diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index 6e036b600330c1..4ce50a84dcb422 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -5621,6 +5621,14 @@ class A:
                     with self.assertRaises(TypeError):
                         a[int]
 
+    def test_orig_class_init(self):
+        # See gh-123777
+        T = TypeVar("T")
+        class OrigClassInit(Generic[T]):
+            def __init__(self):
+                self.attr = self.__orig_class__
+        self.assertEqual(OrigClassInit[int]().attr, OrigClassInit[int])
+
 
 class ClassVarTests(BaseTestCase):
 
diff --git a/Lib/typing.py b/Lib/typing.py
index bcb7bec23a9aa1..a7709414c40979 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -1290,13 +1290,36 @@ def __call__(self, *args, **kwargs):
         if not self._inst:
             raise TypeError(f"Type {self._name} cannot be instantiated; "
                             f"use {self.__origin__.__name__}() instead")
-        result = self.__origin__(*args, **kwargs)
+        clas = self.__origin__
+        safe_new = (clas.__new__ is object.__new__) or isinstance(clas.__new__, types.FunctionType)
+
+        if safe_new:
+            # GH-123777: Some types try and access __orig_class__ in their __init__
+            try:
+                result = clas.__new__(clas, *args, **kwargs)
+            except Exception:
+                # Something about the type doesn't like calling __new__
+                # (For example, _GenericAlias)
+                safe_new = False
+                result = clas(*args, **kwargs)
+        else:
+            # This is a C type with a custom __new__
+            #
+            # I'm worried that trying to set attributes on C types before they've been
+            # fully initialized will be problematic, so let's just disallow them
+            # from using the __orig_class__ in the initializer for now.
+            result = clas(*args, **kwargs)
+
         try:
             result.__orig_class__ = self
         # Some objects raise TypeError (or something even more exotic)
         # if you try to set attributes on them; we guard against that here
         except Exception:
             pass
+
+        if safe_new:
+            result.__init__(*args, **kwargs)
+
         return result
 
     def __mro_entries__(self, bases):
diff --git a/Misc/NEWS.d/next/Library/2024-09-09-16-21-12.gh-issue-123777.sdyP3n.rst b/Misc/NEWS.d/next/Library/2024-09-09-16-21-12.gh-issue-123777.sdyP3n.rst
new file mode 100644
index 00000000000000..df1412213275f3
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-09-09-16-21-12.gh-issue-123777.sdyP3n.rst
@@ -0,0 +1,2 @@
+Allowed the ``__orig_class__`` attribute to be used in the ``__init__`` of
+pure-Python types.