From 05ea2e28e91bc312e12d4745f2ee90a9c11d64dc Mon Sep 17 00:00:00 2001 From: Natalia Florekova Date: Tue, 17 Sep 2024 10:26:22 +0200 Subject: [PATCH] Added model 231 - breast cancer signaling pathways --- bnet_to_aeon.py | 2 +- .../README.md | 37 ++ .../metadata.json | 17 + .../model.aeon | 378 ++++++++++++++++++ .../model.bnet | 111 +++++ .../model.sbml | 1 + models/summary.csv | 1 + report/online_only_table_1.xlsx | Bin 56661 -> 58339 bytes .../citation.bib | 8 + .../metadata.json | 7 + .../notes.md | 11 + .../source.bnet | 111 +++++ 12 files changed, 683 insertions(+), 1 deletion(-) create mode 100644 models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/README.md create mode 100644 models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/metadata.json create mode 100644 models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.aeon create mode 100644 models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.bnet create mode 100644 models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.sbml create mode 100644 sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/citation.bib create mode 100644 sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/metadata.json create mode 100644 sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/notes.md create mode 100644 sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/source.bnet diff --git a/bnet_to_aeon.py b/bnet_to_aeon.py index 1b0fea6..d27f728 100644 --- a/bnet_to_aeon.py +++ b/bnet_to_aeon.py @@ -2,4 +2,4 @@ import sys bn = BooleanNetwork.from_file(sys.argv[1]) -print(bn.to_aeon()) \ No newline at end of file +print(bn.to_aeon()) diff --git a/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/README.md b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/README.md new file mode 100644 index 0000000..354d8b4 --- /dev/null +++ b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/README.md @@ -0,0 +1,37 @@ +# \[231\] BREAST-CANCER-SIGNALLING-PATHWAYS + + - Variables: 110 + - Inputs: 7 + - Regulations: 268 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Rows deleted from the model: + +DLL_i, DLL_i +IGF1, IGF1 +NRG1, NRG1 +PG, PG +ES, ES +EGF, EGF +INS, INS + + +### Model citation + +``` +@article{bbm-231, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/metadata.json b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/metadata.json new file mode 100644 index 0000000..c2f0b0a --- /dev/null +++ b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 231, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 110, + "inputs": 7, + "regulations": 268, + "notes": "### Modifications\n\nRows deleted from the model:\n\nDLL_i, DLL_i\nIGF1, IGF1\nNRG1, NRG1\nPG, PG\nES, ES\nEGF, EGF\nINS, INS\n", + "bib": "@article{bbm-231,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.aeon b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.aeon new file mode 100644 index 0000000..f8d3389 --- /dev/null +++ b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.aeon @@ -0,0 +1,378 @@ +v_GRB2 -? v_ABL1 +v_SRC -? v_ABL1 +v_ABL1 -? v_ABL2 +v_IGF1 -? v_AKT_i +v_IGF1R -? v_AKT_i +v_IRS1 -? v_AKT_i +v_MTORC2_c -? v_AKT_i +v_NRG1 -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_CASP8 -? v_BID +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_NF1 -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_BCLXL -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CASP8 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_PRKACA -? v_CASP9 +v_CASP3 -? v_CDKN2A +v_MYC -? v_CDKN2A +v_SRC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_CREB1 -? v_CEBPB +v_AKT_i -? v_CREB1 +v_PTEN -? v_CREB1 +v_DC -? v_CTNNB1 +v_SRC -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_YAP1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_ESR1 -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_TCF4 -? v_CYCLIN_D_c +v_TEAD1 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_NF1 -? v_DVL1 +v_PRB -? v_E2F1 +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_MEK_i -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_AKT_i -? v_FOXO1 +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_CREB1 -? v_FZD3 +v_WNT1 -? v_FZD3 +v_STAT1 -? v_GATA3 +v_EGFR -? v_GRB2 +v_IRS1 -? v_GRB2 +v_LATS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_INSR -? v_GRB7 +v_PRKACA -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_EGF -? v_HER2 +v_HER3 -? v_HER2 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_CASP3 -? v_HES1 +v_NCID -? v_HES1 +v_NCID -? v_HEY1 +v_IGF1 -? v_HRAS +v_NF1 -? v_HRAS +v_PI3K_c -? v_HRAS +v_SOS1 -? v_HRAS +v_PDPK1 -? v_HSP90AA1 +v_ESR1 -? v_IGF1R +v_FOXO3 -? v_IGF1R +v_IGF1 -? v_IGF1R +v_INS -? v_IGF1R +v_SRC -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_IL6 -? v_IL6R +v_STAT5 -? v_IL8 +v_FOXO3 -? v_INSR +v_INS -? v_INSR +v_IGF1R -? v_IRS1 +v_INSR -? v_IRS1 +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_AKT_i -? v_LCK +v_ERK_i -? v_LCK +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_AKT_i -? v_MDM2 +v_P53 -? v_MDM2 +v_RAF1 -? v_MEK_i +v_IGF1 -? v_MTORC1_c +v_NRG1 -? v_MTORC1_c +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_ERK_i -? v_MYC +v_ESR1 -? v_MYC +v_GSK3B -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_ABL1 -? v_MYOD1 +v_HES1 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_PRKACA -? v_NEDD4L +v_S6K1 -? v_NEDD4L +v_SGK1 -? v_NEDD4L +v_P53 -? v_NF1 +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_MDM2 -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MYC -? v_P21 +v_MDM2 -? v_P53 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_HES1 -? v_PAX7 +v_HEY1 -? v_PAX7 +v_MYOG -? v_PAX7 +v_NOTCH1 -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_ERK_i -? v_PGR +v_ESR1 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_INSR -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_RAS_i -? v_PI3K_c +v_STAT5 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_PRKACA -? v_PRKAA2 +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_AKT_i -? v_RAC1 +v_DVL1 -? v_RAC1 +v_PI3K_c -? v_RAC1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_IGF1 -? v_RAS_i +v_PI3K_c -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_ABL1 -? v_SRC +v_PRKACA -? v_SRC +v_JAK2 -? v_STAT1 +v_SRC -? v_STAT1 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_EGFR -? v_STAT5 +v_JAK2 -? v_STAT5 +v_SRC -? v_STAT5 +v_ERK_i -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_JUN -? v_TCF4 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_AKT_i -? v_TSC2 +v_ERK_i -? v_TSC2 +v_GSK3B -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_AKT_i -? v_TWIST1 +v_ERK_i -? v_TWIST1 +v_MAPK8 -? v_TWIST1 +v_PGR -? v_WNT1 +v_WNT1 -? v_WNT1 +v_ABL1 -? v_YAP1 +v_LATS1 -? v_YAP1 +$v_ABL1: (v_SRC | v_GRB2) +$v_ABL2: v_ABL1 +$v_AKT_i: ((((v_MTORC2_c & v_PDPK1) & v_PIP3) & (v_IRS1 | v_IGF1R)) | (v_NRG1 | v_IGF1)) +$v_APC: v_AXIN1 +$v_AXIN1: (!v_DVL1 & v_GSK3B) +$v_BAD: !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +$v_BAK1: (((v_BIM | v_P53) | v_BID) & !v_MCL1) +$v_BAX: (((v_BIM | v_P53) | v_BID) & !v_MCL1) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 | v_ERK_i)) +$v_BCLXL: (!(v_BAD | v_BIM) & v_CREB1) +$v_BID: v_CASP8 +$v_BIM: (!(v_BCL2 | v_BCLXL) & (v_FOXO3 | v_FOXO1)) +$v_CASP3: v_CASP9 +$v_CASP8: ((v_FADD | v_NF1) & !(v_ERK_i & v_SRC)) +$v_CASP9: (((v_CYCS | v_CASP8) | v_CASP3) & !((v_ERK_i | v_PRKACA) | (v_BCLXL | v_AKT_i))) +$v_CDKN2A: (!(v_MYC | v_SRC) & v_CASP3) +$v_CEBPB: (v_ABL2 | v_CREB1) +$v_CREB1: (v_AKT_i & !v_PTEN) +$v_CTNNB1: (!v_DC & (v_WNT1 | (v_SRC | v_YAP1))) +$v_CYCLIN_D_c: ((v_TCF4 | (v_TEAD1 | (v_ESR1 | v_MYC))) & !(v_GSK3B | (v_CDKN2A | v_P21))) +$v_CYCS: (v_BAK1 | v_BAX) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 | v_NF1) +$v_E2F1: !v_PRB +$v_EGFR: ((v_EGF | (v_HER2 & v_HER3)) & !v_MEK_i) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: (v_AKT_i | (v_FOXO3 | (v_ES | (v_PGR | v_KMT2D)))) +$v_FADD: (v_TRADD | v_FAS) +$v_FAS: ((v_FASLG | v_P53) & !v_AKT_i) +$v_FASLG: (v_FASLG | (v_P53 | v_FOXO3)) +$v_FOXO1: !(v_SGK1 | v_AKT_i) +$v_FOXO3: !v_AKT_i +$v_FZD3: (v_WNT1 | v_CREB1) +$v_GATA3: !v_STAT1 +$v_GRB2: (v_IRS1 | (v_LATS1 | (v_EGFR | v_SRC))) +$v_GRB7: (v_INSR & !v_PRKACA) +$v_GSK3B: !(v_AKT_i | v_ERK_i) +$v_HER2: (v_HER3 | v_EGF) +$v_HER3: (v_NRG1 | v_HER2) +$v_HES1: (v_NCID & !v_CASP3) +$v_HEY1: v_NCID +$v_HRAS: (((v_SOS1 | v_PI3K_c) & !v_NF1) | (v_PI3K_c | v_IGF1)) +$v_HSP90AA1: !v_PDPK1 +$v_IGF1R: ((v_IGF1 | (v_SRC | v_INS)) | (v_FOXO3 | v_ESR1)) +$v_IL1B: (v_NOS3 | v_RELA) +$v_IL6: (v_IL1B | v_IL6) +$v_IL6R: v_IL6 +$v_IL8: v_STAT5 +$v_INSR: (v_INS | v_FOXO3) +$v_IRS1: (!v_S6K1 & (v_INSR | v_IGF1R)) +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: ((v_IL6R | (v_ABL1 | v_IL8)) | v_IRS1) +$v_JUN: ((v_RELA | v_MAPK8) & (v_ERK_i | v_PPARG)) +$v_KMT2D: (v_PAX7 & !v_AKT_i) +$v_KRT14: (v_PAK2 | v_EGFR) +$v_LATS1: (v_NF2 | v_LCK) +$v_LCK: (v_ERK_i & !v_AKT_i) +$v_MAPK8: (v_RAC1 | v_RND1) +$v_MCL1: (!v_GSK3B & v_ERK_i) +$v_MDM2: (v_P53 | v_AKT_i) +$v_MEK_i: v_RAF1 +$v_MTORC1_c: (v_RHEB | (v_NRG1 | v_IGF1)) +$v_MTORC2_c: (v_PIP3 & !v_S6K1) +$v_MYC: ((v_CTNNB1 | (v_PIM | (v_ERK_i | (v_STAT3 | (v_ESR1 | v_EIF4E))))) & !v_GSK3B) +$v_MYOD1: !(v_HES1 | v_ABL1) +$v_MYOG: (!v_HEY1 & v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !(v_S6K1 | (v_SGK1 | v_PRKACA)) +$v_NF1: (!v_TWIST1 & v_P53) +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 | v_AKT_i) +$v_NOTCH1: ((v_DLL_i | (v_CTNNB1 | v_LCK)) | v_MDM2) +$v_P21: !(v_ERK_i | (v_AKT_i | v_MYC)) +$v_P53: !v_MDM2 +$v_PAK1: v_TCF4 +$v_PAK2: (v_RAC1 | v_SRC) +$v_PAX7: (!(v_MYOG | (v_HEY1 | v_HES1)) & v_NOTCH1) +$v_PDPK1: (v_PIP3 | v_IGF1R) +$v_PGR: (v_PG & !(v_ERK_i | v_ESR1)) +$v_PI3K_c: ((v_EGFR | (v_INSR | (v_RAS_i | v_ESR1))) | (v_IRS1 | v_IGF1R)) +$v_PIM: v_STAT5 +$v_PIP3: (v_PI3K_c & !v_PTEN) +$v_PPARG: (!v_GATA3 & v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: (v_STK11 | !v_PRKACA) +$v_PRKACA: (v_AKT_i | v_WNT1) +$v_PTEN: (v_S6K1 & !v_SRC) +$v_RAC1: ((v_PI3K_c | v_DVL1) & !v_AKT_i) +$v_RAF1: (v_HRAS | v_RAS_i) +$v_RAS_i: ((v_SOS1 | v_PI3K_c) | (v_PI3K_c | v_IGF1)) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 | v_DVL1) +$v_S6K1: v_MTORC1_c +$v_SGK1: ((v_MTORC2_c | v_MTORC1_c) | v_PDPK1) +$v_SOS1: v_GRB2 +$v_SRC: (v_PRKACA | v_ABL1) +$v_STAT1: (v_JAK2 | v_SRC) +$v_STAT3: (v_IL1B | (v_SRC | (v_MAPK8 | v_JAK2))) +$v_STAT5: (v_JAK2 | (v_SRC | v_EGFR)) +$v_STK11: !v_ERK_i +$v_TCF4: (v_CTNNB1 | v_JUN) +$v_TEAD1: v_YAP1 +$v_TRADD: !v_KRT14 +$v_TSC2: (!(v_AKT_i | v_ERK_i) & (v_PRKAA2 | v_GSK3B)) +$v_TWIST1: (v_ERK_i | (v_AKT_i | v_MAPK8)) +$v_WNT1: (v_PGR | v_WNT1) +$v_YAP1: (!v_LATS1 & v_ABL1) diff --git a/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.bnet b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.bnet new file mode 100644 index 0000000..5989390 --- /dev/null +++ b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.bnet @@ -0,0 +1,111 @@ +targets,factors +v_ABL1, (v_SRC | v_GRB2) +v_ABL2, v_ABL1 +v_AKT_i, ((((v_MTORC2_c & v_PDPK1) & v_PIP3) & (v_IRS1 | v_IGF1R)) | (v_NRG1 | v_IGF1)) +v_APC, v_AXIN1 +v_AXIN1, (!v_DVL1 & v_GSK3B) +v_BAD, !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +v_BAK1, (((v_BIM | v_P53) | v_BID) & !v_MCL1) +v_BAX, (((v_BIM | v_P53) | v_BID) & !v_MCL1) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 | v_ERK_i)) +v_BCLXL, (!(v_BAD | v_BIM) & v_CREB1) +v_BID, v_CASP8 +v_BIM, (!(v_BCL2 | v_BCLXL) & (v_FOXO3 | v_FOXO1)) +v_CASP3, v_CASP9 +v_CASP8, ((v_FADD | v_NF1) & !(v_ERK_i & v_SRC)) +v_CASP9, (((v_CYCS | v_CASP8) | v_CASP3) & !((v_ERK_i | v_PRKACA) | (v_BCLXL | v_AKT_i))) +v_CDKN2A, (!(v_MYC | v_SRC) & v_CASP3) +v_CEBPB, (v_ABL2 | v_CREB1) +v_CREB1, (v_AKT_i & !v_PTEN) +v_CTNNB1, (!v_DC & (v_WNT1 | (v_SRC | v_YAP1))) +v_CYCLIN_D_c, ((v_TCF4 | (v_TEAD1 | (v_ESR1 | v_MYC))) & !(v_GSK3B | (v_CDKN2A | v_P21))) +v_CYCS, (v_BAK1 | v_BAX) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 | v_NF1) +v_E2F1, !v_PRB +v_EGFR, ((v_EGF | (v_HER2 & v_HER3)) & !v_MEK_i) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, (v_AKT_i | (v_FOXO3 | (v_ES | (v_PGR | v_KMT2D)))) +v_FADD, (v_TRADD | v_FAS) +v_FAS, ((v_FASLG | v_P53) & !v_AKT_i) +v_FASLG, (v_FASLG | (v_P53 | v_FOXO3)) +v_FOXO1, !(v_SGK1 | v_AKT_i) +v_FOXO3, !v_AKT_i +v_FZD3, (v_WNT1 | v_CREB1) +v_GATA3, !v_STAT1 +v_GRB2, (v_IRS1 | (v_LATS1 | (v_EGFR | v_SRC))) +v_GRB7, (v_INSR & !v_PRKACA) +v_GSK3B, !(v_AKT_i | v_ERK_i) +v_HER2, (v_HER3 | v_EGF) +v_HER3, (v_NRG1 | v_HER2) +v_HES1, (v_NCID & !v_CASP3) +v_HEY1, v_NCID +v_HRAS, (((v_SOS1 | v_PI3K_c) & !v_NF1) | (v_PI3K_c | v_IGF1)) +v_HSP90AA1, !v_PDPK1 +v_IGF1R, ((v_IGF1 | (v_SRC | v_INS)) | (v_FOXO3 | v_ESR1)) +v_IL1B, (v_NOS3 | v_RELA) +v_IL6, (v_IL1B | v_IL6) +v_IL6R, v_IL6 +v_IL8, v_STAT5 +v_INSR, (v_INS | v_FOXO3) +v_IRS1, (!v_S6K1 & (v_INSR | v_IGF1R)) +v_IVEBP1, !v_MTORC1_c +v_JAK2, ((v_IL6R | (v_ABL1 | v_IL8)) | v_IRS1) +v_JUN, ((v_RELA | v_MAPK8) & (v_ERK_i | v_PPARG)) +v_KMT2D, (v_PAX7 & !v_AKT_i) +v_KRT14, (v_PAK2 | v_EGFR) +v_LATS1, (v_NF2 | v_LCK) +v_LCK, (v_ERK_i & !v_AKT_i) +v_MAPK8, (v_RAC1 | v_RND1) +v_MCL1, (!v_GSK3B & v_ERK_i) +v_MDM2, (v_P53 | v_AKT_i) +v_MEK_i, v_RAF1 +v_MTORC1_c, (v_RHEB | (v_NRG1 | v_IGF1)) +v_MTORC2_c, (v_PIP3 & !v_S6K1) +v_MYC, ((v_CTNNB1 | (v_PIM | (v_ERK_i | (v_STAT3 | (v_ESR1 | v_EIF4E))))) & !v_GSK3B) +v_MYOD1, !(v_HES1 | v_ABL1) +v_MYOG, (!v_HEY1 & v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !(v_S6K1 | (v_SGK1 | v_PRKACA)) +v_NF1, (!v_TWIST1 & v_P53) +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 | v_AKT_i) +v_NOTCH1, ((v_DLL_i | (v_CTNNB1 | v_LCK)) | v_MDM2) +v_P21, !(v_ERK_i | (v_AKT_i | v_MYC)) +v_P53, !v_MDM2 +v_PAK1, v_TCF4 +v_PAK2, (v_RAC1 | v_SRC) +v_PAX7, (!(v_MYOG | (v_HEY1 | v_HES1)) & v_NOTCH1) +v_PDPK1, (v_PIP3 | v_IGF1R) +v_PGR, (v_PG & !(v_ERK_i | v_ESR1)) +v_PI3K_c, ((v_EGFR | (v_INSR | (v_RAS_i | v_ESR1))) | (v_IRS1 | v_IGF1R)) +v_PIM, v_STAT5 +v_PIP3, (v_PI3K_c & !v_PTEN) +v_PPARG, (!v_GATA3 & v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, (v_STK11 | !v_PRKACA) +v_PRKACA, (v_AKT_i | v_WNT1) +v_PTEN, (v_S6K1 & !v_SRC) +v_RAC1, ((v_PI3K_c | v_DVL1) & !v_AKT_i) +v_RAF1, (v_HRAS | v_RAS_i) +v_RAS_i, ((v_SOS1 | v_PI3K_c) | (v_PI3K_c | v_IGF1)) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 | v_DVL1) +v_S6K1, v_MTORC1_c +v_SGK1, ((v_MTORC2_c | v_MTORC1_c) | v_PDPK1) +v_SOS1, v_GRB2 +v_SRC, (v_PRKACA | v_ABL1) +v_STAT1, (v_JAK2 | v_SRC) +v_STAT3, (v_IL1B | (v_SRC | (v_MAPK8 | v_JAK2))) +v_STAT5, (v_JAK2 | (v_SRC | v_EGFR)) +v_STK11, !v_ERK_i +v_TCF4, (v_CTNNB1 | v_JUN) +v_TEAD1, v_YAP1 +v_TRADD, !v_KRT14 +v_TSC2, (!(v_AKT_i | v_ERK_i) & (v_PRKAA2 | v_GSK3B)) +v_TWIST1, (v_ERK_i | (v_AKT_i | v_MAPK8)) +v_WNT1, (v_PGR | v_WNT1) +v_YAP1, (!v_LATS1 & v_ABL1) diff --git a/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.sbml b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.sbml new file mode 100644 index 0000000..9e1840d --- /dev/null +++ b/models/[id-231]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS]/model.sbml @@ -0,0 +1 @@ +v_SRC1v_GRB21v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_IRS11v_IGF1R1v_NRG11v_IGF11v_AXIN11v_DVL11v_GSK3B1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BIM1v_P531v_BID1v_MCL11v_BAD1v_BIM1v_CREB11v_ERK_i1v_BAD1v_BIM1v_CREB11v_CASP81v_BCL21v_BCLXL1v_FOXO31v_FOXO11v_CASP91v_FADD1v_NF11v_ERK_i1v_SRC1v_CYCS1v_CASP81v_CASP31v_ERK_i1v_PRKACA1v_BCLXL1v_AKT_i1v_MYC1v_SRC1v_CASP31v_ABL21v_CREB11v_AKT_i1v_PTEN1v_DC1v_WNT11v_SRC1v_YAP11v_TCF41v_TEAD11v_ESR11v_MYC1v_GSK3B1v_CDKN2A1v_P211v_BAK11v_BAX1v_APC1v_GSK3B1v_FZD31v_NF11v_PRB1v_EGF1v_HER21v_HER31v_MEK_i1v_IVEBP11v_MEK_i1v_AKT_i1v_FOXO31v_ES1v_PGR1v_KMT2D1v_TRADD1v_FAS1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_AKT_i1v_WNT11v_CREB11v_STAT11v_IRS11v_LATS11v_EGFR1v_SRC1v_INSR1v_PRKACA1v_AKT_i1v_ERK_i1v_HER31v_EGF1v_NRG11v_HER21v_NCID1v_CASP31v_NCID1v_SOS11v_PI3K_c1v_NF11v_PI3K_c1v_IGF11v_PDPK11v_IGF11v_SRC1v_INS1v_FOXO31v_ESR11v_NOS31v_RELA1v_IL1B1v_IL61v_IL61v_STAT51v_INS1v_FOXO31v_S6K11v_INSR1v_IGF1R1v_MTORC1_c1v_IL6R1v_ABL11v_IL81v_IRS11v_RELA1v_MAPK81v_ERK_i1v_PPARG1v_PAX71v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_AKT_i1v_RAC11v_RND11v_GSK3B1v_ERK_i1v_P531v_AKT_i1v_RAF11v_RHEB1v_NRG11v_IGF11v_PIP31v_S6K11v_CTNNB11v_PIM1v_ERK_i1v_STAT31v_ESR11v_EIF4E1v_GSK3B1v_HES11v_ABL11v_HEY11v_MYOD11v_NOTCH11v_S6K11v_SGK11v_PRKACA1v_TWIST11v_P531v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_MDM21v_ERK_i1v_AKT_i1v_MYC1v_MDM21v_TCF41v_RAC11v_SRC1v_MYOG1v_HEY11v_HES11v_NOTCH11v_PIP31v_IGF1R1v_PG1v_ERK_i1v_ESR11v_EGFR1v_INSR1v_RAS_i1v_ESR11v_IRS11v_IGF1R1v_STAT51v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_PRKACA1v_AKT_i1v_WNT11v_S6K11v_SRC1v_PI3K_c1v_DVL11v_AKT_i1v_HRAS1v_RAS_i1v_SOS11v_PI3K_c1v_PI3K_c1v_IGF11v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_PRKACA1v_ABL11v_JAK21v_SRC1v_IL1B1v_SRC1v_MAPK81v_JAK21v_JAK21v_SRC1v_EGFR1v_ERK_i1v_CTNNB11v_JUN1v_YAP11v_KRT141v_AKT_i1v_ERK_i1v_PRKAA21v_GSK3B1v_ERK_i1v_AKT_i1v_MAPK81v_PGR1v_WNT11v_LATS11v_ABL11 \ No newline at end of file diff --git a/models/summary.csv b/models/summary.csv index 36c902f..f119f5e 100644 --- a/models/summary.csv +++ b/models/summary.csv @@ -229,3 +229,4 @@ ID, name, variables, regulations 228, INTEGRATION-OF-SIGNALING-AND-KINETIC-MODELS, 47, 9, 107 229, CALCIUM-SIGNALING-STOMATAL-CLOSURE, 52, 4, 128 230, HEPATOCYTE-GROWTH-FACTOR, 50, 5, 76 +231, BREAST-CANCER-SIGNALLING-PATHWAYS, 110, 7, 268 diff --git a/report/online_only_table_1.xlsx b/report/online_only_table_1.xlsx index 9cb26730db1669b9fe76bb5697242ac7efd0f882..2986780afadf4722bc3cbf0295e95f1f876a7760 100644 GIT binary patch literal 58339 zcmaI6by!^8&OQvqin~+X-JxiK;_k)W-5rXzxVscD3{u>k!r<;&+y{60hCa{lJ?EeA za9wOR!%nhtC%Kcg*h;cc&{z=f-@k`&`oyLM@n2tv;ClmSGg}uH=C^A_LbpOMD^eK9 zCxZT#YxUFnyy8|lsa7&h;x0;i!usz8eZdzupD{6zqHB6%ocse`jEmOf>>1Zssb%%Q zt80CK*G_HXSJF59;^f7`J(};|kIpNp;vh!v9IGgEHS$MfsL;nXP6lEBQeJiva?j-0 z6hiP*xU-(R2m6cZx7`q}<0uR#3yu7R0O+<5c{>{}dub9PZy}CNP4YxCcc6@1fo}tUQrQ7KPL!V6EmfNktag{G0TPS3pOMNhhM zlmTzCMK*?}x=+z54_9>02>2?Jx-z>vL}Xd8z05nP@1v8X&47!%#L!vCAWsv%z6$P5 zErxC9RD340kqM%z*>AKF#|H6w96x<>md3pNvFPVZ(k3IAtHx+Ne6c>J)ODR3vLE~E zpgm%kaKo3NU&fVqjQ%j@M%dRTixSuD%X2*3hX1K=qAd0Th*=qHsVZ6d)F>Q)=l7nl za=UG`vbZY3&yrw#-OF;<|=a42U@;Gl8 z=P|&#ZL5N_TF(P^1sZxzR1Jo+(=fNY9vk$uc94wi_=ka7*)M2lu%z3t=;*_1G_94yQ2S2o4V;iIY zu*y-AOaIM%g#FE=72cni4RhWPngUdhJ9Vvx%LLG#gAk7Q&i^ z70xsHcx(x478nEPyiU-=^*}$Z!(B?m!Y)s>_$f44>}?`8j7UO2yZ?%2e$O{N5_-Am z)ATt)*xTCsRfvhK&ud&}rFgM==D4oZ3``qg7~h077~({9DJC+B_j#u9dm##TyL6ppBkHHebh3KAe0* zYCU#cBO8rQBR1oyPo-D!fdU|aOz49h8^kOA*iD<7dIv`$(@iS(dPF%VotYEZj~GF; zhG{5ho$H09)VElb2!6D=B#)=QZtL2#99UOHQOD{&APk-@V7-aJp|rz5G{~+E^7Sfo znrsb~Q&;Tm;k*x;iZRtMe8*>L1*)Ma$_iGfwQ;ldB1YumL`^=l-rR{xS2RU3tt8gL zO#eRe*_@mszBz29r@hEw==X8)0;7Gz=u^tV-76cu&)q|%{w^Ho{C2*hA5^2dD<&i? z^<30G-H1ph)9~A@CVTx)*t&>fWXgLeW1iB*O|MaN3mf-I#evsaQ`L06%0*xL+Eiup z#wTo6v=jS`v8#l|6GWh)mQ!8(gbq`)Q2V=p!BKbtCA)SeR+euqwTh7FOtK60xvS9- zmFR|k&O*1O4$v2MKbTCuQ9cs82=_4N^h7x`NjCX>IQ?K;1LyNiIOu2nd2pIh+-c2Z zjVHaEu$BdC@HI8TDNQ&0H{x@OWQBz>zyZEX!>6 zREeOzkzA#4-S6YgPcaai(RNtG;Iv)C{zV#I8tYW$Eo1cf7O!l9UuH>j|rbJQw z+ky0GGA&oT+);1R4<8i+Kqe^jf;KlNu+$v|bER5xE{S-ng*s})fuP$w7L+MagLBPw z=mqO0a6fq)Yn9Yg2|5zQD6rUQp^hbrHjn)txNUgRG^$zW#~HA^+GbDkl1u&s_r@yv z)?Y;lp&=lW$o?0rQ2eJcxmcQ+xw^3Y)6M_>!uCcpfBX8Zo}L5Y0Jh(F6)QBBC5gGm zX*Q_GU8#f(?Z>HDHiQ=@x|hDU z?yozN>u1TW*Q(vo^h3r#z$RsSwp>rYv+3?&V4hyz_wgcg@6~EI(e5SXv{=t${9>H3 z6&IIh`Q!oQwkq$C@w*V9ab%wUx@TRlCD(ADn|b6dnBI}8%fn@Jax~g&q1z_lxm!zO z&ce(sJhH#J7@IpcnkwMq<~FO48Bkda!X0&9zGOJed@3Am)9V;U&9<$~Jb9_s^FOtn zJtY=xA&=-N-uPlwl4xx9^nBZ?HOig@61LAAb!PAU`N+lrQHxTn&vMB!NmdXOUzZrj zeHP3eVH(E-Q3J2GUb%+*W!Agiw(P0!2|Wm@S?r4x`?XoCb?ReD<8)=mio3S;%8Ts} zohkNxNIRD4VeSCDY~h%*iLGW*)C@D=^c^tzdufOEy6++VT;Dx%y@ux+|1clays@8@ z^7{|nX>b#lnc6>W#6)$-pq+@*o984Fc|`X;A54=I&^UuWy}nn=znOz|`XP#TL20nA z(YS0&vO|XNTjVi71BsHSka!5%A7waMn6@D^gf===-eRc*Ax;U}@DKe_OsL#o-g z{W48ZiU~KdD_z|4zDK~9PPNFcNb638J&XBP4y2m^OXrK@DorILt+M~V<#?2QmvNN* zPHsx!NHj@QQpqCsH>*z`hsAp@V&1eb$)-V}m04tz+PckNm-Lnqe|*4Z?Q)>;BvK6E z7d` zlPE$#duBTE{(&E#Gw7WnEOK6VN7{qmx1Rkmay+Mijg;i;c-dR&FPF7w8Z&vP-?F~T zU;?m2m3r6#p^g;FyAtCOn0o;=P2T3{+Y6bkcnrQAOadlP-urRJNAP)N;&I!bES_iB z#Uo3k3kv0e4F}=A2R5c#%;;3DAw1_oDQ$NoE-~YPWU<#$*o*20wv|dv8m;E;N20M< z+J3eGPUEW?&7|Ngfc*Pd(X5nC5Me8Xw{D4S7F##!2h&oDM9C8FeROw3kbLTC67WY| zD9O^q8*|Ff)P2!1)ToY_bfwu@vNTgmwB^zt-y76aILwc7zmBSpaC;ua5zyx{hKW*f z4fh-KN)=$D8V>h5m2SdCV@i}A(Z_mxBrJFlsY>G0kjj#K5BZ&nbvzv=*G-<1ecb6KPzS~+`5ag_hI5j6oU9#~ejJ}kT$k5Oo=*(5YLhfe z>vV}_c%sNDMmz}m>}?5OF-OrF`A#knK{ zwXqeFw&V=>4n_u4wRc%uvi;`L@W}k4?DAtxC3f@rxYIdu-2Ji@e4?~25G!%JI}lBf zy7*bOZkJUzWu@yGUhtItCA8<~*Llq3 zO@rh-?M0cxCx$xp?BYACq5EBy!YnJd8Qa2EZ|RR&1V<~DfmLpWF0c?j&X>3|RsYMN z%(vs(@o3515av)$Q&!sCyAyAbLRnPVmNWpFn8@JFk=J?fb*sCxRbel2;Q;x_#cY|5 z!_tmhZD}z;TySwa)p?D`O*2hR8590c^S}b1;lqcm+9;7S!R}V+YqP0tFMS#G-utVu zRp?=r(f7!tGr?%oC3A}kUyfZIjbUqdOsC61fOlDi-?^;hytU15XsEcT+^5!*+#7$4 zxgfBG>xLybhh=FzMP4~4J4#`?zTZH*&L#V5 z;;sS<5rYmv0Ksd{VFs~*#}o|t)r1pS0WJpp9l^UhRWpTeNE4)8x%4igSYKfwU)0hu z3tl*&&q{`}NU?uFeic^Vg)V)E4DnRTPV<@45^cjX??+8PBNIGXVGyw^eLjkE85bft z!W3JI+xbs9gi3|_ih8%rYBWBm_8&iPXlR3?HIXi?Un9O7iWS>)%|1qW#tShOENase zenwmU5j?nj3}116n25$J$4T4j!0nH!d-S7l^8)P;=|Iepc%u$qT}chHy;{WvyOR!3!}N?OeeB8!?}$Gy}p?$9T0cQEC$$k zQ~Zvcf`8C%OFK2|dxlJ|<7OF!*JB5VVVu-u_)>T`(eUVk<8k zX<-edRKDbwh2bGmvEuj%N@O6ierbng7}o}#oN*>VJ(*W23kp`cc_6gcyp4dR5>95A`JY^7H#WuD@T9Kc~o5Fsyba)wdutol1+*@Caj> z%_4wuNN`LAzr}`IssDUR)}4X~fh_y}rRIecfh-bHVX)(`#~)((S%**Lu(4z#IUXF3 z*a>Ca=%1zcLwr54VDgA{4qBadHIMoRkn>0LHcSxe1p7~uZZF5{ zWTjoP-13Bm>0pv?4pFh;=4;k^^>|Mzou?nrVS3<33|6cZ&~(>8 z%f*oD_uHWUK9kv-XEOu+v;MySWY?hz9sMn|QxdsFNR!fJf2GTeMN+kpISWV{kDXoA z(6Z4gF4|9|Ji39g(2rPN|0mp~uiNu?DIL24JZ{%Wj#E4SU0PW_;jw~!*k^d>quV24 z{LlWvzju*WwpPg2)$Ins%WL*vsJjL?rFbcb9t=ITUr%r>Vv0da^5110uc1s9)I{D1O_ zu|#Mo`)=+z+0c~Wy$mFs@r)mZ@3*GD!n_Td^;;22cnA;>v>E?v&?NY0(EMk*{O@y+ zf6k5KNSv6z?2x)X zB%2_jnVwI4NI!nUnCfSHq3>uxY8`zwU@kF%*H)& z{Cb6hG76>hgDt@)$}Gbd($iUxqu8nyI#6}?3`(soJ+Hq^=8;hh3Vd=|fynTq&cyK? zlPa;s8w@P$a94KsJAymHM+0mluuc;uTeE ztG@5vkWoCl_nrd#P4z#|hOquY#>LXe+00bc)!EA4;_v>xUeC&9894cpW6-TKn<-N! z(C0_h(D=zvN+E;+f;RIdAxLT=KUMSng#O-qryvAfJVw1e+SyzslNIEz$<@oN>4B)V zmzx3W#m5v-#BcNGQ;EY!o_1fszcM9=F{0(y z5YAENnr*E?D#%_VSmG+_>=mW5g0$v11Um`7f~O_5&;-d(mF``MUZeN3%=n$+2-AW1>JM=6b92PLCwEj}Iv z+-6?nMqVlc0v2?z1U;Aa8%}pxSIuvWZ{1K4*^ZK1ZS`hkQD){DcnpKq?=QP>lJ7UF z^!z=q7!3_;A;r&-`z&AgO%AI)@H1uf z38@ne3U1&qw`njhk*9kCwWcg3LBuaTD2zy0plL?J&%B(SS07}0Q07^>kCR(Oe$06nHqW2v6`QUAuVlxL>CDxnbKxS>yij+Tic#|xA-)8}wL z-tB^n;!Os&I7ht?S=c>(THmB3@ngfbNBkVDkcbIG#yE?ZvbOV;$|yI36!1z$AYbcE ztT9v9lv$#D2?|%gSi5&Zz>CMBmr$ezefLjaCn{q5jDOul7rG;RObcy<;a>k8YvWVT z-brt4K1*Z*QYD~_*NxZxn0@(Rjrkfu#jTg!NxZf2qe(VejewY%((?cpni4-#0|%2U``?frR@iAnursaBllwrJK%1Rgn()Wf3m1B70b>3tq(1cDe7 zS7LbU7=|aj1+QLG?BaUr$hJ}l`;;gEyn|XSEZ3lr3T3US(5mMus)Yy|N>VL@BsC)R zt8X)bAml0_Q{)<)FDIZAcustOY{BEuzf8-BnRj$k)Xk1Mzm zM}ES?WjwINOQiRGCBIU~&Uy@Vx(Z_#5WSvU*_QN6tT|5}0{KQIw*=-;bO*%S`;? z+U`}_W|1&yMgbE{fA)FibZg4Dl>TsCJ0||gpB&drU)d)&9AL#0?zO?eHhjRK& zf|qYfz+1ZxsnHNejw}*6zn=3sm-s`${VEN0c~1>y?N4liZxM9mwa%Tx;;U1R0E!ZF=-A%NcLfvAYuuPHD?t z4cSncNZp?)da0*{jZ53ZRbK#drsUX6+~MkCVH|_?W^FJo0!5a*cB3oqHj1R`c;tv? zidQ8Lmf+RXf40zFJ|M^V{xaN`w>%r9_F&ARj2rt*>|!l6&CL1^9UDP<3M=sww;W?H z>wETPenr5Nv%nqPhG^<{+rhJns8Iq~qvI(o+rD8Lqm3x7cZ)Q%CCd}#Kc@wc<3 z5%Qyo_08y&6s@O?@E(C>zdcvT(U5aW0~Z1jBM%VR!YVcofSJ5TqRoJQPU)r+A+z)f z&!I~KT6?l^l5|AGT@)qeop)}ka6h*)D|gb7I90_H#xr_a?;;r$g&lGVeFKZsyx;5}wdocm*>J#{{LN#9e6C&&MM zCv?RAUUCEA;XZNL5UrMPNWQ~&HE4> z&}!5t%XQFH2DOk)vpSFvVoiPt@m}*vb)RFcS%#d|to`AM?pm}n1@zF9MG5Gcx6|*@ z)HX;_7n8ifRlPgL5)h2CoCr%MuAp*SgTYZXg~A6;eJAPfvrr(Kg4j32J6oDd%+<6T zD=1lJ(tU1I?GX`Cj*s7=>kwqAaIT8AhS&0LuQhOGg3-dff@tgZcglPsP~*^9b@?r& z%hn_sr>N=!p*;U_+@s62Kw3M~wM(>f3%i6=wr!=F+R2U^XJv74QeTMhcjph@QheTu z_EY%}%2L^+!-e6ldlTdvcG?hQUu#zyPF*uX@xQ|6$Jm}MC-O$wIU}Cq^!;jPQD4nQ zfPnyLYd~2ndc)Jg+gDyUmkc*Cek;JJ&JIxg(nFm39OywZ*+#fO!|Q9jN9xPpBKT{0 zDL1Uko8Qe^Tq2AIZbX%Zz7j2^klWA`nhxg-XDKC+gwxboV@Dx@dKg&PfkM_L)g-4^ ze4EN=q@8=~4Bj(oCa^V1P%6Az$b-xIJY&==_OZ~9MSY4&In~V6?p4tn>W7fWrqar1 zs;aXyYPq6gk-I?WU$Q?}jk9&7*ccZ@!_J@+GW+s2!b zg!`=H?m+QsgD(9AA7O|GWfRGibk;4@2i~RFiRu#6w#taiIHa2r)6Q5AUqb88;Bd`$ zVLt_o{U#Joh3Xo8-S_Ap8h?iq&Lk={1p7 z6F@yBkA7d2VZ)QQw{Cua!Rqq!EDK#x3$<9HMz^hc()L;ofhbX+73Q|m1fg1BTL`tB zW7kast_FbfF{&_KRQ*S=8_g}G)AvFQWeI9F+^*7`QaZ6g(;{{2TQYsP$lzZfWYFMuU1^2 zy^J{D>vwf|-5b?($Ru`+OJYbL!lQ&y=hF0Al8~ZM^~Gp2y2vZT=nw4q*?-yeHkj!a zb6oNo<=-Djg0&A;y6h3oX$8a#-_yUZnp@e`=@?EKCPoW1%Q+#&7jekJtz9)9?i4x> zOot48O_(~yh7I3+-H)JZ}?*ctzsAk3m;#8;kynO*EtF{(Xrx;8qF%>*XgqxHw% zDWKRPkLN{mDpUS1V#813ehMk?*F}xuKpzH|v8XEdM|4T4BB)k$^79VZ?Zr&D&k<(7 z6S{7^OT`Jz8v-KyW($U#(&DlPkj_aXK~AxJLAOpeb( z7%!V#km^WT3*|fQhjf34P7K42vry={Qmg`wMO72gBNP$#Lk0owim6ePz#ncTw9Jb{=DY}J4<#zPos-k zvir(xX>e$PM=^`s>oFa;DR<7D}Eg7hpG%-H_rZIZEIU6=Hts7rPD~Dpfo$rlS4Tlw)QPhmPr^a<zB>_in z^9mYs^d_};v}#F?zm0&3o)+=x2R0>QCE*pl14~}Z!Y1zCEGN8TMR9ul=su^x+(xl` zR>H9lTWr~92xy?8z60LfEz=LbR8%?TbR+zYT0J6DItKUdNyol~QGW@d|5g^pG=0_% zXT?g{0Oyq3cC6rPN&qD{{h4E+tajkkbGX(|^SsWAnT~f=-~=l3GqYl1RqCgtkc{ke zWW%;xD)N%MBcwyCIAC_4E?3;T@*R2lS@$(_aZjNbl!3Zy5I^@8uaLnWti1rfAa_W1 zilB3H$x^*QSKfPP69K|#>9jj_NYd;%aSMLI^PQu?IBJ`kU-V_w`09yq%Moz;csVm$ z{D)@|DIwXc!nG6F*R8p!RAePdrl!aY@L?E%yh~BzZ7tH4kM&LChxP)@>*sW)LD9pT zRVeV02+q?N_r;BQ$XDe%{yb8Fa5#n$v}CtuS<;_`Ym)Br_(foCeUb!_vmsKQz6>89 zUwBeA;Cd=&NE9U^Ha=pa(tb6eQ159iJNy1e(m5+i_Uy6MKR>Q4fnm7Cc$2?v+{~&t zhE?ib8R}1*i+wDzRc~JNJfCFkXnvSnErK_2i(R2ldH~~z#z0W;Hp9?jS|A@*SVHkq zHxA{6`|IH3WMbAT>W6oS1{EFi&~0-CUb*0zt3Ib#KS8Af4--zY4NGifE}TRr5BFwoQ2czFGJ4=-#R zkP%0B95EhCCH+D3h_@8GRe9zcb=Hb^O*TRLyXXYA3LfPW&fV#Ah@!Ct6ujJ<(-yZ1 zvfD~uM-n{hat@$rIvPqlX+?VK;nMbh}T zZ1l`cC6N!?aC;)&8|^s0e4Rg$e)a$&FvzgXt+?#p$+#jkrI z;CvV(fp~Suk|_qiiK)?X!cz@B;^mW$0Xq}o;sb!-$E>n{Tc*1@;YqSkcrm;H6o#5~ zFEQgKZ|sUO?0pY{CtGNg+UOR}6T_H(TOFFB4s$+aGducgFxHM2|IH^a?Zv&{M5w%N zAw23M66zW}8>dgIN*MJimEW`HaqY{*9EZvN}I$Xe=*+ubuPg%js0S;wsS z($cEB{;SH0W2O^Q#$BCF`YU~{P(sjHqv?IpcsyCp{!~=L_N9AJoeSQLiQWw|v7aq{L%r(EzT-?swcu9q%+Xs#&uD}N2&ER^8bHEqd7 z(q9-^`*R1|k{4Z4$NA@;cG>!P$1_S5LvpIm%0sZ}^}wvKHdVYQgVdMtstAKoAUfl~ zH+JU=)A(R}_9K}xGUDeDF#Z^qVxnSggF?1aDEaR0-SB8CNdjeAeuMz&q}vvvAP6O_ zcx0(t?pp-V-P(^BKE!&X*+`%UN@`LYG5_%TDuuCZab`}+EJqLt@gi574ezs~y5!6#a#4kk*@4vsD?CJxSK zZ~sTOQ_*n(wx#}&AGh|5i=5zDThZ*fLPVQW~dy9 z=o{xQmzHIVhFmc79eHL&d@ZlN$=-H!QcOps_ctm_pu*-|%G_67=j}Q~q|r2~n0S?_ zcyk+o&?f{0?3o{vlaw<1xwzePr-y<1A6@1UP+=>z6*u?S__+v{8={x$8Xq2Mu1wBr zjwO+kPc^8%Vx?orec4!8ATQYKn#aicHT1*ao>U)=SW`Dur!)7R>s`Y!6UD4u$0iEy zOY|JV_Exur?w^=U!|Qm&r}wsaca-fVisOKfbkygj1pTN+&W$q0I3fXWo-sme1rMr1LO?|P&of4}|Bi@} zqvKmZvg70(dfwjEd&E}ntCyzJ5urt1;yekd`@mPHlT5{II+U7#)!k_Tfy_Hj^H_hq z;D2yv=vp0)mR!q}v5A0f7@9a_uXDB7o{Xs0*H^Kvph)&Iluc0zD z3b()IJ+9IREaCcXa=t1%%krl-ohCufncizpSb*v=1k5BCwEf^bg{w$i1bSU`73YRx z!e4AAuSQLrcqaC6{XbE%1E^UFrfSORn!~e!nUS-$45x0I6H zgF(pvL-+sx+8*YA!)D^<;_6`c7rC)&gdSF`&_Ams?-!TV;Nqw1B6<1MZsXP(AYB}Q z@{xW%6hWsk;Uq!|(}K@pRH8=XEJy zz70Y~GLqVSEWxraS{U0vPW@=YOd;-|lH;Vp88gZ zSr)}~9dx(mK;~mt;BT?~*RMZw5MNWlt3C&R|8Ku^#2oBh&Fozb)Vv(cT=d@jYF8gs z1pC!_sma)$QNPiR$FZ?7pe)^2TY9prp(Q+p6Y{#|E=I{09uhh|)p7gi?R8Ldpsg{8 zP>!h`J^3D0`CWt+vl^QO%Vqc#fjmvHZ3o*%!USLiFL^DKP?U&4L?yf)5}UrcA>qNX z4u&m>$r5tgnYWExjsbP3M9BGvv^(5KJq@8|gYY8>o-SqQ_6IHv;cQ<$Hgv9>>C6saZnCVyy*_5EYF}@atTYURrVej+; z{fq+;jp&dVx+U+s6SF@9P5w*Ym1SLlO({2vVAG~IkOVNAGG^md<12Ql;~N+MAk20T z{g#NsLEMav;3U+5{a*pY1Bdh9_ecMIP3J!^=(M#fCQ=S0Z+opPLUvo-vVOXMb$mY< ze&$79gx6I68%M{w8F2EG4r0H?F z{yhGAcOE|ea&wbv&>3($4H9jS$eKL5NzY%864Y)aatO|Iz zIU-qmzPh>1ecd{#%6%Odej@37d~7v%d7kfV^Lu=$r3uXSe}3Kz@OpjOtLk{Vn0I)& zxEZJlc-~wccL?x)NCd4tUu?~Ta$m*`UQUJ$0$z4b=GTQ@C52zk%pP|~?{;Dh0$!*0 zI_Z3`Wxw~gf;t{wG8@Qy%Wc*A>)G>TfI!vxrSQ|K){|nV@6GD1a9hA*WWepov~I`aL%6}Z(DUNB z!Rzv}aHroZi?HzP{p0KPsiNYihb@-ZvsM=2mw|vgFnGd#Ate1Ti!2VEkI#FrGrrg3 zqnSLTa8n$6ulFw}>j8e(ox+dTETESTL8kL6Vc%yP6<^p}gO1mmhi65H+=<)Hr)!G4 z05G_{tt2re(`TB&TZ7l5-1V2Uo6K8>PQT~% z-<=(=e-20kUIt=cA5Oy+->rk6JL-Hnd+Ei>s$v4j|HbiJ zc%$&s+2c4##<=j~F4V2>6v-p_ZrlUp|8&V?@OpOjQPA&Q)eGqCDOdKYm&W_~fdusO z@Ko*lG>!U7{Bph88t@9?H{o|F5ShE?e?t=Ra&P5M@^$>>{5+t+Smbp^H|OQ*$YCwu zwUOo=^>qj=@pubX-sSl+fBVu49pH7F3yyEj*k$;ok)yD1qOdhpXlm#7@ayw(gwW&l zYXI@JSixYM(5_9Gg&sD(t(%4o<32zA!F;F^+`c=HD{uz-zc_r{zB-RfbOsjR8^1X4 zZtrZ7u?&&D5~9qv-FvoaJu-CMJKQsHj}Dml-;wZIKJG?ZJvs1NI@=a#H8lI4hrG^{ zxJtpD)CDUT=rWI6B&@%LzT8kfT|ZWV^A4Qm&$T6(K8YyL%fh>gl0I(vXh(O^{(B?m zZ4gh$xi6a}F}I2&uou1yC9ik$G*=D*o|mmGuQx`aB>2M)Q8(BHgZQYOY%Q8m+!g`} zlRHt#Q9>5Bx&v_>?$%Ksw@6Kf@M-WCiT?iMpgMuPf?w zcz|%%aRYTM8I&sYbcR>1U>^*X?G|Jf9o=>xJZm z>#6$jFt%!*btoXXp|Ae&FoQ|-Y5Ke&1k`a+Mb-B;_*pvS6mX{fCz{tx+y}k-k-j4Z zZR>6?#p0{9FqCWkIK(OdRFYfgkXy7xC-U@6%y$ki==aZ*`_TS4=|svpQ|sq=1JQC9ER0@Mul^J2T3#l7c##C3OB_N&n~%mr+7d_`LRc zqu2gNJ>T{?iVBH-)^7o~I;ep99;wzEJR>gl!dbbnBYA+bn6|uD>7C~BXehJ`S#{^1 z`n-mDSWo#Z>6AcyOm|6qihkMzZ2g z{39`KI}=yJwIhaJ;^e?gnTGg%3%OCgewDl1&e(nUbK@X1&$$@pI!tWgw^&oEf_Rz= zyZqTcS9fuVFQd9cR_rUL+M~Jy$w=puJ}w`+btSXxc~4Z9t#Ene7c846tl05%&%Q^o z?uSN-k` zobH3SxtAI&r&jHjRJeJj8!dKp6wgW02ilT+OkX!;S8^@?u;RJbFga_Tjv(Y%D^ zpc>SkawiSb4={Mg#k$5AJ@8PJNS9}I)(niSj75-i#{u+rr=L>L)e<9+iA!n6VtLin z(p6g79;MT3W^UTa{F=uQF75K3CCn)fy*AZq;I#GQOUEbh!p`dOR^w&Qqfb)M_jm*j zX3>}gHxL~NsB8!%ZW3sb(vEScS91SePWn+^6hCI;@UhCfc7k>`=op6}1u=UBE!z3R z2MfVV?Z+}DQ@2JgTU=Ioc5<|fT#dwPI)=rt?IE za?N&k%LRU5)nJj)2B?%TnmIW?a^y;UDe;iku zo08dEEhEb~6#U#vF8WezK%jvxC<R0AQc1o7HtVXMG~Wev4CNMuyG){+iYeIKGfvD(H!CO89BCD z9*fM<*^s7uWDv<5j=>pcNt+}sv65oe&nmOGXci_KczMiTP(O^Mvt!LNzxvi*OAqRMRmf-kNT8+6(`Z3h>{m_&`g}g<$F4;-)$9aG4B{Kj)@e zu=$>=w$XNICIJxOA{&l+GbFo5x6=(yH31y5Y{>`#H+!a5B(L0_N+wCZ@l$p%ekaUt z_zhn-{97(wv#n7ndSPw79#)HHQ5WYsDXB~6W;VhSc}m;J>^j5rVrvd9%i(-)#cC+f zI`m7u5&;Iiw~{@n9>@>3q@ymO(>`RWWd@|7PDxSkUy$CSYlqmZxR2^CQ`SBZ;Kny$ z$+qCZM}R32XdSdXp$1#0#{$Qa9b7Co8i|t{4(!_8_!o0yMP`X?eoPC?BuE;EzjogSJ6PVVyQ?_F$y%Q*}OpL#_V<$C0Y}z+?7i<+pX0c?qQ=XQ| zo1fNd^PSH8WKnvVBBS8Zdzsn)Ixg4>{OkC#(Smqbd&5ZxXvjS)z8){`9W~l1uWUV&e+vdoQmr~%5}NJ(`(I3ei6c|h z{b{D5bLRxDNR0^M`qCP-7y1VkCgCDmiyy%2#zu&;@W5*rn$?eNR0s3p!s;Pw%i#x! z0TeNzktWw;R@3UU2|CR`J0O8j3W_k%c#DlU;k|!_v;Gk-_WbMfsYdvuI*66e9q;1L zY>`Pg+u&})7L|L}#R%XGAQ~@tF<0G_w*8!!5yP1y{RY`sCF_6i&Q&vPJH(b4KoDCS z>2NJ)-L9ZT&7KkjB8Y8C?a?v8HQ<|svJF0py_ITV76QyzEyG);tG3C*-)L{rVDnaa zhfdNhe;Pz6FbO3iLGsy0a1T=9tr1YAy$BkdtL{zv)tkL)M2qG1alE)`?DQYgH|w;t zHt`=MJOI7>Wgd7R_>r_UnLhAGMYesco6aeS8>{6<3KiX}?)`Cjj3SoT<>eke33mRC zRQ2Je76E9oO=)Yry z4USdM{ud*lA9P9#c0bI#TGG*#W6qSK)LuN;ZV%Wl!e6_glZ)7Y?fxb6>Q;3l*I9W zbsGgob{uw#oTcn)r~rD(3qkT_3=CJK-%&EG7@y)~_gMc;Fdp~sYxiIyfUaFcBORF1 zjvcu0{H|dOEP}~EeY)Pm~z-4vsBCNQ3jXzyJLzo{fPA77> z`o-5O^O+>I$NjOu#I#n)_8%9XD+mgz^i8hH*|uW=MHbOc@r{5h83xi^YVR4Ti!syC z;CTaEK|qw2yX8`M;r)pHMjdz&03`7p@=*&-{C~;Ku;Wl&VjN6Ch;3Kp?B-rhMVb+i zzI*gUi}`d!&CT6&wZmyUdgn{kh1bUeY_<_c|FGNtjS_Q!HM6T@_H7|~*>Pqu`SbHW4;TmSlt+y3X5&KN=YL9CKF9z{I|+_h0eroHe@wbECf3K$oY!gaWQ z^9(bOf(Gwhhr0XEo{zD5u-O(KU~U?#ZH-z3)9ZiQ+P~5{dSNT1wg-!5BNt2aCkT1JG-rPFx7D%&?QGtG8D+N~g3l^LX+x5vJ&894%sCiy+hs-7mI6}7NAn-bHXpD8E#qu1l z_G;9OY zYCV5A6}WCggH&_DH#XmUD`ZT5>RTa|b8eTX1|~~fO6VKmd$#Kd6+ixT zbUak0Z4&o4ESPMISFiN@1ukG;_ae516P)t7F(KgojqF~V_j5yb z-k$ro{+}?~BF$z-2ablVBzWR4*m61_orH^cc{HvVfXAaT4|U#XN;|05Xo=I^MjM$a zKlf%M)fK~3LYRO{fFC7zqOZa8D&$=$;|V*w?(gyzJ56juD(4~aT0iOiQ3umBWZQY8 zlP5*!0QDFxp|7@5e=T*p7;CeD#j^kto==X5lDT>E&pOl{qh=9f;$gzuJWTPm962xe zuZ`3YV7#&w|44!8usj{q5Kz1d4#7}*j_Z$EsjgV!5`o9OJmBb%13Jh9U)ulREjj`P7gLq3c(<|J!j--7plF0H30}&;I#Lg~>7T>et_}a{ z@PE^B$^+(wn|tZY#b@y7z`J(H(|`Ef5A+w)C)1KBT94~ACXvwh9VoCSkj#k1DqK}A z<=GBvYbA#Ur6;N8b@{lr|4Z#6T9Llu+cemoRo?AvHEVGODZ@W!2%QmE!j(%g&njeN zRvZ=cHUzH0?eM{m z3dxK=Nn_cEA-*@}CH-b~r(t|J}qMZA9$NO(x5;<@Ynp~Tk znAVb2Suqw&*#dp!h$Svdqa;IvK)OY-pJtRIkedT1E8(S&7JvVB!1g~g!GO;1ezo?6 zv@f>6c8?TkI_~Wh5!6H#N-%;%2ZGV$Akyq4V=;U3TAL&EHC5UvAMW4s?$zKRVn;B} z{>?^(#)#-ra9vg}#Cd#RNmQ`~+UXEe@5tj{+~)Mhuc_v&#O<|9A8>6e5WnTYVmo*V ziK{l?B|H|K|DD`RblSmdm`_`<0m7lCzCAj)Z=_N=ywzsm@VQ9oOsb!ou04!V*pX#$=7U zXellh50sJMnyY6AuIa^DusnEA^Bvn^7}|#oyxl$4Y+p`WumgIiF(ppf0a<3lr4N|4 zPc9MQgde2heGF{hK9xR+KpU~}AZ&=pJhtx@noxhVG`A9JUHOHJS)#K8MqwrGi#>22 ztU|>e$kH1wZH0OE+eSav02^VNc^SE_L`x?IymPaETfxqM8oX1By1m@&aP;?`FkhNQ zb~^Bn;tL}c{iwhyy~jc1(5WFk_eN=O9tXR(=0jgD#{Mq_vP*vz{5mmGS&I&=17ML( z`NHh<7bX#2XqD)_bq8l~84WVOmC?UD-~YBxwe}`%t4%_^14D43r574JdZ!lC7VV(& zfP7y!SV<>+3nq`Z9B`nezvxExXmYw~CO$`y^jsiiwL)+CCE_;Ly+M+@q|^m^_L*lbd(;$<%9 z-Tu%!EMCgH4MmKKYv)4mg;*;Q^bAbj1`V9#*AZPLj8xLLgO%ujnVI?jYwt_Ip=`hZ zrL>TgvV~OkeGRSJ$eJa~*tZDDpdu1cQudKup@eK{tjRLj85GHqU73=#rqD2E{`Wki zqPKV6-*tU||KIih|6Z;ujh^Q|&$-Wi?$0@&bDmpnO%EP7jD5)TzWMsP+bhdlK8LJE zL7#bLwmi-67<0H&@7QF6|Kx42>JeA%o^2ih->Us%rZBTFK`rMt(@4*g z19GLps?Is4Vck32k>lI0ivFnPh!>9`)Mh+Ksyt6t1Ur-n%-k;1oEfeb@Hsdx@<#w{-oNI}||HLF(p|_da#6-c6w5rSDfHBQ zNrod?#$LR$w&yxrb6tv3L@%A-J+lFmeA7t3lWxAiRTknV>+Q3i1(}Bb#Js%<@2-^S zg_~ru@USrRNZE+6r0zxx1~9NJ*sznVAzLQIVM5aDvzC~Sew~tYS#rWGvcg!Ks3t{w{Si?)29{Jt1Pd!uXj#&+ zl!m4tmQ)zR-EtyuE5~^jVcA;K39DLC=_FU{z$aKKtfWs!U#uf2iY|x=XY?BLaECB9 zIv^nE_2wZjdlq3@#fmJ~Qi0k)$4Ym_jRVq6!R`7kETu5y&jiiPiAgwStQPHG8z|x& z6Qq;f(1RO(cxc~VwZr~5%Ildp3=HAu@YOECCkn|M)Br$4wjK%nD z;{B{HN$GJ`4{sye)KJ9zmTJdY`Y>9>fpwq^k^A+6ekN<#T;Gw-2b^lGo%$~MrnSG| z_@l92vq^bioMCN)`+``$PHh9-AVYqC-XS3lk0M=x?pAAkPgW1XO9nTG4uAEH1oO!6 zul_Y0lnk$SEJVg#3&dNQ*rsYCVs>%arn-lVCRh2+DOYlK<-bmAz3P_mP}I=#m3Q~q zqTU_90+CmiMqF00pmgsJoY5y6{hl2j{a-BgGdFoCY6G71XlP&d^3hIbY)dtMSr9R)AyvQ1S(utd5kZUP7J_aOzHib{7VDw=8N3SfEn z%o>4$fL$&|lS|O>xX0x-o?^$D^|rQaxy}76npM|wr_5D1yHd>s33Bw!C%cTC@b1mt zAt42u3}ifXo<#z{=_GaC&sv)N;F$S`vBjolg5r^of@W3X-n-4!j_$%B*X37FtwR*| zH>)n}_357q+*)?7SX{QY#cko?HCd2iELf2Ww|1|FH1l6qG|M?LC1e$gOZT#P1awIW zPX^&RKTG7ZhqLTq3e3)8qMZ#&h{7r+z6V})tFU+?Pp{80M*J6d!Rh0q48+ZCqs6g; z5jOg077wLsu~B?$2l59CpJyLWQd??x1Mnpd>n49JR+d=(J6EBb=^-tt-J1*J~OJ5g`XxcLG> z4r#6+jcm=qz+ZPx8PK8KAvRKbr%jF+BcBt5HHtJ8vpS`RY+crN_JmJ-V^Zs zq%*e)zW?zdqpCC9!U_6DZe73x7e6BNkJj_Pye8dqFo?<7YYqR7Z2pST*5Howv0!{~ z9%Q`N=NRrpdECC!;}vb)A%BHwF&b9Fj;WT2X9k*YAumISn;{HZccU z`HJh?3uYP^4pwYz3+ossO(HDsDNsKw52=zpQNurdspRi5Nn9#{rSR6iP%5^UDyrO#b-ZaFQvp|R7jgs`eYj_;|zpgja z-N|X<=oqvNc5XMnG+GPBr|giFiWUPFL@M60 zkGx+$q?mscwr`8^QLPT z5Dh*=FM21cbX$%^$|3&hTzi`?M)%LpC=xN+nq}7 z7>1up4btv|wbphoZ9{gt=d20PHe_&uJ36^ZYAlMSX+LN6pdr~W{Qb;MWExHCh*+3VHPLbT) z*;91(X$sbr&Flk^TpRLB`BG$Z5OTlSBFAtYS@!~s2ig~?4x9r60=E0q@WbrV1KHL+^Ox1L-bm(kzyN@8i}@B$Y#ecN4-?v? zSa^JF#5Bg(%Fs>3?yMsjj|W3(LV{Z$01a>}d)rVj!ycz^e|E&f4wx59TpjC0oE#i&9)cGmZeYi*7aj@2gZjM~(I9@b zW`((RlDl1qq2hCI&yx%KAw0#3y^M{nV1m{cm++P(C)7aU)HCGJr`TCr?)FajS))|M zk4FO&gdLabfyWr`i}2d85Um`|PDjhOw9VX83?G@$g@Q>xusHlh5tz&z+`otW>L_Hg zaA2};mr}4)^y0q47jBe^U;E8u+Bhn(L6nq+3!Va%+6NrZKA#U!PnVI(dt=NfoS#yb zFuVsjb^rCQeT-%o9wBymGy)0Lp@Ga3c4YNS-3l&0fnc)7)1rO~Xx{-pd*FxmoNW!4 z(Ce)?cG7Or+#`<7KdEat8Ez7*&(htK)KMemAnR(3nlR~CQA1p202nXJKh0sar7dn-r9Yee1 zx$!_7uh$Q_fV15P&SriUsO}9^NAkRA*-pD*?z8}h2mj}2nGAi36jQ3u zwFI#i;6mL80FrR%0{}?@n5I|T1GaH@$@{Nsl{Wy4PT1DPeh_n6{E)N|Ppr1!<)_+) z>AI5D?6Jt?K;-`Py5TsaMT*n{>__@k!@?Pl^k!-o)C-63u5km& za=?YCJwdJ*h7FNmxN{lBrmNf_3HW9nDTh@WVO0b=Jhs}gMKjcP=1aZbk|RK29;69+ z>bbg-dDqQIkn5@rho78%9ATl9(_UFSZ6;_n!ZQEF9)xPe;3B?fZ6ZeqFy|k0*kytz zJUSuQDQ@MNdK>XEp9BI@bppNNd-Q~P>1oRA+ThRc zTcpx*&Fj9YvT+NO%%~t$FA!GlTrB0!Tm3l`F;ADMG#Yh8sq<}Vn&JrvGXZ##Kd?9- zuk?Huv}F;73i|}^(I;(V@3WDXr(Vcy5#lkq1P+E?RL|WZwf(O8uZ`%mv=KoH4}9=B z(tA(4uz&EO6yU=p+TPm~c=X*=-|Ov4eS2l?L7|+GLjxdT=H5?&V4W)U-@>?c0ial#c33qnTl@ICD^aAD!xw7x+wXze36ECIYkP>FethK>3*Mf_jVv$3Qu@689T0+nt zo9KuwxX0ssCy8-v%iMr@z~ZGT%oC5`a1uK3Gz8(EI2q4a4*NXDYD@}T;>?jy;37|; z9EJ*F12{1tS_Gc1cxXUD;F`Zz(U`XNu$!@edy}z5Q4Lx%M0x_&T4yI5z^TCrU>E>t z9TdJG4GOFmWo@;3SUq+cfe`Q>LqG9&LR?8M;-s8VNDGZz6ul~Y$}?ngh_?JC>q=|M z6UW$Bn18fx{z7wdfh2aSmgIi#=3iP&9|I0Nq?BrRG^|FZMJ#sW>qF`xREKz{hv&MA8wr5wu4bKMAi7~dRtx3SUOJ!#Xwt`!56N~qht`= z1*I%MKyXgt#_Q?^c6)$gEw>XrwFYMV0t$98UUl$)^Lb1CF+nS_(F`Who;Hzym(=9x zYt^in{$5+HK-RZA0gCk^?igigUO{SqI&{VLP0vn(lWrhuZ7A4#Zil*&$+y{P16L;6 z2f^N35BA>NWoYz+cnlT%nVvHC7Fv(n(&wWn$sy}@=t|NCxB&pT?}5vZBFO1-#H+i8gNU44|lY?%NKy@M9|0XbEs19AI(e@kaId%X)G=fRqTft5j59PW) z5{SW?U;v>>Vup;u?%Yx{kIS~Mcb605DamNeL_E!CjE3PFw`CZ$J>;ZAgK;Fz3Vndm zF1KP%c(kPTqLi&J8qDDx@L*0v=BduLuQ|hZZmLbL8|FL&P^MW~GLX5Sly4sZT#cOW z{$x3I^QO&@FG)&yf(=-@?SZGR5d9@d+B@bQBhGSd2))hI1$vRAwSXLSk{Ejsn8s4V zd9E%&qZx*}!xqJ-bi}8ShSXQm=KHd>>aonu&2M;y7ddDHJ@G?7J;NYZ6(as&3#E-zEp!p52t466ZBaUM_c>|qWlh7+QAAXNt+eh|d9 z2T#u&j8*w$F_PZ^K-;Y*^?pY34Q+WqXNUQ=Z$HSI$i~DA1EsaVB2XhJ)rXS4T$j&U zsB#iT7w*ip;7j#GXr2OIZ@leQmAWI1^LS`gWlTZU@Z!LBy4b0fb%4`K^bCW{huT(1 z;4i9QkBg*MN;HEqpYa2Cu@S6Sv^`7!H_qG=>3bK;6a22$Z&vXjM;Yw1K(lUZ#ggU7 zQ3E*rf|TH7ke8D;$?2bEOCz@qc_5R$+T_2N$Rn?|mBCue1vosB$yeiOpR@c5fz%ZYU@R45ij@3VLp9xjIdM(2~E9v4&;bUHtCr@&?p#QRCMrJr9zF%EYs>B(OfnTp&(j8Dy{qyzp9F$zjh~A6t{c$pB)sMVcS=4`(OWbwXz7VpRk! zMhLvXW1L1(IWfH71T172`;97 zjfB+aw-9r?ihYdO`j{!yN-6c0HVGo^#&5CFImD_RqhAqbL7KR)Suw+Moq|Qy@W`KCIR!rb^eoS4-Fk#As;=(xzPiS+6CD@%&7*=q_p-vEnA$p`ya% z6OgACC+o}OQUk@3UBND0@2xg^(<(qK8XHpO{VF*SYo zj&_E{4sm8(3EBVvl@?+&Og|v{$CfjYU;$9WJ^&KLs|ZV@tFAP*y0XFm`eN!@gH>s` zbBPo2fMRM@LeV7wne2z$|0B9s)RlPCNDDIs_f0vG7HngCe)-jIkR6_Br%gvF&=%E5 z^*y$$4C(pui2VZ4+r8gzMG3BMp0hdol7wqQH7U2*tMQ74p;CZjgeBxg*T$EsYufjy z3F~~bI<^LKmT3TWOU`oR{J_^1YTGB~FPc@?aJ!qCFbaQt*f;+HxV$tsHt2ZO)!rSU zWlgSXk3f03vD@@6*fz9evr7Zm{AKnQ80val6t&V+NeM(yJ{bxMZnfCK_{2k)gJ63P zT&XyC6=H~Bw~_*6Fb&Nwm_H%iDQ;n#dL6NF9dP7?ZI+&$MZ4c;v}JG64{85mYM8H6 zDFE^ki-M@?P#UIY6Os*=5yT$klJPcP0>%q%XwT21V>7FK0Jh78^gKD|6rIWjc7HdG zAV6*`pk?nTEd#kQ@;(2HEsbw-OG{V;m*w1{T;AMd zY-QseDK6EsPjnunXUNL{_vWlYA@yQeo&9jV-(K4a!oRXs{E{ zoxu(?yXDAm5ovsX!w%B;AV>vw>tigxw!N}k5j@i!v?p$|+pydPEogZS84Q)GtSRau9IuAaw+|_JC@huOF=!JR=No5fF@-*Hi0VH_;DuN0Pg$bxZzYNC57nQPxaOWPl zKx&Hcv1)(}eW|o29bf*61lygYIyPPCOnMDyRL^7N%04^K(0;^)e}02 zO|CaW57S_Z23FJ%DOPSPu(P_mG!JC|(64!X4mN^%BYgtwpf}PlP^=92c8Kd&fsm7O z4h#1iSrbW(1!h4~V*zfX5A}CK+-|IFEI31rh4uVk8PN%?ps^4lAV=M*d?`g|sNrw} z$q@wLC)x`}m9C2CFLg)g?k#mk@<=5Y_AC~8Xd!*?l1j6oEev;}Oq+&tH5T-wcBUg1 z)?OgdSiVQ5?GM>CmWreyZ{miON-G3^BC+Q+V9#gTopNALXb%KL!`{m6dljNuzg8|H z#e_+xhrKq~?dq8q$`OAKrW9nwIt@T&3k9+ z$?%2shaE(E5cjmr(1RpPcuhSRy7DulI(6n}o8<9n4Z?t9xj4x9d_v_*5S7K0iH zQvJfcFb!}*{2gD4Qt!9ThaXi%^fK7p(>Ln@`nYpDNjsSBV{i0gJg})`-Aq!lg2VX3 zyR=5^3ER!K__%_r3?pU#`hQoyluP+*zb`@TdjRHqTPaPM25Mp%DaKnSU;c8m4 zMvc!Iu{Ws;t?C%9GtA9pw%1F!h-|Ol`yi@SDd&FnjaHQgUIF%?v!H6mMhkEVc@u&sz>^t?eqLY#Hn{^&SsM60S@ zO6Td$W1~DHjFBOVc~5R0dT=x+7Kud`%!s!Y!6l++>FZusRKlooZpu1Lp5?rG`ncG! z+K|t>bj#ZUeiv{|vZF}EW!{lZG!C`FymdN6 zSM}bDB8Tf=Uld_9+H~PfPve1&_ivi`ub#>&m7mwwQ0HjZ(%&+stwy| z-vqL$1*dwW;c-~wG<>um*GhBv3v&IMWaOX}rdS;(dge&-iUpuMb7c2V%L<}w$ilpi zu2@UvG_RvS4ROZ1X-U}il`~YwUH@VIOEYJ@>mvsxG49|Wm*3T8y=H~#)3MltY5358 zP#u!P`46gFqak6GRsW+>jv_x*uYrxF19ec4ur(`<4t{gUPgm8%aW2hp?aBp|z^wi0 z^-1Kp0bv_fy0ayE!%tsOAlV2K#<0@+sv;Sdt?@q@O8-c7g*SRS4tq5XpSaST-#kSu zmhCc4+~G6cuObJfF%(sY2p}7HJ6d?%M2ogqdjsMY5I9T1h zpwC$}R~+`#N^`c3Bd;$*Sp`g(I*$7cp&^p8>LfXM#6PGmMHWU`^*<@4CA$(mfjSD1 zFpBPpSehZlHHPK}gspJA-`5zL8!#8eHU1|<33D~+Dqu9#aof)jYF3)l^Dy(%A7K|l z&pU!XR_G)EmXy#FlA|C=S#|z2JS2>w>VH%UUAGcFfjW>d%I+yio+0HmhUUh<(((SX z#x;>(Za_1NYy3}!!dRC8bYV%u)14szuv{M8{{rcMyz6(2^|3^wBrxXxur&XAQ6Q9- zc%zfzu;F|70k1-Rts zdoZwY?DohI8o{LHjDk+*$WN*;CP>7EyNW2|Kr-(askxjhfKfk_39fH+vD%9-%V~h9q3VWA7b4Yu5I3} zN3(AK8dV3CU>Y4h!Rq}B1<_hnp7kBq-|v2c?|t_DVV%*!o`h${J1h28ci2ZSMiC3J zN&19#bifutoc?U4vYtawm5Bb4H>tzM(kAz9-zkwCK* z=7cFpgx)<&Aqs1*PiR8>7~)#@@D8HQm@-r^w9Oelo8NQU{(I+UgLK1L1M+ooVXgy@ zMvUKP?bXW=rOk)ov|?_-TbwV)+xTEm+4z_!VjlLv3Dt_Iav`0lo`(`aQ4Ie!5lrVi zrgQPdQN$wbp#G6d%8kW&28x+F#^0_nKk-(EY))P_(se>Fg=K>a6E9#;e_pnKk%(Hu zBMZVrYm84eJ}ioXQwN(fp@+zP!+b5tKZ{G}m;XW6iAW0mSC1yba9k8z_}?MIGP+)~ zSC}|{*CkqU(AMzV1?Epbfnl^)#B4GAxs2EOTUqTQ&|M!5ALA7*nT5=MZELzH@gLi| z$bitr|0-V#2S7)+BGOCvs@@}^Lg@an*PnCPo}A8i%*E$wCZ2nMW$`zB?6nM}bSr*> zlo`%E>Cmg=7;#!4>gN)Z?$1!GF1CGkpe3&yi#p{Xd-GD#qs; z_7GhZN}%~TM(xMWgYFljAB-O!lWCeo6X!=fn1y__WBtMZmGl!2!Tmq>=42FcrtzzY zF5#gBnCK5cgzo<@8^$HNiGW7Ia4f<^fV2TW?J{_7cr4)Otj)>S&9naq&CnkAL1M-A z3AGep0(!*%b`c;Ni60%6JtGnj)fr4**1>psO4{I4I4GRC=6 zaN&Q42$$%30@??LV-O}|8^E9bJ`4DFh^RFj01!&z zJb*t@$n>G>fM5N+|MjAMjB#)ZF8uEh;S&9dK;}GvKT*g+xybyAg8w103i^b43K06Q z5TO@~!L^eZ#Myf`ZN-Mn*Af(el|$xbgA5cN{SWhubi@B`1Pp|!JQSJp0RBXwAXQ7| zSASoSGS9{bMFIZw_b~CV5CJm%sa!JW$)yyg04IX@)!&CH17V^A#+*Vy>fa%v*3b!r zDH7)a{E0%Cg02Jp^!NVPf<_tQl6AZ zgsFdp2mql-6q)k?{zL&ntI7Q8?;%tn8y^q__|xCJ@V`O?$n*h(LYyaw5`_L|t(gCY zZqENNB5DoI0ECh_58zJ}AQZa3+Ee=H{+dhl94MBMI1k`Y6d)A3zS>iQ+M<+f0U$IV zMdmz2iV(WmQ~K2+req5yTaU#8QVWOe9OyWa8c&E{{pyOAcO4A>e>QslUm{>2)1SyC za~^R@VQRIf^rO|cNaBa$f7@THHGBfX6p8Zy{zM^6LDyG%N>G@hXbYFEMdmz!KT*i^S9?mo!W1Q2fJ`4iD8zZVC_(6IPw5wgQnW>_ zVIqJ~((7k{KT&{C==y3;34&0Hws48=0-3%c4(b_EfKcfAYEKD*P)fD{5L%8RzlsO= z69oue?J50&P)fF7I)?)g8Wu$)^^7RJ0J+*z`t=SkC0qC#4k%n8y+c<=>Nt@aPmg}R zVhhi|GIQeJ{HEQ14*{z+6a!((3S&;{8BqvR(Dl`x5;@bS)L(On9tWAe5zc_bpD2VW z==y3;2?|q`YyrYl5sLgC9pFzC!qjR{=~tMdWD8I%0q^OTMuAuHrYVIf==y3;iTpA$ zrT$v2;VuB7mKX(6&xitqLf2P&O5{wRQh&`Q`Xk8nNw4Ao{zL&nq3a41+M=s%DTu5B z2wgqu^xt`AYxStpUyjQSdfpW(z>*>QSea5K6J91VJdJGh3@io&Ex$ zlzK{J7p8RVYxStpUm%oHPYHrh6zN#l-yQo}J?iuq2&L3hf)ZIuXSTpmCv3ZBuQYM6 zf-L~&zEISR>MgeSt_?LueiNR?n3o8ntY!?d7fY`hj~YyQ;{#{Rkza(TTdue#+FzX| z_R7WG`Al>Vl130vR-X(8nozC=-nC=7um$jMU*J^Uwez{%-=pSi%NB~`yuYUV;Bg-n zh;Y>6SGZ5feDySO%H4<1&*e?*^_efuAmB>}iPh%#PbmDCk0@eS(uZ8)q_6oDf#5@o z@tMbo6YxHZUtbZM%n6gPh~G44G<|R^M11|=;&2#h;VW?_*N5BZOMnjn7Y3fd<&7Iv z0D=Yy;F$z2;`iP`BE}p)3nzRw_aT@Q$Hj?n74Z0d!>_q@kyjg=hz;UEUHls# zJSNGTh|?S-;91O3R`VFt4IljY;39UOi}YP#8nw`$M8G9^FEqiwh4~P^DiA;A`g~15 zEmThv#u$9?0fQ#q^I1)pMSKfp<{2R%X_vw^LiLP7Um|f{)9-8099-Otcu<`1?fK$| zBp+h0!eWPJuK9o$N?hTv_he&zF+ZGmLSbZ5!NhyA@?-IaY2y72@Z2Ui;gtfuiOUD4 zwwUEZsGjyAWF>if60p8qx#bJgLkAzOqvv_O-ZVQ>dx$>E1iQZddOLkx-#yzq9LmjybLq4_&Q~`)r{ab0rruCd zdVYHLJ7%9$a8C|((^&K~--ZO0{;S`=pWZ(?yf(`~XFa2Bz1zFd>5A#u#YM}hc>Vnx zQf_T+ybjLH=R2R?HHgXfr7~7j7-f_ewN$DXE<_ip=D$x>Yxu^~5c>T<%y<7|cl#Zs z&W0P@su7L}x8Ee?reW^jtT4z34)>2u)o2^fMlSS|3?bW7Ij_e9Kz0;?Idr!D1B9BpLLKQBeV8?@tFF2@z z<~7sbyrH)6RkWSqrW_Sf(KY$vgHa}%V(zbxv4>HaG)6~t3w7GVUFPLjDoQN)qlGJ7 zsbTf&oLqc}yc;TIPdRvb4yzWJw8$3r&ayiqhcVzkdwleCdh0P?Wc){Tlu3z-$zg#L zG80lms!#5{=s;S-JtJ#EYfS{w>#~Ie?cX>W9&8o7Vv=uica2^5(brLSCGn;~4Vm5e zT6DBYNqk691GS7J|93`l_tUp*E}Z3NG1vKU5?wGkCA+xG$2F%@_KI1-$>y#J(-M~5 z)6(7Bl{R=Qe&)3{vj~nh!>*H#R&0rRjLVl2sXpglak3?djk#!Uj38Ca?0O#e+_EuN z;oNlIEzQDfjd2S6`BjfX;L;hKr|Gs{tLD$G7-xbHrvG8?f zE&6Ia)B!Dp9wRcP!?z-&&GQou?-`b2=Ds|l6~WBcLC>YsV&`qSk=OA-np7Bls2Haw z>%C5|Y*y7CKUm^9A?+tEsjRh(EUNGPl>4j^42J}A_kA`s*~{{hmgSV{mIo)r)Q?X+ zW8%O6eV=G#ga1Y9Q!FBb?2pWRXm`;LzKofiblhh?JDEA?e%<=@x|oZOzBdDTRy43QUg>RCt&_{$(#x{FJ73M&i5v^sYuAy-Yp1P_&a_dh zdUzD({L*bPH)yo|i{_^{ZO<&AT`V&e*{a)^0RduC|N z^Q#)O+piwzWpUz;u4`;sZ4~#g zuFw~?<|#L+J@=5NFD);MGVrgpW!rT%Rv|!-_qs~=r(4z^a5s)Co=!D!QOt` zQds}D-dTrhgDpk!c1_;lTy}PO>APhHzrWghsy(omidX?YbdE(T+qTGNl&TBK=Ngpl z-Jh%f@vKLs1HsD_A$^|rvvMaxpA(YnTf@CQ=ejbdK6_TgUsz~)fBMOGR4=vU9gYg$ z*6NZghno)WwX09xeH6bZpfjk%o_3o7&)N)^_4gdUC2_a#o(z;lsJwo|r=$0xV2IJS z-Dn^BR_o`cU6=3NmPKr;x_PpVSL#@-1;4T4nE$40d8UudVv`MqSu&XUCK~Gy4wepV z+YWPYzq#oeQ#AOgDsh4{gN1M8&Id5|P14L9;?zCv-NvWDSdWJ;XZf21G#{Zw+*Q5{kBhAig@UApa9Aran=s+(m(aFtZj{jus>)9M=RmF{|p zpaVo|9H=9@9^L+yLW_`7Vocw3TYo!~^^uBN7%xp%>Pt8DbA-d%t@WGK3+~-O0I485iHF=hw*%dRS7MM9r;B z7yt11l;!4w>;og}c>dixweGn+FCF9zt;xP2$s*;eQIOR75Tz>d?gcMl`&N2^YU(X~ z?yP*DIgA~Yp1d8^PblrjOkAO=;#aM?M$I&PcLRf;6!!;PD}^;}J`wq^+&6v9^$RQ8 zwI&;V8GGWe)d64M@ke=#07GQ95;tw$EFiAOAFLu9Y0t9bHVe&q+Z_)u0htM%11G(w z7|+vgE)xXTyXo7E?HfaI(%sQR#SkVC+Y=eKk+1A6hHQPOp*7ygs3u zp~drvK3FK~l(5qy9_2D235l#S-TP)08PBhAe_Q`Rtsv`jy(iw1XKNE}Ln2d2VNE9W z+FaUvRUs2zt|!NjX0<4LX+Wdy<*Es=!}MNu@!q2^6Z$yL*mE+5_K6&^mFr}w$krs< z+e%R?{Gms)g?4-D6?F8M5qplS+mE!~g6UceX3Y(?5aEX3~_VS$gNp$J_F2oGf6&&#fffHWzt69uleug}-j(wMks+Us7;#=jN^L0(f z439oJlQ*`m&NnG_Y@O^E0{w0`X4db9>w6?G1(o7#viyqpMBU2-Dz##GetAI9m$n}f9tAwL%r634%KIRR?YFfb00CI8KpZL^jR{5Z;E;A zq-dD`r7TyTyKtXT`80L7U(=~i&#Rd>yI&mVe(B0E5s`kUQc-Pv%n4r3gA2PpGemXZ zqt02u+p^33+f1IoE7l5RO*CjYygS>Leb@i+quccrArP3xAkk_ zu2=)5EzI963vcJpH@-y#h=mIeKfK}Jn^J~(&#fUMVwCrEv+41+u+i8261t{ao|}tv zF>9#{a3qzejQ0YsLa$S~DZbEb@?6v0qQf9O ziA!g0?0iy-W3}8A{8pD>@W_xV-YVgc_4 z6KWH>_~a&CHYb{w7{Qqr-*c}GE5{DEu944plIwC$e}N%ratfD{Xhx7pB4TH7!~Sp| zqgNk^`!^1i33=CXg$35fBzcP|Z1!0!8t^`H=DXJ1D}6}g9sihjjl2Otg%zIe&Q z(dOcxh8DgL)MBNjq7sOwqT*gL^u>ms&%J18V{_@EI9Yw@2T78wKTbsRGtToh5X1{6 zvvY+&K}JX*S<3S1{87#W?Q@{ zXMphnfhOCQ3!q}+qoO(sx7KonJ6{yHhP&GQ$ujGnXK>-buy`P1>x$v&{L6-0Iy?Vq z^l&HD^%yYf3-|-{UG_B~uxzyT<%^f#7ycxm$xl|q89Z8l{qF*b1gWTuPr#in**IM? u*Y$9=xoG+)0n6Q#b=mW&sLl!hzOuj8R7;HpJdotPbX0A?aQGq8PyYv8XQdYa literal 56661 zcmeFZc|6o>|3BV(B&E)=mGyKgLTItCEeD~YvP_m4hZ15;8T;D8aUxW*WS5Y{B#d<^ zg^)c4W5_zTu^apNUGE{B?$3Sq`QyI7pWo;4aUMOc`;GT?U9a`|dOfde=Dwt{eFy87 zUAuN|5#}h@+p^)m1K`=oTI{;5iKC^BIp*8LNl_=1byO|Fruf7jhB205X5Ds6g99w* zS&_AxCz!t;wc&akSiv0M=253EY3aI^7geb=H(F(5hnxM~l*R4v;M-qzy0B%ABMvi< zqBDYzN#7&X)uBpPGa}W*(mOL=|f)Zrt>>zZhU>6 z%#e0j;nL#PQqOy*eYg2Yh6v>h3AS7~w@g)t0T@0p{_jhjH zvV~#$mMxclWJ*W0trfT!kMqbWctekB@d(4jep_dm+2p#SV zrh(mM0a>DcGW2HO;r(Mvc<%f$l&G1?3kr1osJ#L z;hY^yy<*1hbK@TzjcH2}fgQA2jmM)(9!n*GF-Y1z&!s`MQeH+$j&)KF64*Ws*|i+&t^DYPTn8sPu+rj8<3UvTDQ9 za>|ziw|4Q+D>SB&60E1bvD@71sVc1S%Gy8&&)L^Y11#g+j-GOgwB9lT*lY>7E@fd@ z3W(GVU!I*!67!hM4Kf^DUB<6Uh!DmvDCXTO6veN&7|$)10L(uLRV*>_YfQ( zi+QnJGsCw$QRzve7?9_RJzeyBJ!7!$b8~xVE%y~JF6@h8ZdIgBXxS((RK+OKdi{z# zm%4`>jh8!&m*&cfJc?U8s3Q-SXGUprtd2!Ic`+gL6Zu%r*}3IHUAcXW!%`h?(*tsG zOH<25vw<f@nsxXzD}VhJ_enfY zT|oi1UMIjZd@{Dr`O?Bfp}mx9RDM$d+VC_Dcbj^7ME;el(#=_lG;J|pHbF~iX88k$ zlE-*ihbM5O=j4)>s;AIggXbba%id!)w>61M8)IB5<1_XE#`KV#f{o8A*RlJm2q8T$ z=bWokFJTah)cLIAlzeqoRyO&netf8}zwcQg2O*W@T}8*-;=*2Z8SBUAS`Wru5Y6Xg zD>pM_F;>U45MJx#S`T|JDAxx+nTc9jY>?}l!&%0lBd8SA)dWAN- zP_+1Zeux9)!K8W7+?*UGYl*bTvfNlRTD3f`)V)j_^q6Utq%F@bkv->}0}UNpKJ1g4 z_DCL|t3iJ#MYJED#7e)6nb%Maoiui&VchL%NasXI>qCx4 z+Qjox4da>lLsirM#6rB`$UaLk^c&A5wv;JCw!=~w4qvdd8!O#c|71#-CLtEO&ymJf zX(UN0%38d&XWr+7f)e)#<->T!d^TZJyG*OXtPVco78O%?%(&I+!M>v%7vV0V1J$|0 zMT^BVy}~)eBSLyP?9J-b-ii@^uC@&H?geabI<12DMz6)&awDmjG7k^SSDuoM957{7 zUS1eV>DXeJR($s%T%h#Pj67;&LPD zg@{ClnnVX>?Qt1rJL|z-rirZ6N)PyCtt!b+C}+fY3|;1g--J(RS6e5S{|ScN5fi-t z{)o@^7{`V>T1#DF|FL%Kz-S))qM!@KFO-1eF%WW|%6t*gw{zJm!5oeyr{h~1+lOD3 z|Jgo#6YX)SM2Xw@Or4SRGbS=EG4(@6>iIgosh*Q>QVBsdac)vdaIdG(@ROz@tgemPV$3f| zj56zL8|cWlIE#xX%U9>9XD4VYmg1LAvNJb)9LSE-=)GNRM%0nSOW`gzHfsiN*tzXh zA1UpodeN&mlg8Tg3F*#Xn*8g#-_s5-g)3e^-%!!*Rq2q*NyI@Smwuag)o|`WM=rc7 z-@WlEP51ovl(_p~hogvN31#tfykR>#Cdfevae=+JtIfFd{VCU5>@2LsDi!D77#m~; zYEoNsb5Cc6JF2D#ilqJ-t#@8K<%0}-pl)p6AjA8~P$f0tAeN|9<|HFrR%3H}2r#xo zHZXQXfMnEg76xN}J8P63ZfIb%xJ$vn#fUWhG(`jzzSa0Az8y6&d^gIokG;vX%gq~7 zgInbrrCJ`PNb(pEdx6DziuS>9^zHGO+*ZfX6cL0d?b3opa7tyG00K48uxF8*DcW<& zyxg_muY`muZ?T~!T&@AJ59r=1848S6lxe{S$>3^^$tqE{OsFc+j#kx(NEu3lu`9B9 z)}c`m8nxTCUK_R=Av{s(C`=Zv%B&$S3njYH|G~quP7#V!YIWbu4pbU0GuNQiNCcH; zlY_hJbWwib7kSdnv)L6%VUlnuq@gv@C>4bPhC@X_h8wVGC`Za=J4(VAY%p0}>cT5i z^Ke(MUX(VU|JA8CqBX*Jn}$Z{kjufI)>ctS`EQC3hqA9k>8Mc}mDGDvBh-(eEpL!# zv^4#E5+{E1>8RyGz3^E%TGyBQowIE^ z*@?WNAWKH&!T#MhH3I#LhLnKs6smC_cV4K7>3Tv|mcM7ikL0ce0^H6sivY^oLdpki zRGuFwZ=01+UXnglM}P0AJU7yX5YAtHykB$9@S;yj*+2;8R?C!4(YxAK=1|1q8$Z9FXSZIB%Kh`QJA(FP0Y=|o{YjCwP1iRmE zQRTZ=TBO*jD&R_KYu7g#A$8d%lqfF@bXwfrOPCZ9XgiAJ{?$p=XyO)UW57=w2E*3( zD-#{fxs0kMbJoH&BmZ`00Ykaz_Q%^k@$xsHyN!6PBsHasu#!KOFK!~4<)IzHb^)GCw?H~cVN zyv01iP!dlRJCRedbRU;%wgSQqj(s7nQrSk9Hsh_4KJmE{Mq+zz6-PbKJ?adi)VP8a zC!YQ1koVSV$!u#EM_g{NHD=vI`Er;_e1xH9o6ZGHWnEid`+nM>&me5-*cDI1id=LN|JKN&&dq>(tW=3ps>q*aDXK&eMmxfyTEvWmU95reU z{D6r{z$?~{m5KL(l|U{f#-FajUdKj}qVjv&Nh0t(!+?>H_%Ub0;(3C-U_wyT zvc_r~ca;dPSu#5kWdm)PyRzW`ePV8JdzA=0+%TXo1gL3xol{tZm%<(x%-+yu>W9Jr zA<_SIj=Zi5Fd{)9wIDCK-gGjtq@@M!DWW-!t2HGOZK=J6l01ev?`!A^`JZ}iEtqE7_R6jq13U{1Re+g zvm~SFbj~7(K#lu;*)a<8d(+0}uLW^Xf3A786DzK7v{X{LZS|MgdqvTC7xIAsTu|12 z6X2i`jr4UQ;eCnHpZm1#gRPo-ygffwE-GHwie1`YFyWM1($Eu*Ohe#cqG;pyW)1I& z{GrmE#=rX@gKvEq=Lp>dH-3Dx(^NgZJ33dt@)UMx-w_h27#h9~Cox!%Q z&3`PNHNeY_uJh zTL6$6z(wD+hGD21pgKy1dS>UkSz_w0xj3~Nv1q1v`J%m~Ilp{9hTRaG^{Dlb42VcBT6Xw}xjVOez#Zlg@Gu#*rY z@H^rf8e23&VLsIkd0_8cC5yN2kfTUZ4UKp?1Y*E$ocXrtO!?)Nzsl@ShkIdlI=Vt z7+UR!3zpD8x-Oo;r}g#DtLA1@rBzGjTg%$vT7b=W8O)s^-T?JsWaM+&2x)jwJ;RS{ zvHz*S`ywNTmuYrZF1?HmiTflp3;?0h=KX2eHY=5)jN7onH?Osko*_v2Eseo9IJErv zc&gI+I4_R127By9|Fr;0dJD55!2K9=^Ohq_n=B=ElWVSHi88LN#hDSXkv+5mge7Hz?LcDH%(^gNWX^aa;!! zuiECujg6!^AVWuEum{KTb4A&C@NO14i-llTw|Bt$gGRlWU4g7DvPy!(B8#I%mN)_J zAF>{@BO}MLBczGJkMTX0&i0uF;a0Eetpw2W*F!1fawdb@X>tZ&GR~4>T~q17m=AnN zE%;bhF_T4cZn2_!!5K-)CpQL1!&Pfi;>nHT($l|aJt8la-Al?=U@DCJW1!zfg7D>a zRt5@Njl)Aupy8tbE zN%yyQc7@?qJq@ibO`%J_I7Bc zO%~2Oj;4s=#Z-36yOb>CB_i15n{lj$FORrQCrp+c>aP>7CP?fY%HpVLxsqqC80gNPX&XQiE+t4v+@zqo zL95g*2?Uv4Ysx3L<}5{xHx_XjyIZ=A=TqyTciF)Li9r+Ih>3zj`nBpkXRrs13Eat9 z+5T8CeK`I+n#{97({90XPvZwxJkYjvl#ZZD7O~7ejv$Oqd4PO3OByaA5sd(zTg)EyUPz{iA8bI`j1)AIFDK=dfyme zBMya&XHjvKMj{SCK|2n=3PT@TXYcgTs;Pq=DBwoCODhs@>WaW*0xvEcw zMdfjPmn)(n5%>Ua?J|n$NXd2=TZe*dfQ2lHJf!=mG=VTQ8=~!uXOhgPx96!KXITW5a zE&ErJ?Kt{vPs{b&SsY5`_q&`BEJ;o89SVLTj=vo^(HsCJ@bY9l9Y#MybxRb;A)HH&wI8{0`5 z=TtBAYuO(Nz4^cZd;eDE(?_-o@24}q1`E&sR5FoQs+oEp<-C`gg_Pv^37|-z;HAx)(w@3AO46y zLS4GEgkk1BEozr@4hH|HBf;tzLM+iq{wLro{;UG#;>NDvGxyzdLt~$P$=%~Sw6el9 zr!}EcQFae-BZpFt5}#-Nb9bk=95o-JC=vxkH$_F(>U_J6MLv_fQa=;hg?(F zy}lHCSPW2|%4to6RHtve1f+%v;6F%x14!Lvf++aOaIB)Lf+Jc}8nor#a5v)PRBuzwdsk z=yy?-hB8(uSw7c9u*ka*0UMR%Q6VmKqPCCbSpO`ClKX=?sGsJMuso&WXgbrb71!(9 zO*+k`QDgnWTv8~yMIw60{y2>9#&-Ap1-}pkXF~{y$Ky@I5$9hw)n!KG>LjbIWgp@! zZ(!+1BOn($`tKTV9ZhVx8h*pgrt6x{#SE+82}4)&6y0vN`P3C&yjWYIy`)ld`dSc- zY{^Bb{5Tx{!NT>%sy9th?Yh${!Z44S&!zRJxdxv3`eOXoUwB9gSfrAlH~w zzHGih`1ICZ9G`>|cTXoN0v%8{=Te{ z92syuH-9fx;Ez5S%v73|Yc^ytueEAb85Y$^b@zOyOo%X))XlzKY~T{9ZuK>v{v=hJ zPml~j5-(s;It7v+ANt>KnFYukc=$=5lcJCwQG&sW2lnA+#sG+I3qus$8fULfJ^`m( z@xfZl`Hhkxdc+GUD4o}mA20a_U-(pqYu%wBM7H*Abf{7@P;GeAs?sphN&&W9oek00 zIe)$IMVl=DghrJQ^CzKgej2oAg@@H?u@y|*;e0O@G?8SK-kN5jHe|u6x2na>jFqz@ z5Z>_v-Ae=hA;#mQNoTwKPvRpm+LqPhK{H{j80Joupn;3-VHbxi*)xAREiG8e9gRa{ z(_x9|Y@(`9xn$p3lRC*&wQqUK<})neq*Q%a1nV{C0hJ(1zWaW8rGXsf6`??Z{ZzD6Lgz-il=@OKqI6-}7{N86~5<+U9KzKWy%Z@PB{iozoAj z>Sr;}zRoS4JZn|ttLdBX;BTQXKt#}8c0J#!%R;jol-Whv0yVl5Yb@IJ`2?9gSix0IZ6TsKIC>%`mZz?O&U zPIQ#A5h6(=`DeperI;TJ1yOJy6DP(wZt!{@i(nOFz6*X;0!}a*Oy1(9=SIzgP-4|k zcaNK)Y6W$bz@&;|HAj(cIxe>t$0tt;BHJXEd+dcsN0`TgoRwRTTl9vstEG3P{d{QX zy5VimV1W>V9@fA$FQY5bQP@T(RT_Dl8pbL-GOx2lP@6SU526SxFc~~(d1g_9;3L1) z#IcwIXjYWH2p(2431mT%oPdpsV^?DRgKicAUr^V_LtbV=_+RrNeGcs(eMymsctcjtZECN~voX zTvkU1M9+7#K1DyJhQAwgdDY&|koiZ#ouWdd6OzYy_s1EU#LGW|%`#^mxOW;s%PlLW zBl33h3A;TRntbaUL@4BGeLj!?pBcc%+eO(RT>Y;*Dd?gR+nvu>ek~s zTeH}c&QX_cj((Cg=%5&C2)jwoEff+pk&rg!)47l5SS|c#l)Ld3@;rF$LtLKtr-M59 zEPqE4wXOIFCT!H6+D0pE-A^gUu6B?HyzkqjgfzIduq8Hw{j$JxIxq z5JfZ`Fo5Dn!Jz)`Os)KaV$Fq+B=e*!k|afF5!v~nyd#?=IU?ltdQ2@1K>XX@x`7rI&1q zdb2wEN-+gZ({cUtzvgMWj_CZAcG#**2QLAW3zWh#L>%oHbDZzh`GhkT3k$N(#1TV3 z>(1Vqm_cQy(vAP>b&M9$YT;_8J1Z*bnxoKlBDUyL^s8*8&#ey%ay&F6CcTpq<%N25 zJ{1~c1qM5)($&8Od&=Kfgy(og*-QT1h zO?z*<8!UVy8nR#Et2D@W=zL25n(x#J5yg#G$lnQUhS<1N!f#PP1NZQ`p*H1rX-r7x z_Bp{v2%i*!juF1J@FsmaB@a)#+(U`z zH0L`K=t(*5OcO7P+*W6IL{BHAMYQr53=7^Yd7crd1i2vjtp{-5fVVPXmtVm7hHjm| z5)T(b`zr~2{3}&AR4F?U+ztug;fwu&=cTcC52!bittAXrr;f7)R`<>9hQfya zc+FeO);)DRn-`%CtToo}wDV)P&Zp83kI-Hvi8&JI-l;l&z7p%@A(r&KX~tK>e3G93 z9gYj_1ob7S7KVgTw$QX(`+@M{1S>C%vZDMz?L!OIbFeV$Rx)B&W+79I*1|$sj-5JD zSTw3?lua>m(VhNC7rLT`QkAMfU=>9iHj+j1j7x)%pFNuRvt#m2fyv_1hQhuC|FV=J zAUD|No80ur_@1o5eD^3)xs|)v#XOZTyTwRFP48hj2FKenQ4X?VXlvbhQQj*_u-m>G zNtyVr`j*vfgC5-qhJ)&nKxUjAk@`Xha6)3jlHn#jXEy#w}cinYMtX&*8yHGCdO9rMiD#j1_m75Sw6 zme5UitdqTD5uBc4&?6lot=x;I2V09%ti0i6S}kC1VRsS%ml@_1-_0OcTixq@N2*s8 zL@Cu5{%vFW-G-~=SXb*M4R8&24b4N&?DOlB=tkf+!4a6;2j@GHtGgVnCWzn1Rn zwb?UZAp#v8vkE(0>`|SKS;Z;c=tR24*fchdN=wf+?`KI)ndja;ZR=(I(u%x2xEi5E z=y5H+zhrr96Lu#BgsyBHnWu+@CAn8Id25TN{<53$AP8(cw=VWv1=}~Bqtue!D3fyzYY zlr%QMBm-i}PRDTb!}3B%N=BrwL5DE%TX=VrDCrEimZY%A7fwAfGG535MoSwTj2s*6 zPXz|=Uyulzn${t?Usbwrcf$Idpheh7R-~_b2cjfp6&OJ8wg?anO3j4Pk){-kH=OJR zFMIO_z=FFEocs}$QZZ0)8haz+C^+yXdj!MDLTlR-AW2prfq=%#!kz3jo$L!brfv&e zCv-N-j31Cq9YRqWMAIA_M%?U+DpD}(RvU#LS0G_D8yO{BAS+NH>yb^*tO8lM!NrQ2 zk$doak_mUry($&9| zd)i^_9jklpEFFo~oHZUSXN*!*=QURYMNoparf^XOFgVvfY;`bu(1hQ^ufcrRchpoW zhG_p99x!`dU&YF$BsoazyroNTAv_=pT@`2dp7XB0%s2tR^%>4kF|sbL=#8?5qh;W?r*#Jat)j zVE)qFYo-XTTuP%LKTmzI*}>EywxH@~{Q95)NP}OLjacc11hDq_69bVa24*v3%aZpa zRO=^_WtWc&BeJg@K7y?t_EmL+ZAa2)2Ub7hHKflLP0E;CYh9QEs~H2U1$m>i<@2nD z$A^+#MK-#Z=WLzv#-W0ib&}WT&>=GpnA`PsnBfkKKg7G zviD9O!ou0zPX}OQ_)}S~CGq+EyRdH`0)SB^!-P-L0iAa>Z08y;{O24kEL{Q)QY-Ql2$fc7y;!2Tb~(ZQ)>1hPt> zcC19?Q~sOAx}t>)JO(1BG?7Nm83`Ib3_;Bl?_828pD zgMVyE)xw%2i9colOhpkaW1QrE?<%&^dO7Kv?Mn}BGDc43$InIV^QD=n%1{ssj4qmda~>OipSmlkMqv`b0ideSv8g{HBH^2AIo zfS4J`QF_iY62dNWgtfw+{oc%?g1HRa#0QVPBOy@FtN$jr8?@~+c+eB9xoy;2i@+E| zZ`}5~tNP9)yDYrEiITd1*}Oda;zMHqcNDgmwA1c6cw0JSfV-^&Mizc-K(@2N-dBqt zs7R8qnFBtjB%0PZ^eNxW=yA3u*zW$FfSv0Cl*68+>5;n9^Fsmn&F=`%0%?ZXxe2w= z0n2H~OD)Mr_vnsRAG}nN2!P9cX05^$X}bw~Ap}<14p9>Kw}yAf`#gcsC!mJK1(@F6 zX(GxA7iqgQVZTLm!G7^pv5_d#I{&erd|ze4Gri6g>vur#@eMBLkyq`a-t_lBRf0OO znr`p+iF+x<2OAVe>OVBlaNyPY88BJ*xa`78D{~d3{c3F;ay6;5FMi%VxdT)RYE;rh zLe>j}<)IymCY~Yp^p=Lw!t4mO;~-z>ktYX+R}2p_|C`|xM%_*7r;A^7-@gXtPc3m` zX)dokoUFAab@5gxN`6pR`<`!6wujD9{3ut1a9LTqJU^BgBr&wug+-T|b@9 zAypuB!+-xVxGp2o{)TH+{D)_5V6AyyRdYTFtSGBswHmeZc>pZ&U3JsGs#2X73pw`1 zXnUYIwzUt5Yn-j*+ZL*QNNGembW~UpVVu5FYC41^SJAR!^7y=AM4Fg&9 zIe)R872V}KuuFZd4e=PUVV9ElAz|JqcPQ-BK*fUUWchUPvAeXU_#vjiG!9;#hA_UQ z=WO|Vl?pj{qw4K~Vvb@-t?do54dKX>!0u;P>^{JDf3-+Z;ytWtr@hY-nC=H?-GlJL zuG%JkT8;LrGt%Rv##VGbLi23z0=}zyn$2-V@CMZd6BKE&j*-Mg{DK1Z4nc26J=G7ab?R;nT-r}h4cvC1^d4hG*T3B zqWFg2ZHja~SUcq_A*J)0K79sIQ_Q-bT}-O>7Kd}OTG_-(kdY^Fd%H~R)Ef+kMC3J) ze$zZpQ^-#f;cmHcU6tS9Ep!#$7Cq!6kh8Y;$9kPuib0elUc1R<)Ek6M?>&NDRO9Qf zu!LcAY|obje+v-dHB`^ia_OwtTO54Nt`g$HQeqZ)SaH0qU&`04T9>SA8+}T+~#d!gShFjqvFh(S6L#@)_nABi1-0l@_guu?O?>ywvS-H13 z^jh%*z56IlIxDZDxsd61Vpqb@JwkOK>$Nl!f^ccurIUTDjbAA}GJ58Hx#Ze7G3QM_ z?=24NuIYm6SamL}t?kv`p&(J!#BQe`iY?R+#&lo3O)mA7GoOTx5RkXYYn@}$ zOmP&Kx15yFNZZRCjEH8xiixXW$9VjJU)2+W2Zk%Svd<~E=W056I5hoR51{Z3PArS? z);7n7b1yez;!SJ(eH92@Wucd6krkGU7M#~Ida``}3iMSXbiK+=@2Y7LyGB33$VZNE z*nYY=hRa*2jNz;TaJ+073RjoteLjGPTgb1ZYc71sW?JVx`dKPo7H*dxGDD3RI@d1w3_!q}? zEBgYsw~jb*irK()^K6h+cr zqF#o7mPr_3!`QqI!%)Y8w<3@yH<)XxIFbusicnwM%P`EIn|!^xXmvsf3JZq&1DR>U zeQgplZs431K+d;#3tLxtU|uH-6Lf++s}lw|5~56S@p?zlJm~XNI(K5dszt!L2Q|5? z8nz0dYcye%5_eX^K(Mem+FWUqNwn7rW+L-9OoodUOk8MDOYch?r~~ba1m3jj8ytm0 za1>-@e9|(}(8@;Wb*|b~Ops|6%vYl9bDx^DRYiH^{$qjcZ1SE1#+rBg=OxZN(M4ZH zL&Qcj90F(vD-MqUXn5td%#9h%;`%GqeTfwbn0o|TnwGDGW7QJ`onu*jGkDWRgM*#l z^zoNK3j`cY3o3}yU3e3b*l^rANx{ta3b6Sou=%T1n=ky$<}<~S5neJQ1l)^Pa)(j&=tG*GN`<%D>) z_<4kva+yXLC}QH#YH8X7BIA$s_+Fd=9aG26mVhAB`jZv*ufpuKOI~EmK_|r6u#GK; zNjsgfk1_99q%clPJ*f5CdEdlYBL#bpMN%B^re`Zb#(B z(DJS25P9HT4}}ytU37jq+F9^xc|lKbrJ2^<;rZzoX>UI}I7jun^nzOIh`@4hIA$e8 zJRbrQSk!|9=IJ3dQgYt(jf68pd7qqn;fvsWxG1__H>73teBF`cFtC2OJA|s6u1~O% zk%k~wxx=|}4yp%bL0 zEVL6bA*kS&E|=Zc3D_hI;KlZGAG21jBnGzeg2UY=K+Z4;v>44omi$?da0lo3*)IRC z5-#u3_T)$Crzz=p5>rm?{y6!f-b=IRb7*sbFt8Q>5^OtbkVSSJWW}M z6K-vPfNLN?_X7mEM9oG+qO;=*Rtr?9W7WjRW$1u^H0%jV=^4|E@}tu6m>`}>uo@j!$Mj!{iK+JONFl-uC(R~ zV6)thwJQFFYiN>Vdrl!F?ZSg4Zo}lb-tfT%=KfSWQklFTRh0NB4O&5Nl5PsLtFt^! zhbMUcTZzX7Dic-f9Kv0a&f%8kwJCrvJs~Jkil@O<$Hd^fBqtYj0!j;8JPH}WoluqU z8K}Orc0`i&d?=`2Rsr14**DBJ~X?-;aloL5Lp zq~GsAw^jannlypvMGlkjiPU;l#Xly0YZvm}*L+Oz*NJmljYKA$b|F{^18c#=;SRw^ zXx7Lbt(Den^y7AP$1&>Kt(O4S?X0->zGm^~Lo2hNAJ%GI;_%vkto_bcM9Lz`))kb45A%cPI1IbMl#Z|zOZ zH0WRx9^<@`qu2B;j%VyU;-m&Hu{yHq^IsChE@1PIs%sn(C&42CXL}6lNzrBDJiY z&hhQ4@?uYDR&P`oV&G9^L4QhE+tv{?&r~Gp|J=?@)KTQh$1&U}gNq{LYPYepjp$ ztPf|h?5;8GjXvwJ-`DHOmE%k;W;MPtd8iz7|F`CQXNGtGP3w=*2s4Jb3&#XY-abN5 zUmrL}3~_A|a&5A$NvpkRaoIQZDay;?T&MoU;TGME3vNxbZ#$hd{H!|~5%;Y2Ijf-{ zaTmp_I3uh%BW3tkR>q?VSJ~fIMzaN79LhCEww(Tv5&Q0hV9um`-YP=ga^^c@M{eJu zd`?X;#C!Oyc?ox|Ewe?iOl&Xr77PB&VM4dy zF!?)uZ!>RM7Y}o$QYKax+I&mw-_z4gvoESNG|$S`D9K$~y*&c&rNTP_`W`qWha zQ%`iRDf6w!?UAP#q`~BW>5g}|nQv8af0bs~63!^1o*w+xzgF{@yx#+bZtgAXk=3`Q zOy->+<_`GfzgCu;yd~-L)_@-=@lS*^tpRduh?W2C!r9iion&yT-imy-UH-dpO1G`~ zRc_aYaQZ64;AF-;_M zhw_K@|Cw+ASpFXC|I39tm1~YT$zT_`UDk}b|NBr6cKvB1i1ytHz?=aw%=4YY{=p`- zx0(B&%EbOKC1k6&MxBB-|3Utj$;4_yoBtsHf&6wL{{eXX)BL9g01x?&=Ckc!^S|f+ z_bCSCuNB0cDf>~N{1fASj}!k5<6RulH~zd;fqVyKh0FKieP1nN$=tQVm@_|&z>X!9RoJBGO*U_1Foa0leapJD);|G>93GO_SJu=$UCE5k4aeEY-X z{wK!!2jBkKctNg`teAK2Wd69+cjxYR;$6)(f3%@%Fl9a<&9J9}`^2puh2D1ZowLuj z|Mb0YzZdV1uiPh&L7V>oqxM8@|H%y6{9l(SApg7A&s(?u$hScL15ahZ=07N9K>quu z7{KQL+PDA2cwx=o)$RX=@p_{DOSn(iG9L(*`J?AM@$^OxUf<9jg>6@<-Wq?3;o%R( z`y}&+PT!r!-}&|*#gk!p2z>jm+6p?X946nn{0!RsU&9KJ|AY|c-KQV<7RavxeEY+^ zeT;ec^7GciKlJT?ZM=Wz$$o4+P%^YnGF*(@&TqyX_I>F6L&*LN%WzZ<$Gg7gzID#F<^;q3?>cxO2)%SN6RO{@8&RZ)T7^Ai$1X-`0i;>cnPjH{3KNL8{r8ro=LB$Cj!G^0v9*L%h#v!CKb#pQMD=F zH#)y*z0KH*+f0p3U^%u4%bQhW_h!xA>{vEig3Xp-vnBYS;2H~n3Z2$!7IrR<{yP;y zu2Uf@phAV8Sg4;_sDKKY|D6iK*QwAFph993UJ8?5ctC}o{hbO0uTvpUz|{QYO={## zusw{fe`jh=8<<*0ALIWq@zA~ywf?V&?(4SGpH`XV%4H9r)|_U{7T=#{eSaXcrH|3| zDCFX>4aXhtfxEvQvCt&7nmOp+2ObA5=HGA=F{U1U;@drLQ56eS8S?%c;Bnw$#tj#s z1y2Mnu3ozgqbI%GA4A?B1|A14-f+pi6S!M@^}2U~C~sm+_x`4Mo7OAdjJ?g&*aVhM zSpNTa)mT=_8{sD4Sa&_|4@PyD40aU>VHF>bSN~}n$349=5sBM>1XsDW(+!&{8xHKhRWcJ@dwc-YWOW5 z;||DmWC$!G6gmSHI<=;}l&D^6&vZUs?bSbQUqAc1R+xEE<^{utQKKy^w6y54vgk1Z z`g$)e3Yos1c>P$`((Spx=L|K27b2zAGsBFYaIM*ETC*(BdL~!+*-q*?H(iJlSFB^{ zYdIoP&wh>UO7$vA5m-zYSbPAjcS118_dtrg)eB8dAmgO<6Lw3#^hpKR;*Lg0E!ywU zdSOr1lppFwOI#7~2QoTKs`+J>G|xpVbdC-}YI#0~*1K5o;NUcpXZJKE_nl_W}e;+nAr$xU>7qEUVV7(E+P1bNX0HCGAw3okv2|)gh zV7Yg_5)8Mn;8LIkBKjG*T#MJ?J8TVfuhm4qK|l*M|E|@%v7mfdD+4?LyeWgw0{kw; zr5mvu{Je^|%^3pLaA*O^Iu^-|)#Sul4JeCNFac$$H2Td0NV9d|{&T%5QHL3cjnD$H zDM+*RQgU&v0Hm91{ku%lF}-hgoNtU}`3~Rm*4VY$w#b#=v1hdcDw!|4W(@I-bt`=p zplwy6Z9lVKC#9(5s@Z*8==H6pWx0KLp5e`=!&Ynmf5c&%vAo_BZKnAq0&W%uI?vd| zn*X6cWOkkF%udO**kjr&O2LFf!Nh#S zG1y-4^XeJjVham31zI4#pHXfjv&&gycHMy48AA&+D{D2kY&a_Xp#1HCkH?ehwKNDV zAnHxZ#JU;#zu5Aq5dx=l(dmT=ey`z`=N2eM;y+sQ5?pa=vz51#dj4te}%>kH0a(M zZ({+UaJV(?wcWKC%md^4t=*0_#w8%{THHCv$UybF-w%!JpWfKDMk6(ys9ql$S(t|z z8S0>M{bL|MuU+j$jSVyUqzG^~voJr0#`VvW9R6#Kx^=d&FvGQ^-w1I34vp*dPG$cZ zA1%%h;7*Ia^@o=9U(mSjbbp}eDwFgw*ZQ{^Xe^(88|TplUCnJ-|DcHHwV8;{)sK^q zhdt2_OWQpb85Tb(eJ%6ca%}BGC(EU@f`j1B5BjjkqRc`^1Y&v1|5;mZ2HR#fZo<{- zC(ZsdaJ89Yn<=)LVw))z^gq}#ZDPGD!z2f_!ahwtWP&4XM!iDf$*GG;ZLvm)Cgh1HfwwT#6qnbb@)0H}cx& z>%2Bbq0?#F>#%Dvmf`DKl^)n^Dqg4;GzE$Ii) zxPi7ES)*+)0Br+b@ctNm>lbL;K-<*TXqy_KZFw%m4-`7VyayX;+mkig76h&%?WVn0 zT#LaxFs{?KBkQycd>3(GkWql@71R%n>%8{DI;E|d>_<31SkF1nBs%$Lb!>CX1p#_ z81K(`JsyU}gZ2;Sdz#;+Kd$>|q4HMXbGmn3g@r}{<&kUgORCp<*WwHG@u94WyRG%t z=1&%;;)h#U`kIR^%rcLbIebzu(Qz&Qs$g=2KC1A57qRP{GY_$$FMxSufI#3RcVVBEZ zY6a}&<~j&_cmu4@ZFnH{A+D#HIalD}O|1h30zfS=etvoFi$K{=0sas9RZfHT14JI` zsTkT?`?RsBWC`qPX8~$~@y3^vgF)A}m#L_*#2*Cfm$9n|$BW3|&W|w0x3c^+$_Uf~ zx0c%=xVvOLwx1 zJaTiFW8_=^z>+(rMls+Jq$mud|b%mZ&Mm&dz1xugy)k;;q};YA*|-Q8!Vo)88| z4JjV3p9<&Z86+8>lFtZltHOLewvB@MdSqJ}`JMg_&6>M@yCP$@@4s7#`MMAobY!bm z*ai8eCh~>LKVutoV*0$pZ+c+`;c=wo|@xmSF)&Wn~~b<@?{ve!#c$6{(bn z>e1Sc&b~~MY`2MTMM3YZ{CV7gtI?*Lf}_8qo1dCZeC1$>&eo;i#^d#}h%Wi5i9T9)gCgVrljP`2w8N_1E1y_+*Vl<1!Po%C0oS6@wm zUe(WXr8?BSB4uQ|>QSQcq>P(0!<1;sEy_!;_68EkuP%$7`#viqT)aOhFcq z{BF*4QIIeG^BL1a=So?@_mg|G;yjLW@Y}d!54tNCgOHrNtF^9NT z?`)<<(E{+BPRh9~CN#$@gj4<{N-@#xy;%&8zEI|E~S&w;yTV z-jytUAw}9tkNX9j``mHn`s2)T>tzMdPJNT1jP>PObzR^)kYoAb5gCd+UN;2<~Y=b7p74!PR*E;pbx%Q=>wsc^> zXaJt#1*dHkz?tDX7mp&V!#+bB=bgHO8CvY)Xk~tGMNz zCOtmp^3wC$U$NZT8uZ7i@n!Bm7o=hl=fxjYdu}(( zAkLdTeCnK>9^WT0aW5<{&YL?t^E{J+_<#@lJ&XGNBCK^U4jWu}uBMS$`+HEd#UWpQ zSlu}`Sl)B*L$1gtaDm+k{WS&QI_3v*vDuAD@>CnSG)xYtBeMUN55| zZT`4gzgWi4uKJg1{TG;!Th+fsWq4uO2O^I~W?Ud2?~MHRYGvHKfrcdS#$|*9r1INq3mj18ZiN0q+sMZN7dTjPGh>H!LZA8De`jJn=M-`op)}zq_KSm>y}-+ zc5M;nDA(Jv;lIP+*~wbW5p8RQu`n~U!-yH%nptDS=s%nkbwXK-LO(Ym5NKla&r3U( z_T9a^jk4X@d}KyMQeT|7_sy9GpBqe5sIwZGFxBTfF3*k8=BwE#AAQ5p%AU)ddgRj_ zfDIJ*kZXRUdXMMq_@wQ4*ERe=xbDKl9t~;N%h?%?1(ssQ(Mx24l(M{Q9V*2EDWZp3 znix(TsrGQ2PU52>#9oQGYdJQ)&gZbZ@c;Go6+m%r%hrRtI|O%kC&4YaySokUHW1w1 zB@o=*-Q9w_y95XX3%ul<|GsnX`QN=gRa0YoRefuB_wMOlHM7@>eO#)LR%Y zqt`fVE3DS7;2O7+WMNea9Fo_KkVjm>9cT-EKGy;MFY2jsUo(G1uCQ6 z|ILk)nnuunb1}0?JFC=aCXGTd6LjizM+!l|RDW9}28siCELWzm@Z^h}x#lGnp>TdS z%a;I~H`QMt<-5P7G6UaZD-dGmjqVlNe<1BgLG5v?k_>BJ~7L5wnnm+aSje%n?b~Qy%eU z{szv1lCTAXeI2$GQy_38QY9$%+HsBIPQb5|NbY(H=PC^o`wMKY2wQC%Q+2Zo_Z({} zq+C|S1p~TzsOh|Cz4hwrck{*4Tf0w|X|yOqw8jsKL89adKhjE8t)GolJ}JbU&`FSS zexL#ogxeau1;&aS3dV_e21ddIjCX8j4ix;~G^Vh6AlOCO$;88|h2QC-!5_79<$~YM zMDwCT3u+Bh1WS;Z3WItXVibo=e?9`kTA7)FpT!*L5MPQp*aBo&278f=NmO2X%QTwOuyqx%WpD3XLx z@7*6GXx~xY;;{G^q5xJNGa;Lw5`=^x?d^oz$l2k{K8Q|~E##~PqPB9lPsty*X99JY z+jaDEz8oc=u}eqb<+vZ%@(WTQ<3Azua92c4|*(`Ffs~vhSovXgq$r%4=pRXVrK{Ieqp@P!)#rerZCPBq-b_YszpwpfxK$115FVH^Cn?8%J_lmFfYGbH} z&y^b=RB351!EHHBlAf;4nwaNsZ%c1vI~&+&X;A1wLR4avb#xP6`iV0fH+kwvHhuv zH1p_-ZE;FEZ%o%*`0Aa>D)X zY?FrVTm8{?QjXTxS71wzxWGHbJ3i$0L?=V=`-us-3B)IGq~=m8Hg4agDusOt{1GJ) zn&o_{()ZAk5UJ_GgkUW%6;x18{eCRs=o7fN<{-^9%&d=NbTu(sHz{fNTvP#V`pmR+ z60q@hz(;I_&EkGp≪DWar{u2bkUtA(C}_&Ig9WZFB2aRW?qW7JP1I6CV_ z_vYU0>_p7O9gpb{^2$! zTNwp2*9pORr1Kwty>2DBvGrNjbP;p}&)1=OcH?&~33Kl=L1A!BhuQ zNV?L;37GHU4)wZz%W$PP%4nAb4H*8-LR)s6xJdP)y94D^%`=sUWtUm=mt(S$fmbK6 zmMRX((&z^{YglVI&FpDfQ{xRyQiQj!HiAyk@GUmCicD%XL#-X#c=cnmnwKdS)C-8T>4~A`&xL{jv-dA(^bptCsG#=(}Vp?F^ae(Zq{5DLv*~Ta*{!ln?u@fNMPSz^OfcV(^nxZ@8y&(y2~Vye<}HPOuPB ztlk1OA<3j*Bz&Is8b$;QxdS|C3;?H+XaL zQ%PCJEqLP|x_D6On8;(jS@R~xg;^(QPNV9A`Pu~bop85ZY7`Ylgu?okSsC9fW_P6Q z&%u&AGD(@cuF@%__Bb%I##v^OItJ~Xs$4?%ivu4OU$W{4_!fq%4?hkfHRo!#hRGGr z8)kV)h+pk**ze6`L=4W1L>VU6E>UVQ@S+~-6R~h>MB}RUtPl+ zz7rLqu#DAiLuKpflL&kx&OUHCK+LM<5t-E$YmxYi7E#LbV+<8f zmQkn2JWMC`#(J->@t-XB-m~AzQP1#te#f;>Knsb5)GyHUIA-m+bB^E0-0J|MigSg= z3Tv5ein2g|JId%C?Km_=+@5aiAiF`%cjTjCyE4b?Kb+N=)D5z z5Cb)|t%+MBtsA7sectT{I+}%MWd#dq(xl1CC@kg@y4)^zA5l;NE+YsT=SGOfXgdzZ z9==m#zg$(o%<&%>G1y5>)qRQtbYGl_-dbmBFk3Tp-cr^6)ZHdprF1-+w61OIAU)Hm zIZxgA*l==X$Q+*!p*cCk(2vsChZ{zuO?<+8_uwxewlTcX`9%D?EG-pjhme2=01z_( z|D`O&__Hi^u{5(YWB%j*k6Lt6V-2`Yg8DP?6=Juucd3)MU8ycpjaXalwCR++_PVfl z8Jx@NwF}qV&POKSoZQR+e2+bpoxLY+yu2F^3MD9#!@|bWKob=ed*5hmm-FS$`OOn7 zATBL9?J%lh2LtV!_3a6IwW$ajcoIJbeMd-m(jYu38Vx%(j;CIQ zmYqbri57d(PEzk`ZugL2Y(57`y8w@Q&}c*uMnqu(Q$hnODoYk^bZ8JN?e-zXO-jO? zXi^C1M)Y$sO3hBE-Yc3w*P1di5sRLv%p1w7Za%co0c!J7H@*f$pZ5{vhvHp=T`wPe z&?g~rR^2sc?AOimTIdpd|45Sg>h1Dl@ex+k%WrJ8Sve+o;J|i#v5~KVP zvro)_Sk;hwg{ui8J4k<$}l))t70ge zywh31yLx+154y9Hby^q(o%RE6w`375EsNXxIIizr*a#}1YH0)JKFtdHK0-8BcLVCa zrl~?>-h5*t!D4VcH6<9R?K+zW{X*C<>0)Sb z`$2`-W%gL3$4lIS`yl@3gH1={QpQ+CBVZs-EjquI92VNp44V&VOcf$A zjtAfQq?-oynT6Yk?HZPO0=yNVwQYom3KFuw!M z>`QV(VkgEZoKX&o^FS|V%MKB2#rE^<+njE6CXn?WCSc`{@aO6$e+99 zMtyCtW&;^jU$;}D>)^+WePZ1;4|N}tlGhF1oR?GHH1$7x=^9}~Kz184BVgLPYJTQk zUxL7uA4-0lv@m`qn7pLoaO^>Z^hX z7@Nk&EX0gRB0`2D+vw1Qv1G~6v~2W43u>__rsmC2%;{r}S&&0>k_)6$T_N=j-3h+w z35O;liek>6RX?U&^#@ddmaC4?yv@CVZ{#Cl9j^%lD4`T?cHAHP(*(vV$Lr1X_Pc>7 z&vH%p=YVWz07FfR-_MPB@sL`(_>qs)#1&f9;c0AdE$d9&k_6c}FD6>BnqZ07VY)QW zo6*AE!j{v@&6(c_QkBKP0u*qI=b`O%YHiSleH}VkZZ=3R7|S2`&=;``&0L6vp-6w? zJ@HiLA%D|2jc zptdONJT~6x^bZulHTGtg-XgGpH`XseYKgIZJWGD15Qhz92+N3~;DUS4Exo~GN*`UE z10^&0^f1aPl1}v@jQd`SEt(kcAb{R-63Ws=Ed(AHWG|XXY8jEwEu^w7zgHt7lw0JG z#_oTP zBqZ1E7ikngsT*>W>I==7k6vq-0IKQ?U!aJ)K!h|@Yxm_!L=*???(Ayr%lS1m{c$yp zGYJiZu!t94$W#=?Wg2g%Yeb;@J1SK7QVTSy1dYIevJ70CkVbF)(yPXNRSt~G8BB-t zrOyQX!%4|OCSwk#JQGURQkOWZnIM$~qy`Ck@USpM7pyc2tC5Dan7*J8#gn5Hb41Oo z__%O?4+*Tp3TCQBJOoq!5`_Fbay&thvzxaYe%}t?M!HyT4wT>R5WA&msQp@6u6}`>Qz!6Ck(EQm3}szLy8O0(4kV_1_^KYJ(SS1#B`PtQZcF6 zo>RenJww1d$A_s>Q8&%skvs*>3V^B$ZPPb{T0=PGz%VG`P^k)x)|B-3%v>`XbgNOK zAn2kx3`KyUL~;S2w4~8jxAmAPIP-=Ddf;ujFX0~sKWz01n|}8xTE>9-Lao2n55`i7 zY9`*N55RY$=|Q)=?~N$sEI8K%_N8snV!dncr7w-5i42Ka=d0`8GYD5`bn4pw=Awv9 zfy)ps4&=BCxQ_1caRSj%UP|@}5c-fELwyRSNpFLGC_q2lfOKTz^GieZ*QPH+UvZuT zv#LCjztYQf>%(ZsGK_oMg_ku91%tA%h^_S5%xSsz#T0Qdk_J9(4`u&6GUipHkcv=8 zT-**qli{3`9?Y*aAZ@13sKQMH0c=}yMRM!N)X@W2Y!JR%RN*|`m1WoQC@DWww|4|} zmqJJ@yCC5_D|;BjyP-({XIL+D_9^Quq1X~B2_dxk?)uXn=3_*;K{L3}46$Cd5oHM; zbqM8|M!G4sX|3b%L-{ya?NdSN(PDRP92che(R7K9RmWf~AjrL#ee4)k1Hn4cuya%z zi|dVfeDI>xR9Uzn?wq1V#ZZp#2KKIOQ}yY6MUIR-_yU@v(#9VMhr3fE%J}$<+EboF zRid|5e@G?8+@Yv%LHXLyC zcwLau6g1dE$RL+O;yk!d7${U2($SkGbk7QLp<-VEJQp!K|D(t834x zBsg@C_50I#q5)7Q5kjZ*{;G?MESgs`y|^4Ehjbrh48Z~_PZ@io-u$Jh6+$_*8XIm1 zvF>3goT+2=0auZ!F@rpap0WucL!dY$+(u*FMbL>TfWdhQ}NiKiIh_}X`GD00dCTrncj3|Hw;x zoIph?R2PESMej~J-7#`6;!yDlJ@&+cPEJE7u}IbVo_ntKYWxPyWzhG7?O}J3YD!%Q zYKL#G`T=gu9OQ^Uq7@Z?-kE!G!Z2#%ChKBf1Z*IDxVAs?Y>1@fmd*>S2U2E>5c{F| zz|V)QN&}a1e!?a+tBi@1lU<}A9yHSn-w5Woqr*G7GFxdu4z}72B2P$(piOSqP4*7AfV19!o?Q0%R5jeWbr|f7)qpp zLA*+z*cbLNlZ#1GdC2ayiljcl5h~YY0kz}JRJH@kCU4&Z8fZo{Kx{kpJ5e-2U%o0d zUTAnMbaPL(g=DNkz0NvHHrxla1J><_FKi&pVqb@ z2E?Kpi*MMfC1d3*@Ms3(oMYa6K%$71pQCd9VR8yB&%RI6YCx|cI#K2HG&az*b>rKl z?Fjn%s}vE0;A$R;eDrHI@fVbbnha3%89l50yy5o@EA_TV<+22yIk7FUiInap&Me9v zpR9e4nST_Xd0#TEs{GWZ1Ho>LiBX$hUkc5iG?l@j7x~nV#qRs+4jaZ+Wg(7wWwK;E z_{qd8undtq5K+gzasA~3jhihx{T9mM8fWfBZ;Lwb$7hQ8nt1GNpR4Xjf_wjV;5;gv zX`(*|l->dbhaj#egFRoOr=TadR%De_+E^|uTF^q7kamEU0RzM#;3g?e--9qP$e%g9XA2e5C6fF3#MOIn_mSiM_yfs{ z$}CH4m0Z4a5OM(+V`!L4`(?_;>9mGZ;Mx#o6G{N=MqG?!e^aIVdBl)WT2}!D!?Wo1 z=~1xI;)@7fIQ3qXW0`JujmZY06#&IX?wCC(qcJ8EVpYiw`Xu@P*K3w z`qpR;T(ofrM2ePzSpyzE*y01s;-uA211y(Xp8U-H5o~opyvdmu15eLbz>c)q3)LeOAPv6t%xn$SOR1=;^DuMy zoAND+L;kqZTFS-e1eZCZawOMxDJh_|o3FZ&pmGDw0}5BA-b_kF;-Up}q7OEsGQ)?B@ilb0KT1Z9iXh0_1`M1usZf`~uAt?Tw`b6#&k%Yu23MAp7pd zWmDs$WOQMeC+Q&nJ*X;~fMKCoHIb4tKnlt3P&M%o3H=auIrz3SH`vB7Zp^Sg(V4-m zO$P9_YFh&>)abaC+aSN8ms}o?TeMVS4F)$F`qR9M`nwso6p|qa(@73i(bAZoaj-i z0ZuH0a4P1?fc@|n3!CWa4+J`Rk)udIfEs5j0!<&$317v7YfFCslpy<(-$y610Ivp{ z9hSZ>GoQh6n?AUmYQcxUtM#tGrB3!%oBK8UHc83LEXVvY_TO+c?JHnH zYeWU>cE>6iV*O6lY51|eVFla`t>`wHZgY0h#x31ScM)9`N_AKsqdH?v0^a7tg0hSp z3GxU1%;URHGMz>=srF{FD!Qnsv5X*X z@R(1o*W*x^gH>I6`m4k(V9G9*-EcZUauZFDoK&U~RcB>2J0o4B>?-V;TRePye_zpD zZlVba61N+%Mrl7?I^E}<0V8`HFk{Y9g03Tiy3G_qj6}gRzLr zH8nMkBmVg6|GRILeMk*`j|KqTNd33I5z_zb8@YJen*Gr*I?%9FSYttbg?dIw=~gK& zG=`uQR!p%nScc)VGT0cfVt7I4Ws-Tk<6o0Au*B1fN5v?`TysAK} zS~po2IwE^deQTO=n`*n~#4Sf=V73rh=Z!Krknd`ugy&+?*r|7$J#MR^EWf16HWE71 zW~e4f`B(?Q5KBiUmo#0|bLhHocgfmoIv*v8wkj68gaw(LhB_Zmb0_bd`jxQ*f8xe) zjytFBv)fgs;Qr)l$f;W_-!NXS!`UG9ds_KH^-iK0f!BoU)?)Chnd<5{$r?8SXH=F? zKT_P{&c2yd`HFZ~eoE~QezJ^tzw3E^PdsV$y>{s{?f}B+uPgxZk1*y$jJAzpoS>) z5RzT#43~W7vYtZ{arva#1E%Xer+H0Yw-HAaTJOMGWQ7jb7OwfoyX8~&c2UL7XVnXH zU@O1OMhU06Q&2aY<X=D}BU#CAt?dt_UXf<-|ARgK~c|rH07i5sR)C9hicA7UHr;u*Zx*zHf;t zhD62*&_M$3Dv*9pnTI`YMo94(^1H~Hfr!KeE8F@~v3bAR$inoxuNdC;pTx{nju2Yd`)FELA25TmRY= zafKQFu$85{MCFg+S#mU{Yeg`qbIWYCl%#U2Pxske+kB`ZIQrplgD-D0mi0gJy{-dj z-FxXvBG4hdFl>)>psqqwpQ%yP8=Bith_Is4jC8i_^lO&}*jHRx5s~q#mCg4Y zW?Es<-fwY`B4ub6sY}?!w28OUjZ3B<;wc)KMs%vh-8X?d;*!5o^K-~qIN(fJ2`OmM zQCu@PeU@iT2sH5IDi7=z(znoL9F4O&e?+1VtM5|l)^FH63A&F)XZDb1ZMN?fV1T>D zn`7k{dxA)>AXfcQG&mATtlx1OO?EKG)DPuL_+_0#L3VS z>!cSSZ0Ww^Jpe&Tn~}PX#&8he+DOaHGnxhz5p3x}H~s|rAmP3*P(oyZ$L3`DwTN7B zJWayBCDA$w`jKh+$9gw`qHkKoEV$1X1jCEdZ^W5xKt&HS*WB45Vl0Dj3K@GAculHT z3c<~=A%?u3@&tbY&CWl-7_Vs$>g8OzIA6VJ>aA`4CFA+JZ=I%-XU*_pLZYC+dTpOV0RYi*s&aXOt zlx8Khv_`G3Kj11*BNG!R`x$}EVS^)*z! z#%zjo5<+Zvl=5uaJF-96eS|le-5=py!YRnF!?K(=1v%>NV$wIHhVOLz(qg*n57zC% z8WcHyF^&iMn{_a7Ou%1qLKtJKPf)+!gZUM%xW9P+cl#wSG<7m^|2ocva60i0RK6n z{wKiS%ckg#RtV{<-w;ne_L`^_PV${4X8< z%A5aO{P(2tJK6qa=u3Yr{tv15pE!Sy*xxDWFB4n-w}kZ1g@1Rtf9IZg<^K$CMHwjQ S-{|naZW+H)Vd3iUXa565V0&!< diff --git a/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/citation.bib b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/citation.bib new file mode 100644 index 0000000..809c357 --- /dev/null +++ b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/citation.bib @@ -0,0 +1,8 @@ +@article{bbm-231, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + diff --git a/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/metadata.json b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/metadata.json new file mode 100644 index 0000000..64f4414 --- /dev/null +++ b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/metadata.json @@ -0,0 +1,7 @@ +{ + "id": 231, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": ["source (?)","curated (?)","repaired (?)", "multi-valued (?)"] +} diff --git a/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/notes.md b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/notes.md new file mode 100644 index 0000000..d911734 --- /dev/null +++ b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/notes.md @@ -0,0 +1,11 @@ +### Modifications + +Rows deleted from the source file: + +DLL_i, DLL_i +IGF1, IGF1 +NRG1, NRG1 +PG, PG +ES, ES +EGF, EGF +INS, INS diff --git a/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/source.bnet b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/source.bnet new file mode 100644 index 0000000..3d1f0cc --- /dev/null +++ b/sources/231_BREAST-CANCER-SIGNALLING-PATHWAYS/source.bnet @@ -0,0 +1,111 @@ +IL6, IL1B|IL6 +IL6R, IL6 +JAK2, (IL6R|ABL1|IL8)|IRS1 +STAT5, JAK2|SRC|EGFR +IL8, STAT5 +PIM, STAT5 +STAT3, IL1B|SRC|MAPK8 |JAK2 +STAT1, JAK2|SRC +GATA3, !STAT1 +PPARG, !GATA3&CEBPB +WNT1, PGR|WNT1 +FZD3, WNT1|CREB1 +DVL1, FZD3|NF1 +AXIN1, !DVL1&GSK3B +APC, AXIN1 +DC, APC&GSK3B +CTNNB1, !DC&(WNT1|SRC|YAP1) +TCF4, CTNNB1|JUN +PAK1, TCF4 +NOTCH1, (DLL_i|CTNNB1|LCK)|MDM2 +NFKB1, NOTCH1 +RELA, NFKB1|PIM +JUN, (RELA|MAPK8)&(ERK_i|PPARG) +NCID, NOTCH1 +HES1, NCID&!CASP3 +HEY1, NCID +MYOD1, !(HES1|ABL1) +MYOG, !HEY1&MYOD1 +PAX7, !(MYOG|HEY1|HES1)&NOTCH1 +KMT2D, PAX7&!AKT_i +IGF1R, (IGF1|SRC|INS)|(FOXO3|ESR1) +HER3, NRG1|HER2 +HER2, HER3|EGF +PGR, PG &!(ERK_i|ESR1) +ESR1, AKT_i|FOXO3|(ES|PGR|KMT2D) +EGFR, (EGF|(HER2&HER3))&!MEK_i +GRB2, IRS1|(LATS1|(EGFR|SRC)) +SOS1, GRB2 +HRAS, ((SOS1|PI3K_c)&!NF1)|(PI3K_c|IGF1) +RAS_i, (SOS1|PI3K_c)|(PI3K_c|IGF1) +RAF1, (HRAS|RAS_i) +MEK_i, RAF1 +ERK_i, MEK_i +LCK, ERK_i&!AKT_i +TWIST1, ERK_i|AKT_i|MAPK8 +NF1, !TWIST1&P53 +PI3K_c, (EGFR|INSR|RAS_i|ESR1)|(IRS1|IGF1R ) +PTEN, S6K1&!SRC +PIP3, PI3K_c&!PTEN +PDPK1, PIP3|IGF1R +MTORC2_c, PIP3&!S6K1 +AKT_i, (((MTORC2_c&PDPK1)&PIP3)&(IRS1|IGF1R))|(NRG1|IGF1) +FOXO3, !AKT_i +FOXO1, !(SGK1|AKT_i) +CREB1, AKT_i&!PTEN +GSK3B, !(AKT_i|ERK_i) +TSC2, !(AKT_i|ERK_i)&(PRKAA2|GSK3B) +RHEB, !TSC2 +MTORC1_c, RHEB|(NRG1|IGF1) +S6K1, MTORC1_c +IRS1, !S6K1&(INSR|IGF1R) +SGK1, (MTORC2_c|MTORC1_c)|PDPK1 +NEDD4L, !(S6K1|SGK1|PRKACA) +NF2, NEDD4L +LATS1, NF2|LCK +YAP1, !LATS1&ABL1 +TEAD1, YAP1 +IVEBP1, !MTORC1_c +EIF4E, !IVEBP1 +MYC, (CTNNB1|PIM|ERK_i|STAT3|ESR1|EIF4E)&!GSK3B +P21, !(ERK_i|AKT_i|MYC) +CYCLIN_D_c, ((TCF4|TEAD1|ESR1|MYC)&!(GSK3B|(CDKN2A|P21))) +PRB, !CYCLIN_D_c +E2F1, !PRB +P53, !MDM2 +MDM2, P53|AKT_i +MCL1, !GSK3B&ERK_i +BAD, !( PAK1|AKT_i|ERK_i|PIM) +BCL2, !(BAD|BIM)&(CREB1|ERK_i) +BCLXL, !(BAD|BIM)&CREB1 +BIM, !(BCL2|BCLXL)&(FOXO3|FOXO1) +BID, CASP8 +BAK1, ((BIM|P53)|BID)&!MCL1 +BAX, ((BIM|P53)|BID)&!MCL1 +CYCS, BAK1|BAX +CASP9, ((CYCS|CASP8)|CASP3)&!((ERK_i|PRKACA)|(BCLXL|AKT_i)) +CASP3, CASP9 +HSP90AA1, !PDPK1 +NOS3, HSP90AA1|AKT_i +IL1B, NOS3|RELA +STK11, !ERK_i +PRKAA2, STK11|!PRKACA +PAK2, RAC1|SRC +KRT14, PAK2|EGFR +TRADD, !KRT14 +FASLG, FASLG|P53|FOXO3 +FAS, (FASLG|P53)&!AKT_i +FADD, TRADD|FAS +CASP8, (FADD|NF1)&!(ERK_i&SRC) +PRKACA, AKT_i|WNT1 +SRC, PRKACA|ABL1 +ABL1, (SRC|GRB2) +ABL2, ABL1 +CEBPB, ABL2|CREB1 +CDKN2A, !(MYC|SRC)&CASP3 +INSR, INS|FOXO3 +GRB7, INSR&!PRKACA +RND1, GRB7|DVL1 +RAC1, (PI3K_c|DVL1)&!AKT_i +MAPK8, RAC1|RND1 +