Lab website: https://elegrandi.wixsite.com/grandilab
Ou major focus is on constructing biophysically detailed quantitative representations of the human heart cell function, integrating membrane ion transport, Ca handling and signaling, to unravel the cellular and molecular bases of arrhythmia in health and common widespread cardiovascular diseases, such as congestive and ischemic heart failure (HF) and atrial fibrillation (AF). Computational models are used throughout in association with experimental approaches.
(1) Modeling of Na and Ca homeostasis in atrial and ventricular myocytes, to predict the consequences of local [Ca]i and [Na]i signaling in cardiac excitation-contraction in normal and diseased states
(2) Modeling of AF, to study (i) the consequences of structural and autonomic remodeling on AF initiation and maintenance, and (ii) the role of Na-CaMKII feedback in the promotion and perpetuation of AF.
