diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md new file mode 100644 index 0000000..e00efe3 --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md @@ -0,0 +1,37 @@ +# \[233\] BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE + + - Variables: 109 + - Inputs: 8 + - Regulations: 260 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Removed regulations: +WNT1, WNT1 +PG, PG +NRG1, NRG1 +INS, INS +IGF1, IGF1 +ES, ES +EGF, EGF +DLL_i, DLL_i + + +### Model citation + +``` +@article{bbm-233, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json new file mode 100644 index 0000000..d50915c --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 233, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 109, + "inputs": 8, + "regulations": 260, + "notes": "### Modifications\n\nRemoved regulations:\nWNT1, WNT1\nPG, PG\nNRG1, NRG1\nINS, INS\nIGF1, IGF1\nES, ES\nEGF, EGF\nDLL_i, DLL_i\n", + "bib": "@article{bbm-233,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon new file mode 100644 index 0000000..d8edfc8 --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon @@ -0,0 +1,369 @@ +v_GRB2 -? v_ABL1 +v_ABL1 -? v_ABL2 +v_EGF -? v_AKT_i +v_EGFR -? v_AKT_i +v_IGF1R -? v_AKT_i +v_IRS1 -? v_AKT_i +v_MTORC2_c -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_CASP8 -? v_BID +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP8 -? v_CASP3 +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CASP8 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_CASP3 -? v_CDKN2A +v_MYC -? v_CDKN2A +v_SRC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_AKT_i -? v_CREB1 +v_SGK1 -? v_CREB1 +v_DC -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_EIF4E -? v_CYCLIN_D_c +v_ERK_i -? v_CYCLIN_D_c +v_ESR1 -? v_CYCLIN_D_c +v_FOXO3 -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_IGF1 -? v_CYCLIN_D_c +v_KMT2D -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_NRG1 -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_TCF4 -? v_CYCLIN_D_c +v_TEAD1 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_YAP1 -? v_DVL1 +v_PRB -? v_E2F1 +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_MEK_i -? v_EGFR +v_RELA -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_AKT_i -? v_FOXO1 +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_WNT1 -? v_FZD3 +v_STAT1 -? v_GATA3 +v_EGFR -? v_GRB2 +v_HER2 -? v_GRB2 +v_IRS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_INSR -? v_GRB7 +v_PRKACA -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_ESR1 -? v_HER2 +v_FOXO3 -? v_HER2 +v_HER3 -? v_HER2 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_NCID -? v_HES1 +v_NCID -? v_HEY1 +v_NF1 -? v_HRAS +v_PIP3 -? v_HRAS +v_SOS1 -? v_HRAS +v_ESR1 -? v_HSP90AA1 +v_PDPK1 -? v_HSP90AA1 +v_ESR1 -? v_IGF1R +v_FOXO3 -? v_IGF1R +v_IGF1 -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_IL6 -? v_IL6R +v_STAT3 -? v_IL6R +v_STAT5 -? v_IL8 +v_FOXO3 -? v_INSR +v_INS -? v_INSR +v_IGF1R -? v_IRS1 +v_INSR -? v_IRS1 +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_AKT_i -? v_LCK +v_ERK_i -? v_LCK +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_AKT_i -? v_MDM2 +v_P53 -? v_MDM2 +v_RAF1 -? v_MEK_i +v_IGF1 -? v_MTORC1_c +v_NRG1 -? v_MTORC1_c +v_PIM -? v_MTORC1_c +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_ERK_i -? v_MYC +v_ESR1 -? v_MYC +v_FOXO3 -? v_MYC +v_GSK3B -? v_MYC +v_IGF1 -? v_MYC +v_JAK2 -? v_MYC +v_KMT2D -? v_MYC +v_NRG1 -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_HES1 -? v_MYOD1 +v_NF2 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_SGK1 -? v_NEDD4L +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MYC -? v_P21 +v_MDM2 -? v_P53 +v_PDPK1 -? v_PAK1 +v_RAC1 -? v_PAK1 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_MYOG -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_ERK_i -? v_PGR +v_ESR1 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_NFKB1 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_AKT_i -? v_RAC1 +v_DVL1 -? v_RAC1 +v_PI3K_c -? v_RAC1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_PIP3 -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_ERK_i -? v_S6K1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_PRKACA -? v_SRC +v_EGFR -? v_STAT1 +v_JAK2 -? v_STAT1 +v_SRC -? v_STAT1 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_JAK2 -? v_STAT5 +v_ERK_i -? v_STK11 +v_FOXO3 -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_JUN -? v_TCF4 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_AKT_i -? v_TSC2 +v_ERK_i -? v_TSC2 +v_GSK3B -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_ERK_i -? v_TWIST1 +v_ABL1 -? v_YAP1 +v_LATS1 -? v_YAP1 +$v_ABL1: v_GRB2 +$v_ABL2: v_ABL1 +$v_AKT_i: (((v_MTORC2_c | v_PDPK1) & v_PIP3) & (v_IRS1 | (v_IGF1R | (v_EGFR & v_EGF)))) +$v_APC: v_AXIN1 +$v_AXIN1: (!v_DVL1 & v_GSK3B) +$v_BAD: !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +$v_BAK1: (((v_BIM & v_P53) | v_BID) & !v_MCL1) +$v_BAX: (((v_BIM & v_P53) | v_BID) & !v_MCL1) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +$v_BCLXL: (!(v_BAD | v_BIM) & v_CREB1) +$v_BID: v_CASP8 +$v_BIM: (!(v_BCL2 | v_BCLXL) & (v_FOXO3 & v_FOXO1)) +$v_CASP3: (v_CASP9 & v_CASP8) +$v_CASP8: (v_FADD & !(v_ERK_i | v_SRC)) +$v_CASP9: (((v_CASP8 & v_CYCS) | v_CASP3) & !(v_AKT_i & v_ERK_i)) +$v_CDKN2A: (!(v_MYC | v_SRC) & v_CASP3) +$v_CEBPB: v_ABL2 +$v_CREB1: (v_AKT_i & v_SGK1) +$v_CTNNB1: (!v_DC & v_WNT1) +$v_CYCLIN_D_c: (((v_TCF4 | v_TEAD1) & !(v_GSK3B | (v_CDKN2A & v_P21))) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_MYC & v_EIF4E) | (v_MYC & (v_ERK_i & (v_IGF1 | v_NRG1)))))) +$v_CYCS: (v_BAK1 & v_BAX) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 & !v_YAP1) +$v_E2F1: !v_PRB +$v_EGFR: ((v_EGF & (v_RELA & (v_HER2 & v_HER3))) & !v_MEK_i) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: (v_ES | (v_AKT_i | (v_FOXO3 & (v_KMT2D & v_PGR)))) +$v_FADD: (v_TRADD & v_FAS) +$v_FAS: ((v_FASLG | v_P53) | !v_AKT_i) +$v_FASLG: (v_FASLG & (v_P53 & v_FOXO3)) +$v_FOXO1: !(v_SGK1 | v_AKT_i) +$v_FOXO3: !v_AKT_i +$v_FZD3: v_WNT1 +$v_GATA3: !v_STAT1 +$v_GRB2: ((v_IRS1 & v_SRC) & (v_EGFR & v_HER2)) +$v_GRB7: (v_INSR | !v_PRKACA) +$v_GSK3B: !(v_AKT_i | v_ERK_i) +$v_HER2: (v_HER3 | (v_FOXO3 & v_ESR1)) +$v_HER3: (v_NRG1 | v_HER2) +$v_HES1: v_NCID +$v_HEY1: v_NCID +$v_HRAS: ((v_SOS1 & v_PIP3) | !v_NF1) +$v_HSP90AA1: (!v_PDPK1 | v_ESR1) +$v_IGF1R: (v_IGF1 | (v_FOXO3 & v_ESR1)) +$v_IL1B: (v_NOS3 & v_RELA) +$v_IL6: (v_IL1B & v_IL6) +$v_IL6R: (v_IL6 | v_STAT3) +$v_IL8: v_STAT5 +$v_INSR: (v_INS & v_FOXO3) +$v_IRS1: (!v_S6K1 & (v_INSR & v_IGF1R)) +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +$v_JUN: ((v_RELA & (v_MAPK8 & v_PPARG)) & v_ERK_i) +$v_KMT2D: (v_PAX7 | !v_AKT_i) +$v_KRT14: (v_PAK2 & v_EGFR) +$v_LATS1: (v_NF2 | v_LCK) +$v_LCK: (v_ERK_i | !v_AKT_i) +$v_MAPK8: (v_RAC1 & v_RND1) +$v_MCL1: (!v_GSK3B & v_ERK_i) +$v_MDM2: (v_P53 | v_AKT_i) +$v_MEK_i: v_RAF1 +$v_MTORC1_c: ((v_RHEB | v_PIM) | (v_NRG1 | v_IGF1)) +$v_MTORC2_c: (v_PIP3 | !v_S6K1) +$v_MYC: (((v_CTNNB1 | (v_PIM | v_ERK_i)) & !v_GSK3B) | ((v_STAT3 & v_JAK2) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_ERK_i & (v_IGF1 | v_NRG1)) | v_EIF4E)))) +$v_MYOD1: !(v_HES1 | v_NF2) +$v_MYOG: (!v_HEY1 | v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !v_SGK1 +$v_NF1: !v_TWIST1 +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 & v_AKT_i) +$v_NOTCH1: (v_DLL_i & (v_CTNNB1 & v_LCK)) +$v_P21: !(v_ERK_i | (v_AKT_i | v_MYC)) +$v_P53: !v_MDM2 +$v_PAK1: (v_TCF4 | (v_RAC1 | v_PDPK1)) +$v_PAK2: (v_RAC1 | v_SRC) +$v_PAX7: !v_MYOG +$v_PDPK1: (v_PIP3 | v_IGF1R) +$v_PGR: (v_PG | !(v_ESR1 & v_ERK_i)) +$v_PI3K_c: ((v_EGFR | v_ESR1) | (v_IRS1 & v_IGF1R)) +$v_PIM: v_NFKB1 +$v_PIP3: (v_PI3K_c | !v_PTEN) +$v_PPARG: (!v_GATA3 & v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: v_STK11 +$v_PRKACA: (v_AKT_i & v_WNT1) +$v_PTEN: (v_S6K1 | !v_SRC) +$v_RAC1: ((v_PI3K_c & v_DVL1) & !v_AKT_i) +$v_RAF1: (v_HRAS | v_RAS_i) +$v_RAS_i: (v_SOS1 & v_PIP3) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 | v_DVL1) +$v_S6K1: (v_MTORC1_c & v_ERK_i) +$v_SGK1: ((v_MTORC2_c & v_MTORC1_c) & v_PDPK1) +$v_SOS1: v_GRB2 +$v_SRC: v_PRKACA +$v_STAT1: (v_JAK2 & (v_SRC & v_EGFR)) +$v_STAT3: ((v_IL1B & v_MAPK8) | (v_JAK2 | v_SRC)) +$v_STAT5: v_JAK2 +$v_STK11: (!v_ERK_i & v_FOXO3) +$v_TCF4: (v_CTNNB1 & v_JUN) +$v_TEAD1: v_YAP1 +$v_TRADD: !v_KRT14 +$v_TSC2: (!(v_AKT_i & v_ERK_i) | (v_PRKAA2 | v_GSK3B)) +$v_TWIST1: v_ERK_i +$v_YAP1: (!v_LATS1 | v_ABL1) diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet new file mode 100644 index 0000000..121704f --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet @@ -0,0 +1,110 @@ +targets,factors +v_ABL1, v_GRB2 +v_ABL2, v_ABL1 +v_AKT_i, (((v_MTORC2_c | v_PDPK1) & v_PIP3) & (v_IRS1 | (v_IGF1R | (v_EGFR & v_EGF)))) +v_APC, v_AXIN1 +v_AXIN1, (!v_DVL1 & v_GSK3B) +v_BAD, !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +v_BAK1, (((v_BIM & v_P53) | v_BID) & !v_MCL1) +v_BAX, (((v_BIM & v_P53) | v_BID) & !v_MCL1) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +v_BCLXL, (!(v_BAD | v_BIM) & v_CREB1) +v_BID, v_CASP8 +v_BIM, (!(v_BCL2 | v_BCLXL) & (v_FOXO3 & v_FOXO1)) +v_CASP3, (v_CASP9 & v_CASP8) +v_CASP8, (v_FADD & !(v_ERK_i | v_SRC)) +v_CASP9, (((v_CASP8 & v_CYCS) | v_CASP3) & !(v_AKT_i & v_ERK_i)) +v_CDKN2A, (!(v_MYC | v_SRC) & v_CASP3) +v_CEBPB, v_ABL2 +v_CREB1, (v_AKT_i & v_SGK1) +v_CTNNB1, (!v_DC & v_WNT1) +v_CYCLIN_D_c, (((v_TCF4 | v_TEAD1) & !(v_GSK3B | (v_CDKN2A & v_P21))) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_MYC & v_EIF4E) | (v_MYC & (v_ERK_i & (v_IGF1 | v_NRG1)))))) +v_CYCS, (v_BAK1 & v_BAX) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 & !v_YAP1) +v_E2F1, !v_PRB +v_EGFR, ((v_EGF & (v_RELA & (v_HER2 & v_HER3))) & !v_MEK_i) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, (v_ES | (v_AKT_i | (v_FOXO3 & (v_KMT2D & v_PGR)))) +v_FADD, (v_TRADD & v_FAS) +v_FAS, ((v_FASLG | v_P53) | !v_AKT_i) +v_FASLG, (v_FASLG & (v_P53 & v_FOXO3)) +v_FOXO1, !(v_SGK1 | v_AKT_i) +v_FOXO3, !v_AKT_i +v_FZD3, v_WNT1 +v_GATA3, !v_STAT1 +v_GRB2, ((v_IRS1 & v_SRC) & (v_EGFR & v_HER2)) +v_GRB7, (v_INSR | !v_PRKACA) +v_GSK3B, !(v_AKT_i | v_ERK_i) +v_HER2, (v_HER3 | (v_FOXO3 & v_ESR1)) +v_HER3, (v_NRG1 | v_HER2) +v_HES1, v_NCID +v_HEY1, v_NCID +v_HRAS, ((v_SOS1 & v_PIP3) | !v_NF1) +v_HSP90AA1, (!v_PDPK1 | v_ESR1) +v_IGF1R, (v_IGF1 | (v_FOXO3 & v_ESR1)) +v_IL1B, (v_NOS3 & v_RELA) +v_IL6, (v_IL1B & v_IL6) +v_IL6R, (v_IL6 | v_STAT3) +v_IL8, v_STAT5 +v_INSR, (v_INS & v_FOXO3) +v_IRS1, (!v_S6K1 & (v_INSR & v_IGF1R)) +v_IVEBP1, !v_MTORC1_c +v_JAK2, ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +v_JUN, ((v_RELA & (v_MAPK8 & v_PPARG)) & v_ERK_i) +v_KMT2D, (v_PAX7 | !v_AKT_i) +v_KRT14, (v_PAK2 & v_EGFR) +v_LATS1, (v_NF2 | v_LCK) +v_LCK, (v_ERK_i | !v_AKT_i) +v_MAPK8, (v_RAC1 & v_RND1) +v_MCL1, (!v_GSK3B & v_ERK_i) +v_MDM2, (v_P53 | v_AKT_i) +v_MEK_i, v_RAF1 +v_MTORC1_c, ((v_RHEB | v_PIM) | (v_NRG1 | v_IGF1)) +v_MTORC2_c, (v_PIP3 | !v_S6K1) +v_MYC, (((v_CTNNB1 | (v_PIM | v_ERK_i)) & !v_GSK3B) | ((v_STAT3 & v_JAK2) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_ERK_i & (v_IGF1 | v_NRG1)) | v_EIF4E)))) +v_MYOD1, !(v_HES1 | v_NF2) +v_MYOG, (!v_HEY1 | v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !v_SGK1 +v_NF1, !v_TWIST1 +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 & v_AKT_i) +v_NOTCH1, (v_DLL_i & (v_CTNNB1 & v_LCK)) +v_P21, !(v_ERK_i | (v_AKT_i | v_MYC)) +v_P53, !v_MDM2 +v_PAK1, (v_TCF4 | (v_RAC1 | v_PDPK1)) +v_PAK2, (v_RAC1 | v_SRC) +v_PAX7, !v_MYOG +v_PDPK1, (v_PIP3 | v_IGF1R) +v_PGR, (v_PG | !(v_ESR1 & v_ERK_i)) +v_PI3K_c, ((v_EGFR | v_ESR1) | (v_IRS1 & v_IGF1R)) +v_PIM, v_NFKB1 +v_PIP3, (v_PI3K_c | !v_PTEN) +v_PPARG, (!v_GATA3 & v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, v_STK11 +v_PRKACA, (v_AKT_i & v_WNT1) +v_PTEN, (v_S6K1 | !v_SRC) +v_RAC1, ((v_PI3K_c & v_DVL1) & !v_AKT_i) +v_RAF1, (v_HRAS | v_RAS_i) +v_RAS_i, (v_SOS1 & v_PIP3) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 | v_DVL1) +v_S6K1, (v_MTORC1_c & v_ERK_i) +v_SGK1, ((v_MTORC2_c & v_MTORC1_c) & v_PDPK1) +v_SOS1, v_GRB2 +v_SRC, v_PRKACA +v_STAT1, (v_JAK2 & (v_SRC & v_EGFR)) +v_STAT3, ((v_IL1B & v_MAPK8) | (v_JAK2 | v_SRC)) +v_STAT5, v_JAK2 +v_STK11, (!v_ERK_i & v_FOXO3) +v_TCF4, (v_CTNNB1 & v_JUN) +v_TEAD1, v_YAP1 +v_TRADD, !v_KRT14 +v_TSC2, (!(v_AKT_i & v_ERK_i) | (v_PRKAA2 | v_GSK3B)) +v_TWIST1, v_ERK_i +v_YAP1, (!v_LATS1 | v_ABL1) diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml new file mode 100644 index 0000000..be5786a --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml @@ -0,0 +1 @@ +v_GRB21v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_IRS11v_IGF1R1v_EGFR1v_EGF1v_AXIN11v_DVL11v_GSK3B1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BIM1v_P531v_BID1v_MCL11v_BAD1v_BIM1v_CREB11v_ERK_i1v_BAD1v_BIM1v_CREB11v_CASP81v_BCL21v_BCLXL1v_FOXO31v_FOXO11v_CASP91v_CASP81v_FADD1v_ERK_i1v_SRC1v_CASP81v_CYCS1v_CASP31v_AKT_i1v_ERK_i1v_MYC1v_SRC1v_CASP31v_ABL21v_AKT_i1v_SGK11v_DC1v_WNT11v_TCF41v_TEAD11v_GSK3B1v_CDKN2A1v_P211v_ESR11v_KMT2D1v_FOXO31v_MYC1v_EIF4E1v_MYC1v_ERK_i1v_IGF11v_NRG11v_BAK11v_BAX1v_APC1v_GSK3B1v_FZD31v_YAP11v_PRB1v_EGF1v_RELA1v_HER21v_HER31v_MEK_i1v_IVEBP11v_MEK_i1v_ES1v_AKT_i1v_FOXO31v_KMT2D1v_PGR1v_TRADD1v_FAS1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_AKT_i1v_WNT11v_STAT11v_IRS11v_SRC1v_EGFR1v_HER21v_INSR1v_PRKACA1v_AKT_i1v_ERK_i1v_HER31v_FOXO31v_ESR11v_NRG11v_HER21v_NCID1v_NCID1v_SOS11v_PIP31v_NF11v_PDPK11v_ESR11v_IGF11v_FOXO31v_ESR11v_NOS31v_RELA1v_IL1B1v_IL61v_IL61v_STAT31v_STAT51v_INS1v_FOXO31v_S6K11v_INSR1v_IGF1R1v_MTORC1_c1v_IL6R1v_ABL11v_IL81v_IRS11v_RELA1v_MAPK81v_PPARG1v_ERK_i1v_PAX71v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_AKT_i1v_RAC11v_RND11v_GSK3B1v_ERK_i1v_P531v_AKT_i1v_RAF11v_RHEB1v_PIM1v_NRG11v_IGF11v_PIP31v_S6K11v_CTNNB11v_PIM1v_ERK_i1v_GSK3B1v_STAT31v_JAK21v_ESR11v_KMT2D1v_FOXO31v_ERK_i1v_IGF11v_NRG11v_EIF4E1v_HES11v_NF21v_HEY11v_MYOD11v_NOTCH11v_SGK11v_TWIST11v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_ERK_i1v_AKT_i1v_MYC1v_MDM21v_TCF41v_RAC11v_PDPK11v_RAC11v_SRC1v_MYOG1v_PIP31v_IGF1R1v_PG1v_ESR11v_ERK_i1v_EGFR1v_ESR11v_IRS11v_IGF1R1v_NFKB11v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_AKT_i1v_WNT11v_S6K11v_SRC1v_PI3K_c1v_DVL11v_AKT_i1v_HRAS1v_RAS_i1v_SOS11v_PIP31v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_ERK_i1v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_PRKACA1v_JAK21v_SRC1v_EGFR1v_IL1B1v_MAPK81v_JAK21v_SRC1v_JAK21v_ERK_i1v_FOXO31v_CTNNB11v_JUN1v_YAP11v_KRT141v_AKT_i1v_ERK_i1v_PRKAA21v_GSK3B1v_ERK_i1v_LATS11v_ABL11 \ No newline at end of file diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md new file mode 100644 index 0000000..29787b0 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md @@ -0,0 +1,45 @@ +# \[234\] BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE + + - Variables: 111 + - Inputs: 6 + - Regulations: 271 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i + +Regulation: + +CYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +was updated to: + +CYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +as the analysis + + +### Model citation + +``` +@article{bbm-234, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json new file mode 100644 index 0000000..bffc4c2 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 234, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 111, + "inputs": 6, + "regulations": 271, + "notes": "### Modifications\n\nRemoved regulations:\nPG, PG\nNRG1, NRG1\nINS, INS\nES, ES\nEGF, EGF\nDLL_i, DLL_i\n\nRegulation:\n\nCYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nwas updated to:\n\nCYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nas the analysis\n", + "bib": "@article{bbm-234,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon new file mode 100644 index 0000000..333aa21 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon @@ -0,0 +1,382 @@ +v_GRB2 -? v_ABL1 +v_SRC -? v_ABL1 +v_ABL1 -? v_ABL2 +v_MTORC2_c -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_CASP8 -? v_BID +v_AKT_i -? v_BIM +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP8 -? v_CASP3 +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_BCLXL -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_JAK2 -? v_CASP9 +v_PRKACA -? v_CASP9 +v_MYC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_ERK_i -? v_CEBPB +v_GSK3B -? v_CEBPB +v_INS -? v_CEBPB +v_AKT_i -? v_CREB1 +v_AKT_i -? v_CTNNB1 +v_DC -? v_CTNNB1 +v_SRC -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_EIF4E -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_STAT3 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_YAP1 -? v_DVL1 +v_PRB -? v_E2F1 +v_ABL1 -? v_EGFR +v_CTNNB1 -? v_EGFR +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_ERK_i -? v_FOXO3 +v_NFKB1 -? v_FOXO3 +v_CREB1 -? v_FZD3 +v_WNT1 -? v_FZD3 +v_STAT1 -? v_GATA3 +v_IRS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_INSR -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_HER3 -? v_HER2 +v_EGFR -? v_HER3 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_CASP3 -? v_HES1 +v_NCID -? v_HES1 +v_NCID -? v_HEY1 +v_NF1 -? v_HRAS +v_PIP3 -? v_HRAS +v_SOS1 -? v_HRAS +v_ABL1 -? v_HSP90AA1 +v_PDPK1 -? v_HSP90AA1 +v_IGF1 -? v_IGF1 +v_STAT5 -? v_IGF1 +v_IGF1 -? v_IGF1R +v_IGF1R -? v_IGF1R +v_IL8 -? v_IGF1R +v_INS -? v_IGF1R +v_SRC -? v_IGF1R +v_STAT5 -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_IL6 -? v_IL6R +v_JAK2 -? v_IL8 +v_STAT5 -? v_IL8 +v_TWIST1 -? v_IL8 +v_FOXO3 -? v_INSR +v_INS -? v_INSR +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_ESR1 -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_ESR1 -? v_KMT2D +v_JUN -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_ERK_i -? v_LCK +v_ESR1 -? v_LCK +v_JUN -? v_MAPK8 +v_MYC -? v_MAPK8 +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_MAPK8 -? v_MCL1 +v_AKT_i -? v_MDM2 +v_P53 -? v_MDM2 +v_EGFR -? v_MEK_i +v_RAF1 -? v_MEK_i +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_ESR1 -? v_MYC +v_GSK3B -? v_MYC +v_JAK2 -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_HES1 -? v_MYOD1 +v_NF2 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_SGK1 -? v_NEDD4L +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MYC -? v_P21 +v_MYOG -? v_P21 +v_MDM2 -? v_P53 +v_AKT_i -? v_PAK1 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_MYOG -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_AKT_i -? v_PGR +v_ERK_i -? v_PGR +v_ESR1 -? v_PGR +v_P21 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_IGF1 -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_JUN -? v_PI3K_c +v_STAT5 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_STAT1 -? v_PRKAA2 +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_AKT_i -? v_RAC1 +v_DVL1 -? v_RAC1 +v_PI3K_c -? v_RAC1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_PIP3 -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_ERK_i -? v_S6K1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_STAT3 -? v_SOS1 +v_ESR1 -? v_SRC +v_PRKACA -? v_SRC +v_EGFR -? v_STAT1 +v_JAK2 -? v_STAT1 +v_SRC -? v_STAT1 +v_EGFR -? v_STAT3 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_EGFR -? v_STAT5 +v_JAK2 -? v_STAT5 +v_SRC -? v_STAT5 +v_ERK_i -? v_STK11 +v_FOXO3 -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_FOXO1 -? v_TCF4 +v_JUN -? v_TCF4 +v_ABL1 -? v_TEAD1 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_NFKB1 -? v_TRADD +v_AKT_i -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_ERK_i -? v_TWIST1 +v_JUN -? v_TWIST1 +v_MYC -? v_TWIST1 +v_PGR -? v_WNT1 +v_WNT1 -? v_WNT1 +v_LATS1 -? v_YAP1 +$v_ABL1: (v_SRC & v_GRB2) +$v_ABL2: v_ABL1 +$v_AKT_i: ((v_MTORC2_c | v_PDPK1) & v_PIP3) +$v_APC: v_AXIN1 +$v_AXIN1: (!v_DVL1 & v_GSK3B) +$v_BAD: !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +$v_BAK1: (((v_BIM | v_P53) | v_BID) | !v_MCL1) +$v_BAX: (((v_BIM & v_P53) & v_BID) | !v_MCL1) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +$v_BCLXL: (!(v_BAD | v_BIM) & v_CREB1) +$v_BID: v_CASP8 +$v_BIM: (!(v_BCL2 | (v_BCLXL | v_AKT_i)) & (v_FOXO3 & v_FOXO1)) +$v_CASP3: (v_CASP9 & v_CASP8) +$v_CASP8: (v_FADD | !(v_ERK_i & v_SRC)) +$v_CASP9: ((v_CYCS | v_CASP3) & !((v_ERK_i & v_JAK2) | (v_AKT_i & (v_PRKACA & v_BCLXL)))) +$v_CDKN2A: !v_MYC +$v_CEBPB: (v_ERK_i | (v_ABL2 | (v_GSK3B | v_INS))) +$v_CREB1: v_AKT_i +$v_CTNNB1: (!v_DC | (v_WNT1 | (v_SRC | v_AKT_i))) +$v_CYCLIN_D_c: ((v_STAT3 & !(v_GSK3B & (v_CDKN2A & v_P21))) & (v_EIF4E & (v_MYC & v_STAT3))) +$v_CYCS: (v_BAK1 | v_BAX) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 & !v_YAP1) +$v_E2F1: !v_PRB +$v_EGFR: (v_EGF | (v_ABL1 | (v_CTNNB1 | (v_HER2 & v_HER3)))) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: (v_ES & (v_AKT_i & (v_PGR & (v_KMT2D & v_FOXO3)))) +$v_FADD: (v_TRADD | v_FAS) +$v_FAS: ((v_FASLG | v_P53) & !v_AKT_i) +$v_FASLG: (v_FASLG & (v_P53 & v_FOXO3)) +$v_FOXO1: !v_SGK1 +$v_FOXO3: (!(v_AKT_i | v_ERK_i) | v_NFKB1) +$v_FZD3: (v_WNT1 | v_CREB1) +$v_GATA3: !v_STAT1 +$v_GRB2: (v_IRS1 & v_SRC) +$v_GRB7: v_INSR +$v_GSK3B: !(v_AKT_i & v_ERK_i) +$v_HER2: v_HER3 +$v_HER3: (v_NRG1 & (v_EGFR & v_HER2)) +$v_HES1: (v_NCID | !v_CASP3) +$v_HEY1: v_NCID +$v_HRAS: ((v_SOS1 & v_PIP3) | !v_NF1) +$v_HSP90AA1: (!v_PDPK1 & v_ABL1) +$v_IGF1: (v_IGF1 & v_STAT5) +$v_IGF1R: ((v_IGF1R & (v_IGF1 & (v_INS & v_SRC))) | (v_IL8 & v_STAT5)) +$v_IL1B: (v_NOS3 & v_RELA) +$v_IL6: (v_IL1B & v_IL6) +$v_IL6R: v_IL6 +$v_IL8: (v_TWIST1 | (v_JAK2 & v_STAT5)) +$v_INSR: (v_INS | v_FOXO3) +$v_IRS1: !v_S6K1 +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: (v_IRS1 | (v_ABL1 & (v_IL8 & v_IL6R))) +$v_JUN: ((v_MAPK8 & v_PPARG) | (v_RELA & (v_ERK_i & v_ESR1))) +$v_KMT2D: ((v_JUN & (v_PAX7 & v_ESR1)) & !v_AKT_i) +$v_KRT14: (v_PAK2 | v_EGFR) +$v_LATS1: (v_NF2 & v_LCK) +$v_LCK: (v_ERK_i & v_ESR1) +$v_MAPK8: (v_RAC1 | (v_RND1 | (v_JUN | v_MYC))) +$v_MCL1: (!v_GSK3B | (v_ERK_i | v_MAPK8)) +$v_MDM2: (v_P53 & v_AKT_i) +$v_MEK_i: (v_RAF1 | v_EGFR) +$v_MTORC1_c: v_RHEB +$v_MTORC2_c: (v_PIP3 & !v_S6K1) +$v_MYC: (((v_ESR1 | (v_CTNNB1 | v_PIM)) & !v_GSK3B) | (v_JAK2 & (v_EIF4E & v_STAT3))) +$v_MYOD1: !(v_HES1 | v_NF2) +$v_MYOG: (!v_HEY1 & v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !v_SGK1 +$v_NF1: !v_TWIST1 +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 | v_AKT_i) +$v_NOTCH1: (v_DLL_i | (v_CTNNB1 | v_LCK)) +$v_P21: (!(v_ERK_i | (v_AKT_i | v_MYC)) & v_MYOG) +$v_P53: !v_MDM2 +$v_PAK1: (v_TCF4 | v_AKT_i) +$v_PAK2: (v_RAC1 & v_SRC) +$v_PAX7: !v_MYOG +$v_PDPK1: (v_PIP3 & v_IGF1R) +$v_PGR: ((v_P21 & v_PG) & !(v_ESR1 | (v_ERK_i | v_AKT_i))) +$v_PI3K_c: ((v_JUN | (v_EGFR | v_ESR1)) | (v_IRS1 & (v_IGF1R & v_IGF1))) +$v_PIM: v_STAT5 +$v_PIP3: (v_PI3K_c & !v_PTEN) +$v_PPARG: (!v_GATA3 & v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: (v_STK11 | v_STAT1) +$v_PRKACA: (v_AKT_i | v_WNT1) +$v_PTEN: (v_S6K1 & !v_SRC) +$v_RAC1: ((v_PI3K_c & v_DVL1) & !v_AKT_i) +$v_RAF1: (v_HRAS & v_RAS_i) +$v_RAS_i: (v_SOS1 | v_PIP3) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 & v_DVL1) +$v_S6K1: (v_MTORC1_c & v_ERK_i) +$v_SGK1: ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +$v_SOS1: (v_GRB2 | v_STAT3) +$v_SRC: (v_PRKACA & v_ESR1) +$v_STAT1: (v_JAK2 | (v_SRC | v_EGFR)) +$v_STAT3: ((v_IL1B | (v_SRC | v_MAPK8)) | (v_JAK2 | v_EGFR)) +$v_STAT5: (v_JAK2 & (v_SRC | v_EGFR)) +$v_STK11: (!v_ERK_i & v_FOXO3) +$v_TCF4: ((v_CTNNB1 & v_JUN) & !v_FOXO1) +$v_TEAD1: (v_YAP1 & v_ABL1) +$v_TRADD: (!v_KRT14 | v_NFKB1) +$v_TSC2: (!v_AKT_i & v_PRKAA2) +$v_TWIST1: (v_ERK_i & (v_JUN & v_MYC)) +$v_WNT1: (v_PGR & v_WNT1) +$v_YAP1: !v_LATS1 diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet new file mode 100644 index 0000000..9eac06c --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet @@ -0,0 +1,112 @@ +targets,factors +v_ABL1, (v_SRC & v_GRB2) +v_ABL2, v_ABL1 +v_AKT_i, ((v_MTORC2_c | v_PDPK1) & v_PIP3) +v_APC, v_AXIN1 +v_AXIN1, (!v_DVL1 & v_GSK3B) +v_BAD, !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +v_BAK1, (((v_BIM | v_P53) | v_BID) | !v_MCL1) +v_BAX, (((v_BIM & v_P53) & v_BID) | !v_MCL1) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +v_BCLXL, (!(v_BAD | v_BIM) & v_CREB1) +v_BID, v_CASP8 +v_BIM, (!(v_BCL2 | (v_BCLXL | v_AKT_i)) & (v_FOXO3 & v_FOXO1)) +v_CASP3, (v_CASP9 & v_CASP8) +v_CASP8, (v_FADD | !(v_ERK_i & v_SRC)) +v_CASP9, ((v_CYCS | v_CASP3) & !((v_ERK_i & v_JAK2) | (v_AKT_i & (v_PRKACA & v_BCLXL)))) +v_CDKN2A, !v_MYC +v_CEBPB, (v_ERK_i | (v_ABL2 | (v_GSK3B | v_INS))) +v_CREB1, v_AKT_i +v_CTNNB1, (!v_DC | (v_WNT1 | (v_SRC | v_AKT_i))) +v_CYCLIN_D_c, ((v_STAT3 & !(v_GSK3B & (v_CDKN2A & v_P21))) & (v_EIF4E & (v_MYC & v_STAT3))) +v_CYCS, (v_BAK1 | v_BAX) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 & !v_YAP1) +v_E2F1, !v_PRB +v_EGFR, (v_EGF | (v_ABL1 | (v_CTNNB1 | (v_HER2 & v_HER3)))) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, (v_ES & (v_AKT_i & (v_PGR & (v_KMT2D & v_FOXO3)))) +v_FADD, (v_TRADD | v_FAS) +v_FAS, ((v_FASLG | v_P53) & !v_AKT_i) +v_FASLG, (v_FASLG & (v_P53 & v_FOXO3)) +v_FOXO1, !v_SGK1 +v_FOXO3, (!(v_AKT_i | v_ERK_i) | v_NFKB1) +v_FZD3, (v_WNT1 | v_CREB1) +v_GATA3, !v_STAT1 +v_GRB2, (v_IRS1 & v_SRC) +v_GRB7, v_INSR +v_GSK3B, !(v_AKT_i & v_ERK_i) +v_HER2, v_HER3 +v_HER3, (v_NRG1 & (v_EGFR & v_HER2)) +v_HES1, (v_NCID | !v_CASP3) +v_HEY1, v_NCID +v_HRAS, ((v_SOS1 & v_PIP3) | !v_NF1) +v_HSP90AA1, (!v_PDPK1 & v_ABL1) +v_IGF1, (v_IGF1 & v_STAT5) +v_IGF1R, ((v_IGF1R & (v_IGF1 & (v_INS & v_SRC))) | (v_IL8 & v_STAT5)) +v_IL1B, (v_NOS3 & v_RELA) +v_IL6, (v_IL1B & v_IL6) +v_IL6R, v_IL6 +v_IL8, (v_TWIST1 | (v_JAK2 & v_STAT5)) +v_INSR, (v_INS | v_FOXO3) +v_IRS1, !v_S6K1 +v_IVEBP1, !v_MTORC1_c +v_JAK2, (v_IRS1 | (v_ABL1 & (v_IL8 & v_IL6R))) +v_JUN, ((v_MAPK8 & v_PPARG) | (v_RELA & (v_ERK_i & v_ESR1))) +v_KMT2D, ((v_JUN & (v_PAX7 & v_ESR1)) & !v_AKT_i) +v_KRT14, (v_PAK2 | v_EGFR) +v_LATS1, (v_NF2 & v_LCK) +v_LCK, (v_ERK_i & v_ESR1) +v_MAPK8, (v_RAC1 | (v_RND1 | (v_JUN | v_MYC))) +v_MCL1, (!v_GSK3B | (v_ERK_i | v_MAPK8)) +v_MDM2, (v_P53 & v_AKT_i) +v_MEK_i, (v_RAF1 | v_EGFR) +v_MTORC1_c, v_RHEB +v_MTORC2_c, (v_PIP3 & !v_S6K1) +v_MYC, (((v_ESR1 | (v_CTNNB1 | v_PIM)) & !v_GSK3B) | (v_JAK2 & (v_EIF4E & v_STAT3))) +v_MYOD1, !(v_HES1 | v_NF2) +v_MYOG, (!v_HEY1 & v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !v_SGK1 +v_NF1, !v_TWIST1 +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 | v_AKT_i) +v_NOTCH1, (v_DLL_i | (v_CTNNB1 | v_LCK)) +v_P21, (!(v_ERK_i | (v_AKT_i | v_MYC)) & v_MYOG) +v_P53, !v_MDM2 +v_PAK1, (v_TCF4 | v_AKT_i) +v_PAK2, (v_RAC1 & v_SRC) +v_PAX7, !v_MYOG +v_PDPK1, (v_PIP3 & v_IGF1R) +v_PGR, ((v_P21 & v_PG) & !(v_ESR1 | (v_ERK_i | v_AKT_i))) +v_PI3K_c, ((v_JUN | (v_EGFR | v_ESR1)) | (v_IRS1 & (v_IGF1R & v_IGF1))) +v_PIM, v_STAT5 +v_PIP3, (v_PI3K_c & !v_PTEN) +v_PPARG, (!v_GATA3 & v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, (v_STK11 | v_STAT1) +v_PRKACA, (v_AKT_i | v_WNT1) +v_PTEN, (v_S6K1 & !v_SRC) +v_RAC1, ((v_PI3K_c & v_DVL1) & !v_AKT_i) +v_RAF1, (v_HRAS & v_RAS_i) +v_RAS_i, (v_SOS1 | v_PIP3) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 & v_DVL1) +v_S6K1, (v_MTORC1_c & v_ERK_i) +v_SGK1, ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +v_SOS1, (v_GRB2 | v_STAT3) +v_SRC, (v_PRKACA & v_ESR1) +v_STAT1, (v_JAK2 | (v_SRC | v_EGFR)) +v_STAT3, ((v_IL1B | (v_SRC | v_MAPK8)) | (v_JAK2 | v_EGFR)) +v_STAT5, (v_JAK2 & (v_SRC | v_EGFR)) +v_STK11, (!v_ERK_i & v_FOXO3) +v_TCF4, ((v_CTNNB1 & v_JUN) & !v_FOXO1) +v_TEAD1, (v_YAP1 & v_ABL1) +v_TRADD, (!v_KRT14 | v_NFKB1) +v_TSC2, (!v_AKT_i & v_PRKAA2) +v_TWIST1, (v_ERK_i & (v_JUN & v_MYC)) +v_WNT1, (v_PGR & v_WNT1) +v_YAP1, !v_LATS1 diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml new file mode 100644 index 0000000..43016c7 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml @@ -0,0 +1 @@ +v_SRC1v_GRB21v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_AXIN11v_DVL11v_GSK3B1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BIM1v_P531v_BID1v_MCL11v_BAD1v_BIM1v_CREB11v_ERK_i1v_BAD1v_BIM1v_CREB11v_CASP81v_BCL21v_BCLXL1v_AKT_i1v_FOXO31v_FOXO11v_CASP91v_CASP81v_FADD1v_ERK_i1v_SRC1v_CYCS1v_CASP31v_ERK_i1v_JAK21v_AKT_i1v_PRKACA1v_BCLXL1v_MYC1v_ERK_i1v_ABL21v_GSK3B1v_INS1v_AKT_i1v_DC1v_WNT11v_SRC1v_AKT_i1v_STAT31v_GSK3B1v_CDKN2A1v_P211v_EIF4E1v_MYC1v_STAT31v_BAK11v_BAX1v_APC1v_GSK3B1v_FZD31v_YAP11v_PRB1v_EGF1v_ABL11v_CTNNB11v_HER21v_HER31v_IVEBP11v_MEK_i1v_ES1v_AKT_i1v_PGR1v_KMT2D1v_FOXO31v_TRADD1v_FAS1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_ERK_i1v_NFKB11v_WNT11v_CREB11v_STAT11v_IRS11v_SRC1v_INSR1v_AKT_i1v_ERK_i1v_HER31v_NRG11v_EGFR1v_HER21v_NCID1v_CASP31v_NCID1v_SOS11v_PIP31v_NF11v_PDPK11v_ABL11v_IGF11v_STAT51v_IGF1R1v_IGF11v_INS1v_SRC1v_IL81v_STAT51v_NOS31v_RELA1v_IL1B1v_IL61v_IL61v_TWIST11v_JAK21v_STAT51v_INS1v_FOXO31v_S6K11v_MTORC1_c1v_IRS11v_ABL11v_IL81v_IL6R1v_MAPK81v_PPARG1v_RELA1v_ERK_i1v_ESR11v_JUN1v_PAX71v_ESR11v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_ESR11v_RAC11v_RND11v_JUN1v_MYC1v_GSK3B1v_ERK_i1v_MAPK81v_P531v_AKT_i1v_RAF11v_EGFR1v_RHEB1v_PIP31v_S6K11v_ESR11v_CTNNB11v_PIM1v_GSK3B1v_JAK21v_EIF4E1v_STAT31v_HES11v_NF21v_HEY11v_MYOD11v_NOTCH11v_SGK11v_TWIST11v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_ERK_i1v_AKT_i1v_MYC1v_MYOG1v_MDM21v_TCF41v_AKT_i1v_RAC11v_SRC1v_MYOG1v_PIP31v_IGF1R1v_P211v_PG1v_ESR11v_ERK_i1v_AKT_i1v_JUN1v_EGFR1v_ESR11v_IRS11v_IGF1R1v_IGF11v_STAT51v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_STAT11v_AKT_i1v_WNT11v_S6K11v_SRC1v_PI3K_c1v_DVL11v_AKT_i1v_HRAS1v_RAS_i1v_SOS11v_PIP31v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_ERK_i1v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_STAT31v_PRKACA1v_ESR11v_JAK21v_SRC1v_EGFR1v_IL1B1v_SRC1v_MAPK81v_JAK21v_EGFR1v_JAK21v_SRC1v_EGFR1v_ERK_i1v_FOXO31v_CTNNB11v_JUN1v_FOXO11v_YAP11v_ABL11v_KRT141v_NFKB11v_AKT_i1v_PRKAA21v_ERK_i1v_JUN1v_MYC1v_PGR1v_WNT11v_LATS11 \ No newline at end of file diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md new file mode 100644 index 0000000..df179f7 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md @@ -0,0 +1,46 @@ +# \[235\] BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE + + - Variables: 110 + - Inputs: 7 + - Regulations: 270 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i +IGF1, IGF1 + +Regulation: + +CYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +was updated to: + +CYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +as the analysis stated that TEAD1 and TCF4 have no effect on CYCLIN_D_c. + + +### Model citation + +``` +@article{bbm-235, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json new file mode 100644 index 0000000..b11bf95 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 235, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 110, + "inputs": 7, + "regulations": 270, + "notes": "### Modifications\n\nRemoved regulations:\nPG, PG\nNRG1, NRG1\nINS, INS\nES, ES\nEGF, EGF\nDLL_i, DLL_i\nIGF1, IGF1\n\nRegulation:\n\nCYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nwas updated to:\n\nCYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nas the analysis stated that TEAD1 and TCF4 have no effect on CYCLIN_D_c.\n", + "bib": "@article{bbm-235,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon new file mode 100644 index 0000000..1764fb6 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon @@ -0,0 +1,380 @@ +v_GRB2 -? v_ABL1 +v_JUN -? v_ABL1 +v_SRC -? v_ABL1 +v_ABL1 -? v_ABL2 +v_EGFR -? v_AKT_i +v_IGF1R -? v_AKT_i +v_IRS1 -? v_AKT_i +v_MTORC2_c -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_FOXO1 -? v_APC +v_CREB1 -? v_AXIN1 +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_JUN -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BCL2 -? v_BAK1 +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BCL2 -? v_BAX +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BCLXL -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BCL2 -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_BCLXL -? v_BID +v_CASP8 -? v_BID +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CASP8 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_PRKACA -? v_CASP9 +v_MYC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_ESR1 -? v_CEBPB +v_AKT_i -? v_CREB1 +v_DC -? v_CTNNB1 +v_RELA -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_STAT3 -? v_CYCLIN_D_c +v_TCF4 -? v_CYCLIN_D_c +v_TEAD1 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_P53 -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_JUN -? v_DVL1 +v_PRB -? v_E2F1 +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_MEK_i -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_JUN -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_AKT_i -? v_FOXO1 +v_ESR1 -? v_FOXO1 +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_WNT1 -? v_FZD3 +v_ESR1 -? v_GATA3 +v_STAT1 -? v_GATA3 +v_EGFR -? v_GRB2 +v_IRS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_ESR1 -? v_GRB7 +v_INSR -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_EGFR -? v_HER2 +v_HER3 -? v_HER2 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_NCID -? v_HES1 +v_WNT1 -? v_HES1 +v_NCID -? v_HEY1 +v_NF1 -? v_HRAS +v_PIP3 -? v_HRAS +v_SOS1 -? v_HRAS +v_PDPK1 -? v_HSP90AA1 +v_STAT1 -? v_HSP90AA1 +v_ESR1 -? v_IGF1R +v_FOXO3 -? v_IGF1R +v_IGF1 -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_STAT1 -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_ESR1 -? v_IL6R +v_IL6 -? v_IL6R +v_ERK_i -? v_IL8 +v_ESR1 -? v_IL8 +v_JAK2 -? v_IL8 +v_STAT5 -? v_IL8 +v_INS -? v_INSR +v_INSR -? v_INSR +v_IGF1R -? v_IRS1 +v_INSR -? v_IRS1 +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_ERK_i -? v_LCK +v_JUN -? v_MAPK8 +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_MAPK8 -? v_MCL1 +v_P53 -? v_MDM2 +v_RAF1 -? v_MEK_i +v_ERK_i -? v_MTORC1_c +v_PIM -? v_MTORC1_c +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_GSK3B -? v_MYC +v_JAK2 -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_ESR1 -? v_MYOD1 +v_HES1 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_SGK1 -? v_NEDD4L +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MDM2 -? v_P53 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_FOXO1 -? v_PAX7 +v_MYOG -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_ESR1 -? v_PGR +v_GATA3 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_HRAS -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_RAS_i -? v_PI3K_c +v_GATA3 -? v_PIM +v_STAT5 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_EGFR -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_PI3K_c -? v_RAC1 +v_AKT_i -? v_RAF1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_PIP3 -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_ESR1 -? v_S6K1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_PRKACA -? v_SRC +v_EGFR -? v_STAT1 +v_JAK2 -? v_STAT1 +v_MAPK8 -? v_STAT1 +v_SRC -? v_STAT1 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_EGFR -? v_STAT5 +v_JAK2 -? v_STAT5 +v_MAPK8 -? v_STAT5 +v_SRC -? v_STAT5 +v_ERK_i -? v_STK11 +v_STAT5 -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_JUN -? v_TCF4 +v_PGR -? v_TCF4 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_P53 -? v_TRADD +v_AKT_i -? v_TSC2 +v_ERK_i -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_ERK_i -? v_TWIST1 +v_STAT3 -? v_TWIST1 +v_PGR -? v_WNT1 +v_WNT1 -? v_WNT1 +v_ABL1 -? v_YAP1 +v_LATS1 -? v_YAP1 +$v_ABL1: (v_SRC | (v_GRB2 | v_JUN)) +$v_ABL2: v_ABL1 +$v_AKT_i: (((v_MTORC2_c | v_PDPK1) & v_PIP3) | (v_IRS1 | (v_IGF1R | v_EGFR))) +$v_APC: (v_AXIN1 & v_FOXO1) +$v_AXIN1: (!v_DVL1 | (v_GSK3B | (v_CREB1 & v_JUN))) +$v_BAD: !(v_PAK1 & (v_AKT_i & (v_ERK_i & v_PIM))) +$v_BAK1: (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +$v_BAX: (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 & (v_ERK_i & v_BCLXL))) +$v_BCLXL: (!(v_BAD & v_BIM) | (v_CREB1 | v_BCL2)) +$v_BID: (v_CASP8 & !v_BCLXL) +$v_BIM: (!(v_BCL2 | v_BCLXL) & (v_FOXO3 | v_FOXO1)) +$v_CASP3: v_CASP9 +$v_CASP8: (v_FADD | !(v_ERK_i & v_SRC)) +$v_CASP9: (((v_CYCS & v_CASP8) | v_CASP3) & !(v_AKT_i & (v_ERK_i & v_PRKACA))) +$v_CDKN2A: !v_MYC +$v_CEBPB: (v_ABL2 & v_ESR1) +$v_CREB1: v_AKT_i +$v_CTNNB1: (!v_DC | (v_WNT1 | v_RELA)) +$v_CYCLIN_D_c: ((v_TCF4 | (v_TEAD1 | (v_STAT3 | v_MYC))) & !(v_GSK3B | (v_CDKN2A | v_P21))) +$v_CYCS: (v_BAK1 & (v_BAX & v_P53)) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 | v_JUN) +$v_E2F1: !v_PRB +$v_EGFR: ((v_EGF | (v_HER2 & v_HER3)) | !v_MEK_i) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: ((v_ES & (v_AKT_i & v_KMT2D)) & (v_PGR & v_FOXO3)) +$v_FADD: (v_TRADD | (v_FAS | v_JUN)) +$v_FAS: ((v_FASLG | v_P53) & !v_AKT_i) +$v_FASLG: (v_FASLG & (v_P53 & v_FOXO3)) +$v_FOXO1: (!(v_SGK1 | v_AKT_i) & v_ESR1) +$v_FOXO3: !v_AKT_i +$v_FZD3: v_WNT1 +$v_GATA3: (!v_STAT1 & v_ESR1) +$v_GRB2: ((v_IRS1 & v_SRC) | v_EGFR) +$v_GRB7: (v_INSR & v_ESR1) +$v_GSK3B: !(v_AKT_i | v_ERK_i) +$v_HER2: (v_HER3 & v_EGFR) +$v_HER3: (v_NRG1 & v_HER2) +$v_HES1: (v_NCID & v_WNT1) +$v_HEY1: v_NCID +$v_HRAS: (v_SOS1 | (v_PIP3 | !v_NF1)) +$v_HSP90AA1: (!v_PDPK1 | v_STAT1) +$v_IGF1R: (v_IGF1 & (v_FOXO3 & v_ESR1)) +$v_IL1B: (v_NOS3 & (v_RELA & v_STAT1)) +$v_IL6: (v_IL1B | v_IL6) +$v_IL6R: (v_IL6 & v_ESR1) +$v_IL8: ((v_JAK2 & v_STAT5) & (v_ERK_i & v_ESR1)) +$v_INSR: (v_INS | v_INSR) +$v_IRS1: (!v_S6K1 & (v_INSR | v_IGF1R)) +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +$v_JUN: ((v_RELA | (v_MAPK8 | v_PPARG)) | v_ERK_i) +$v_KMT2D: (v_PAX7 & !v_AKT_i) +$v_KRT14: (v_PAK2 & v_EGFR) +$v_LATS1: (v_NF2 & v_LCK) +$v_LCK: v_ERK_i +$v_MAPK8: (v_RAC1 | (v_RND1 | v_JUN)) +$v_MCL1: (!v_GSK3B | (v_ERK_i | v_MAPK8)) +$v_MDM2: v_P53 +$v_MEK_i: v_RAF1 +$v_MTORC1_c: (v_RHEB | (v_ERK_i & v_PIM)) +$v_MTORC2_c: (v_PIP3 | !v_S6K1) +$v_MYC: ((((v_CTNNB1 | v_PIM) & v_EIF4E) & !v_GSK3B) | (v_STAT3 & (v_JAK2 & v_EIF4E))) +$v_MYOD1: (!v_HES1 & v_ESR1) +$v_MYOG: (!v_HEY1 & v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !v_SGK1 +$v_NF1: !v_TWIST1 +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 | v_AKT_i) +$v_NOTCH1: (v_DLL_i | (v_CTNNB1 | v_LCK)) +$v_P21: !(v_ERK_i & v_AKT_i) +$v_P53: !v_MDM2 +$v_PAK1: v_TCF4 +$v_PAK2: (v_RAC1 | v_SRC) +$v_PAX7: (!v_MYOG & v_FOXO1) +$v_PDPK1: (v_PIP3 | v_IGF1R) +$v_PGR: ((v_GATA3 & v_PG) & !v_ESR1) +$v_PI3K_c: (v_EGFR | ((v_ESR1 & (v_IRS1 | v_IGF1R)) & (v_HRAS & v_RAS_i))) +$v_PIM: (v_STAT5 | !v_GATA3) +$v_PIP3: (v_PI3K_c | !v_PTEN) +$v_PPARG: (!v_GATA3 | v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: v_STK11 +$v_PRKACA: ((v_AKT_i & v_WNT1) | v_EGFR) +$v_PTEN: (v_S6K1 | !v_SRC) +$v_RAC1: v_PI3K_c +$v_RAF1: ((v_HRAS | v_RAS_i) | !v_AKT_i) +$v_RAS_i: (v_SOS1 | v_PIP3) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 & v_DVL1) +$v_S6K1: (v_MTORC1_c & v_ESR1) +$v_SGK1: ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +$v_SOS1: v_GRB2 +$v_SRC: v_PRKACA +$v_STAT1: ((v_SRC & v_MAPK8) | (v_JAK2 & v_EGFR)) +$v_STAT3: ((v_IL1B & (v_SRC & v_MAPK8)) & v_JAK2) +$v_STAT5: (v_JAK2 | (v_SRC | (v_EGFR | v_MAPK8))) +$v_STK11: (!v_ERK_i | v_STAT5) +$v_TCF4: ((v_CTNNB1 & v_JUN) & v_PGR) +$v_TEAD1: v_YAP1 +$v_TRADD: (!v_KRT14 & v_P53) +$v_TSC2: (!(v_AKT_i | v_ERK_i) & v_PRKAA2) +$v_TWIST1: (v_ERK_i & v_STAT3) +$v_WNT1: (v_PGR | v_WNT1) +$v_YAP1: (!v_LATS1 | v_ABL1) diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet new file mode 100644 index 0000000..9bbf0fd --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet @@ -0,0 +1,111 @@ +targets,factors +v_ABL1, (v_SRC | (v_GRB2 | v_JUN)) +v_ABL2, v_ABL1 +v_AKT_i, (((v_MTORC2_c | v_PDPK1) & v_PIP3) | (v_IRS1 | (v_IGF1R | v_EGFR))) +v_APC, (v_AXIN1 & v_FOXO1) +v_AXIN1, (!v_DVL1 | (v_GSK3B | (v_CREB1 & v_JUN))) +v_BAD, !(v_PAK1 & (v_AKT_i & (v_ERK_i & v_PIM))) +v_BAK1, (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +v_BAX, (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 & (v_ERK_i & v_BCLXL))) +v_BCLXL, (!(v_BAD & v_BIM) | (v_CREB1 | v_BCL2)) +v_BID, (v_CASP8 & !v_BCLXL) +v_BIM, (!(v_BCL2 | v_BCLXL) & (v_FOXO3 | v_FOXO1)) +v_CASP3, v_CASP9 +v_CASP8, (v_FADD | !(v_ERK_i & v_SRC)) +v_CASP9, (((v_CYCS & v_CASP8) | v_CASP3) & !(v_AKT_i & (v_ERK_i & v_PRKACA))) +v_CDKN2A, !v_MYC +v_CEBPB, (v_ABL2 & v_ESR1) +v_CREB1, v_AKT_i +v_CTNNB1, (!v_DC | (v_WNT1 | v_RELA)) +v_CYCLIN_D_c, ((v_TCF4 | (v_TEAD1 | (v_STAT3 | v_MYC))) & !(v_GSK3B | (v_CDKN2A | v_P21))) +v_CYCS, (v_BAK1 & (v_BAX & v_P53)) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 | v_JUN) +v_E2F1, !v_PRB +v_EGFR, ((v_EGF | (v_HER2 & v_HER3)) | !v_MEK_i) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, ((v_ES & (v_AKT_i & v_KMT2D)) & (v_PGR & v_FOXO3)) +v_FADD, (v_TRADD | (v_FAS | v_JUN)) +v_FAS, ((v_FASLG | v_P53) & !v_AKT_i) +v_FASLG, (v_FASLG & (v_P53 & v_FOXO3)) +v_FOXO1, (!(v_SGK1 | v_AKT_i) & v_ESR1) +v_FOXO3, !v_AKT_i +v_FZD3, v_WNT1 +v_GATA3, (!v_STAT1 & v_ESR1) +v_GRB2, ((v_IRS1 & v_SRC) | v_EGFR) +v_GRB7, (v_INSR & v_ESR1) +v_GSK3B, !(v_AKT_i | v_ERK_i) +v_HER2, (v_HER3 & v_EGFR) +v_HER3, (v_NRG1 & v_HER2) +v_HES1, (v_NCID & v_WNT1) +v_HEY1, v_NCID +v_HRAS, (v_SOS1 | (v_PIP3 | !v_NF1)) +v_HSP90AA1, (!v_PDPK1 | v_STAT1) +v_IGF1R, (v_IGF1 & (v_FOXO3 & v_ESR1)) +v_IL1B, (v_NOS3 & (v_RELA & v_STAT1)) +v_IL6, (v_IL1B | v_IL6) +v_IL6R, (v_IL6 & v_ESR1) +v_IL8, ((v_JAK2 & v_STAT5) & (v_ERK_i & v_ESR1)) +v_INSR, (v_INS | v_INSR) +v_IRS1, (!v_S6K1 & (v_INSR | v_IGF1R)) +v_IVEBP1, !v_MTORC1_c +v_JAK2, ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +v_JUN, ((v_RELA | (v_MAPK8 | v_PPARG)) | v_ERK_i) +v_KMT2D, (v_PAX7 & !v_AKT_i) +v_KRT14, (v_PAK2 & v_EGFR) +v_LATS1, (v_NF2 & v_LCK) +v_LCK, v_ERK_i +v_MAPK8, (v_RAC1 | (v_RND1 | v_JUN)) +v_MCL1, (!v_GSK3B | (v_ERK_i | v_MAPK8)) +v_MDM2, v_P53 +v_MEK_i, v_RAF1 +v_MTORC1_c, (v_RHEB | (v_ERK_i & v_PIM)) +v_MTORC2_c, (v_PIP3 | !v_S6K1) +v_MYC, ((((v_CTNNB1 | v_PIM) & v_EIF4E) & !v_GSK3B) | (v_STAT3 & (v_JAK2 & v_EIF4E))) +v_MYOD1, (!v_HES1 & v_ESR1) +v_MYOG, (!v_HEY1 & v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !v_SGK1 +v_NF1, !v_TWIST1 +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 | v_AKT_i) +v_NOTCH1, (v_DLL_i | (v_CTNNB1 | v_LCK)) +v_P21, !(v_ERK_i & v_AKT_i) +v_P53, !v_MDM2 +v_PAK1, v_TCF4 +v_PAK2, (v_RAC1 | v_SRC) +v_PAX7, (!v_MYOG & v_FOXO1) +v_PDPK1, (v_PIP3 | v_IGF1R) +v_PGR, ((v_GATA3 & v_PG) & !v_ESR1) +v_PI3K_c, (v_EGFR | ((v_ESR1 & (v_IRS1 | v_IGF1R)) & (v_HRAS & v_RAS_i))) +v_PIM, (v_STAT5 | !v_GATA3) +v_PIP3, (v_PI3K_c | !v_PTEN) +v_PPARG, (!v_GATA3 | v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, v_STK11 +v_PRKACA, ((v_AKT_i & v_WNT1) | v_EGFR) +v_PTEN, (v_S6K1 | !v_SRC) +v_RAC1, v_PI3K_c +v_RAF1, ((v_HRAS | v_RAS_i) | !v_AKT_i) +v_RAS_i, (v_SOS1 | v_PIP3) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 & v_DVL1) +v_S6K1, (v_MTORC1_c & v_ESR1) +v_SGK1, ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +v_SOS1, v_GRB2 +v_SRC, v_PRKACA +v_STAT1, ((v_SRC & v_MAPK8) | (v_JAK2 & v_EGFR)) +v_STAT3, ((v_IL1B & (v_SRC & v_MAPK8)) & v_JAK2) +v_STAT5, (v_JAK2 | (v_SRC | (v_EGFR | v_MAPK8))) +v_STK11, (!v_ERK_i | v_STAT5) +v_TCF4, ((v_CTNNB1 & v_JUN) & v_PGR) +v_TEAD1, v_YAP1 +v_TRADD, (!v_KRT14 & v_P53) +v_TSC2, (!(v_AKT_i | v_ERK_i) & v_PRKAA2) +v_TWIST1, (v_ERK_i & v_STAT3) +v_WNT1, (v_PGR | v_WNT1) +v_YAP1, (!v_LATS1 | v_ABL1) diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml new file mode 100644 index 0000000..f284be7 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml @@ -0,0 +1 @@ +v_SRC1v_GRB21v_JUN1v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_IRS11v_IGF1R1v_EGFR1v_AXIN11v_FOXO11v_DVL11v_GSK3B1v_CREB11v_JUN1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BCL21v_BIM1v_P531v_BID1v_MCL11v_BCL21v_BAD1v_BIM1v_CREB11v_ERK_i1v_BCLXL1v_BAD1v_BIM1v_CREB11v_BCL21v_CASP81v_BCLXL1v_BCL21v_BCLXL1v_FOXO31v_FOXO11v_CASP91v_FADD1v_ERK_i1v_SRC1v_CYCS1v_CASP81v_CASP31v_AKT_i1v_ERK_i1v_PRKACA1v_MYC1v_ABL21v_ESR11v_AKT_i1v_DC1v_WNT11v_RELA1v_TCF41v_TEAD11v_STAT31v_MYC1v_GSK3B1v_CDKN2A1v_P211v_BAK11v_BAX1v_P531v_APC1v_GSK3B1v_FZD31v_JUN1v_PRB1v_EGF1v_HER21v_HER31v_MEK_i1v_IVEBP11v_MEK_i1v_ES1v_AKT_i1v_KMT2D1v_PGR1v_FOXO31v_TRADD1v_FAS1v_JUN1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_ESR11v_AKT_i1v_WNT11v_STAT11v_ESR11v_IRS11v_SRC1v_EGFR1v_INSR1v_ESR11v_AKT_i1v_ERK_i1v_HER31v_EGFR1v_NRG11v_HER21v_NCID1v_WNT11v_NCID1v_SOS11v_PIP31v_NF11v_PDPK11v_STAT11v_IGF11v_FOXO31v_ESR11v_NOS31v_RELA1v_STAT11v_IL1B1v_IL61v_IL61v_ESR11v_JAK21v_STAT51v_ERK_i1v_ESR11v_INS1v_INSR1v_S6K11v_INSR1v_IGF1R1v_MTORC1_c1v_IL6R1v_ABL11v_IL81v_IRS11v_RELA1v_MAPK81v_PPARG1v_ERK_i1v_PAX71v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_RAC11v_RND11v_JUN1v_GSK3B1v_ERK_i1v_MAPK81v_P531v_RAF11v_RHEB1v_ERK_i1v_PIM1v_PIP31v_S6K11v_CTNNB11v_PIM1v_EIF4E1v_GSK3B1v_STAT31v_JAK21v_EIF4E1v_HES11v_ESR11v_HEY11v_MYOD11v_NOTCH11v_SGK11v_TWIST11v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_ERK_i1v_AKT_i1v_MDM21v_TCF41v_RAC11v_SRC1v_MYOG1v_FOXO11v_PIP31v_IGF1R1v_GATA31v_PG1v_ESR11v_EGFR1v_ESR11v_IRS11v_IGF1R1v_HRAS1v_RAS_i1v_STAT51v_GATA31v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_AKT_i1v_WNT11v_EGFR1v_S6K11v_SRC1v_PI3K_c1v_HRAS1v_RAS_i1v_AKT_i1v_SOS11v_PIP31v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_ESR11v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_PRKACA1v_SRC1v_MAPK81v_JAK21v_EGFR1v_IL1B1v_SRC1v_MAPK81v_JAK21v_JAK21v_SRC1v_EGFR1v_MAPK81v_ERK_i1v_STAT51v_CTNNB11v_JUN1v_PGR1v_YAP11v_KRT141v_P531v_AKT_i1v_ERK_i1v_PRKAA21v_ERK_i1v_STAT31v_PGR1v_WNT11v_LATS11v_ABL11 \ No newline at end of file diff --git a/models/summary.csv b/models/summary.csv index 36c902f..9e48638 100644 --- a/models/summary.csv +++ b/models/summary.csv @@ -229,3 +229,8 @@ ID, name, variables, regulations 228, INTEGRATION-OF-SIGNALING-AND-KINETIC-MODELS, 47, 9, 107 229, CALCIUM-SIGNALING-STOMATAL-CLOSURE, 52, 4, 128 230, HEPATOCYTE-GROWTH-FACTOR, 50, 5, 76 +231, BREAST-CANCER-SIGNALLING-PATHWAYS, 110, 7, 268 +232, BREAST-CANCER-PATHWAYS-MCF7-COMPLETE, 109, 8, 275 +233, BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE, 109, 8, 260 +234, BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE, 111, 6, 271 +235, BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE, 110, 7, 270 diff --git a/report/.~lock.online_only_table_1.xlsx# b/report/.~lock.online_only_table_1.xlsx# new file mode 100644 index 0000000..e4678b5 --- /dev/null +++ b/report/.~lock.online_only_table_1.xlsx# @@ -0,0 +1 @@ +,natalie,natalie-IdeaPad-5-Pro-14ITL6,22.09.2024 09:06,file:///home/natalie/.config/libreoffice/4; \ No newline at end of file diff --git a/report/online_only_table_1.xlsx b/report/online_only_table_1.xlsx index 9cb2673..3b3ff88 100644 Binary files a/report/online_only_table_1.xlsx and b/report/online_only_table_1.xlsx differ diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib new file mode 100644 index 0000000..595a916 --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib @@ -0,0 +1,8 @@ +@article{bbm-233, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json new file mode 100644 index 0000000..04aab91 --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json @@ -0,0 +1,7 @@ +{ + "id": 233, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": ["source (?)","curated (?)","repaired (?)", "multi-valued (?)"] +} diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md new file mode 100644 index 0000000..ba2e26e --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md @@ -0,0 +1,11 @@ +### Modifications + +Removed regulations: +WNT1, WNT1 +PG, PG +NRG1, NRG1 +INS, INS +IGF1, IGF1 +ES, ES +EGF, EGF +DLL_i, DLL_i diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet new file mode 100644 index 0000000..57db0a2 --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet @@ -0,0 +1,110 @@ +IL6, IL1B & IL6 +IL6R, IL6 | STAT3 +JAK2, (IL6R & ABL1 & IL8) & IRS1 +STAT5, JAK2 +IL8, STAT5 +PIM, NFKB1 +STAT3, (IL1B & MAPK8) | JAK2 | SRC +STAT1, JAK2 & SRC & EGFR +GATA3, !STAT1 +PPARG, !GATA3 & CEBPB +FZD3, WNT1 +DVL1, FZD3 & !YAP1 +AXIN1, !DVL1 & GSK3B +APC, AXIN1 +DC, APC & GSK3B +CTNNB1, !DC & WNT1 +TCF4, CTNNB1 & JUN +PAK1, TCF4 | RAC1 | PDPK1 +NOTCH1, DLL_i & CTNNB1 & LCK +NFKB1, NOTCH1 +RELA, NFKB1 | PIM +JUN, (RELA & MAPK8 & PPARG) & ERK_i +NCID, NOTCH1 +HES1, NCID +HEY1, NCID +MYOD1, !(HES1 | NF2) +MYOG, !HEY1 | MYOD1 +PAX7, !MYOG +KMT2D, PAX7 | !AKT_i +IGF1R, IGF1 | (FOXO3 & ESR1) +HER3, NRG1 | HER2 +HER2, HER3 | (FOXO3 & ESR1) +PGR, PG | !(ESR1 & ERK_i) +ESR1, ES | AKT_i | (FOXO3 & (KMT2D & PGR)) +EGFR, (EGF & RELA & (HER2 & HER3)) & !MEK_i +GRB2, (IRS1 & SRC) & (EGFR & HER2) +SOS1, GRB2 +HRAS, (SOS1 & PIP3) | !NF1 +RAS_i, SOS1 & PIP3 +RAF1, (HRAS | RAS_i) +MEK_i, RAF1 +ERK_i, MEK_i +LCK, ERK_i | !AKT_i +TWIST1, ERK_i +NF1, !TWIST1 +PI3K_c, (EGFR | ESR1) | (IRS1 & IGF1R) +PTEN, S6K1 | !SRC +PIP3, PI3K_c | !PTEN +PDPK1, PIP3 | IGF1R +MTORC2_c, PIP3 | !S6K1 +AKT_i, ((MTORC2_c | PDPK1) & PIP3) & (IRS1 | (IGF1R | (EGFR & EGF))) +FOXO3, !AKT_i +FOXO1, !(SGK1 | AKT_i) +CREB1, AKT_i & SGK1 +GSK3B, !(AKT_i | ERK_i) +TSC2, !(AKT_i & ERK_i) | (PRKAA2 | GSK3B) +RHEB, !TSC2 +MTORC1_c, (RHEB | PIM) | (NRG1 | IGF1) +S6K1, MTORC1_c & ERK_i +IRS1, !S6K1 & (INSR & IGF1R) +SGK1, (MTORC2_c & MTORC1_c) & PDPK1 +NEDD4L, !SGK1 +NF2, NEDD4L +LATS1, NF2 | LCK +YAP1, !LATS1 | ABL1 +TEAD1, YAP1 +IVEBP1, !MTORC1_c +EIF4E, !IVEBP1 +MYC, (((CTNNB1 | PIM | ERK_i) & !GSK3B) | ((STAT3 & JAK2) | (ESR1 & KMT2D & FOXO3 ) | (ERK_i & (IGF1 | NRG1)) | EIF4E)) +P21, !(ERK_i | AKT_i | MYC) +CYCLIN_D_c, ((TCF4 | TEAD1) & !(GSK3B | (CDKN2A & P21))) | ((ESR1 & KMT2D & FOXO3) | (MYC & EIF4E) | (MYC & ERK_i & (IGF1 | NRG1))) +PRB, !CYCLIN_D_c +E2F1, !PRB +P53, !MDM2 +MDM2, P53 | AKT_i +MCL1, !GSK3B & ERK_i +BAD, !( PAK1 | AKT_i | ERK_i | PIM) +BCL2, !(BAD | BIM) & (CREB1 & ERK_i) +BCLXL, !(BAD | BIM) & CREB1 +BIM, !(BCL2 | BCLXL) & (FOXO3 & FOXO1) +BID, CASP8 +BAK1, ((BIM & P53) | BID) & !MCL1 +BAX, ((BIM & P53) | BID) & !MCL1 +CYCS, BAK1 & BAX +CASP9, ((CASP8 & CYCS) | CASP3) & !(AKT_i & ERK_i) +CASP3, CASP9 & CASP8 +HSP90AA1, !PDPK1 | ESR1 +NOS3, HSP90AA1 & AKT_i +IL1B, NOS3 & RELA +STK11, !ERK_i & FOXO3 +PRKAA2, STK11 +PAK2, RAC1 | SRC +KRT14, PAK2 & EGFR +TRADD, !KRT14 +FASLG, FASLG & P53 & FOXO3 +FAS, (FASLG | P53) | !AKT_i +FADD, TRADD & FAS +CASP8, FADD & !(ERK_i | SRC) +PRKACA, AKT_i & WNT1 +SRC, PRKACA +ABL1, GRB2 +ABL2, ABL1 +CEBPB, ABL2 +CDKN2A, !(MYC | SRC) & CASP3 +INSR, INS & FOXO3 +GRB7, INSR | !PRKACA +RND1, GRB7 | DVL1 +RAC1, (PI3K_c & DVL1) & !AKT_i +MAPK8, RAC1 & RND1 + diff --git a/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/citation.bib b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/citation.bib new file mode 100644 index 0000000..0379713 --- /dev/null +++ b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/citation.bib @@ -0,0 +1,8 @@ +@article{bbm-234, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + diff --git a/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/metadata.json b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/metadata.json new file mode 100644 index 0000000..8815b9f --- /dev/null +++ b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/metadata.json @@ -0,0 +1,7 @@ +{ + "id": 234, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": ["source (?)","curated (?)","repaired (?)", "multi-valued (?)"] +} diff --git a/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/notes.md b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/notes.md new file mode 100644 index 0000000..e2bacdd --- /dev/null +++ b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/notes.md @@ -0,0 +1,19 @@ +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i + +Regulation: + +CYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +was updated to: + +CYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +as the analysis stated that TEAD1 and TCF4 have no effect on CYCLIN_D_c. diff --git a/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/source.bnet b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/source.bnet new file mode 100644 index 0000000..be0bd7e --- /dev/null +++ b/sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/source.bnet @@ -0,0 +1,112 @@ +IL6, IL1B & IL6 +IL6R, IL6 +JAK2, IRS1 | (ABL1 & IL8 & IL6R) +STAT5, JAK2 & (SRC | EGFR) +IL8, TWIST1 | (JAK2 & STAT5) +PIM, STAT5 +STAT3, (IL1B | SRC | MAPK8) | JAK2 | EGFR +STAT1, JAK2 | SRC | EGFR +GATA3, !STAT1 +PPARG, !GATA3 & CEBPB +WNT1, PGR & WNT1 +FZD3, WNT1 | CREB1 +DVL1, FZD3 & !YAP1 +AXIN1, !DVL1 & GSK3B +APC, AXIN1 +DC, APC & GSK3B +CTNNB1, !DC | (WNT1 | SRC | AKT_i) +TCF4, (CTNNB1 & JUN) & !FOXO1 +PAK1, TCF4 | AKT_i +NOTCH1, DLL_i | CTNNB1 | LCK +NFKB1, NOTCH1 +RELA, NFKB1 | PIM +JUN, (MAPK8 & PPARG) | (RELA & ERK_i & ESR1) +NCID, NOTCH1 +HES1, NCID | !CASP3 +HEY1, NCID +MYOD1, !(HES1 | NF2) +MYOG, !HEY1 & MYOD1 +PAX7, !MYOG +KMT2D, (JUN & PAX7 & ESR1) & !AKT_i +IGF1, IGF1 & STAT5 +IGF1R, (IGF1R & IGF1 & INS & SRC) | (IL8 & STAT5) +HER3, NRG1 & EGFR & HER2 +HER2, HER3 +PGR, (P21 & PG) & !(ESR1 | ERK_i | AKT_i) +ESR1, ES & AKT_i & PGR & KMT2D & FOXO3 +EGFR, EGF | ABL1 | CTNNB1 | (HER2 & HER3) +GRB2, IRS1 & SRC +SOS1, GRB2 | STAT3 +HRAS, (SOS1 & PIP3) | !NF1 +RAS_i, SOS1 | PIP3 +RAF1, (HRAS & RAS_i) +MEK_i, RAF1 | EGFR +ERK_i, MEK_i +LCK, ERK_i & ESR1 +TWIST1, ERK_i & JUN & MYC +NF1, !TWIST1 +PI3K_c, (JUN | (EGFR | ESR1)) | (IRS1 & IGF1R & IGF1) +PTEN, S6K1 & !SRC +PIP3, PI3K_c & !PTEN +PDPK1, PIP3 & IGF1R +MTORC2_c, PIP3 & !S6K1 +AKT_i, (MTORC2_c | PDPK1) & PIP3 +FOXO3, !(AKT_i | ERK_i) | NFKB1 +FOXO1, !SGK1 +CREB1, AKT_i +GSK3B, !(AKT_i & ERK_i) +TSC2, !AKT_i & PRKAA2 +RHEB, !TSC2 +MTORC1_c, RHEB +S6K1, MTORC1_c & ERK_i +IRS1, !S6K1 +SGK1, (MTORC2_c | MTORC1_c) & PDPK1 +NEDD4L, !SGK1 +NF2, NEDD4L +LATS1, NF2 & LCK +YAP1, !LATS1 +TEAD1, YAP1 & ABL1 +IVEBP1, !MTORC1_c +EIF4E, !IVEBP1 +MYC, ((ESR1 | CTNNB1 | PIM) & !GSK3B) | (JAK2 & EIF4E & STAT3) +P21, !(ERK_i | AKT_i | MYC) & MYOG +CYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) +PRB, !CYCLIN_D_c +E2F1, !PRB +P53, !MDM2 +MDM2, P53 & AKT_i +MCL1, !GSK3B | (ERK_i | MAPK8) +BAD, !(PAK1 | AKT_i | ERK_i | PIM) +BCL2, !(BAD | BIM) & (CREB1 & ERK_i) +BCLXL, !(BAD | BIM) & CREB1 +BIM, !(BCL2 | BCLXL | AKT_i) & (FOXO3 & FOXO1) +BID, CASP8 +BAK1, ((BIM | P53) | BID) | !MCL1 +BAX, ((BIM & P53) & BID) | !MCL1 +CYCS, BAK1 | BAX +CASP9, (CYCS | CASP3) & !((ERK_i & JAK2) | (AKT_i & PRKACA & BCLXL)) +CASP3, CASP9 & CASP8 +HSP90AA1, !PDPK1 & ABL1 +NOS3, HSP90AA1 | AKT_i +IL1B, NOS3 & RELA +STK11, !ERK_i & FOXO3 +PRKAA2, STK11 | STAT1 +PAK2, RAC1 & SRC +KRT14, PAK2 | EGFR +TRADD, !KRT14 | NFKB1 +FASLG, FASLG & P53 & FOXO3 +FAS, (FASLG | P53) & !AKT_i +FADD, TRADD | FAS +CASP8, FADD | !(ERK_i & SRC) +PRKACA, AKT_i | WNT1 +SRC, PRKACA & ESR1 +ABL1, SRC & GRB2 +ABL2, ABL1 +CEBPB, (ERK_i | ABL2 | GSK3B | INS) +CDKN2A, !MYC +INSR, INS | FOXO3 +GRB7, INSR +RND1, GRB7 & DVL1 +RAC1, (PI3K_c & DVL1) & !AKT_i +MAPK8, RAC1 | RND1 | JUN | MYC + diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib new file mode 100644 index 0000000..fac7a46 --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib @@ -0,0 +1,8 @@ +@article{bbm-235, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json new file mode 100644 index 0000000..cc42f7d --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json @@ -0,0 +1,7 @@ +{ + "id": 235, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": ["source (?)","curated (?)","repaired (?)", "multi-valued (?)"] +} diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md new file mode 100644 index 0000000..aaba544 --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md @@ -0,0 +1,10 @@ +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i +IGF1, IGF1 diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet new file mode 100644 index 0000000..01fb1ff --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet @@ -0,0 +1,111 @@ +IL6, IL1B | IL6 +IL6R, IL6 & ESR1 +JAK2, (IL6R & ABL1 & IL8) & IRS1 +STAT5, JAK2 | SRC | EGFR | MAPK8 +IL8, (JAK2 & STAT5) & ERK_i & ESR1 +PIM, STAT5 | !GATA3 +STAT3, (IL1B & SRC & MAPK8) & JAK2 +STAT1, (SRC & MAPK8) | (JAK2 & EGFR) +GATA3, !STAT1 & ESR1 +PPARG, !GATA3 | CEBPB +WNT1, PGR | WNT1 +FZD3, WNT1 +DVL1, FZD3 | JUN +AXIN1, !DVL1 | (GSK3B | (CREB1 & JUN)) +APC, AXIN1 & FOXO1 +DC, APC & GSK3B +CTNNB1, !DC | (WNT1 | RELA) +TCF4, (CTNNB1 & JUN) & PGR +PAK1, TCF4 +NOTCH1, DLL_i | CTNNB1 | LCK +NFKB1, NOTCH1 +RELA, NFKB1 | PIM +JUN, (RELA | MAPK8 | PPARG) | ERK_i +NCID, NOTCH1 +HES1, NCID & WNT1 +HEY1, NCID +MYOD1, !HES1 & ESR1 +MYOG, !HEY1 & MYOD1 +PAX7, !MYOG & FOXO1 +KMT2D, PAX7 & !AKT_i +IGF1R, IGF1 & (FOXO3 & ESR1) +HER3, NRG1 & HER2 +HER2, HER3 & EGFR +PGR, (GATA3 & PG) & !ESR1 +ESR1, (ES & AKT_i & KMT2D) & (PGR & FOXO3) +EGFR, (EGF | (HER2 & HER3)) | !MEK_i +GRB2, (IRS1 & SRC) | EGFR +SOS1, GRB2 +HRAS, SOS1 | (PIP3 | !NF1) +RAS_i, SOS1 | PIP3 +RAF1, (HRAS | RAS_i) | !AKT_i +MEK_i, RAF1 +ERK_i, MEK_i +LCK, ERK_i +TWIST1, ERK_i & STAT3 +NF1, !TWIST1 +PI3K_c, EGFR | ((ESR1 & (IRS1 | IGF1R)) & (HRAS & RAS_i)) +PTEN, S6K1 | !SRC +PIP3, PI3K_c | !PTEN +PDPK1, PIP3 | IGF1R +MTORC2_c, PIP3 | !S6K1 +AKT_i, ((MTORC2_c | PDPK1) & PIP3) | (IRS1 | IGF1R | EGFR) +FOXO3, !AKT_i +FOXO1, !(SGK1 | AKT_i) & ESR1 +CREB1, AKT_i +GSK3B, !(AKT_i | ERK_i) +TSC2, !(AKT_i | ERK_i) & PRKAA2 +RHEB, !TSC2 +MTORC1_c, (RHEB | (ERK_i & PIM)) +S6K1, MTORC1_c & ESR1 +IRS1, !S6K1 & (INSR | IGF1R) +SGK1, (MTORC2_c | MTORC1_c) & PDPK1 +NEDD4L, !SGK1 +NF2, NEDD4L +LATS1, NF2 & LCK +YAP1, !LATS1 | ABL1 +TEAD1, YAP1 +IVEBP1, !MTORC1_c +EIF4E, !IVEBP1 +MYC, (((CTNNB1 | PIM) & EIF4E) & !GSK3B) | (STAT3 & JAK2 & EIF4E) +P21, !(ERK_i & AKT_i) +CYCLIN_D_c, (TCF4 | TEAD1 | (STAT3 | MYC)) & !(GSK3B | (CDKN2A | P21)) +PRB, !CYCLIN_D_c +E2F1, !PRB +P53, !MDM2 +MDM2, P53 +MCL1, !GSK3B | ERK_i | MAPK8 +BAD, !( PAK1 & AKT_i & ERK_i & PIM) +BCL2, !(BAD | BIM) & (CREB1 & ERK_i & BCLXL) +BCLXL, !(BAD & BIM) | (CREB1 | BCL2) +BIM, !(BCL2 | BCLXL) & (FOXO3 | FOXO1) +BID, CASP8 & !BCLXL +BAK1, ((BIM | P53) | BID) | !(MCL1 & BCL2) +BAX, ((BIM | P53) | BID) | !(MCL1 & BCL2) +CYCS, BAK1 & BAX & P53 +CASP9, ((CYCS & CASP8) | CASP3) & !(AKT_i & ERK_i & PRKACA) +CASP3, CASP9 +HSP90AA1, !PDPK1 | STAT1 +NOS3, HSP90AA1 | AKT_i +IL1B, NOS3 & RELA & STAT1 +STK11, !ERK_i | STAT5 +PRKAA2, STK11 +PAK2, RAC1 | SRC +KRT14, PAK2 & EGFR +TRADD, !KRT14 & P53 +FASLG, FASLG & P53 & FOXO3 +FAS, (FASLG | P53) & !AKT_i +FADD, TRADD | FAS | JUN +CASP8, FADD | !(ERK_i & SRC) +PRKACA, (AKT_i & WNT1) | EGFR +SRC, PRKACA +ABL1, SRC | GRB2 | JUN +ABL2, ABL1 +CEBPB, ABL2 & ESR1 +CDKN2A, !MYC +INSR, INS | INSR +GRB7, INSR & ESR1 +RND1, GRB7 & DVL1 +RAC1, PI3K_c +MAPK8, RAC1 | RND1 | JUN +