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Updating model tree
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MichaelClerx committed Aug 1, 2024
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# Model tree

## Abbrev
Type
- A Atrial
- V Ventricular
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## 2008 Mahajan RV

## 2008 Pasek GV

## 2008 Ten Tusscher HP
Base: [Ten Tusscher 2006](#2006-ten-tusscher-hv)
| [Paper](https://doi.org/10.1016/j.pbiomolbio.2007.07.026) Ten Tusscher, Panfilov (2008) Modelling of the ventricular conduction system

## 2008 Terkildsen RV
Base: [Pandit 2001](#2001-pandit-lv), Niederer 2006(?), Hinch 2004

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**Included**
| Base: [Grandi 2010](#2010-grandi-hv)
| [Original matlab code](https://github.com/drgrandilab/Grandi-et-al-2011-Human-Atrial-Model)
| [Paper](https://doi.org/10.1161/CIRCRESAHA.111.253955) Grandi, Pandit et al., Bers (2011) Human atrial action potential and Ca model; sinus rhythm and chronic atrial fibrillation
| [Paper](https://doi.org/10.1161/CIRCRESAHA.111.253955) Grandi*, Pandit*, Voigt* et al., Bers (2011) Human atrial action potential and Ca model; sinus rhythm and chronic atrial fibrillation (*shared first authorship)

Known as: Grandi 2011 model. But note Grandi, Pandit, and Voigt share first authorship of the paper.
Known as: Grandi 2011 model.

Modifications:
- Scaled gK1
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- Replaced INa with Courtemanche 1998 one
- Modified IK1 (changed gK1 and a)

## 2014 Chang HA
Base: [Grandi 2011](#2011-grandi-pandit-voigt-ha)
| [Paper](https://doi.org/10.1371/journal.pcbi.1004011) Chang, Bayer, Trayanova (2014) Disrupted calcium release as a mechanism for atrial alternans associated with human atrial fibrillation


## 2014 Morotti MV
Base: [Soltis 2010](#2010-soltis-rv)
| [Original matlab code](https://github.com/drgrandilab/Morotti-et-al-2014-Mouse-Ventricular-Model)
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Bits:
- Myofilament contraction from Negroni 2015

## 2018 Colman HA
Base: This model has 4 variants
| [Original code](https://github.com/michaelcolman/hAM_WL)
| [Paper](https://doi.org/10.3389/fphys.2018.01211) Colman, Saxena, Kettlewell, Workman (2018) Description of the Human Atrial Action Potential Derived From a Single, Congruent Data Source; Novel Computational Models for Integrated Experimental-Numerical Study of Atrial Arrhythmia Mechanisms

## 2018 Paci Hi
**Included**
| Base: [Paci 2013](#2013-paci-hi)
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Also cites a 2020 Ni paper, but that refers to Ellinwood.

## Ni 2023 HA
## 2023 Ni HA
Base: [Morotti 2017](#2016-morotti-ha)
| [Original C++ code](https://github.com/drgrandilab/Ni-et-al-2023-Human-Atrial-Signaling-Model)
| [Paper](https://doi.org/10.1093/cvr/cvad118) Ni, Morotti et al., Grandi (2023) Integrative human atrial modelling unravels interactive PKA and CaMKII signalling as key determinants of atrial arrhythmogenesis
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