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Uniprot-RefSeq cross-ref tool #4

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bj8th opened this issue Nov 6, 2019 · 2 comments
Open

Uniprot-RefSeq cross-ref tool #4

bj8th opened this issue Nov 6, 2019 · 2 comments

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@bj8th
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bj8th commented Nov 6, 2019

Current ProteomeScout uses PICR tools - no longer active

@bj8th
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bj8th commented Nov 6, 2019

May be able to use Uniprot to cross-ref with RefSeq

How Uniprot cross-references with RefSeq:
https://www.uniprot.org/help/ncbi_mappings
As per a protocol we have formalized with the NCBI, we create a RefSeq protein-centric mapping. If a UniProtKB protein (canonical or isoform sequence)

  • is 100% identical (over the entire sequence length) to a RefSeq protein and is from the same organism or
  • has common EMBL/DDBJ/GenBank protein accession numbers (CDS, protein_id)

then that RefSeq accession is mapped to the UniProtKB protein and consequently the entry will also get the corresponding GeneID cross-reference.

@bj8th
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bj8th commented Dec 3, 2019

updated picr_tools to use Uniprot API for reference into Uniprot and RefSeq

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