From 87c5e5ffe27fea06203ea20381c9bf37069af075 Mon Sep 17 00:00:00 2001 From: martinjrobins Date: Wed, 7 Feb 2024 19:37:57 +0000 Subject: [PATCH] update default units --- .../src/features/model/param_default.ts | 5382 +++++++++-------- .../models/ParametersValue_Species.xlsx | Bin 25694 -> 26054 bytes 2 files changed, 2807 insertions(+), 2575 deletions(-) diff --git a/frontend-v2/src/features/model/param_default.ts b/frontend-v2/src/features/model/param_default.ts index 02a37ba0..09759616 100644 --- a/frontend-v2/src/features/model/param_default.ts +++ b/frontend-v2/src/features/model/param_default.ts @@ -1,2580 +1,2812 @@ -export const param_default: { - [key: string]: { - [key: string]: { - [key: string]: { [key: string]: { value: number; unit: string } }; - }; - }; -} = { - one_compartment: { - tlag: { - M: { - SM: { - value: 0, - unit: "h", - }, - LM: { - value: 0, - unit: "h", - }, - }, - R: { - SM: { - value: 0, - unit: "h", - }, - LM: { - value: 0, - unit: "h", - }, - }, - K: { - SM: { - value: 0, - unit: "h", - }, - LM: { - value: 0, - unit: "h", - }, - }, - H: { - SM: { - value: 0, - unit: "h", - }, - LM: { - value: 0, - unit: "h", - }, - }, +export const param_default: {[key: string]: {[key: string]: {[key: string]: {[key: string]: { value: number, unit: string}}}}} = { + one_compartment: { + tlag: { + M: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + R: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + K: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + H: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + + }, + ka: { + M: { + SM: { + value: 2.5, + unit: '1/h', + }, + LM: { + value: 0.05, + unit: '1/h', + }, + }, + R: { + SM: { + value: 2, + unit: '1/h', + }, + LM: { + value: 0.04, + unit: '1/h', + }, + }, + K: { + SM: { + value: 1.5, + unit: '1/h', + }, + LM: { + value: 0.025, + unit: '1/h', + }, + }, + H: { + SM: { + value: 1, + unit: '1/h', + }, + LM: { + value: 0.01, + unit: '1/h', + }, + }, + + }, + F: { + M: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + + }, + V1: { + M: { + SM: { + value: 4, + unit: 'L/kg', + }, + LM: { + value: 80, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 4, + unit: 'L/kg', + }, + LM: { + value: 80, + unit: 'mL/kg', + }, + }, + K: { + SM: { + value: 4, + unit: 'L/kg', + }, + LM: { + value: 80, + unit: 'mL/kg', + }, + }, + H: { + SM: { + value: 300, + unit: 'L', + }, + LM: { + value: 6000, + unit: 'mL', + }, + }, + + }, + CL: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + CLmax: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + Km: { + M: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + H: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + + }, + ke0: { + M: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + R: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + K: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + H: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + + }, + Kpu: { + M: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + + }, + }, - ka: { - M: { - SM: { - value: 2.5, - unit: "1/h", - }, - LM: { - value: 0.05, - unit: "1/h", - }, - }, - R: { - SM: { - value: 2, - unit: "1/h", - }, - LM: { - value: 0.04, - unit: "1/h", - }, - }, - K: { - SM: { - value: 1.5, - unit: "1/h", - }, - LM: { - value: 0.025, - unit: "1/h", - }, - }, - H: { - SM: { - value: 1, - unit: "1/h", - }, - LM: { - value: 0.01, - unit: "1/h", - }, - }, + two_compartment: { + tlag: { + M: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + R: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + K: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + H: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + + }, + ka: { + M: { + SM: { + value: 2.5, + unit: '1/h', + }, + LM: { + value: 0.05, + unit: '1/h', + }, + }, + R: { + SM: { + value: 2, + unit: '1/h', + }, + LM: { + value: 0.04, + unit: '1/h', + }, + }, + K: { + SM: { + value: 1.5, + unit: '1/h', + }, + LM: { + value: 0.025, + unit: '1/h', + }, + }, + H: { + SM: { + value: 1, + unit: '1/h', + }, + LM: { + value: 0.01, + unit: '1/h', + }, + }, + + }, + F: { + M: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + + }, + V1: { + M: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + K: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + H: { + SM: { + value: 150, + unit: 'L', + }, + LM: { + value: 3000, + unit: 'mL', + }, + }, + + }, + V2: { + M: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + K: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + H: { + SM: { + value: 150, + unit: 'L', + }, + LM: { + value: 3000, + unit: 'mL', + }, + }, + + }, + CL: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + Q1: { + M: { + SM: { + value: 2700, + unit: 'mL/h/kg', + }, + LM: { + value: 1.75, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 1650, + unit: 'mL/h/kg', + }, + LM: { + value: 2, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 1300, + unit: 'mL/h/kg', + }, + LM: { + value: 1.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 50, + unit: 'L/h', + }, + LM: { + value: 40, + unit: 'mL/h', + }, + }, + + }, + CLmax: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + Km: { + M: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + H: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + + }, + ke0: { + M: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + R: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + K: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + H: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + + }, + Kpu: { + M: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + + }, + }, - F: { - M: { - SM: { - value: 0.5, - unit: "dimensionless", - }, - LM: { - value: 0.5, - unit: "dimensionless", - }, - }, - R: { - SM: { - value: 0.5, - unit: "dimensionless", - }, - LM: { - value: 0.5, - unit: "dimensionless", - }, - }, - K: { - SM: { - value: 0.5, - unit: "dimensionless", - }, - LM: { - value: 0.5, - unit: "dimensionless", - }, - }, - H: { - SM: { - value: 0.5, - unit: "dimensionless", - }, - LM: { - value: 0.5, - unit: "dimensionless", - }, - }, + three_compartment: { + tlag: { + M: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + R: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + K: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + H: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + + }, + ka: { + M: { + SM: { + value: 2.5, + unit: '1/h', + }, + LM: { + value: 0.05, + unit: '1/h', + }, + }, + R: { + SM: { + value: 2, + unit: '1/h', + }, + LM: { + value: 0.04, + unit: '1/h', + }, + }, + K: { + SM: { + value: 1.5, + unit: '1/h', + }, + LM: { + value: 0.025, + unit: '1/h', + }, + }, + H: { + SM: { + value: 1, + unit: '1/h', + }, + LM: { + value: 0.01, + unit: '1/h', + }, + }, + + }, + F: { + M: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + + }, + V1: { + M: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + K: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + H: { + SM: { + value: 150, + unit: 'L', + }, + LM: { + value: 3000, + unit: 'mL', + }, + }, + + }, + V2: { + M: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + K: { + SM: { + value: 2, + unit: 'L/kg', + }, + LM: { + value: 40, + unit: 'mL/kg', + }, + }, + H: { + SM: { + value: 150, + unit: 'L', + }, + LM: { + value: 3000, + unit: 'mL', + }, + }, + + }, + V3: { + M: { + SM: { + value: 1, + unit: 'L/kg', + }, + LM: { + value: 20, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 1, + unit: 'L/kg', + }, + LM: { + value: 20, + unit: 'mL/kg', + }, + }, + K: { + SM: { + value: 1, + unit: 'L/kg', + }, + LM: { + value: 20, + unit: 'mL/kg', + }, + }, + H: { + SM: { + value: 75, + unit: 'L', + }, + LM: { + value: 1500, + unit: 'mL', + }, + }, + + }, + CL: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + Q1: { + M: { + SM: { + value: 2700, + unit: 'mL/h/kg', + }, + LM: { + value: 1.75, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 1650, + unit: 'mL/h/kg', + }, + LM: { + value: 2, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 1300, + unit: 'mL/h/kg', + }, + LM: { + value: 1.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 50, + unit: 'L/h', + }, + LM: { + value: 40, + unit: 'mL/h', + }, + }, + + }, + Q2: { + M: { + SM: { + value: 54, + unit: 'mL/h/kg', + }, + LM: { + value: 0.035, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 33, + unit: 'mL/h/kg', + }, + LM: { + value: 0.04, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 26, + unit: 'mL/h/kg', + }, + LM: { + value: 0.025, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 1, + unit: 'L/h', + }, + LM: { + value: 0.8, + unit: 'mL/h', + }, + }, + + }, + CLmax: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + Km: { + M: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + H: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + + }, + ke0: { + M: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + R: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + K: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + H: { + SM: { + value: 0.5, + unit: '1/h', + }, + LM: { + value: 0.1, + unit: '1/h', + }, + }, + + }, + Kpu: { + M: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + + }, + }, - V1: { - M: { - SM: { - value: 4, - unit: "L/kg", - }, - LM: { - value: 80, - unit: "mL/kg", - }, - }, - R: { - SM: { - value: 4, - unit: "L/kg", - }, - LM: { - value: 80, - unit: "mL/kg", - }, - }, - K: { - SM: { - value: 4, - unit: "L/kg", - }, - LM: { - value: 80, - unit: "mL/kg", - }, - }, - H: { - SM: { - value: 300, - unit: "L", - }, - LM: { - value: 6000, - unit: "mL", - }, - }, + one_compartment_tmdd: { + tlag: { + M: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + R: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + K: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + H: { + SM: { + value: 0, + unit: 'h', + }, + LM: { + value: 0, + unit: 'h', + }, + }, + + }, + ka: { + M: { + SM: { + value: 2.5, + unit: '1/h', + }, + LM: { + value: 0.05, + unit: '1/h', + }, + }, + R: { + SM: { + value: 2, + unit: '1/h', + }, + LM: { + value: 0.04, + unit: '1/h', + }, + }, + K: { + SM: { + value: 1.5, + unit: '1/h', + }, + LM: { + value: 0.025, + unit: '1/h', + }, + }, + H: { + SM: { + value: 1, + unit: '1/h', + }, + LM: { + value: 0.01, + unit: '1/h', + }, + }, + + }, + F: { + M: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.5, + unit: 'dimensionless', + }, + LM: { + value: 0.5, + unit: 'dimensionless', + }, + }, + + }, + V1: { + M: { + SM: { + value: 4, + unit: 'L/kg', + }, + LM: { + value: 80, + unit: 'mL/kg', + }, + }, + R: { + SM: { + value: 4, + unit: 'L/kg', + }, + LM: { + value: 80, + unit: 'mL/kg', + }, + }, + K: { + SM: { + 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+ }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + H: { + SM: { + value: 10000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + + }, + koff: { + M: { + SM: { + value: 0.6931471805599453, + unit: '1/h', + }, + LM: { + value: 0.6931471805599453, + unit: '1/h', + }, + }, + R: { + SM: { + value: 0.6931471805599453, + unit: '1/h', + }, + LM: { + value: 0.6931471805599453, + unit: '1/h', + }, + }, + K: { + SM: { + value: 0.6931471805599453, + unit: '1/h', + }, + LM: { + value: 0.6931471805599453, + unit: '1/h', + }, + }, + H: { + SM: { + value: 0.6931471805599453, + unit: '1/h', + }, + LM: { + value: 0.6931471805599453, + unit: '1/h', + }, + }, + + }, + kdeg: { + M: { + SM: { + value: 0.07124809851593399, + unit: '1/h', + }, + LM: { + value: 0.07124809851593399, + unit: '1/h', + }, + }, + R: { + SM: { + value: 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}, + }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + H: { + SM: { + value: 10000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + + }, + CLmax: { + M: { + SM: { + value: 540, + unit: 'mL/h/kg', + }, + LM: { + value: 0.35, + unit: 'mL/h/kg', + }, + }, + R: { + SM: { + value: 330, + unit: 'mL/h/kg', + }, + LM: { + value: 0.4, + unit: 'mL/h/kg', + }, + }, + K: { + SM: { + value: 260, + unit: 'mL/h/kg', + }, + LM: { + value: 0.25, + unit: 'mL/h/kg', + }, + }, + H: { + SM: { + value: 10, + unit: 'L/h', + }, + LM: { + value: 8, + unit: 'mL/h', + }, + }, + + }, + Km: { + M: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1000, + unit: 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unit: 'dimensionless', + }, + }, + R: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + K: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + H: { + SM: { + value: 0.02, + unit: 'dimensionless', + }, + LM: { + value: 0.2, + unit: 'dimensionless', + }, + }, + + }, + CT1_0: { + M: { + SM: { + value: 1, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + R: { + SM: { + value: 1, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + K: { + SM: { + value: 1, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + H: { + SM: { + value: 1, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + + }, + KD: { + M: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', + }, + }, + R: { + SM: { + value: 1000, + unit: 'nmol/L', + }, + LM: { + value: 1, + unit: 'nmol/L', 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