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A calculator to adjust equilibrium constants in the Creatine Kinase Bioenergetic Clamp. Also, a calculator to adjust the Gibbs Energy of ATP Hydrolysis, the Creatine Kinase Equilibrium constant, and the Adenylate Kinase equilibrium constant for temperature, ionic strength, pH, and free magnesium.

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Bioenergetic Calculators

To cite this calculator, please reference the following publication:

Fisher-Wellman, K.H., Davidson, M.T., Narowski, T.M., Lin, C.-T., Koves, T.R., and Muoio, D.M. (2018). Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes. Cell Reports 24, 3593-3606.e10.

DOI: 10.1016/j.celrep.2018.08.091

PMID: 30257218

References

Teague, Golding, and Dobson were not involved in the generation of this site. However, their manuscript, constants, and equations formed the bedrock of this calculator.

  • Teague, W. E., Golding, E. M. & Dobson, G. P. Adjustment of K’ for the creatine kinase, adenylate kinase and ATP hydrolysis equilibria to varying temperature and ionic strength. Journal of Experimental Biology 199, 509–512 (1996).

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LICENSE: Copyright 2017 Michael Davidson

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM. OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

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A calculator to adjust equilibrium constants in the Creatine Kinase Bioenergetic Clamp. Also, a calculator to adjust the Gibbs Energy of ATP Hydrolysis, the Creatine Kinase Equilibrium constant, and the Adenylate Kinase equilibrium constant for temperature, ionic strength, pH, and free magnesium.

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