GitHub - ModelDBRepository/266823: Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

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Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

modeldb.science/266823

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
Essential_Elements		Essential_Elements
Fig1_Diplay-Traces		Fig1_Diplay-Traces
Fig2_Ball-Stick_var-gAMPA		Fig2_Ball-Stick_var-gAMPA
Fig3a-d_Ball-Stick_var-tauAMPA		Fig3a-d_Ball-Stick_var-tauAMPA
Fig3e_Ball-stick_NMDA_Effect		Fig3e_Ball-stick_NMDA_Effect
Fig3f-h_Ball-stick_AP_Effect		Fig3f-h_Ball-stick_AP_Effect
Fig4_Ball-stick_spatial-relation		Fig4_Ball-stick_spatial-relation
Fig5_Ball-stick_temp-Rel		Fig5_Ball-stick_temp-Rel
Fig6a-c_Ball-stick_temp-Rel_var-tauAMPA_var-tauGABA		Fig6a-c_Ball-stick_temp-Rel_var-tauAMPA_var-tauGABA
Fig6de_Ball-stick_tonic_GABA		Fig6de_Ball-stick_tonic_GABA
Fig7_e-h_Real_Cell_Cl_1GDP_Var-Cl-var-gAMPA		Fig7_e-h_Real_Cell_Cl_1GDP_Var-Cl-var-gAMPA
Fig7cd_Real_Cell_GDP_one for display		Fig7cd_Real_Cell_GDP_one for display
Fig8_Real_Cell_Cl_1GDP_Var-Cl-var-tauAMPA		Fig8_Real_Cell_Cl_1GDP_Var-Cl-var-tauAMPA
Fig9ab_Real_Cell_Cl_1GDP_Var-Cl-var-SpatialCorr		Fig9ab_Real_Cell_Cl_1GDP_Var-Cl-var-SpatialCorr
Fig9c-f_Real_Cell_Cl_1GDP_Var-Cl-var-TempCorr		Fig9c-f_Real_Cell_Cl_1GDP_Var-Cl-var-TempCorr
Suppl1_Ball-stick_var-tau-membr		Suppl1_Ball-stick_var-tau-membr
Suppl3_Real_Cell_Cl_1GDP_tonicGABA_Var_Cl_var-gAMPA		Suppl3_Real_Cell_Cl_1GDP_tonicGABA_Var_Cl_var-gAMPA
Suppl4_Real_Cell_Cl_1GDP_Var-Cl-var-gNMDA		Suppl4_Real_Cell_Cl_1GDP_Var-Cl-var-gNMDA
Suppl5_Real_Cell_Mild-var-SpatialCorr		Suppl5_Real_Cell_Mild-var-SpatialCorr
Readme.txt		Readme.txt

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This folders contain the .hoc, .ses and .mod files used for the manuscript:

"Coincident glutamatergic depolarizations enhance GABAA receptor-dependent 
Cl- influx in mature and suppress Cl- efflux in immature neurons"

by Aniello Lombardi, Peter Jedlicka, Heiko J. Luhmann, and Werner Kilb

To run the programs you first have to compile the .mod files using mknrndll for EACH folder.

The simulations are ordered in seperate folders according to the figures/panes in the manuscript. They should run from
each folder after compiling the .mod-files.

The essential parts of the models (mod-files for the GABA-currents and Chloride-Bicarbonate-handling
as well as the hoc-file with the reconstructed CA3 hippocampal neuron) are in addition isoltaed to
the folder "Essential Elements". 

The simulations can by automatically started using the Start_xxx.hoc files.