An SGC Open Chemistry Networks Project (number 23) devoted to improving a hit found against SARS-CoV-2 RdRp. The project is run as part of the READDI-AViDD consortium.
You contribute synthetic chemistry and in return the SGC/READDI offers biology. Together we can generate tool compounds to understand biology and validate drug targets to help cure disease. Everything is open, with all content governed by a CC-BY-4.0 licence.
If this sounds interesting, and you agree to the simple RULES, you can get started.
For the science background, head to the wiki or check out the living paper that is being written (here) (need link) (link is also (Need tinyurl link).
For answers to all the questions you have, go to the FAQs.
If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. (Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. There's also an email address ([email protected]) you can use to ask questions. You can read more about all this in the "How To" Area
Some humans involved in this CNP:
Dr Hadia Almahli, Chemist at University College London @HadiaAmahli
Professor Matthew Todd, University College London. Head of Chemistry Networks at the SGC (medchem) @mattodd
Dr Santha Santhakumar, SGC (project management) @Santha-SGC
Professor Tim Willson, University of North Carolina Chapel Hill - @tmw20653
Dr Peter Brown, University North Carolina Chapel Hill, project manager
Dr Anwar Hossain, University North Carolina Chapel Hill, compound managment - @ahsgc
Pharma Champion: Vacant.
The Sir James Murray Student Champion: Vacant.
Other Contributors To Date: For biological assay:
Picogreen assay: Jim Sacchettini, TAMU
Picogreen assay: Arunima, Ken's Lab, UNC
Gel-based screening: Egor, Matthia's Lab, U Alberta
In-vitro antiviral: Tim Sheahan, UNC
In-vitro antiviral: Sara Chery, U Penn
Solubility, Microsomal Stability: Analiza
GSH Stability: WuXi
Toxicity: In parallel to in-vitro antiviral assay, in the respective lab
Potential Contributors:
You can see other contributors in the Issues (tab above).
The licence for the content of this project is, unless otherwise stated, and as for all OCN projects, CC-BY-4.0. This means you can do whatever you like with the project content, including making money, provided you cite the project.
This project is part of the SGC's Open Chemistry Networks initiative.
