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ohara_rudy_cipa_v1_2017.cellml
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<?xml version='1.0'?>
<model cmeta:id="ohara_rudy_cipa_v1_2017" name="ohara_rudy_cipa_v1_2017" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="millisecond">
<unit prefix="milli" units="second"/>
</units>
<units name="per_millisecond">
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="millivolt_per_millimole">
<unit prefix="milli" units="volt"/>
<unit exponent="-1" units="millimolar"/>
</units>
<units name="per_millivolt">
<unit exponent="-1" units="millivolt"/>
</units>
<units name="per_millivolt_millisecond">
<unit exponent="-1" units="millivolt"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millimolar">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="per_millimolar">
<unit exponent="-1" units="millimolar"/>
</units>
<units name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="per_millimolar_per_millisecond">
<unit exponent="-1" units="millimolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millisecond_per_millimolar">
<unit units="millisecond"/>
<unit exponent="-1" units="millimolar"/>
</units>
<units name="picoA">
<unit prefix="pico" units="ampere"/>
</units>
<units name="microA_per_microF">
<unit prefix="micro" units="ampere"/>
<unit exponent="-1" prefix="micro" units="farad"/>
</units>
<units name="milliS_per_microF">
<unit prefix="milli" units="siemens"/>
<unit exponent="-1" prefix="micro" units="farad"/>
</units>
<units name="microF">
<unit prefix="micro" units="farad"/>
</units>
<units name="micrometre_3">
<unit exponent="3" prefix="micro" units="metre"/>
</units>
<units name="per_micrometre_3">
<unit exponent="-3" prefix="micro" units="metre"/>
</units>
<units name="mm2">
<unit exponent="2" prefix="milli" units="metre"/>
</units>
<units name="centimeter">
<unit prefix="centi" units="metre"/>
</units>
<units name="centimeter_squared">
<unit exponent="2" units="centimeter"/>
</units>
<units name="microliter_per_centimeter_cubed">
<unit units="microliter"/>
<unit exponent="-3" units="centimeter"/>
</units>
<units name="microF_per_centimeter_squared">
<unit units="microF"/>
<unit exponent="-1" units="centimeter_squared"/>
</units>
<units name="microliter">
<unit prefix="micro" units="liter"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit exponent="-1" prefix="kilo" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="coulomb_per_mole_millivolt">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
<unit exponent="-1" units="millivolt"/>
</units>
<component name="environment">
<variable cmeta:id="time" name="time" public_interface="out" units="millisecond"/>
<variable initial_value="0" name="celltype" public_interface="out" units="dimensionless"/>
</component>
<component name="extracellular">
<variable cmeta:id="extracellular_sodium_concentration" initial_value="140" name="nao" public_interface="out" units="millimolar"/>
<variable cmeta:id="extracellular_calcium_concentration" initial_value="1.8" name="cao" public_interface="out" units="millimolar"/>
<variable cmeta:id="extracellular_potassium_concentration" initial_value="5.4" name="ko" public_interface="out" units="millimolar"/>
</component>
<component name="physical_constants">
<variable initial_value="8314" name="R" public_interface="out" units="joule_per_kilomole_kelvin"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="coulomb_per_mole"/>
<variable initial_value="1" name="zna" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="zca" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="zk" public_interface="out" units="dimensionless"/>
</component>
<component name="cell_geometry">
<variable initial_value="0.01" name="L" units="centimeter"/>
<variable initial_value="0.0011" name="rad" units="centimeter"/>
<variable name="vcell" public_interface="out" units="microliter"/>
<variable name="Ageo" public_interface="out" units="centimeter_squared"/>
<variable name="Acap" public_interface="out" units="centimeter_squared"/>
<variable name="vmyo" public_interface="out" units="microliter"/>
<variable name="vnsr" public_interface="out" units="microliter"/>
<variable name="vjsr" public_interface="out" units="microliter"/>
<variable name="vss" public_interface="out" units="microliter"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vcell</ci>
<apply>
<times/>
<cn cellml:units="microliter_per_centimeter_cubed">1000</cn>
<cn cellml:units="dimensionless">3.14</cn>
<ci>rad</ci>
<ci>rad</ci>
<ci>L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ageo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">3.14</cn>
<ci>rad</ci>
<ci>rad</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">3.14</cn>
<ci>rad</ci>
<ci>L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Acap</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Ageo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>vmyo</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.68</cn>
<ci>vcell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>vnsr</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0552</cn>
<ci>vcell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>vjsr</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0048</cn>
<ci>vcell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>vss</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02</cn>
<ci>vcell</ci>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable cmeta:id="membrane_voltage" initial_value="-88.00190465" name="v" public_interface="out" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<!--var vffrt: coulomb_per_mole {pub: out};-->
<variable name="vfrt" public_interface="out" units="dimensionless"/>
<variable name="ffrt" public_interface="out" units="coulomb_per_mole_millivolt"/>
<variable name="frt" public_interface="out" units="per_millivolt"/>
<variable name="INa" public_interface="in" units="microA_per_microF"/>
<variable name="INaL" public_interface="in" units="microA_per_microF"/>
<variable name="Ito" public_interface="in" units="microA_per_microF"/>
<variable name="ICaL" public_interface="in" units="microA_per_microF"/>
<variable name="ICaNa" public_interface="in" units="microA_per_microF"/>
<variable name="ICaK" public_interface="in" units="microA_per_microF"/>
<variable name="IKr" public_interface="in" units="microA_per_microF"/>
<variable name="IKs" public_interface="in" units="microA_per_microF"/>
<variable name="IK1" public_interface="in" units="microA_per_microF"/>
<variable name="INaCa_i" public_interface="in" units="microA_per_microF"/>
<variable name="INaCa_ss" public_interface="in" units="microA_per_microF"/>
<variable name="INaK" public_interface="in" units="microA_per_microF"/>
<variable name="INab" public_interface="in" units="microA_per_microF"/>
<variable name="IKb" public_interface="in" units="microA_per_microF"/>
<variable name="IpCa" public_interface="in" units="microA_per_microF"/>
<variable name="ICab" public_interface="in" units="microA_per_microF"/>
<variable cmeta:id="membrane_stimulus_current" name="Istim" public_interface="out" units="microA_per_microF"/>
<variable cmeta:id="membrane_stimulus_current_offset" initial_value="10" name="i_Stim_Start" units="millisecond"/>
<variable initial_value="100000000000000000" name="i_Stim_End" units="millisecond"/>
<variable cmeta:id="membrane_stimulus_current_amplitude" initial_value="-80" name="i_Stim_Amplitude" units="microA_per_microF"/>
<variable cmeta:id="membrane_stimulus_current_period" initial_value="1000" name="i_Stim_Period" units="millisecond"/>
<variable cmeta:id="membrane_stimulus_current_duration" initial_value="0.5" name="i_Stim_PulseDuration" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Istim</ci>
<piecewise>
<piece>
<ci>i_Stim_Amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>i_Stim_Start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>i_Stim_End</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>i_Stim_Start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>i_Stim_Start</ci>
</apply>
<ci>i_Stim_Period</ci>
</apply>
</apply>
<ci>i_Stim_Period</ci>
</apply>
</apply>
<ci>i_Stim_PulseDuration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="microA_per_microF">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>frt</ci>
<apply>
<divide/>
<ci>F</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ffrt</ci>
<apply>
<times/>
<ci>F</ci>
<ci>frt</ci>
</apply>
</apply>
<!--vffrt = v*ffrt;-->
<apply>
<eq/>
<ci>vfrt</ci>
<apply>
<times/>
<ci>v</ci>
<ci>frt</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>v</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>INa</ci>
<ci>INaL</ci>
<ci>Ito</ci>
<ci>ICaL</ci>
<ci>ICaNa</ci>
<ci>ICaK</ci>
<ci>IKr</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>INaCa_i</ci>
<ci>INaCa_ss</ci>
<ci>INaK</ci>
<ci>INab</ci>
<ci>IKb</ci>
<ci>IpCa</ci>
<ci>ICab</ci>
<ci>Istim</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CaMK">
<variable initial_value="0.15" name="KmCaMK" public_interface="out" units="millimolar"/>
<variable initial_value="0.05" name="aCaMK" units="per_millimolar_per_millisecond"/>
<variable initial_value="0.00068" name="bCaMK" units="per_millisecond"/>
<variable initial_value="0.05" name="CaMKo" units="dimensionless"/>
<variable initial_value="0.0015" name="KmCaM" units="millimolar"/>
<variable name="CaMKb" public_interface="out" units="millimolar"/>
<variable name="CaMKa" public_interface="out" units="millimolar"/>
<variable initial_value="0.0125840447" name="CaMKt" units="millimolar"/>
<variable name="cass" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>CaMKb</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CaMKo</ci>
<apply>
<minus/>
<cn cellml:units="millimolar">1</cn>
<ci>CaMKt</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>KmCaM</ci>
<ci>cass</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaMKa</ci>
<apply>
<plus/>
<ci>CaMKb</ci>
<ci>CaMKt</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaMKt</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>aCaMK</ci>
<ci>CaMKb</ci>
<apply>
<plus/>
<ci>CaMKb</ci>
<ci>CaMKt</ci>
</apply>
</apply>
<apply>
<times/>
<ci>bCaMK</ci>
<ci>CaMKt</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ions">
<variable initial_value="0.05" name="cmdnmax_b" units="millimolar"/>
<variable name="cmdnmax" units="millimolar"/>
<variable initial_value="0.00238" name="kmcmdn" units="millimolar"/>
<variable initial_value="0.07" name="trpnmax" units="millimolar"/>
<variable initial_value="0.0005" name="kmtrpn" units="millimolar"/>
<variable initial_value="0.047" name="BSRmax" units="millimolar"/>
<variable initial_value="0.00087" name="KmBSR" units="millimolar"/>
<variable initial_value="1.124" name="BSLmax" units="millimolar"/>
<variable initial_value="0.0087" name="KmBSL" units="millimolar"/>
<variable initial_value="10" name="csqnmax" units="millimolar"/>
<variable initial_value="0.8" name="kmcsqn" units="millimolar"/>
<variable cmeta:id="cytosolic_sodium_concentration" initial_value="7.268004498" name="nai" public_interface="out" units="millimolar"/>
<variable initial_value="7.268089977" name="nass" public_interface="out" units="millimolar"/>
<variable cmeta:id="cytosolic_potassium_concentration" initial_value="144.6555918" name="ki" public_interface="out" units="millimolar"/>
<variable initial_value="144.6555651" name="kss" public_interface="out" units="millimolar"/>
<variable initial_value="8.49e-05" name="cass" public_interface="out" units="millimolar"/>
<variable initial_value="1.619574538" name="cansr" public_interface="out" units="millimolar"/>
<variable initial_value="1.571234014" name="cajsr" public_interface="out" units="millimolar"/>
<variable cmeta:id="cytosolic_calcium_concentration" initial_value="8.6e-05" name="cai" public_interface="out" units="millimolar"/>
<variable name="celltype" public_interface="in" units="dimensionless"/>
<variable name="Acap" public_interface="in" units="centimeter_squared"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="INa" public_interface="in" units="microA_per_microF"/>
<variable name="INaL" public_interface="in" units="microA_per_microF"/>
<variable name="INaCa_i" public_interface="in" units="microA_per_microF"/>
<variable name="INaCa_ss" public_interface="in" units="microA_per_microF"/>
<variable name="ICaNa" public_interface="in" units="microA_per_microF"/>
<variable name="INaK" public_interface="in" units="microA_per_microF"/>
<variable name="INab" public_interface="in" units="microA_per_microF"/>
<variable name="IK1" public_interface="in" units="microA_per_microF"/>
<variable name="IKb" public_interface="in" units="microA_per_microF"/>
<variable name="IKr" public_interface="in" units="microA_per_microF"/>
<variable name="IKs" public_interface="in" units="microA_per_microF"/>
<variable name="Istim" public_interface="in" units="microA_per_microF"/>
<variable name="Ito" public_interface="in" units="microA_per_microF"/>
<variable name="ICab" public_interface="in" units="microA_per_microF"/>
<variable name="IpCa" public_interface="in" units="microA_per_microF"/>
<variable name="ICaL" public_interface="in" units="microA_per_microF"/>
<variable name="JdiffNa" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="Jdiff" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="Jup" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="JdiffK" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="Jrel" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="Jtr" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="ICaK" public_interface="in" units="microA_per_microF"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="vmyo" public_interface="in" units="microliter"/>
<variable name="vnsr" public_interface="in" units="microliter"/>
<variable name="vss" public_interface="in" units="microliter"/>
<variable name="vjsr" public_interface="in" units="microliter"/>
<variable name="Bcai" units="dimensionless"/>
<variable name="Bcajsr" units="dimensionless"/>
<variable name="Bcass" units="dimensionless"/>
<variable initial_value="1" name="cm" public_interface="out" units="microF_per_centimeter_squared"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>cmdnmax</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>cmdnmax_b</ci>
<cn cellml:units="dimensionless">1.3</cn>
</apply>
<apply>
<eq/>
<ci>celltype</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<ci>cmdnmax_b</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>nai</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>INa</ci>
<ci>INaL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>INaCa_i</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>INaK</ci>
</apply>
<ci>INab</ci>
</apply>
</apply>
<ci>Acap</ci>
<ci>cm</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>vmyo</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>JdiffNa</ci>
<ci>vss</ci>
</apply>
<ci>vmyo</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>nass</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ICaNa</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>INaCa_ss</ci>
</apply>
</apply>
</apply>
<ci>cm</ci>
<ci>Acap</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>vss</ci>
</apply>
</apply>
<ci>JdiffNa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ki</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ito</ci>
<ci>IKr</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>IKb</ci>
<ci>Istim</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaK</ci>
</apply>
</apply>
</apply>
<ci>cm</ci>
<ci>Acap</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>vmyo</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>JdiffK</ci>
<ci>vss</ci>
</apply>
<ci>vmyo</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>kss</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>ICaK</ci>
</apply>
<ci>cm</ci>
<ci>Acap</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>vss</ci>
</apply>
</apply>
<ci>JdiffK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Bcai</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>cmdnmax</ci>
<ci>kmcmdn</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>kmcmdn</ci>
<ci>cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>trpnmax</ci>
<ci>kmtrpn</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>kmtrpn</ci>
<ci>cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cai</ci>
</apply>
<apply>
<times/>
<ci>Bcai</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>IpCa</ci>
<ci>ICab</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaCa_i</ci>
</apply>
</apply>
</apply>
<ci>cm</ci>
<ci>Acap</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>vmyo</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jup</ci>
<ci>vnsr</ci>
</apply>
<ci>vmyo</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jdiff</ci>
<ci>vss</ci>
</apply>
<ci>vmyo</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Bcass</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>BSRmax</ci>
<ci>KmBSR</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>KmBSR</ci>
<ci>cass</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>BSLmax</ci>
<ci>KmBSL</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>KmBSL</ci>
<ci>cass</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cass</ci>
</apply>
<apply>
<times/>
<ci>Bcass</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<ci>ICaL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaCa_ss</ci>
</apply>
</apply>
</apply>
<ci>cm</ci>
<ci>Acap</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>vss</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jrel</ci>
<ci>vjsr</ci>
</apply>
<ci>vss</ci>
</apply>
</apply>
<ci>Jdiff</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cansr</ci>
</apply>
<apply>
<minus/>
<ci>Jup</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Jtr</ci>
<ci>vjsr</ci>
</apply>
<ci>vnsr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Bcajsr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>csqnmax</ci>
<ci>kmcsqn</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>kmcsqn</ci>
<ci>cajsr</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cajsr</ci>
</apply>
<apply>
<times/>
<ci>Bcajsr</ci>
<apply>
<minus/>
<ci>Jtr</ci>
<ci>Jrel</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="reversal_potentials">
<variable initial_value="0.01833" name="PKNa" units="dimensionless"/>
<variable name="ENa" public_interface="out" units="millivolt"/>
<variable name="EK" public_interface="out" units="millivolt"/>
<variable name="EKs" public_interface="out" units="millivolt"/>
<variable name="nao" public_interface="in" units="millimolar"/>
<variable name="ko" public_interface="in" units="millimolar"/>
<variable name="nai" public_interface="in" units="millimolar"/>
<variable name="ki" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>