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Merge branch 'master' of https://github.com/HSL/PoulinHaddad
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thehoglet committed Dec 15, 2017
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Expand Up @@ -23,17 +23,17 @@ Refer to Poulin & Haddad to determine whether the model implemented in this add-

In a worksheet cell, use the __Vss__ function. The three arguments required are:

1. Log octanol:water partition coefficient, log Pow
1. Log octanol:water partition coefficient, log P<sub>ow</sub>
2. Ionization class (N, WB, SB, A, or Z)
3. Does drug chemical structure consist of at least one oxygen atom? (TRUE or FALSE)

If the drug or chemical is not neutral (class N), supply a fourth argument:
If the drug or chemical is not neutral (not class N), supply a fourth argument:

4. pKa
4. pK<sub>a</sub>

If the drug or chemical is a zwitterion (class Z), supply a fifth argument:

5. pKa,base
5. pK<sub>a</sub>,base

Example:

Expand All @@ -43,4 +43,4 @@ Example:

### Other Computations

To view other functions available with this add-in, in the Excel function wizard, select __Poulin Haddad__ from the _Category_ drop-down.
To view other functions available with this add-in, in the Excel function wizard, select __Poulin Haddad__ from the _Category_ drop-down.

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