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whitead authored Sep 11, 2024
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Expand Up @@ -18,8 +18,6 @@ pqa ask 'How can carbon nanotubes be manufactured at a large scale?'

### Example Output

Here's an example of output from PaperQA2

Question: Has anyone designed neural networks that compute with proteins or DNA?

The claim that neural networks have been designed to compute with DNA is supported by multiple sources. The work by Qian, Winfree, and Bruck demonstrates the use of DNA strand displacement cascades to construct neural network components, such as artificial neurons and associative memories, using a DNA-based system (Qian2011Neural pages 1-2, Qian2011Neural pages 15-16, Qian2011Neural pages 54-56). This research includes the implementation of a 3-bit XOR gate and a four-neuron Hopfield associative memory, showcasing the potential of DNA for neural network computation. Additionally, the application of deep learning techniques to genomics, which involves computing with DNA sequences, is well-documented. Studies have applied convolutional neural networks (CNNs) to predict genomic features such as transcription factor binding and DNA accessibility (Eraslan2019Deep pages 4-5, Eraslan2019Deep pages 5-6). These models leverage DNA sequences as input data, effectively using neural networks to compute with DNA. While the provided excerpts do not explicitly mention protein-based neural network computation, they do highlight the use of neural networks in tasks related to protein sequences, such as predicting DNA-protein binding (Zeng2016Convolutional pages 1-2). However, the primary focus remains on DNA-based computation.
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