diff --git a/.github/workflows/docs.yml b/.github/workflows/docs.yml
index f13a3de1f2e3..8bded1d380aa 100644
--- a/.github/workflows/docs.yml
+++ b/.github/workflows/docs.yml
@@ -38,7 +38,7 @@ jobs:
         with:
           python-version: '3.8'
       - name: Install tox
-        run: pip install --upgrade 'setuptools!=50' tox==4.11.0
+        run: pip install tox==4.11.0
       - name: Setup tox environment
         run: tox run -e ${{ env.TOXENV }} --notest
       - name: Test
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 98a737a78b3b..01d5876635b0 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -147,6 +147,24 @@ jobs:
     - name: Test
       run: tox run -e ${{ matrix.toxenv }} --skip-pkg-install -- ${{ matrix.tox_extra_args }}
 
+  python-nightly:
+    runs-on: ubuntu-latest
+    name: Test suite with Python nightly
+    steps:
+      - uses: actions/checkout@v3
+      - uses: actions/setup-python@v4
+        with:
+          python-version: '3.13-dev'
+      - name: Install tox
+        run: pip install setuptools==68.2.2 tox==4.11.0
+      - name: Setup tox environment
+        run: tox run -e py --notest
+      - name: Test
+        run: tox run -e py --skip-pkg-install -- "-n 4"
+        continue-on-error: true
+      - name: Mark as a success
+        run: exit 0
+
   python_32bits:
     runs-on: ubuntu-latest
     name: Test mypyc suite with 32-bit Python
diff --git a/test-requirements.in b/test-requirements.in
index 637f5b948055..5a888811bfcd 100644
--- a/test-requirements.in
+++ b/test-requirements.in
@@ -8,8 +8,6 @@ black==24.3.0  # must match version in .pre-commit-config.yaml
 filelock>=3.3.0
 # lxml 4.9.3 switched to manylinux_2_28, the wheel builder still uses manylinux2014
 lxml>=4.9.1,<4.9.3; (python_version<'3.11' or sys_platform!='win32') and python_version<'3.12'
-pre-commit
-pre-commit-hooks==4.5.0
 psutil>=4.0
 pytest>=8.1.0
 pytest-xdist>=1.34.0
diff --git a/test-requirements.txt b/test-requirements.txt
index 9005daab2876..75a970c5bf0e 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -8,22 +8,14 @@ attrs==23.1.0
     # via -r test-requirements.in
 black==24.3.0
     # via -r test-requirements.in
-cfgv==3.4.0
-    # via pre-commit
 click==8.1.7
     # via black
 coverage==7.3.2
     # via pytest-cov
-distlib==0.3.7
-    # via virtualenv
 execnet==2.0.2
     # via pytest-xdist
 filelock==3.12.4
-    # via
-    #   -r test-requirements.in
-    #   virtualenv
-identify==2.5.30
-    # via pre-commit
+    # via -r test-requirements.in
 iniconfig==2.0.0
     # via pytest
 lxml==4.9.2 ; (python_version < "3.11" or sys_platform != "win32") and python_version < "3.12"
@@ -32,8 +24,6 @@ mypy-extensions==1.0.0
     # via
     #   -r mypy-requirements.txt
     #   black
-nodeenv==1.8.0
-    # via pre-commit
 packaging==23.2
     # via
     #   black
@@ -41,15 +31,9 @@ packaging==23.2
 pathspec==0.11.2
     # via black
 platformdirs==3.11.0
-    # via
-    #   black
-    #   virtualenv
+    # via black
 pluggy==1.4.0
     # via pytest
-pre-commit==3.5.0
-    # via -r test-requirements.in
-pre-commit-hooks==4.5.0
-    # via -r test-requirements.in
 psutil==5.9.6
     # via -r test-requirements.in
 pytest==8.1.1
@@ -61,12 +45,6 @@ pytest-cov==4.1.0
     # via -r test-requirements.in
 pytest-xdist==3.3.1
     # via -r test-requirements.in
-pyyaml==6.0.1
-    # via pre-commit
-ruamel-yaml==0.17.40
-    # via pre-commit-hooks
-ruamel-yaml-clib==0.2.8
-    # via ruamel-yaml
 ruff==0.2.0
     # via -r test-requirements.in
 tomli==2.0.1
@@ -75,13 +53,9 @@ types-psutil==5.9.5.17
     # via -r build-requirements.txt
 types-setuptools==68.2.0.0
     # via -r build-requirements.txt
-typing-extensions==4.8.0
+typing-extensions==4.12.2
     # via -r mypy-requirements.txt
-virtualenv==20.24.5
-    # via pre-commit
 
 # The following packages are considered to be unsafe in a requirements file:
 setuptools==68.2.2
-    # via
-    #   -r test-requirements.in
-    #   nodeenv
+    # via -r test-requirements.in