Releases: Open-Systems-Pharmacology/OSP-PBPK-Model-Library
Version 11.3.1
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 Update 3 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
7E3
Added based on version 1.0. See the release notes for 7E3 v. 1.0 for details
BAY794620
Added based on version 1.0. See the release notes for BAY794620 v. 1.0 for details
CDA1
Added based on version 1.0. See the release notes for CDA1 v. 1.0 for details
dAb2
Added based on version 1.0. See the release notes for dAb2 v. 1.0 for details
Digoxin
Added based on version 2.0. See the release notes for Digoxin v. 2.0 for details
Inulin
Added based on version 1.0. See the release notes for Inulin v. 1.0 for details
MEDI524
Added based on version 1.0. See the release notes for MEDI524 v. 1.0 for details
MEDI524YTE
Added based on version 1.0. See the release notes for MEDI524YTE v. 1.0 for details
Tefibazumab
Added based on version 1.0. See the release notes for Tefibazumab v. 1.0 for details
Updates
Verapamil
Updated based on version 2.0. See the release notes for Verapamil v. 2.0 for details
Version 11.3
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 Update 3 and are available here.
Version 11.2.1
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 Update 2 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
No new models added.
Updates
Carbamazepine
Updated based on version 1.3. See the release notes for Carbamazepine v. 1.3 for details
Cimetidine
Updated based on version 1.2. See the release notes for Cimetidine v. 1.2 for details.
Sildenafil
Updated based on version 1.1. See the release notes for Sildenafil v. 1.1 for details.
Version 11.2
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 Update 2 and are available here.
Version 11.1
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 Update 1 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
Carbamazepine
added based on version 1.2
Version 11.0.1
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
Felodipine
added based on version 1.0
Sildenafil
added based on version 1.0
Version 11.0
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 11 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
Ethinylestradiol
added based on version 1.1
Mexiletine
added based on version 1.1
Moclobemide
added based on version 1.1
Omeprazole
added based on version 1.1
S-Mephenytoin
added based on version 1.1
Tizanidine
added based on version 1.1
Updates
Atazanavir
updated based on version 1.2
- Minor bugfixes in the report (typos, broken links)
Dapagliflozin
updated based on version 1.2
- Minor bugfixes in the report (typos, broken links)
Erythromycin
updated based on version 1.3
- Minor bugfixes in the report (typos, broken links)
Fluvoxamine
updated based on version 1.2
- Minor bugfixes in the report (typos, broken links)
Mefenamic acid
updated based on version 1.2
- Minor bugfixes in the report (typos, broken links)
Version 10.0
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 10 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
Amikacin
added based on version 1.2
Fluconazole
added based on version 1.0
Montelukast
added based on version 1.2
Raltegravir
added based on version 1.2
Sufentanil
added based on version 1.2
Vancomycin
added based on version 1.2
Updates
Alfentanil
updated based on version 2.2
- Model updated to reflect the changes in PK-Sim 10
Alprazolam
updated based on version 1.1
- Model updated to reflect the changes in PK-Sim 10
Cimetidine
updated based on version 1.1
- Model updated to reflect the changes in PK-Sim 10
Clarithromycin
updated based on version 1.2
- Model updated to reflect the changes in PK-Sim 10
Efavirenz
updated based on version 1.1
- Model updated to reflect the changes in PK-Sim 10
Erythromycin
updated based on version 1.2
- Model updated to reflect the changes in PK-Sim 10
Itraconazole
updated based on version 1.3
- Model updated to reflect the changes in PK-Sim 10
Midazolam
updated based on version 1.1
- Model updated to reflect the changes in PK-Sim 10
Rifampicin
updated based on version 1.2
- Model updated to reflect the changes in PK-Sim 10
Triazolam
updated based on version 1.1
- Model updated to reflect the changes in PK-Sim 10
Verapamil
updated based on version 1.2
- Model updated to reflect the changes in PK-Sim 10
Version 9.1.1
This release contains the OSP PBPK substance model library.
All models are published as a PK-Sim project model file along with a model evaluation report.
The project model files and evaluation reports of this release are created with OSP 9.1 and are available here.
Release Notes
Notes are listed below for new or updated model files/evaluation reports. All other model files/evaluation reports are unchanged compared to the previous release.
New models
Cimetidine
added based on version 1.0
Updates
Alfentanil
updated based on version 2.1
Clarithromycin
updated based on version 1.1
- Editorial bug fix in links to references
Erythromycin
updated based on version 1.1
- Editorial bug fixes in static text blocks
Fluvoxamine
updated based on version 1.1
- Editorial bug fix in links to references in static text block
Itraconazole
updated based on version 1.2
Rifampicin
updated based on version 1.1
- Editorial bug fix in links to references in static text blocks
Verapamil
updated based on version 1.1
- Editorial bug fix in links to references in static text blocks