Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Imputation for haploid organisms #485

Open
adomron24 opened this issue Mar 18, 2024 · 2 comments
Open

Imputation for haploid organisms #485

adomron24 opened this issue Mar 18, 2024 · 2 comments

Comments

@adomron24
Copy link

Hello,

I would like to use bigsnpr to compare the output of clumping vs pruning in my snps dataset from Zymoseptoria tritici. As it is an haploid organism, and I have selected only bialellic snps, I only have 0 (reference) or 2 (alternate) values for my variants after converting the .bed file from plink to bigsnp object.

However, when I try to impute the missing values I end up having "1" values, which would be incorrect since no heterozygous variants should be found. Is there any additional parameter recommended to fix this?

Thank you,

Alex

@privefl
Copy link
Owner

privefl commented Mar 19, 2024

  • Which function are you using for imputation?
  • What's the typical proportion of missing values per variant you have?

@privefl
Copy link
Owner

privefl commented Apr 12, 2024

Any update on this?

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

2 participants