diff --git a/mypyc/irbuild/expression.py b/mypyc/irbuild/expression.py
index 5cdd9a432a12..81e37953809f 100644
--- a/mypyc/irbuild/expression.py
+++ b/mypyc/irbuild/expression.py
@@ -80,6 +80,7 @@
 from mypyc.irbuild.constant_fold import constant_fold_expr
 from mypyc.irbuild.for_helpers import (
     comprehension_helper,
+    raise_error_if_contains_unreachable_names,
     translate_list_comprehension,
     translate_set_comprehension,
 )
@@ -1020,6 +1021,9 @@ def transform_set_comprehension(builder: IRBuilder, o: SetComprehension) -> Valu
 
 
 def transform_dictionary_comprehension(builder: IRBuilder, o: DictionaryComprehension) -> Value:
+    if raise_error_if_contains_unreachable_names(builder, o):
+        return builder.none()
+
     d = builder.maybe_spill(builder.call_c(dict_new_op, [], o.line))
     loop_params = list(zip(o.indices, o.sequences, o.condlists, o.is_async))
 
diff --git a/mypyc/irbuild/for_helpers.py b/mypyc/irbuild/for_helpers.py
index 61dbbe960eb2..5d8315e88f72 100644
--- a/mypyc/irbuild/for_helpers.py
+++ b/mypyc/irbuild/for_helpers.py
@@ -12,10 +12,12 @@
 from mypy.nodes import (
     ARG_POS,
     CallExpr,
+    DictionaryComprehension,
     Expression,
     GeneratorExpr,
     Lvalue,
     MemberExpr,
+    NameExpr,
     RefExpr,
     SetExpr,
     TupleExpr,
@@ -28,6 +30,7 @@
     IntOp,
     LoadAddress,
     LoadMem,
+    RaiseStandardError,
     Register,
     TupleGet,
     TupleSet,
@@ -229,6 +232,9 @@ def set_item(item_index: Value) -> None:
 
 
 def translate_list_comprehension(builder: IRBuilder, gen: GeneratorExpr) -> Value:
+    if raise_error_if_contains_unreachable_names(builder, gen):
+        return builder.none()
+
     # Try simplest list comprehension, otherwise fall back to general one
     val = sequence_from_generator_preallocate_helper(
         builder,
@@ -251,7 +257,30 @@ def gen_inner_stmts() -> None:
     return builder.read(list_ops)
 
 
+def raise_error_if_contains_unreachable_names(
+    builder: IRBuilder, gen: GeneratorExpr | DictionaryComprehension
+) -> bool:
+    """Raise a runtime error and return True if generator contains unreachable names.
+
+    False is returned if the generator can be safely transformed without crashing.
+    (It may still be unreachable!)
+    """
+    if any(isinstance(s, NameExpr) and s.node is None for s in gen.indices):
+        error = RaiseStandardError(
+            RaiseStandardError.RUNTIME_ERROR,
+            "mypyc internal error: should be unreachable",
+            gen.line,
+        )
+        builder.add(error)
+        return True
+
+    return False
+
+
 def translate_set_comprehension(builder: IRBuilder, gen: GeneratorExpr) -> Value:
+    if raise_error_if_contains_unreachable_names(builder, gen):
+        return builder.none()
+
     set_ops = builder.maybe_spill(builder.new_set_op([], gen.line))
     loop_params = list(zip(gen.indices, gen.sequences, gen.condlists, gen.is_async))
 
diff --git a/mypyc/test-data/run-misc.test b/mypyc/test-data/run-misc.test
index f77ba3a1302b..14bb5be979ae 100644
--- a/mypyc/test-data/run-misc.test
+++ b/mypyc/test-data/run-misc.test
@@ -1097,8 +1097,10 @@ B = sys.platform == 'x' and sys.foobar
 C = sys.platform == 'x' and f(a, -b, 'y') > [c + e, g(y=2)]
 C = sys.platform == 'x' and cast(a, b[c])
 C = sys.platform == 'x' and (lambda x: y + x)
-# TODO: This still doesn't work
-# C = sys.platform == 'x' and (x for y in z)
+C = sys.platform == 'x' and (x for y in z)
+C = sys.platform == 'x' and [x for y in z]
+C = sys.platform == 'x' and {x: x for y in z}
+C = sys.platform == 'x' and {x for y in z}
 
 assert not A
 assert not B