cadb..9d7ee964fe 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 Django==2.2.28
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
index 0a042a1bf5..9c21d2dfd4 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 Django==3.2.25
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
index 4f49efb39e..d3a55aae34 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 backports.zoneinfo==0.2.1
 Deprecated==1.2.14
 Django==4.2.15
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
index 9be1266014..89923379d3 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 Django==4.2.15
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
index 29d7bec6cc..e086d2c335 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/src/opentelemetry/instrumentation/elasticsearch/version.py b/instrumentation/opentelemetry-instrumentation-elasticsearch/src/opentelemetry/instrumentation/elasticsearch/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/src/opentelemetry/instrumentation/elasticsearch/version.py
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/src/opentelemetry/instrumentation/elasticsearch/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
index 07ea98e4d6..55eabe1ef5 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 elasticsearch==6.8.2
 elasticsearch-dsl==6.4.0
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
index 228601485d..2fab7287ad 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 elasticsearch==7.17.9
 elasticsearch-dsl==7.4.1
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
index 272675c119..5f2ccd41ac 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 elasticsearch==8.13.1
 elasticsearch-dsl==8.13.1
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml b/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
index 6f505f60ae..f118ff4296 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
@@ -26,10 +26,10 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-wsgi == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
   "packaging >= 20.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
index 1a252b9a16..2dce5f1ef5 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
@@ -268,7 +268,7 @@ def __init__(self, *args, **kwargs):
         self.duration_histogram = self._otel_meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="Duration of HTTP server requests.",
+            description="Measures the duration of inbound HTTP requests.",
         )
         self.active_requests_counter = self._otel_meter.create_up_down_counter(
             name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/version.py b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/version.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
index d0f6381b42..6967c57b6d 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 falcon==1.4.1
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
index 5a84f224f1..e535925b14 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 falcon==2.0.0
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
index 0790e8a4cb..30d21e2773 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 falcon==3.1.1
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
index 3017dc040a..89f6602e86 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
@@ -26,10 +26,10 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-asgi == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-asgi == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
index 37a293764e..7e4d0aac07 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
@@ -179,7 +179,7 @@ def client_response_hook(span: Span, scope: dict[str, Any], message: dict[str, A
 from __future__ import annotations
 
 import logging
-from typing import Collection
+from typing import Collection, Literal
 
 import fastapi
 from starlette.routing import Match
@@ -222,7 +222,7 @@ class FastAPIInstrumentor(BaseInstrumentor):
 
     @staticmethod
     def instrument_app(
-        app: fastapi.FastAPI,
+        app,
         server_request_hook: ServerRequestHook = None,
         client_request_hook: ClientRequestHook = None,
         client_response_hook: ClientResponseHook = None,
@@ -232,8 +232,28 @@ def instrument_app(
         http_capture_headers_server_request: list[str] | None = None,
         http_capture_headers_server_response: list[str] | None = None,
         http_capture_headers_sanitize_fields: list[str] | None = None,
+        exclude_spans: list[Literal["receive", "send"]] | None = None,
     ):
-        """Instrument an uninstrumented FastAPI application."""
+        """Instrument an uninstrumented FastAPI application.
+
+        Args:
+            app: The fastapi ASGI application callable to forward requests to.
+            server_request_hook: Optional callback which is called with the server span and ASGI
+                          scope object for every incoming request.
+            client_request_hook: Optional callback which is called with the internal span, and ASGI
+                          scope and event which are sent as dictionaries for when the method receive is called.
+            client_response_hook: Optional callback which is called with the internal span, and ASGI
+                          scope and event which are sent as dictionaries for when the method send is called.
+            tracer_provider: The optional tracer provider to use. If omitted
+                the current globally configured one is used.
+            meter_provider: The optional meter provider to use. If omitted
+                the current globally configured one is used.
+            excluded_urls: Optional comma delimited string of regexes to match URLs that should not be traced.
+            http_capture_headers_server_request: Optional list of HTTP headers to capture from the request.
+            http_capture_headers_server_response: Optional list of HTTP headers to capture from the response.
+            http_capture_headers_sanitize_fields: Optional list of HTTP headers to sanitize.
+            exclude_spans: Optionally exclude HTTP `send` and/or `receive` spans from the trace.
+        """
         if not hasattr(app, "_is_instrumented_by_opentelemetry"):
             app._is_instrumented_by_opentelemetry = False
 
@@ -273,6 +293,7 @@ def instrument_app(
                 http_capture_headers_server_request=http_capture_headers_server_request,
                 http_capture_headers_server_response=http_capture_headers_server_response,
                 http_capture_headers_sanitize_fields=http_capture_headers_sanitize_fields,
+                exclude_spans=exclude_spans,
             )
             app._is_instrumented_by_opentelemetry = True
             if app not in _InstrumentedFastAPI._instrumented_fastapi_apps:
@@ -323,6 +344,7 @@ def _instrument(self, **kwargs):
             else parse_excluded_urls(_excluded_urls)
         )
         _InstrumentedFastAPI._meter_provider = kwargs.get("meter_provider")
+        _InstrumentedFastAPI._exclude_spans = kwargs.get("exclude_spans")
         fastapi.FastAPI = _InstrumentedFastAPI
 
     def _uninstrument(self, **kwargs):
@@ -373,6 +395,7 @@ def __init__(self, *args, **kwargs):
             http_capture_headers_server_request=_InstrumentedFastAPI._http_capture_headers_server_request,
             http_capture_headers_server_response=_InstrumentedFastAPI._http_capture_headers_server_response,
             http_capture_headers_sanitize_fields=_InstrumentedFastAPI._http_capture_headers_sanitize_fields,
+            exclude_spans=_InstrumentedFastAPI._exclude_spans,
         )
         self._is_instrumented_by_opentelemetry = True
         _InstrumentedFastAPI._instrumented_fastapi_apps.add(self)
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/version.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/version.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
index 00242d5410..927e68f94e 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
@@ -1,6 +1,6 @@
 annotated-types==0.6.0
 anyio==4.3.0
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 charset-normalizer==3.3.2
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
index ffafdbacc6..0e74ca331f 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
@@ -26,10 +26,10 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-wsgi == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
   "packaging >= 21.0",
   "importlib-metadata >= 4.0",
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
index 0093715ae1..192e044655 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
@@ -568,14 +568,14 @@ def __init__(self, *args, **kwargs):
             duration_histogram_old = meter.create_histogram(
                 name=MetricInstruments.HTTP_SERVER_DURATION,
                 unit="ms",
-                description="measures the duration of the inbound HTTP request",
+                description="Measures the duration of inbound HTTP requests.",
             )
         duration_histogram_new = None
         if _report_new(_InstrumentedFlask._sem_conv_opt_in_mode):
             duration_histogram_new = meter.create_histogram(
                 name=HTTP_SERVER_REQUEST_DURATION,
                 unit="s",
-                description="measures the duration of the inbound HTTP request",
+                description="Duration of HTTP server requests.",
             )
         active_requests_counter = meter.create_up_down_counter(
             name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
@@ -701,14 +701,14 @@ def instrument_app(
                 duration_histogram_old = meter.create_histogram(
                     name=MetricInstruments.HTTP_SERVER_DURATION,
                     unit="ms",
-                    description="measures the duration of the inbound HTTP request",
+                    description="Measures the duration of inbound HTTP requests.",
                 )
             duration_histogram_new = None
             if _report_new(sem_conv_opt_in_mode):
                 duration_histogram_new = meter.create_histogram(
                     name=HTTP_SERVER_REQUEST_DURATION,
                     unit="s",
-                    description="measures the duration of the inbound HTTP request",
+                    description="Duration of HTTP server requests.",
                 )
             active_requests_counter = meter.create_up_down_counter(
                 name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/version.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/version.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
index a222e011a7..0bd176848d 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 click==8.1.7
 Deprecated==1.2.14
 Flask==2.1.3
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
index e799218273..d73ab497b5 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 click==8.1.7
 Deprecated==1.2.14
 Flask==2.2.0
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
index 91ae64700c..299a347d66 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 blinker==1.7.0
 click==8.1.7
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml b/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml
index d0a7d54298..fd84d6aac0 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml
@@ -26,14 +26,14 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
 [project.optional-dependencies]
 instruments = [
-  "grpcio ~= 1.27",
+  "grpcio >= 1.42.0",
 ]
 
 [project.entry-points.opentelemetry_instrumentor]
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/package.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/package.py
index 91bdeab555..66ef914bdb 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/package.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/package.py
@@ -13,4 +13,4 @@
 # limitations under the License.
 
 
-_instruments = ("grpcio ~= 1.27",)
+_instruments = ("grpcio >= 1.42.0",)
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/version.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/version.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt
index 457c285715..83ec6e8e70 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 grpcio==1.62.0
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt
index 221359e184..d77d67148a 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 grpcio==1.63.0
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
index 5e4629e281..599091716b 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/version.py b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/version.py
+++ b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
index 35ebe6b954..28b475a3a4 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
@@ -1,5 +1,5 @@
 anyio==3.7.1
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 Deprecated==1.2.14
 exceptiongroup==1.2.0
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
index c70677f06b..42c032a546 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
@@ -1,5 +1,5 @@
 anyio==4.3.0
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 Deprecated==1.2.14
 exceptiongroup==1.2.0
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml b/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml
index f74b8ca488..40159c3485 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml
@@ -26,7 +26,7 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/src/opentelemetry/instrumentation/jinja2/version.py b/instrumentation/opentelemetry-instrumentation-jinja2/src/opentelemetry/instrumentation/jinja2/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/src/opentelemetry/instrumentation/jinja2/version.py
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/src/opentelemetry/instrumentation/jinja2/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt
index 05d94d6fb0..59eabe6997 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/tests/test_jinja2.py b/instrumentation/opentelemetry-instrumentation-jinja2/tests/test_jinja2.py
index 26ba98e69b..98344c47e4 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/tests/test_jinja2.py
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/tests/test_jinja2.py
@@ -143,7 +143,7 @@ def test_generate_inline_template(self):
     def test_file_template_with_root(self):
         with self.tracer.start_as_current_span("root"):
             loader = jinja2.loaders.FileSystemLoader(TMPL_DIR)
-            env = jinja2.Environment(loader=loader)
+            env = jinja2.Environment(loader=loader, autoescape=True)
             template = env.get_template("template.html")
             self.assertEqual(
                 template.render(name="Jinja"), "Message: Hello Jinja!"
@@ -164,7 +164,7 @@ def test_file_template_with_root(self):
 
     def test_file_template(self):
         loader = jinja2.loaders.FileSystemLoader(TMPL_DIR)
-        env = jinja2.Environment(loader=loader)
+        env = jinja2.Environment(loader=loader, autoescape=True)
         template = env.get_template("template.html")
         self.assertEqual(
             template.render(name="Jinja"), "Message: Hello Jinja!"
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml b/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
index c256c71b94..d47672fa07 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.5",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/version.py b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/version.py
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/src/opentelemetry/instrumentation/kafka/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
index 7b587031ec..05e169a7e3 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt
index 4adc515de7..6582cf875b 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml b/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml
index 2c1b2ad897..62656bea22 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml
@@ -26,7 +26,7 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-logging/src/opentelemetry/instrumentation/logging/version.py b/instrumentation/opentelemetry-instrumentation-logging/src/opentelemetry/instrumentation/logging/version.py
index e0bef4b1e3..79e27849a4 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/src/opentelemetry/instrumentation/logging/version.py
+++ b/instrumentation/opentelemetry-instrumentation-logging/src/opentelemetry/instrumentation/logging/version.py
@@ -12,6 +12,6 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
 
 _instruments = tuple()
diff --git a/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt
index eca8ce5f34..c0d2f044c8 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml b/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml
index 3c7d0c9166..629ab5325e 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/src/opentelemetry/instrumentation/mysql/version.py b/instrumentation/opentelemetry-instrumentation-mysql/src/opentelemetry/instrumentation/mysql/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/src/opentelemetry/instrumentation/mysql/version.py
+++ b/instrumentation/opentelemetry-instrumentation-mysql/src/opentelemetry/instrumentation/mysql/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
index 75ee9797b8..bf93434850 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
index dd609e594a..1a58c16a05 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml b/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
index 0ede691e36..0cc4553384 100644
--- a/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/src/opentelemetry/instrumentation/mysqlclient/version.py b/instrumentation/opentelemetry-instrumentation-mysqlclient/src/opentelemetry/instrumentation/mysqlclient/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-mysqlclient/src/opentelemetry/instrumentation/mysqlclient/version.py
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/src/opentelemetry/instrumentation/mysqlclient/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
index 534c7869cb..8c3ed72f35 100644
--- a/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
index 145439b242..bc01323ee4 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
@@ -25,7 +25,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "opentelemetry-api ~= 1.5",
   "packaging >= 20.0",
   "wrapt >= 1.0.0, < 2.0.0",
diff --git a/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/version.py b/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/version.py
+++ b/instrumentation/opentelemetry-instrumentation-pika/src/opentelemetry/instrumentation/pika/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt
index cc874af2cc..e06bc0b395 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt
index 4a09147744..8928f655c8 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml
index 717257821d..513064ae7f 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml
@@ -27,8 +27,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/src/opentelemetry/instrumentation/psycopg/version.py b/instrumentation/opentelemetry-instrumentation-psycopg/src/opentelemetry/instrumentation/psycopg/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/src/opentelemetry/instrumentation/psycopg/version.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/src/opentelemetry/instrumentation/psycopg/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
index e60531b112..42bbac77d9 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 backports.zoneinfo==0.2.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
index 6ad211f9c0..1f7fb59f2d 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml b/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
index 7db83dcc5c..592c15b4db 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/version.py b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/version.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/src/opentelemetry/instrumentation/psycopg2/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
index 4d6682b3d6..aa98fa93d0 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
index 369d63d5cf..6671073043 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
@@ -18,6 +18,7 @@
 import psycopg2
 
 import opentelemetry.instrumentation.psycopg2
+from opentelemetry import trace
 from opentelemetry.instrumentation.psycopg2 import Psycopg2Instrumentor
 from opentelemetry.sdk import resources
 from opentelemetry.test.test_base import TestBase
@@ -269,3 +270,14 @@ def test_sqlcommenter_disabled(self, event_mocked):
         cursor.execute(query)
         kwargs = event_mocked.call_args[1]
         self.assertEqual(kwargs["enable_commenter"], False)
+
+    def test_no_op_tracer_provider(self):
+        Psycopg2Instrumentor().instrument(
+            tracer_provider=trace.NoOpTracerProvider()
+        )
+        cnx = psycopg2.connect(database="test")
+        cursor = cnx.cursor()
+        query = "SELECT * FROM test"
+        cursor.execute(query)
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 0)
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
index 47df236c42..c20ffd3dee 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/src/opentelemetry/instrumentation/pymemcache/version.py b/instrumentation/opentelemetry-instrumentation-pymemcache/src/opentelemetry/instrumentation/pymemcache/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/src/opentelemetry/instrumentation/pymemcache/version.py
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/src/opentelemetry/instrumentation/pymemcache/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
index 28a62d84b4..2c6e0e2749 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
index 4be0dbee52..36db8d4416 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
index f07d79374a..3e0359f731 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
index 4e4871147c..916c9c9c3a 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
index 28fe27f0ef..e90a138ff8 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml
index ccd75ffeaa..61f4fd2b72 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/version.py b/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/version.py
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
index eb41ee6bd9..6c8de553b6 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 dnspython==2.6.1
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml
index 08ee94fd9e..9e1bc1a881 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/version.py b/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/version.py
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/src/opentelemetry/instrumentation/pymysql/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
index 8338f79b65..7ad69f2b81 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
index 9da43f444c..2a559e6c60 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
@@ -26,10 +26,10 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-wsgi == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
index 09f1645384..6a526f2235 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
@@ -141,7 +141,7 @@ def trace_tween_factory(handler, registry):
     duration_histogram = meter.create_histogram(
         name=MetricInstruments.HTTP_SERVER_DURATION,
         unit="ms",
-        description="Duration of HTTP server requests.",
+        description="Measures the duration of inbound HTTP requests.",
     )
     active_requests_counter = meter.create_up_down_counter(
         name=MetricInstruments.HTTP_SERVER_ACTIVE_REQUESTS,
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/version.py b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/version.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
index aa387f8177..6f33f33449 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 hupper==1.12.1
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml b/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml
index d39bda20a5..c262363fab 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "wrapt >= 1.12.1",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-redis/src/opentelemetry/instrumentation/redis/version.py b/instrumentation/opentelemetry-instrumentation-redis/src/opentelemetry/instrumentation/redis/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/src/opentelemetry/instrumentation/redis/version.py
+++ b/instrumentation/opentelemetry-instrumentation-redis/src/opentelemetry/instrumentation/redis/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt
index 43d4bd9788..7b8d8459b7 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 async-timeout==4.0.3
 Deprecated==1.2.14
 fakeredis==2.23.3
diff --git a/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml b/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml
index 8b2b3679a9..7f3041b887 100644
--- a/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-remoulade/src/opentelemetry/instrumentation/remoulade/version.py b/instrumentation/opentelemetry-instrumentation-remoulade/src/opentelemetry/instrumentation/remoulade/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-remoulade/src/opentelemetry/instrumentation/remoulade/version.py
+++ b/instrumentation/opentelemetry-instrumentation-remoulade/src/opentelemetry/instrumentation/remoulade/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt
index 727c15ec4e..b850e46f9f 100644
--- a/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml b/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
index 88996d2540..dafe3b4d3a 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/version.py b/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/version.py
+++ b/instrumentation/opentelemetry-instrumentation-requests/src/opentelemetry/instrumentation/requests/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
index 03d0a793a6..9f40c6d5b2 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 charset-normalizer==3.3.2
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml b/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml
index 21021fb590..d6cc3f71d9 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
   "packaging >= 21.0",
   "wrapt >= 1.11.2",
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/version.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/version.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
index 407222e8f6..45992bc2e1 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 cffi==1.15.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
index 9b1b15debc..eb1ee371b7 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
@@ -1,5 +1,5 @@
 aiosqlite==0.20.0
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 greenlet==3.0.3
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml b/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml
index e86fb99235..60ec47b16e 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/version.py b/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/version.py
index e0bef4b1e3..79e27849a4 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/version.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/src/opentelemetry/instrumentation/sqlite3/version.py
@@ -12,6 +12,6 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
 
 _instruments = tuple()
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
index 8c98e702b4..e260861814 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml b/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
index 6e6d370b53..9cdd968ca0 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
@@ -26,10 +26,10 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-instrumentation-asgi == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-instrumentation-asgi == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/src/opentelemetry/instrumentation/starlette/version.py b/instrumentation/opentelemetry-instrumentation-starlette/src/opentelemetry/instrumentation/starlette/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/src/opentelemetry/instrumentation/starlette/version.py
+++ b/instrumentation/opentelemetry-instrumentation-starlette/src/opentelemetry/instrumentation/starlette/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
index 1d5b91e188..d81a15a40c 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
@@ -1,5 +1,5 @@
 anyio==4.3.0
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 charset-normalizer==3.3.2
 Deprecated==1.2.14
diff --git a/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml b/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml
index 6a1e83912f..a405c668f7 100644
--- a/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml
@@ -25,7 +25,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "opentelemetry-api ~= 1.11",
   "psutil >= 5.9.0, < 7",
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-system-metrics/src/opentelemetry/instrumentation/system_metrics/version.py b/instrumentation/opentelemetry-instrumentation-system-metrics/src/opentelemetry/instrumentation/system_metrics/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-system-metrics/src/opentelemetry/instrumentation/system_metrics/version.py
+++ b/instrumentation/opentelemetry-instrumentation-system-metrics/src/opentelemetry/instrumentation/system_metrics/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt
index 506499ea13..76f2f2a4e7 100644
--- a/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml b/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml
index 16088e7de3..43f92d2034 100644
--- a/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml
@@ -26,7 +26,7 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-threading/src/opentelemetry/instrumentation/threading/version.py b/instrumentation/opentelemetry-instrumentation-threading/src/opentelemetry/instrumentation/threading/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-threading/src/opentelemetry/instrumentation/threading/version.py
+++ b/instrumentation/opentelemetry-instrumentation-threading/src/opentelemetry/instrumentation/threading/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt
index 45ee66cf01..2d13857e9e 100644
--- a/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml b/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
index 0096deb8fd..f3f9a4b4fc 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
index 1b56db3876..0b5e06b526 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
@@ -296,7 +296,7 @@ def _create_server_histograms(meter) -> Dict[str, Histogram]:
         MetricInstruments.HTTP_SERVER_DURATION: meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_DURATION,
             unit="ms",
-            description="Duration of HTTP server requests.",
+            description="Measures the duration of inbound HTTP requests.",
         ),
         MetricInstruments.HTTP_SERVER_REQUEST_SIZE: meter.create_histogram(
             name=MetricInstruments.HTTP_SERVER_REQUEST_SIZE,
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/version.py b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/version.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
index fb542966de..236c45f87b 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 blinker==1.7.0
 certifi==2024.7.4
 charset-normalizer==3.3.2
diff --git a/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml b/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml
index 04d81e1894..82ccbc6a79 100644
--- a/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-tortoiseorm/src/opentelemetry/instrumentation/tortoiseorm/version.py b/instrumentation/opentelemetry-instrumentation-tortoiseorm/src/opentelemetry/instrumentation/tortoiseorm/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-tortoiseorm/src/opentelemetry/instrumentation/tortoiseorm/version.py
+++ b/instrumentation/opentelemetry-instrumentation-tortoiseorm/src/opentelemetry/instrumentation/tortoiseorm/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt
index cb31845d66..31b044a2f3 100644
--- a/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt
@@ -1,6 +1,6 @@
 aiosqlite==0.17.0
 annotated-types==0.6.0
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml b/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
index 4f0d2681f9..97b611b095 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/src/opentelemetry/instrumentation/urllib/version.py b/instrumentation/opentelemetry-instrumentation-urllib/src/opentelemetry/instrumentation/urllib/version.py
index e0bef4b1e3..79e27849a4 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/src/opentelemetry/instrumentation/urllib/version.py
+++ b/instrumentation/opentelemetry-instrumentation-urllib/src/opentelemetry/instrumentation/urllib/version.py
@@ -12,6 +12,6 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
 
 _instruments = tuple()
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
index 9e11fb272f..06bc8322dc 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 httpretty==1.1.4
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml b/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
index 03c9f26fbc..3c1eaaa6d0 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/src/opentelemetry/instrumentation/urllib3/version.py b/instrumentation/opentelemetry-instrumentation-urllib3/src/opentelemetry/instrumentation/urllib3/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/src/opentelemetry/instrumentation/urllib3/version.py
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/src/opentelemetry/instrumentation/urllib3/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
index 1d6ebc18af..e7392b0c31 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 httpretty==1.1.4
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
index 06df34d16b..21cb3acbe6 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 httpretty==1.1.4
 importlib-metadata==6.11.0
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
index b38f1829aa..a5e81ee8e5 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
-  "opentelemetry-semantic-conventions == 0.48b0.dev",
-  "opentelemetry-util-http == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
+  "opentelemetry-semantic-conventions == 0.49b0.dev",
+  "opentelemetry-util-http == 0.49b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
index 88704f35ab..c0384d594b 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
@@ -571,14 +571,14 @@ def __init__(
             self.duration_histogram_old = self.meter.create_histogram(
                 name=MetricInstruments.HTTP_SERVER_DURATION,
                 unit="ms",
-                description="measures the duration of the inbound HTTP request",
+                description="Measures the duration of inbound HTTP requests.",
             )
         self.duration_histogram_new = None
         if _report_new(sem_conv_opt_in_mode):
             self.duration_histogram_new = self.meter.create_histogram(
                 name=HTTP_SERVER_REQUEST_DURATION,
                 unit="s",
-                description="measures the duration of the inbound HTTP request",
+                description="Duration of HTTP server requests.",
             )
         # We don't need a separate active request counter for old/new semantic conventions
         # because the new attributes are a subset of the old attributes
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/version.py b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/version.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
index 0f7c7ced73..d63bd5a637 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/opentelemetry-contrib-instrumentations/pyproject.toml b/opentelemetry-contrib-instrumentations/pyproject.toml
index 6c7716bad2..9c40f9c2a3 100644
--- a/opentelemetry-contrib-instrumentations/pyproject.toml
+++ b/opentelemetry-contrib-instrumentations/pyproject.toml
@@ -29,53 +29,53 @@ classifiers = [
     "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-    "opentelemetry-instrumentation-aio-pika==0.48b0.dev",
-    "opentelemetry-instrumentation-aiohttp-client==0.48b0.dev",
-    "opentelemetry-instrumentation-aiohttp-server==0.48b0.dev",
-    "opentelemetry-instrumentation-aiopg==0.48b0.dev",
-    "opentelemetry-instrumentation-asgi==0.48b0.dev",
-    "opentelemetry-instrumentation-asyncio==0.48b0.dev",
-    "opentelemetry-instrumentation-asyncpg==0.48b0.dev",
-    "opentelemetry-instrumentation-aws-lambda==0.48b0.dev",
-    "opentelemetry-instrumentation-boto==0.48b0.dev",
-    "opentelemetry-instrumentation-boto3sqs==0.48b0.dev",
-    "opentelemetry-instrumentation-botocore==0.48b0.dev",
-    "opentelemetry-instrumentation-cassandra==0.48b0.dev",
-    "opentelemetry-instrumentation-celery==0.48b0.dev",
-    "opentelemetry-instrumentation-confluent-kafka==0.48b0.dev",
-    "opentelemetry-instrumentation-dbapi==0.48b0.dev",
-    "opentelemetry-instrumentation-django==0.48b0.dev",
-    "opentelemetry-instrumentation-elasticsearch==0.48b0.dev",
-    "opentelemetry-instrumentation-falcon==0.48b0.dev",
-    "opentelemetry-instrumentation-fastapi==0.48b0.dev",
-    "opentelemetry-instrumentation-flask==0.48b0.dev",
-    "opentelemetry-instrumentation-grpc==0.48b0.dev",
-    "opentelemetry-instrumentation-httpx==0.48b0.dev",
-    "opentelemetry-instrumentation-jinja2==0.48b0.dev",
-    "opentelemetry-instrumentation-kafka-python==0.48b0.dev",
-    "opentelemetry-instrumentation-logging==0.48b0.dev",
-    "opentelemetry-instrumentation-mysql==0.48b0.dev",
-    "opentelemetry-instrumentation-mysqlclient==0.48b0.dev",
-    "opentelemetry-instrumentation-pika==0.48b0.dev",
-    "opentelemetry-instrumentation-psycopg==0.48b0.dev",
-    "opentelemetry-instrumentation-psycopg2==0.48b0.dev",
-    "opentelemetry-instrumentation-pymemcache==0.48b0.dev",
-    "opentelemetry-instrumentation-pymongo==0.48b0.dev",
-    "opentelemetry-instrumentation-pymysql==0.48b0.dev",
-    "opentelemetry-instrumentation-pyramid==0.48b0.dev",
-    "opentelemetry-instrumentation-redis==0.48b0.dev",
-    "opentelemetry-instrumentation-remoulade==0.48b0.dev",
-    "opentelemetry-instrumentation-requests==0.48b0.dev",
-    "opentelemetry-instrumentation-sqlalchemy==0.48b0.dev",
-    "opentelemetry-instrumentation-sqlite3==0.48b0.dev",
-    "opentelemetry-instrumentation-starlette==0.48b0.dev",
-    "opentelemetry-instrumentation-system-metrics==0.48b0.dev",
-    "opentelemetry-instrumentation-threading==0.48b0.dev",
-    "opentelemetry-instrumentation-tornado==0.48b0.dev",
-    "opentelemetry-instrumentation-tortoiseorm==0.48b0.dev",
-    "opentelemetry-instrumentation-urllib==0.48b0.dev",
-    "opentelemetry-instrumentation-urllib3==0.48b0.dev",
-    "opentelemetry-instrumentation-wsgi==0.48b0.dev",
+    "opentelemetry-instrumentation-aio-pika==0.49b0.dev",
+    "opentelemetry-instrumentation-aiohttp-client==0.49b0.dev",
+    "opentelemetry-instrumentation-aiohttp-server==0.49b0.dev",
+    "opentelemetry-instrumentation-aiopg==0.49b0.dev",
+    "opentelemetry-instrumentation-asgi==0.49b0.dev",
+    "opentelemetry-instrumentation-asyncio==0.49b0.dev",
+    "opentelemetry-instrumentation-asyncpg==0.49b0.dev",
+    "opentelemetry-instrumentation-aws-lambda==0.49b0.dev",
+    "opentelemetry-instrumentation-boto==0.49b0.dev",
+    "opentelemetry-instrumentation-boto3sqs==0.49b0.dev",
+    "opentelemetry-instrumentation-botocore==0.49b0.dev",
+    "opentelemetry-instrumentation-cassandra==0.49b0.dev",
+    "opentelemetry-instrumentation-celery==0.49b0.dev",
+    "opentelemetry-instrumentation-confluent-kafka==0.49b0.dev",
+    "opentelemetry-instrumentation-dbapi==0.49b0.dev",
+    "opentelemetry-instrumentation-django==0.49b0.dev",
+    "opentelemetry-instrumentation-elasticsearch==0.49b0.dev",
+    "opentelemetry-instrumentation-falcon==0.49b0.dev",
+    "opentelemetry-instrumentation-fastapi==0.49b0.dev",
+    "opentelemetry-instrumentation-flask==0.49b0.dev",
+    "opentelemetry-instrumentation-grpc==0.49b0.dev",
+    "opentelemetry-instrumentation-httpx==0.49b0.dev",
+    "opentelemetry-instrumentation-jinja2==0.49b0.dev",
+    "opentelemetry-instrumentation-kafka-python==0.49b0.dev",
+    "opentelemetry-instrumentation-logging==0.49b0.dev",
+    "opentelemetry-instrumentation-mysql==0.49b0.dev",
+    "opentelemetry-instrumentation-mysqlclient==0.49b0.dev",
+    "opentelemetry-instrumentation-pika==0.49b0.dev",
+    "opentelemetry-instrumentation-psycopg==0.49b0.dev",
+    "opentelemetry-instrumentation-psycopg2==0.49b0.dev",
+    "opentelemetry-instrumentation-pymemcache==0.49b0.dev",
+    "opentelemetry-instrumentation-pymongo==0.49b0.dev",
+    "opentelemetry-instrumentation-pymysql==0.49b0.dev",
+    "opentelemetry-instrumentation-pyramid==0.49b0.dev",
+    "opentelemetry-instrumentation-redis==0.49b0.dev",
+    "opentelemetry-instrumentation-remoulade==0.49b0.dev",
+    "opentelemetry-instrumentation-requests==0.49b0.dev",
+    "opentelemetry-instrumentation-sqlalchemy==0.49b0.dev",
+    "opentelemetry-instrumentation-sqlite3==0.49b0.dev",
+    "opentelemetry-instrumentation-starlette==0.49b0.dev",
+    "opentelemetry-instrumentation-system-metrics==0.49b0.dev",
+    "opentelemetry-instrumentation-threading==0.49b0.dev",
+    "opentelemetry-instrumentation-tornado==0.49b0.dev",
+    "opentelemetry-instrumentation-tortoiseorm==0.49b0.dev",
+    "opentelemetry-instrumentation-urllib==0.49b0.dev",
+    "opentelemetry-instrumentation-urllib3==0.49b0.dev",
+    "opentelemetry-instrumentation-wsgi==0.49b0.dev",
 ]
 
 [project.urls]
diff --git a/opentelemetry-contrib-instrumentations/src/opentelemetry/contrib-instrumentations/version.py b/opentelemetry-contrib-instrumentations/src/opentelemetry/contrib-instrumentations/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/opentelemetry-contrib-instrumentations/src/opentelemetry/contrib-instrumentations/version.py
+++ b/opentelemetry-contrib-instrumentations/src/opentelemetry/contrib-instrumentations/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/opentelemetry-distro/pyproject.toml b/opentelemetry-distro/pyproject.toml
index 2397e9182a..686eeaba95 100644
--- a/opentelemetry-distro/pyproject.toml
+++ b/opentelemetry-distro/pyproject.toml
@@ -27,13 +27,13 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.48b0.dev",
+  "opentelemetry-instrumentation == 0.49b0.dev",
   "opentelemetry-sdk ~= 1.13",
 ]
 
 [project.optional-dependencies]
 otlp = [
-  "opentelemetry-exporter-otlp == 1.27.0.dev",
+  "opentelemetry-exporter-otlp == 1.28.0.dev",
 ]
 
 [project.entry-points.opentelemetry_configurator]
diff --git a/opentelemetry-distro/src/opentelemetry/distro/version.py b/opentelemetry-distro/src/opentelemetry/distro/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/opentelemetry-distro/src/opentelemetry/distro/version.py
+++ b/opentelemetry-distro/src/opentelemetry/distro/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/opentelemetry-distro/test-requirements.txt b/opentelemetry-distro/test-requirements.txt
index d9190daa26..050054c39b 100644
--- a/opentelemetry-distro/test-requirements.txt
+++ b/opentelemetry-distro/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/opentelemetry-instrumentation/README.rst b/opentelemetry-instrumentation/README.rst
index 6f66edb623..3ed88c213f 100644
--- a/opentelemetry-instrumentation/README.rst
+++ b/opentelemetry-instrumentation/README.rst
@@ -40,7 +40,7 @@ to figure out which instrumentation packages the user might want to install. By
 prints out a list of the default and detected instrumentation packages that can be added to a
 requirements.txt file. It also supports installing the packages when run with
 :code:`--action=install` or :code:`-a install` flag. All default and detectable
-instrumentation packages are defined `here <https://github.com/flands/opentelemetry-python-contrib/blob/main/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py>`.
+instrumentation packages are defined `here <https://github.com/open-telemetry/opentelemetry-python-contrib/blob/main/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py>`.
 
 
 opentelemetry-instrument
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index c31863bd31..616675ee80 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -18,179 +18,179 @@
 libraries = [
     {
         "library": "aio_pika >= 7.2.0, < 10.0.0",
-        "instrumentation": "opentelemetry-instrumentation-aio-pika==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-aio-pika==0.49b0.dev",
     },
     {
         "library": "aiohttp ~= 3.0",
-        "instrumentation": "opentelemetry-instrumentation-aiohttp-client==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-aiohttp-client==0.49b0.dev",
     },
     {
         "library": "aiohttp ~= 3.0",
-        "instrumentation": "opentelemetry-instrumentation-aiohttp-server==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-aiohttp-server==0.49b0.dev",
     },
     {
         "library": "aiopg >= 0.13.0, < 2.0.0",
-        "instrumentation": "opentelemetry-instrumentation-aiopg==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-aiopg==0.49b0.dev",
     },
     {
         "library": "asgiref ~= 3.0",
-        "instrumentation": "opentelemetry-instrumentation-asgi==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-asgi==0.49b0.dev",
     },
     {
         "library": "asyncpg >= 0.12.0",
-        "instrumentation": "opentelemetry-instrumentation-asyncpg==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-asyncpg==0.49b0.dev",
     },
     {
         "library": "boto~=2.0",
-        "instrumentation": "opentelemetry-instrumentation-boto==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-boto==0.49b0.dev",
     },
     {
         "library": "boto3 ~= 1.0",
-        "instrumentation": "opentelemetry-instrumentation-boto3sqs==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-boto3sqs==0.49b0.dev",
     },
     {
         "library": "botocore ~= 1.0",
-        "instrumentation": "opentelemetry-instrumentation-botocore==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-botocore==0.49b0.dev",
     },
     {
         "library": "cassandra-driver ~= 3.25",
-        "instrumentation": "opentelemetry-instrumentation-cassandra==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-cassandra==0.49b0.dev",
     },
     {
         "library": "scylla-driver ~= 3.25",
-        "instrumentation": "opentelemetry-instrumentation-cassandra==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-cassandra==0.49b0.dev",
     },
     {
         "library": "celery >= 4.0, < 6.0",
-        "instrumentation": "opentelemetry-instrumentation-celery==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-celery==0.49b0.dev",
     },
     {
         "library": "confluent-kafka >= 1.8.2, <= 2.4.0",
-        "instrumentation": "opentelemetry-instrumentation-confluent-kafka==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-confluent-kafka==0.49b0.dev",
     },
     {
         "library": "django >= 1.10",
-        "instrumentation": "opentelemetry-instrumentation-django==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-django==0.49b0.dev",
     },
     {
         "library": "elasticsearch >= 6.0",
-        "instrumentation": "opentelemetry-instrumentation-elasticsearch==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-elasticsearch==0.49b0.dev",
     },
     {
         "library": "falcon >= 1.4.1, < 3.1.2",
-        "instrumentation": "opentelemetry-instrumentation-falcon==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-falcon==0.49b0.dev",
     },
     {
         "library": "fastapi ~= 0.58",
-        "instrumentation": "opentelemetry-instrumentation-fastapi==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-fastapi==0.49b0.dev",
     },
     {
         "library": "flask >= 1.0",
-        "instrumentation": "opentelemetry-instrumentation-flask==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-flask==0.49b0.dev",
     },
     {
-        "library": "grpcio ~= 1.27",
-        "instrumentation": "opentelemetry-instrumentation-grpc==0.48b0.dev",
+        "library": "grpcio >= 1.42.0",
+        "instrumentation": "opentelemetry-instrumentation-grpc==0.49b0.dev",
     },
     {
         "library": "httpx >= 0.18.0",
-        "instrumentation": "opentelemetry-instrumentation-httpx==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-httpx==0.49b0.dev",
     },
     {
         "library": "jinja2 >= 2.7, < 4.0",
-        "instrumentation": "opentelemetry-instrumentation-jinja2==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-jinja2==0.49b0.dev",
     },
     {
         "library": "kafka-python >= 2.0, < 3.0",
-        "instrumentation": "opentelemetry-instrumentation-kafka-python==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-kafka-python==0.49b0.dev",
     },
     {
         "library": "kafka-python-ng >= 2.0, < 3.0",
-        "instrumentation": "opentelemetry-instrumentation-kafka-python==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-kafka-python==0.49b0.dev",
     },
     {
         "library": "mysql-connector-python >= 8.0, < 10.0",
-        "instrumentation": "opentelemetry-instrumentation-mysql==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-mysql==0.49b0.dev",
     },
     {
         "library": "mysqlclient < 3",
-        "instrumentation": "opentelemetry-instrumentation-mysqlclient==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-mysqlclient==0.49b0.dev",
     },
     {
         "library": "pika >= 0.12.0",
-        "instrumentation": "opentelemetry-instrumentation-pika==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-pika==0.49b0.dev",
     },
     {
         "library": "psycopg >= 3.1.0",
-        "instrumentation": "opentelemetry-instrumentation-psycopg==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-psycopg==0.49b0.dev",
     },
     {
         "library": "psycopg2 >= 2.7.3.1",
-        "instrumentation": "opentelemetry-instrumentation-psycopg2==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-psycopg2==0.49b0.dev",
     },
     {
         "library": "pymemcache >= 1.3.5, < 5",
-        "instrumentation": "opentelemetry-instrumentation-pymemcache==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-pymemcache==0.49b0.dev",
     },
     {
         "library": "pymongo >= 3.1, < 5.0",
-        "instrumentation": "opentelemetry-instrumentation-pymongo==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-pymongo==0.49b0.dev",
     },
     {
         "library": "PyMySQL < 2",
-        "instrumentation": "opentelemetry-instrumentation-pymysql==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-pymysql==0.49b0.dev",
     },
     {
         "library": "pyramid >= 1.7",
-        "instrumentation": "opentelemetry-instrumentation-pyramid==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-pyramid==0.49b0.dev",
     },
     {
         "library": "redis >= 2.6",
-        "instrumentation": "opentelemetry-instrumentation-redis==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-redis==0.49b0.dev",
     },
     {
         "library": "remoulade >= 0.50",
-        "instrumentation": "opentelemetry-instrumentation-remoulade==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-remoulade==0.49b0.dev",
     },
     {
         "library": "requests ~= 2.0",
-        "instrumentation": "opentelemetry-instrumentation-requests==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-requests==0.49b0.dev",
     },
     {
         "library": "sqlalchemy",
-        "instrumentation": "opentelemetry-instrumentation-sqlalchemy==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-sqlalchemy==0.49b0.dev",
     },
     {
         "library": "starlette ~= 0.13.0",
-        "instrumentation": "opentelemetry-instrumentation-starlette==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-starlette==0.49b0.dev",
     },
     {
         "library": "psutil >= 5",
-        "instrumentation": "opentelemetry-instrumentation-system-metrics==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-system-metrics==0.49b0.dev",
     },
     {
         "library": "tornado >= 5.1.1",
-        "instrumentation": "opentelemetry-instrumentation-tornado==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-tornado==0.49b0.dev",
     },
     {
         "library": "tortoise-orm >= 0.17.0",
-        "instrumentation": "opentelemetry-instrumentation-tortoiseorm==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-tortoiseorm==0.49b0.dev",
     },
     {
         "library": "pydantic >= 1.10.2",
-        "instrumentation": "opentelemetry-instrumentation-tortoiseorm==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-tortoiseorm==0.49b0.dev",
     },
     {
         "library": "urllib3 >= 1.0.0, < 3.0.0",
-        "instrumentation": "opentelemetry-instrumentation-urllib3==0.48b0.dev",
+        "instrumentation": "opentelemetry-instrumentation-urllib3==0.49b0.dev",
     },
 ]
 default_instrumentations = [
-    "opentelemetry-instrumentation-asyncio==0.48b0.dev",
-    "opentelemetry-instrumentation-dbapi==0.48b0.dev",
-    "opentelemetry-instrumentation-logging==0.48b0.dev",
-    "opentelemetry-instrumentation-sqlite3==0.48b0.dev",
-    "opentelemetry-instrumentation-threading==0.48b0.dev",
-    "opentelemetry-instrumentation-urllib==0.48b0.dev",
-    "opentelemetry-instrumentation-wsgi==0.48b0.dev",
+    "opentelemetry-instrumentation-asyncio==0.49b0.dev",
+    "opentelemetry-instrumentation-dbapi==0.49b0.dev",
+    "opentelemetry-instrumentation-logging==0.49b0.dev",
+    "opentelemetry-instrumentation-sqlite3==0.49b0.dev",
+    "opentelemetry-instrumentation-threading==0.49b0.dev",
+    "opentelemetry-instrumentation-urllib==0.49b0.dev",
+    "opentelemetry-instrumentation-wsgi==0.49b0.dev",
 ]
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/version.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/version.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/opentelemetry-instrumentation/test-requirements.txt b/opentelemetry-instrumentation/test-requirements.txt
index 6cd12fad24..31f1ef76ab 100644
--- a/opentelemetry-instrumentation/test-requirements.txt
+++ b/opentelemetry-instrumentation/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/processor/opentelemetry-processor-baggage/src/opentelemetry/processor/baggage/version.py b/processor/opentelemetry-processor-baggage/src/opentelemetry/processor/baggage/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/processor/opentelemetry-processor-baggage/src/opentelemetry/processor/baggage/version.py
+++ b/processor/opentelemetry-processor-baggage/src/opentelemetry/processor/baggage/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt b/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt
index 8589a794a4..4587d87629 100644
--- a/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt
+++ b/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 certifi==2024.7.4
 charset-normalizer==3.3.2
 Deprecated==1.2.14
diff --git a/propagator/opentelemetry-propagator-ot-trace/src/opentelemetry/propagators/ot_trace/version.py b/propagator/opentelemetry-propagator-ot-trace/src/opentelemetry/propagators/ot_trace/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/propagator/opentelemetry-propagator-ot-trace/src/opentelemetry/propagators/ot_trace/version.py
+++ b/propagator/opentelemetry-propagator-ot-trace/src/opentelemetry/propagators/ot_trace/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt b/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt
index 0a72c3c823..b556c4f0cc 100644
--- a/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt
+++ b/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/resource/opentelemetry-resource-detector-azure/test-requirements.txt b/resource/opentelemetry-resource-detector-azure/test-requirements.txt
index 028c41e65d..2b29359fbb 100644
--- a/resource/opentelemetry-resource-detector-azure/test-requirements.txt
+++ b/resource/opentelemetry-resource-detector-azure/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/resource/opentelemetry-resource-detector-container/src/opentelemetry/resource/detector/container/version.py b/resource/opentelemetry-resource-detector-container/src/opentelemetry/resource/detector/container/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/resource/opentelemetry-resource-detector-container/src/opentelemetry/resource/detector/container/version.py
+++ b/resource/opentelemetry-resource-detector-container/src/opentelemetry/resource/detector/container/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/resource/opentelemetry-resource-detector-container/test-requirements.txt b/resource/opentelemetry-resource-detector-container/test-requirements.txt
index 8a926fff71..f7b5b71fcf 100644
--- a/resource/opentelemetry-resource-detector-container/test-requirements.txt
+++ b/resource/opentelemetry-resource-detector-container/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt b/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt
index 27199627a1..1fa968a8b3 100644
--- a/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt
+++ b/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
diff --git a/tox.ini b/tox.ini
index 8552948b6b..600929a6ec 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1190,7 +1190,7 @@ basepython: python3
 deps =
   aiopg==1.4.0
   amqp==5.2.0
-  asgiref==3.7.2
+  asgiref==3.8.1
   async-timeout==4.0.3
   asyncpg==0.29.0
   attrs==23.2.0
diff --git a/util/opentelemetry-util-http/src/opentelemetry/util/http/version.py b/util/opentelemetry-util-http/src/opentelemetry/util/http/version.py
index 4d21fcb843..ee5a6342e7 100644
--- a/util/opentelemetry-util-http/src/opentelemetry/util/http/version.py
+++ b/util/opentelemetry-util-http/src/opentelemetry/util/http/version.py
@@ -12,4 +12,4 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-__version__ = "0.48b0.dev"
+__version__ = "0.49b0.dev"
diff --git a/util/opentelemetry-util-http/test-requirements.txt b/util/opentelemetry-util-http/test-requirements.txt
index cb1ffe135b..1769daa094 100644
--- a/util/opentelemetry-util-http/test-requirements.txt
+++ b/util/opentelemetry-util-http/test-requirements.txt
@@ -1,4 +1,4 @@
-asgiref==3.7.2
+asgiref==3.8.1
 Deprecated==1.2.14
 importlib-metadata==6.11.0
 iniconfig==2.0.0
@@ -8,4 +8,4 @@ py-cpuinfo==9.0.0
 pytest==7.4.4
 tomli==2.0.1
 typing_extensions==4.10.0
--e opentelemetry-instrumentation
\ No newline at end of file
+-e opentelemetry-instrumentation