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These do not appear to be on by default and provide a consistent speed-up. I noticed this while comparing the conda-forge build flags to ours.
It's not clear why they're not enabled. The upstream documentation says they are enabled by default on support compilers and the configure-code is quite straight-forward. Furthermore, we have problems with computed-gotos in PGO / BOLT so they must be available in some capacity? Discussion with the upstream suggests this may be a sysconfig bug — which would mean the following performance improvement isn't true. It's possible there's some other difference I need to dig into.
Using a benchmark derived from #535 on macOS aarch64:
I plan to test an artifact with the pyperformance suite on Linux as well