diff --git a/frontend-v2/src/components/TextField.tsx b/frontend-v2/src/components/TextField.tsx
index 36db383e..9f4f2c68 100644
--- a/frontend-v2/src/components/TextField.tsx
+++ b/frontend-v2/src/components/TextField.tsx
@@ -16,6 +16,7 @@ type Props<T extends FieldValues> = {
   rules?: Record<string, unknown>;
   mode?: "onChange" | "onBlur";
   textFieldProps?: material.TextFieldProps;
+  autoShrink?: boolean;
   sx?: material.SxProps
 };
 
@@ -26,6 +27,7 @@ function TextField<T extends FieldValues>({
   rules,
   mode,
   textFieldProps,
+  autoShrink,
   sx
 }: Props<T>): React.ReactElement {
   const [fieldValue, setFieldValue] = useFieldState({ name, control });
@@ -66,6 +68,7 @@ function TextField<T extends FieldValues>({
             }
             name={name}
             id={name}
+            InputLabelProps={autoShrink !== undefined ? { shrink: autoShrink } : {}}
             variant="outlined"
             value={
               fieldValue === undefined || fieldValue === null ? "" : fieldValue
diff --git a/frontend-v2/src/features/login/login.tsx b/frontend-v2/src/features/login/login.tsx
index 37449afd..06edd9af 100644
--- a/frontend-v2/src/features/login/login.tsx
+++ b/frontend-v2/src/features/login/login.tsx
@@ -47,6 +47,7 @@ const Login: React.FC<LoginProps> = ({ onLogin, isLoading, errorMessage }) => {
             control={control}
             textFieldProps={{ autoComplete: "username" }}
             mode="onChange"
+            autoShrink={true}
           />
           <TextField
             label="Password"
@@ -54,6 +55,7 @@ const Login: React.FC<LoginProps> = ({ onLogin, isLoading, errorMessage }) => {
             control={control}
             textFieldProps={{ autoComplete: "password", type: "password" }}
             mode="onChange"
+            autoShrink={true}
           />
           <Button
             type="submit"
diff --git a/frontend-v2/src/features/model/MapVariablesTab.tsx b/frontend-v2/src/features/model/MapVariablesTab.tsx
index 0b7038a2..f45a6b9a 100644
--- a/frontend-v2/src/features/model/MapVariablesTab.tsx
+++ b/frontend-v2/src/features/model/MapVariablesTab.tsx
@@ -3,6 +3,7 @@ import {
   CombinedModelRead,
   CompoundRead,
   ProjectRead,
+  ProjectSpeciesEnum,
   UnitRead,
   VariableRead,
 } from "../../app/backendApi";
@@ -39,10 +40,13 @@ const MapVariablesTab: React.FC<Props> = ({
   compound,
 }: Props) => {
   const [dosings, setDosing] = React.useState<
-    { key: number; hasDosingSelected: boolean, projectId: number }[]
+    { key: number; hasDosingSelected: boolean; projectId: number, species: ProjectSpeciesEnum | undefined  }[]
   >([]);
   const [linkToPds, setLinkToPd] = React.useState<
-    { key: number; hasPdSelected: boolean, projectId: number }[]
+    { key: number; hasPdSelected: boolean; projectId: number, species: ProjectSpeciesEnum | undefined }[]
+  >([]);
+  const [lagTimes, setLagTimes] = React.useState<
+    { key: number; hasLagTimeSelected: boolean; projectId: number, species: ProjectSpeciesEnum | undefined }[]
   >([]);
 
   const iconRef = React.useRef<HTMLDivElement | null>(null);
@@ -54,6 +58,10 @@ const MapVariablesTab: React.FC<Props> = ({
     .filter(({ projectId }) => projectId === project?.id)
     .map(({ hasPdSelected }) => hasPdSelected)
     .some(Boolean);
+  const isAnyLagTimeSelected = lagTimes
+    .filter(({ projectId }) => projectId === project?.id)
+    .map(({ hasLagTimeSelected }) => hasLagTimeSelected)
+    .some(Boolean);
   const isPreclinical = project.species !== "H" && model.is_library_model;
   const concentrationUnit = units.find((unit) => unit.symbol === "pmol/L");
   const amountUnit = isPreclinical
@@ -154,18 +162,38 @@ const MapVariablesTab: React.FC<Props> = ({
 
   const updateDosings = (key: number, value: boolean) => {
     setDosing((prevDosings) => [
-      ...prevDosings.filter(({ key: dosingKey }) => key !== dosingKey),
-      { key, hasDosingSelected: value, projectId: project?.id },
+      ...prevDosings.filter(({ key: dosingKey, species, projectId }) => key !== dosingKey && species === project.species && projectId === project.id),
+      { key, hasDosingSelected: value, projectId: project?.id, species: project?.species },
     ]);
   };
 
   const updateLinksToPd = (key: number, value: boolean) => {
     setLinkToPd((prevLinks) => [
-      ...prevLinks.filter(({ key: linkKey }) => key !== linkKey),
-      { key, hasPdSelected: value, projectId: project?.id },
+      ...prevLinks.filter(({ key: linkKey, species, projectId }) => key !== linkKey && species === project.species && projectId === project.id),
+      { key, hasPdSelected: value, projectId: project?.id, species: project?.species },
     ]);
   };
 
+  const updateLagTimes = (key: number, value: boolean) => {
+    setLagTimes((prevLags) => [
+      ...prevLags.filter(({ key: lagKey, species, projectId }) => key !== lagKey && species === project.species && projectId === project.id),
+      { key, hasLagTimeSelected: value, projectId: project?.id, species: project?.species },
+    ]);
+  };
+
+  const sortVariables = (variable1: VariableRead, variable2: VariableRead) => {
+    if (variable1.name.startsWith('C') && variable2.name.startsWith('A')) {
+      return -1;
+    }
+
+    if (variable1.name.startsWith('A') && variable2.name.startsWith('C')) {
+      return 1;
+    }
+
+    return variable1.name < variable2.name ? -1 : 1;
+  }
+
+
   return (
     <TableContainer sx={{ width: "90%" }}>
       <Table>
@@ -196,7 +224,7 @@ const MapVariablesTab: React.FC<Props> = ({
               <TableCell>
                 <div style={{ ...defaultHeaderSx }}>
                   {" "}
-                  Lag Time
+                  Lag Time <span style={{ color: "red" }}>*</span>
                   <HelpButton title={"Lag Time"}>{lagTimeHelp}</HelpButton>
                 </div>
               </TableCell>
@@ -265,7 +293,7 @@ const MapVariablesTab: React.FC<Props> = ({
               <TableCell colSpan={5}>No variables found</TableCell>
             </TableRow>
           )}
-          {timeVaryingVariables.map((variable) => (
+          {timeVaryingVariables.sort(sortVariables).map((variable) => (
             <VariableRow
               key={variable.id}
               variable={variable}
@@ -280,6 +308,8 @@ const MapVariablesTab: React.FC<Props> = ({
               isAnyDosingSelected={isAnyDosingSelected}
               updateLinksToPd={updateLinksToPd}
               isAnyLinkToPdSelected={isAnyLinkToPdSelected}
+              updateLagTimes={updateLagTimes}
+              isAnyLagTimeSelected={isAnyLagTimeSelected}
             />
           ))}
         </TableBody>
diff --git a/frontend-v2/src/features/model/VariableRow.tsx b/frontend-v2/src/features/model/VariableRow.tsx
index 857d5334..1702a045 100644
--- a/frontend-v2/src/features/model/VariableRow.tsx
+++ b/frontend-v2/src/features/model/VariableRow.tsx
@@ -38,6 +38,8 @@ interface Props {
   isAnyDosingSelected: boolean;
   updateLinksToPd: (key: number, value: boolean) => void;
   isAnyLinkToPdSelected: boolean;
+  updateLagTimes: (key: number, value: boolean) => void;
+  isAnyLagTimeSelected: boolean;
 }
 
 type DerivedVariableType = "RO" | "FUP" | "BPR" | "TLG";
@@ -57,6 +59,8 @@ const VariableRow: React.FC<Props> = ({
   isAnyDosingSelected,
   updateLinksToPd,
   isAnyLinkToPdSelected,
+  updateLagTimes,
+  isAnyLagTimeSelected,
 }) => {
   const {
     fields: mappings,
@@ -125,6 +129,21 @@ const VariableRow: React.FC<Props> = ({
     : mappings.find((mapping) => mapping.pk_variable === variable.id) !==
       undefined;
 
+  const onClickDerived = (type: DerivedVariableType) => () => {
+    const index = derivedIndex(type);
+    return index >= 0 ? removeDerived(index) : addDerived(type);
+  };
+
+  const derivedIndex = (type: DerivedVariableType) => {
+    return derivedVariables.findIndex(
+      (ro) => ro.pk_variable === variable.id && ro.type === type,
+    );
+  };
+
+  const isLinkedTo = (type: DerivedVariableType) => {
+    return derivedIndex(type) >= 0;
+  };
+
   useEffect(() => {
     updateDosings(variable.id, hasProtocol);
   }, [hasProtocol]);
@@ -133,6 +152,10 @@ const VariableRow: React.FC<Props> = ({
     updateLinksToPd(variable.id, linkToPD);
   }, [linkToPD]);
 
+  useEffect(() => {
+    updateLagTimes(variable.id, isLinkedTo("TLG"));
+  }, [isLinkedTo("TLG")]);
+
   if (
     variable.constant ||
     variable.name === "t" ||
@@ -247,21 +270,6 @@ const VariableRow: React.FC<Props> = ({
     derivedVariablesRemove(index);
   };
 
-  const onClickDerived = (type: DerivedVariableType) => () => {
-    const index = derivedIndex(type);
-    return index >= 0 ? removeDerived(index) : addDerived(type);
-  };
-
-  const derivedIndex = (type: DerivedVariableType) => {
-    return derivedVariables.findIndex(
-      (ro) => ro.pk_variable === variable.id && ro.type === type,
-    );
-  };
-
-  const isLinkedTo = (type: DerivedVariableType) => {
-    return derivedIndex(type) >= 0;
-  };
-
   const noMapToPD = isPD || effectVariable === undefined || !isConcentration;
   const noDerivedVariables = !isConcentration || isPD;
   const isC1 = model.is_library_model && variable.qname.endsWith(".C1");
@@ -315,6 +323,11 @@ const VariableRow: React.FC<Props> = ({
             <FormControlLabel
               control={
                 <MuiCheckbox
+                  sx={{
+                    "& .MuiSvgIcon-root": {
+                      color: isAnyLagTimeSelected ? "inherit" : "red",
+                    },
+                  }}
                   checked={isLinkedTo("TLG")}
                   onClick={onClickDerived("TLG")}
                   data-cy={`checkbox-tlag-${variable.name}`}
diff --git a/frontend-v2/src/features/simulation/Simulations.tsx b/frontend-v2/src/features/simulation/Simulations.tsx
index 5c37ab8f..40c57d59 100644
--- a/frontend-v2/src/features/simulation/Simulations.tsx
+++ b/frontend-v2/src/features/simulation/Simulations.tsx
@@ -233,6 +233,8 @@ const Simulations: React.FC = () => {
     setParametersHeight(height);
   }, [parametersRef?.current?.clientHeight])
 
+  const updateWindowDimensions = () => window.innerWidth < 1000 && setLayout('horizontal');
+  window.addEventListener("resize", updateWindowDimensions);
 
   // reset form and sliders if simulation changes
   useEffect(() => {
@@ -495,8 +497,8 @@ const Simulations: React.FC = () => {
   };
 
   return (
-    <Grid container xl={12} sx={{ marginBottom: layout === 'horizontal' ? `${parametersHeight}px` : 0}}>
-      <Grid item xs={layout === "vertical" ? 7 : 12}>
+    <Grid container sx={{ marginBottom: layout === 'vertical' ? 0 : `${parametersHeight}px` }}>
+      <Grid item xl={layout === "vertical" ? 8 : 12} md={layout === "vertical" ? 7 : 12} xs={layout === "vertical" ? 6 : 12}>
         <Stack direction={"row"} alignItems={"center"}>
           <DropdownButton
             useIcon={false}
@@ -507,33 +509,6 @@ const Simulations: React.FC = () => {
             Add new plot
           </DropdownButton>
         </Stack>
-        <Grid container spacing={1}>
-          {plots.map((plot, index) => (
-            <Grid item xs={12} xl={layout === "vertical" ? 12 : 6} key={index}>
-              {data && model ? (
-                <SimulationPlotView
-                  index={index}
-                  plot={plot}
-                  data={data}
-                  variables={variables || []}
-                  control={control}
-                  setValue={setValue}
-                  remove={removePlot}
-                  units={units}
-                  compound={compound}
-                  model={model}
-                />
-              ) : (
-                <div>Loading...</div>
-              )}
-            </Grid>
-          ))}
-        </Grid>
-        <Snackbar open={Boolean(simulateError)} autoHideDuration={6000}>
-          <Alert severity="error">
-            Error simulating model: {simulateError?.error || "unknown error"}
-          </Alert>
-        </Snackbar>
         {plots.length > 0 && (
           <>
             <Stack
@@ -561,15 +536,44 @@ const Simulations: React.FC = () => {
             </Stack>
           </>
         )}
+        <Grid container spacing={1}>
+          {plots.map((plot, index) => (
+            <Grid item xl={layout === "vertical" ? 12 : 6} md={layout === "vertical" ? 12 : 6} xs={layout === "vertical" ? 12 : 12} key={index}>
+              {data && model ? (
+                <SimulationPlotView
+                  index={index}
+                  plot={plot}
+                  data={data}
+                  variables={variables || []}
+                  control={control}
+                  setValue={setValue}
+                  remove={removePlot}
+                  units={units}
+                  compound={compound}
+                  model={model}
+                />
+              ) : (
+                <div>Loading...</div>
+              )}
+            </Grid>
+          ))}
+        </Grid>
+        <Snackbar open={Boolean(simulateError)} autoHideDuration={6000}>
+          <Alert severity="error">
+            Error simulating model: {simulateError?.error || "unknown error"}
+          </Alert>
+        </Snackbar>
       </Grid>
       <Grid
         ref={parametersRef}
         item
-        xl={layout === "vertical" ? 4 : 12}
+        xl={layout === "vertical" ? 3 : 12}
+        md={layout === "vertical" ? 4 : 12}
+        xs={layout === "vertical" ? 5 : 12}
         sx={
           layout === "vertical"
             ? { position: "fixed", right: 0, paddingLeft: "1rem", width: '100%' }
-            : { position: "fixed", bottom: 0, height: 'auto', backgroundColor: 'white', width: '-webkit-fill-available' }
+            : { position: "fixed", bottom: 0, paddingBottom: '3rem', height: 'auto', backgroundColor: 'white', width: '-webkit-fill-available' }
         }
       >
         <Stack direction="column">
diff --git a/frontend-v2/src/features/trial/Doses.tsx b/frontend-v2/src/features/trial/Doses.tsx
index 0f35ed1e..370960c4 100644
--- a/frontend-v2/src/features/trial/Doses.tsx
+++ b/frontend-v2/src/features/trial/Doses.tsx
@@ -1,5 +1,5 @@
 import React, { useEffect } from "react";
-import { TableCell, TableRow, IconButton, Button } from "@mui/material";
+import { TableCell, TableRow, IconButton, Button, Stack } from "@mui/material";
 import {
   ProjectRead,
   Protocol,
@@ -14,6 +14,7 @@ import UnitField from "../../components/UnitField";
 import FloatField from "../../components/FloatField";
 import IntegerField from "../../components/IntegerField";
 import useDirty from "../../hooks/useDirty";
+import HelpButton from "../../components/HelpButton";
 
 interface Props {
   project: ProjectRead;
@@ -186,13 +187,19 @@ const Doses: React.FC<Props> = ({ project, protocol, units }) => {
           </TableCell>
         </TableRow>
       ))}
-      <Button
-        onClick={handleAddRow}
-        variant="outlined"
-        sx={{ fontSize: ".5rem" }}
-      >
-        Add New Row
-      </Button>
+      <Stack direction='row' width='max-content'>
+        <Button
+          onClick={handleAddRow}
+          variant="outlined"
+          sx={{ fontSize: ".5rem" }}
+        >
+          Add New Row
+        </Button>
+        <HelpButton title="Add Dose Line">
+          Adding an additional dosing line allows defining complex dosing
+          regimens (e.g. changing dosing frequency and/or dosing levels)
+        </HelpButton>
+      </Stack>
     </>
   );
 };
diff --git a/frontend-v2/src/features/trial/Protocols.tsx b/frontend-v2/src/features/trial/Protocols.tsx
index 13feacef..701f58c6 100644
--- a/frontend-v2/src/features/trial/Protocols.tsx
+++ b/frontend-v2/src/features/trial/Protocols.tsx
@@ -124,12 +124,7 @@ const Protocols: React.FC = () => {
             <TableCell align="right">
               <div style={{ ...defaultHeaderSx }}>
                 {" "}
-                Add Dose Line{" "}
-                <HelpButton title="Add Dose Line">
-                  Adding an additional dosing line allows defining complex
-                  dosing regimens (e.g. changing dosing frequency and/or dosing
-                  levels)
-                </HelpButton>
+                Remove{" "}
               </div>
             </TableCell>
           </TableRow>