GitHub - ModelDBRepository/243446: Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

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Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

modeldb.science/243446

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Name		Name	Last commit message	Last commit date
Latest commit History 3 Commits
mod		mod
Purkinje19b972-1.nrn		Purkinje19b972-1.nrn
cfdistrib.hoc		cfdistrib.hoc
dendv_arnd21.ses		dendv_arnd21.ses
distri.hoc		distri.hoc
electrode.hoc		electrode.hoc
purkinje_demo.hoc		purkinje_demo.hoc
readme		readme

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This model is from the following paper:

Yunliang Zang, Stéphane Dieudonné& Erik De Schutter. Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells. Cell Reports in press.

type the following commands on the terminal to implement the demo code, which generates both simple spikes and complex spikes (at 400 ms)

nrnivmodl mod
nrngui purkinje_demo.hoc

To get the dissociated PC model, add the following 
"dendA1_00 disconnect()
dendA1_01 disconnect()"
into purkinje_demo.hoc, which only preserves the dendritic trunk. 

To achieve voltage-regulated dendritic and somatic responses, change the values of stim1.amp in Purkinje_demo.hoc

The Na entry ratio is defined as the ratio of total Na+ influx (1 ms before and after spike peak) to the Na+ influx (1 ms before spike peak).

If you need to simulate some properties the present model can't do,please contact [email protected]. I may know the answer.


Changelog
---------

cdp_*.mod files are updated due to issue mentioned in neuronsimulator/nrn#1955.
CONSTANT block has no effect in the initialization of ion variables.