diff --git a/src/bus.rs b/src/bus.rs
index eb9c781..c36bad7 100644
--- a/src/bus.rs
+++ b/src/bus.rs
@@ -111,7 +111,7 @@ impl<USB: UsbPeripheral> UsbBus<USB> {
         }
     }
 
-    fn deconfigure_all(&self, cs: CriticalSection<'_>) {
+    fn deconfigure_all(&self, cs: CriticalSection<'_>, core_id: u32) {
         let regs = self.regs.borrow(cs);
 
         // disable interrupts
@@ -125,7 +125,7 @@ impl<USB: UsbPeripheral> UsbBus<USB> {
 
         for ep in &self.allocator.endpoints_out {
             if let Some(ep) = ep {
-                ep.deconfigure(cs);
+                ep.deconfigure(cs, core_id);
             }
         }
     }
@@ -605,7 +605,7 @@ impl<USB: UsbPeripheral> usb_device::bus::UsbBus for UsbBus<USB> {
             if reset != 0 {
                 write_reg!(otg_global, regs.global(), GINTSTS, USBRST: 1);
 
-                self.deconfigure_all(cs);
+                self.deconfigure_all(cs, core_id);
 
                 // Flush RX
                 modify_reg!(otg_global, regs.global(), GRSTCTL, RXFFLSH: 1);
diff --git a/src/endpoint.rs b/src/endpoint.rs
index c6e3be1..d8380fe 100644
--- a/src/endpoint.rs
+++ b/src/endpoint.rs
@@ -189,15 +189,18 @@ impl EndpointOut {
         }
     }
 
-    pub fn deconfigure(&self, _cs: CriticalSection<'_>) {
+    pub fn deconfigure(&self, _cs: CriticalSection<'_>, core_id: u32) {
         let regs = self.usb.endpoint_out(self.index() as usize);
 
-        // deactivating endpoint
-        modify_reg!(endpoint_out, regs, DOEPCTL, USBAEP: 0);
+        // GD32VF103 doesn't support endpoint deactivation after reset, so skip this.
+        if core_id > 0x0000_1000 {
+            // deactivating endpoint
+            modify_reg!(endpoint_out, regs, DOEPCTL, USBAEP: 0);
 
-        // disabling endpoint
-        if read_reg!(endpoint_out, regs, DOEPCTL, EPENA) != 0 && self.index() != 0 {
-            modify_reg!(endpoint_out, regs, DOEPCTL, EPDIS: 1)
+            // disabling endpoint
+            if read_reg!(endpoint_out, regs, DOEPCTL, EPENA) != 0 && self.index() != 0 {
+                modify_reg!(endpoint_out, regs, DOEPCTL, EPDIS: 1)
+            }
         }
 
         // clean EP interrupts