GitHub - ModelDBRepository/244922: Conductance based model for short term plasticity at CA3-CA1 synapses (Mukunda & Narayanan 2017)

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Conductance based model for short term plasticity at CA3-CA1 synapses (Mukunda & Narayanan 2017)

modeldb.science/244922

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Name		Name	Last commit message	Last commit date
Latest commit History 2 Commits
data		data
BPF.hoc		BPF.hoc
EPSC_1.txt		EPSC_1.txt
cal2.mod		cal2.mod
cal4.mod		cal4.mod
can2.mod		can2.mod
ghkampaC.mod		ghkampaC.mod
h.mod		h.mod
kadist.mod		kadist.mod
kdr.mod		kdr.mod
minmax.mod		minmax.mod
mosinit.hoc		mosinit.hoc
nahh.mod		nahh.mod
plot_ca_data.m		plot_ca_data.m
pulses.mod		pulses.mod
readme.html		readme.html
screenshot.png		screenshot.png
stp.mod		stp.mod

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<html>
<p>This is the readme for the model associated with the paper:
</p><p>Mukunda CL, Narayanan R (2017) Degeneracy in the regulation of short-term 
plasticity and synaptic filtering by presynaptic mechanisms. J Physiol 
595:2611-2637
  <br/>
  <a href="http://dx.doi.org/10.1113/JP273482">http://dx.doi.org/10.1113/JP273482</a>
</p><p>This NEURON code was contributed by CL Mukunda. The NEURON simulator is freely 
available from <a href="http://neuron.yale.edu">http://neuron.yale.edu</a>
</p><p>The model contains Na, KDr, KA, CaL, CaN and h-currents. AMPA receptor at the 
spine has been implemented with GHK equations. Most of the .mod files were 
obtained from previous studies except stp.mod, which implements 
Neurotransmitter dynamics at the terminal and cleft. 
</p><p>Output will be written to a "data" folder. Running the file 
"BPF.hoc" generates .txt files consisting data of EPSCs at spine, voltage at 
soma and terminal, Calcium concentration at the terminal, Neurotransmitter 
concentration at terminal and the synaptic cleft, for 1-50 Hz frequency 
stimulation. The EPSCs are inverted as per convention of inward currents being 
negative. High pass and Low pass filter profiles can be simulated by plugging 
in the values mentioned in the paper.
</p><p>EPSC_1.txt file is an example data generated by running BPF.hoc<p/>
  Note that the mod files must be compiled prior to running BPF.hoc.  If you need more help to run the model please see <br/>
  <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a><br/>
  The included matlab file plot_ca_data plots this data in a format similar to Figure 2 C:
<p/>
<img src="./screenshot.png" alt="screenshot" width="750">
</html>