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@startuml | ||
skinparam SwimlaneTitleFontStyle bold | ||
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start | ||
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:==Normal BAM | ||
--- | ||
Input Normal BAM; | ||
:==Input Validation | ||
--- | ||
Validate the input BAM and corresponding index file; | ||
fork | ||
if (run_discovery) is (true) then | ||
split | ||
:==DELLY gSV | ||
--- | ||
Call germline SVs using DELLY | ||
(BCF); | ||
:==DELLY gCNV | ||
--- | ||
Call germline CNVs using DELLY | ||
(BCF); | ||
:==QC | ||
--- | ||
Quality Check variant calls; | ||
:==Output Validation | ||
--- | ||
Validate BCF output; | ||
split again | ||
:==Manta gSV | ||
--- | ||
Call germline SVs using Manta | ||
(VCF); | ||
end split | ||
else (false) | ||
endif | ||
stop | ||
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fork again | ||
if (run_regenotyping) is (true) then | ||
split | ||
:==Regenotype gSV | ||
--- | ||
Regenotype SVs | ||
using DELLY gSV calls | ||
(BCF); | ||
note right: input\nmerged\ngSV sites | ||
split again | ||
:==Regenotype gCNV | ||
--- | ||
Regenotype CNVs | ||
using DELLY gCNV calls | ||
(BCF); | ||
note left: input\nmerged\ngCNV sites | ||
end split | ||
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else (false) | ||
endif | ||
stop | ||
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@enduml |
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