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Updated Grandi 2010 stimulus
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MichaelClerx committed Sep 4, 2024
1 parent ae7f387 commit d637914
Showing 1 changed file with 4 additions and 5 deletions.
9 changes: 4 additions & 5 deletions c/grandi-2010.mmt
Original file line number Diff line number Diff line change
Expand Up @@ -9,8 +9,8 @@ desc: """
matlab code [3]. It was checked against the original code numerically
by comparing the calculated derivatives.

The stimulus was set to 1ms at -40 [A/F] and the model was paced towards a
state state at 1Hz.
In this Myokit implementation, the stimulus was set to 0.5 [ms] and
approximately twice the threshold value for depolarisation.

[1] Grandi, E., Pasqualini, F. S., & Bers, D. M. (2010). A novel
computational model of the human ventricular action potential and Ca
Expand Down Expand Up @@ -106,7 +106,7 @@ i_ion = I_Na_tot + I_Cl_tot + I_Ca_tot + potassium.I_K_tot
[stimulus]
i_stim = engine.pace * amplitude
in [A/F]
amplitude = -40 [A/F]
amplitude = -38 [A/F] * 2
in [A/F]


Expand Down Expand Up @@ -844,10 +844,9 @@ dot(Na_i) = J_Na_slmyo / Vmyo * (Na_sl - Na_i)
I_K_tot = ito.Ito + ikr.IKr + iks.IKs + ik1.IK1 - 2 * inak.INaK + ical.ICaL_K + ikp.IKp
in [A/F]


[[protocol]]
# Level Start Length Period Multiplier
1 100 1 1000 0
0.5 50 1 1000 0

[[script]]
import matplotlib.pyplot as plt
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