R scripts related to "Altering the mRNA-1273 Prime-boost Dose Interval Impacts the Kinetics, Quality, and Magnitude of Immune Responses in Mice"

This repository reproduces key analyses, tables, and figures related to the article "Altering the mRNA-1273 Prime-boost Dose Interval Impacts the Kinetics, Quality, and Magnitude of Immune Responses in Mice".

Scripts generating manuscript figures and tables

• Figure 2: scripts/analyses/ELISA.R
• Figure 3: scripts/analyses/ADCC.Rmd
• Figure 4: scripts/analyses/ELISpot.R
• Figure 5: scripts/analyses/tcell_polyfunctionality.Rmd
• Supplementary Figure 1: scripts/analyses/ELISA.R
• Supplementary Figure 2: scripts/analyses/ELISA.R
• Supplementary Figure 3: scripts/analyses/ADCC.Rmd
• Supplementary Figure 4: scripts/analyses/Tcell.R
• Supplementary Table 1: scripts/analyses/ELISA.R
• Supplementary Table 2: scripts/analyses/ADCC.Rmd
• Supplementary Table 3: scripts/analyses/ELISpot.R
• Supplementary Table 4: scripts/analyses/ELISpot.R
• Supplementary Table 5: scripts/analyses/tcell_polyfunctionality.Rmd
• Supplementary Table 6: scripts/analyses/Tcell.R
• Supplementary Table 7: scripts/analyses/Tcell.R
• Supplementary Table 8: scripts/analyses/antiPEG.Rmd

Output

• Figure 2: 2A - figures_tables/ELISA/ELISA_Titers_F2.pdf, 2B - output/ELISA/ELISA_Titers_F2B.pdf
• Figure 3: figures_tables/ADCC/ADCC_trend.pdf
• Figure 4: 4A and 4B - figures_tables/ELISpot/ELISpot_boxplot_F4A.png, 4C and 4D - figures_tables/ELISpot/ELISpot_boxplot_F4B.pdf
• Figure 5: figures_tables/polyfunctional_tcell/stacked_barchart.pdf
• Figure 6: figures_tables/antiPEG/antiPEG_dotplots.png
• Figure S1: figures_tables/ELISA/ELISA_foldchange_SF1.pdf
• Figure S2: figures_tables/ELISA/ELISA_foldchange_SF2.pdf
• Figure S4: S4A and S4B - figures_tables/Tcell/Tcell_CD4_SF4.png, S4C and S4D - figures_tables/Tcell/Tcell_CD4_SF4B.pdf