GitHub - ModelDBRepository/244679: Cerebellum Purkinje cell: dendritic ion channels activated by climbing fibre (Ait Ouares et al 2019)

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Cerebellum Purkinje cell: dendritic ion channels activated by climbing fibre (Ait Ouares et al 2019)

modeldb.science/244679

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Name		Name	Last commit message	Last commit date
Latest commit History 3 Commits
CaT3_1.mod		CaT3_1.mod
KA1.mod		KA1.mod
KC3.mod		KC3.mod
SK2.mod		SK2.mod
c6f1.dat		c6f1.dat
c6f2.dat		c6f2.dat
c6f3.dat		c6f3.dat
c6v1.dat		c6v1.dat
c6v2.dat		c6v2.dat
c6v3.dat		c6v3.dat
cdp5.mod		cdp5.mod
cf.mod		cf.mod
graphs.ses		graphs.ses
kdr1.mod		kdr1.mod
leak.mod		leak.mod
mosinitD.hoc		mosinitD.hoc
mosinitH.hoc		mosinitH.hoc
mosinitI.hoc		mosinitI.hoc
newCaP1.mod		newCaP1.mod
purkinje.hoc		purkinje.hoc
readme.html		readme.html
rund.hoc		rund.hoc
runh.hoc		runh.hoc
runi.hoc		runi.hoc
screenshot_dep.png		screenshot_dep.png
screenshot_hyp.png		screenshot_hyp.png
screenshot_int.png		screenshot_int.png

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<html>
This is the readme for the model associated with the paper:<p/>

Ait Ouares K, Filipis L, Tzilivaki A, Poirazi P, Canepari M (2019) Two
distinct sets of Ca2+ and K+ channels are activated at different
membrane potentials by the climbing fibre synaptic potential in
Purkinje neuron dendrites. J Neurosci<p/>

This model was contributed by Luiza Filipis and reproduces Cell1 of
Figure 9 on paper. If you need more help than the below in running the model
please consult the web page: <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>
<p/>
MSWIN<br/>
-----<p/>
Run mknrndll, cd to the expanded directory and click on the make
nrnmech.dll button. Under windows explorer double click on the
mosinitD.hoc, mosinitH.hoc or mosinitI.hoc file to see the result for the
Depolarised, Hyperpolarised or Intermediate state respectively.
<p/>
LINUX/UNIX<br/>
----------<p/>
Run nrnivmodl in the expanded archive folder. Then type
nrngui mosinitD.hoc, mosinitH.hoc or mosinitI.hoc file to see the result for
the Depolarised, Hyperpolarised or Intermediate state respectively.
<p/>
MAC OS X<br/>
--------<p/>
Drag and drop the expanded folder onto the mknrndll icon. Drag and
drop the mosinitD.hoc, mosinitH.hoc or mosinitI.hoc file onto the nrngui icon
to see the result for the Depolarised, Hyperpolarised or Intermediate state
respectively.
<p/>Depolarized:<p/>
<img src="./screenshot_dep.png" alt="screenshot depolarized">
<p/>Hyperpolarized:<p/>
<img src="./screenshot_hyp.png" alt="screenshot hyperpolarized">
<p/>Intermediate:<p/>
<img src="./screenshot_int.png" alt="screenshot intermediate">
Changelog<br/>
----------<p/>
* cdp5.mod is updated due to issue mentioned in neuronsimulator/nrn#1955.
   CONSTANT block has no effect in the initialization of ion variables.
</html>