GitHub - ModelDBRepository/217882: Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)

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Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)

modeldb.science/217882

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Name		Name	Last commit message	Last commit date
Latest commit History 3 Commits
FR3cablepas.hoc		FR3cablepas.hoc
FRMot3dendNaHH.hoc		FRMot3dendNaHH.hoc
Gfluctdv.mod		Gfluctdv.mod
GraphicsKmModulators.hoc		GraphicsKmModulators.hoc
Km.mod		Km.mod
L_Ca.mod		L_Ca.mod
ModifiedFRMotoneuron.hoc		ModifiedFRMotoneuron.hoc
Tools.ses		Tools.ses
XE991.png		XE991.png
buttons.png		buttons.png
ctrl.png		ctrl.png
gKm0.png		gKm0.png
ghchan.mod		ghchan.mod
kca2.mod		kca2.mod
kdrRL.mod		kdrRL.mod
kv1_gp.mod		kv1_gp.mod
mAHP.mod		mAHP.mod
mosinit.hoc		mosinit.hoc
na3n.mod		na3n.mod
na3rp.mod		na3rp.mod
naps.mod		naps.mod
napsi.mod		napsi.mod
readme.html		readme.html
retigabine.png		retigabine.png
standard_0.hoc		standard_0.hoc

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<html><pre>
This is the readme for the models associated with the paper:

Lombardo J, Harrington MA (2016) Non-reciprocal mechanisms of up- and
down-regulation of spinal motoneuron excitability by modulators of
KCNQ/Kv7 channels. J Neurophysiol

These NEURON models were contributed by J Lombardo and includes
contributions from previous models available in modeldb (see paper for
details).

Usage:

Either auto-launch from ModelDB or download and extract this archive
and compile the mod files, and then start with

nrngui mosinit.hoc

on the command line for unix/linux or double click on the mosinit.hoc
in file explorer for
mswin. See <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.html">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.html</a>
for more details on downloading and running the model.

After the model starts click on one of the buttons in the window
<img src="./buttons.png" alt="Set and run window" width="150">
and then the run button.

The CTRL, gKM=0, RETIGABINE, buttons produce (respectively)
<img src="./ctrl.png" alt="CTRL figure" width="550">
<img src="./gKm0.png" alt="gKM=0 figure" width="550">
<img src="./retigabine.png" alt="retigabine figure" width="550">
similar to Figure 4 in the paper.

XE991 produces the following:
<img src="./XE991.png" alt="XE991 figure" width="550">

<b> Changelog </b>

<ul>
  <li>20220924: Update MOD files to avoid declaring variables and functions with the same name. See https://github.com/neuronsimulator/nrn/pull/1992</li>
</ul>