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Replace weighted average with general kinetic model for multi-PLD data #298

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tsalo opened this issue May 25, 2023 · 2 comments · May be fixed by #381
Open

Replace weighted average with general kinetic model for multi-PLD data #298

tsalo opened this issue May 25, 2023 · 2 comments · May be fixed by #381
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tsalo commented May 25, 2023

Summary

This was originally part of #268, but I wanted to get that merged ASAP, so I am happy to deal with this issue in a later PR. Basically, I need to decide between the Juttukonda 2021 unweighted average and the Dai 2012 weighted average for multi-PLD PCASL CBF calculation (or another approach entirely).

@tsalo tsalo added the enhancement New feature or request label May 25, 2023
@tsalo tsalo self-assigned this May 25, 2023
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tsalo commented Sep 13, 2023

Manuel Taso provided some very useful advice recently. Namely, we should only use the weighted-delay approach when vascular crushing is enabled. When the scan doesn't have vascular crushing, this approach could cause CBF over-estimation.

Instead, Manuel recommends using a 2-3 compartment model (with an intravascular compartment), which can fit arterial bolus arrival time, transit time, and CBF all at once, as recommended in this preprint: https://osf.io/4tskr

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tsalo commented Nov 7, 2023

It looks like I really need to implement the general kinetic model.

@tsalo tsalo changed the title Determine best way to combine CBF across delays Replace weighted average with general kinetic model for multi-PLD data Dec 15, 2023
@tsalo tsalo linked a pull request Jan 3, 2024 that will close this issue
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