FAQ

1 .Why does vmware crash on startup when used with lessfs?
VMware tries to use shared writable mmap for paging files but it can't 
detect that it's not always supported.
Workaround: Set "mainMem.useNamedFile=FALSE" in the .vmx file. 
It will disable paging files and VMware will work fine, often with much better performance.
Another workaround is to create a large (sparse) file on lessfs. 
Format the file with your favorit fs and mount it with -o loop. 
You can now run your VM deduplicated from this filesystem. 

Another workaround is to use ietd and iscsi as an intermediate protocol.

2. Can I use lessfs with NFS/IETD or SAMBA?

Fuse and kernelspace NFS does not seem to be stable yet. However your mileage may vary.
You might want to try userspace NFS instead: http://sourceforge.net/projects/unfs3/

Samba and lessfs should work fine.

Ietd and lessfs should also work. You can export an sparse file as ietd disk:
cd /to/your/lessfs/mount
dd if=/dev/zero of=ietddata bs=1 count=0 seek=10000M
# create a 10000M large sparse file

# Add this to your ietd.conf file.
Lun 0 Path=/fuse/ietddata,Type=fileio