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Modeling the effects of dopamine on network synchronization (Komek et al. 2012)

modeldb.science/146734

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
images		images
BatchThetaTonic.ode		BatchThetaTonic.ode
ThetaPeriodic.ode		ThetaPeriodic.ode
ThetaTonic.ode		ThetaTonic.ode
WBperiodic.ode		WBperiodic.ode
WBtonic.ode		WBtonic.ode
readme.html		readme.html

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<html><pre>
This is the readme for the model associated with the paper

Komek K, Bard Ermentrout G, Walker CP, Cho RY (2012) Dopamine and
gamma band synchrony in schizophrenia--insights from computational and
empirical studies. Eur J Neurosci 36:2146-55

These xpp model files were contributed by Kubra Komek. xpp is free
software by Bard Ermentrout available at http://www.pitt.edu/~phase/

Usage:

You can start under uniz/linux with a command like
xppaut ThetaPeriodic.ode

If you then click on Initialconds -> (G)o and then Window/Zoom ->
(F)it you should see a graph like (corresponds to paper fig 7)

<img src="./images/ThetaPeriodic.png" alt="images/ThetaPeriodic.png" width="550">

Running the following files similarly, leads to these images which
correspond to the paper figures in parentheses:

WBtonic.png: (fig 3)
<img src="./images/WBtonic.png" alt="images/WBtonic.png" width="550">

ThetaTonic.ode: (fig 5)
<img src="./images/ThetaTonic.png" alt="images/ThetaTonic.png" width="550">

WBperiodic.ode: (fig 6)
<img src="./images/WBperiodic.png" alt="images/WBperiodic.png" width="550">

The procedure for the simulations was to run the code for 20 seconds,
divide the results into 1 second bins, run FFT on LFP in Wang-Buzsaki
model and on SE in the theta neuron model, then average across
those. Also I varied some parameters in each simulation as described
in the paper. This meant running the code in batch mode for a range of
the specified parameter as described in the paper.

The neuron models that I used were Wang-Buzsaki neuron and theta
neuron. Wang-Buzsaki neuron was modeled after their original paper,
Wang XJ, Buzsaki G (1996) Gamma oscillation by synaptic inhibition in
a hippocampal interneuronal network model. J. Neurosci., 16, 6402-
6413.  Theta neuron model is also known as the Ermentrout-Kopell
canonical model (a link to the scholarpedia page describing it
<a href="http://www.scholarpedia.org/article/Ermentrout-Kopell_canonical_model">http://www.scholarpedia.org/article/Ermentrout-Kopell_canonical_model</a>).

An example batch file, BatchThetaTonic.ode, is identical to
ThetaTonic.ode except that it has added lines (and added descriptions
of those new lines) that control the running of the program in batch
mode. To run the batch file make sure you are in the same directory as
the ode file and type

xppaut BatchThetaTonic.ode -silent 

on the command line. It runs without a GUI and will create 57 output
files in the same directory starting with output.dat.0 and ending with
output.dat.56 which indeed is the same as the first one.  It takes
about 5 minutes to complete on a 2008 Dell Lattitude E6400 laptop.
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