Detects high variance signals and generates dose-response curves to futher investigate candidate signals from MALDI cell based assays. More information in Unger et. Al. 2021
The main function in this package is fitCurve() which will not only do logistic regression and variance filtering but also handle all preprocessing nessesary:
- Spectral alignment ("single-point recalibration").
- Normalization by an internal standard or known endogenous signal
All these function can also be called on there own.
This package makes heavy use of the MALDIquant framework.