GitHub - ModelDBRepository/267157: Initiation of spreading depolarization by GABAergic neuron hyperactivity & NaV 1.1 (Chever et al 21)

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Initiation of spreading depolarization by GABAergic neuron hyperactivity & NaV 1.1 (Chever et al 21)

modeldb.science/267157

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Name		Name	Last commit message	Last commit date
Latest commit History 2 Commits
ic		ic
par		par
screenshots		screenshots
2_neurons.ode		2_neurons.ode
readme.html		readme.html

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<h1>Usage</h1>
We give here <a href="http://www.math.pitt.edu/~bard/xpp/xpp.html" target="_blank">XPP</a> files corresponding to the simulations shown in Figure 5 of <a href="https://www.jci.org/articles/view/142203" target="_blank">https://www.jci.org/articles/view/142203</a>. Initial condition and parameter value files for the different conditions are given in the folders "ic" and "par". From the folder containing "2_neurons.ode", type the commands below in a terminal and then click on "Initialconds", "Go". 

<h2>Control condition</h2>
xppaut 2_neurons.ode -parfile par/1.0.par -icfile ic/1.0.ic<br/><br/>
<img src="screenshots/v_e_trace_control.png" alt="screenshot" width="500"><br/><br/>

<h2>FHM-3 mutations of NaV1.1</h2>
xppaut 2_neurons.ode -parfile par/6.0.par -icfile ic/6.0.ic<br/><br/>
<img src="screenshots/v_e_trace_csd.png" alt="screenshot" width="500"><br/><br/>


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