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TODO: Add O-antigen subtype information to the output #85

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kbessonov1984 opened this issue Jan 14, 2022 · 0 comments
Open

TODO: Add O-antigen subtype information to the output #85

kbessonov1984 opened this issue Jan 14, 2022 · 0 comments
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@kbessonov1984
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There is a talk and reference and diagnostic lab requests for adding O-antigen subtype information due to different phenotypic and clinical manifestations associated with these subtypes. The subtypes of interest are O18ab/ac, O28ac/ab, O112ab/ac, O125ab/ac, O128ab/ac, O141ab/ac, O174ab/ac.

Challenge: Some of the above pairs are very similar genetically and are difficult to resolve.

Possible solution: Incorporate additional metadata into the ECTYPER alleles database. Provide a command line option for user to get subtype information in the O-type field in the output (e.g. --with-O-subtypes). Add additional warning message to alert user to possible limit of resolution due to high degree of similarity between subgroups.

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