If you develop plugins for Obsidian.md, you may be familiar with the frequent need to either restart/reload Obsidian, or else go into its plugin settings to disable and re-enable the plugin you're working on.
Well, you don't need to do that any more. Just install this plugin, and let it do all the work. When enabled, this plugin automatically watches for changes to the main.js or styles.css of any plugin whose directory includes a .git subdirectory or a file called .hotreload, and then automatically disables and re-enables that plugin once changes have stopped for about three-quarters of a second. A notice will appear briefly in Obsidian when the reload occurs. (The verbose logs in the developer tools will also reflect this.)
The plugin also watches for changes to manifest.json files, and the addition or removal of .git or .hotreload, and updates its watch lists accordingly. So there's no configuration needed to add or remove plugins from the hot reload list: just put your new plugin(s) under revision control or create a .hotreload file in them.
(And, since Obsidian only includes main.js and styles.css in plugin downloads, you don't have to worry about .hotreload escaping into the wild: when other people download your plugin from the Obsidian marketplace, it won't be hot-reloaded, even if they're using the hot-reload plugin, too.)
Note, however, that if you have this plugin enabled, then it can enable plugins that are not currently enabled in the settings, so long as you've checked them out using git or have added a .hotreload file. (For development, this is actually a good thing, because when you make a change that breaks the plugin load process, all you need to do is save your file(s) again, and hotreload will try to enable it again, saving you from having to reload or go back to the settings again.)
Finally, note that while this plugin takes care of the grunt work of reloading your plugin, please keep in mind that it's your plugin's job to properly clean up after itself. If you're not making good use of onunload() and the various registerX() methods to ensure all your changes unload properly, then you may leave Obsidian in an unstable state, forcing you to restart or reload to restore the app to a working state.
This is an Obsidian plugin like any other, and must be cloned or unzipped into your vault's .obsidian/plugins/ directory (or similar one if you've overridden the .obsidian directory name in the Obsidian settings), then enabled in the Obsidian configuration. It's not registered as a standard community plugin for downloading or updating within Obsidian, because it's intended for developer use only, and because it can enable other plugins.