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Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism

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XSLiuLab/ecDNA_immune

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ecDNA and immune escape

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Table of content


Overview

This repository provides the analysis reports, code and data for readers who are insterest in this project and make it easier to reproduce the whole analysis procedure. And the whole analysis can be read online

Contents

  • code : R functions and scripts that do not include in the analysis report.
  • data The data used and produced by analysis report.
  • docs Website pages and figures used for showing analysis reports.
  • report Rmarkdown files of analysis report and related html web page files.

Citation

Wu, T., Wu, C., Zhao, X. et al. Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression. Sci Rep 12, 3590 (2022). https://doi.org/10.1038/s41598-022-07530-8

Acknowledgement

We thank ShanghaiTech University High Performance Computing Public Service Platform for computing services. We thank Raymond Shuter for editing the text. We thank multi-omics facility, molecular and cell biology core facility of ShanghaiTech University for technical help. This work was supported by Shanghai Science and Technology Commission (21ZR1442400), the National Natural Science Foundation of China (31771373), and startup funding from ShanghaiTech University.

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Cancer Biology Group @ShanghaiTech

Research group led by Xue-Song Liu in ShanghaiTech University

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Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism

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