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We also need to simulate some datasets where the ground truth is known.
Maybe try it with SRTsim:
https://xzhoulab.github.io/SRTsim/02_Reference_Based_Example/
scGCO proposed a specific method for simulating SVGs:
https://github.com/WangPeng-Lab/scGCO/tree/master/code/analysis/Simulation
The simulation process is as follows:
- Find spatial transcriptomics data with clear spatial patterns which can be different cell types or tissue structures
- Using Splatter to generate synthetic data
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