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Add amino acid substitution models #114

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richelbilderbeek opened this issue Apr 23, 2020 · 0 comments
Open

Add amino acid substitution models #114

richelbilderbeek opened this issue Apr 23, 2020 · 0 comments

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@richelbilderbeek
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Is your feature request related to a problem? Please describe.

Currently, there is only a nucleotide substitution model. This is unhelpful when working with proteomes.

Describe the solution you'd like

I would like to have the standard amino acid substition models implemented.

Describe alternatives you've considered

None.

Additional context

These are:

  • Blosum62: Amino acid substitution matrices from protein blocks
  • Dayhoff: 22 a model of evolutionary change in proteins
  • JTT: The rapid generation of mutation data matrices from protein sequences
  • CPREV: Plastid genome phylogeny and a model of amino acid substitution for proteins encoded by chloroplast DNA
  • MTREV24: Model of amino acid substitution in proteins encoded by mitochondrial DNA
  • WAG: A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach
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