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Louis 347
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Female brown mouse
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G6f in layer 2/3
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DOB 9-14-14
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Implanted with 5 mm implants on 9-14-14
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Cage : 3546222 from 3597868
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Experimental days
- 07/07/2015 : Mouse was given 1 block all go trials for 20 min, no lick necessary and 1 blocks of 40 min of go trials with lick necessary for reward delivery. The mouse was not positioned well on the ball so locomotion was not detected accurately. Second mouse on the setup in this experiment run. We checked lick detector and therefore the 40 min block was initially splitter in many small trials. The last trial was properly set up with 40 min long session. Mouse proved to be well aware of its licking capabilities initially but lost interest as it became satiated.
- 07/08/2015 : Mouse was given two blocks of 30 min, all go trials, with lick necessary. We need to check lick detector with this mouse. It seems that one drop of water centered on implant is necessary to make it to work and conduct current from implant to water tube but still not entirely sure. Check mice implant tomorrow for deposit around contact points. Otherwise is doing well. It is walking a lot and licking constantly.
- 07/09/2015 : Mouse was given 2 blocks of 30 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out8s. We had trouble with visual screen stimulus at the beginning, distance to screen was set to empty by mistake. As a result first trials were cancelled quickly to solve the problem. We first restarted the computer and therefore lost some time with the mouse head-fixed.
- 07/10/2015 : Mouse was given 2 blocks of 30 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s. We had lick detection problems again at the end of the second block. Something is not conductive in this mouse. Next session, we will work on adding a cream or lube that does not dry out to ensure conductivity all through out the session. We will also go back to a full go session to make sure the mouse is not confused.
- 07/11/2015: Started by testing the lick detector (works ok). Mouse was given 2 blocks of 30 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s. Despite adding soap, the lick detector stopped working in the middle of the first block very briefly. I added more water and the mouse started his regular behavior again. At the end of the second block, I tested the lickometer again and it wasn't working. From my observations, the mouse also didn't lick duirng the second block, but the licometer problem early on might have caused that.
Block 1: Hits 88 % FA 86 %
Block 2: Hits 4 % FA 3 % - 07/12/2015: Started by testing the lick detector (works ok). Mouse was given 2 blocks of 30 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s. Despite adding soap, the lick detector stopped working in the middle of the first block very briefly. Same behavior as day before, as if lick detector stopped working during first block. I added a piece of wet paper to keep contact just before the beginning of the second block.
- 07/13/2015: Started by testing the lick detector (works ok). Mouse was given 2 blocks of 30 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s.
Block 1 : Hit: 79 %, FA: 27 %
Block 2 : Hit: 94 %, FA: 16 % - 07/14/2015: Started by testing the lick detector (works ok). Mouse was given 2 blocks of 30 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s. first block, reward delay was -1; second block reward delay was 0;
Block 1 : Hit: 100 %, FA: 23 %
Block 2 : Hit: 98 %, FA: 10 % - 07/15/2015: Started by testing the lick detector (works ok). Mouse was given 3 blocks of 20 min with go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s. first block, reward delay was 0; second block reward delay was 0.5; third block reward delay was 0.5
Block 1 : Hit 100 % FA 35 %
Block 2 : Hit:98 % FA: 16 %
Block 3 : Hit:94 % FA: 34 % - 07/16/2015: Started by testing the lick detector . Mouse was given blocks of go+no go trials 100 % contrasts with air puff and time out on no go trials. time out 8s. reward delay was 0.5.
first block was 10 min only go (MISTAKE!).
Second block was go+no go - 20min
third block was 10 min WITH air puff out of response window. Mouse doesn't seem to care about air puff fourth block was 20 min WITH air puff. I moved air puff closer. 20 min long
Block 1 : Hit 100 % FA 0 % (mistake, no no go) presented Block 2 : Hit: % FA: %
Block 3 : Hit: 100 % FA: 0 % Mouse get perfect score but licks often - 07/17/2015 Started by testing the lick detector. Block 1, 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. Test the lick detector (ok). Block 2, the same parameters. Test the lick detector (ok). Block 3, the same parameters
Block 1: Hit 82 % FA 25 %
Block 2: Hit 72 % FA 4 %
Block 3: Hit 78 % FA 16 % - 07/18/2015 Started by testing the lick detector. Block 1, 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. Mouse initially is quite bad, a little lost but it learned again to hold its licking until the sound.
Block 1: Hit 34 % FA 22 %
Block 2: Hit 37 % FA 24 %
Block 3: Hit 26 % FA 12 % - 07/19/2015 Started by testing the lick detector. Block 1, 30 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff. block 2, the same. tested lick detector in between blocks (ok)
Block 1: Hit 52% FA XX % Block 2: Hit 79 % FA XX % - 07/20/2015 Started by testing the lick detector. Block 1, 30 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff. block 2, the same. Mouse is discriminating. Licking is a little excessive. It tends to lick at the tone but not always. It never lick during No Go visual stimulus but very often along the go stimulus. Reward duration is 0.06. Block 1: Hit 94 % FA xx % Block 2: Hit 69 % FA 65 %
- 07/21/2015 Started by testing the lick detector. 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff. Reward duration is 0.06.
Block 1: Hit 77 % FA XX %
Block 2: Hit 85 % FA XX %
Block 2: Hit 58 % FA XX % - 07/22/2015 started by testing the lick detector. 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff. Reward duration is 0.06. Block 2, same parameters.
In Block 3 we introduce a 1s timeout for random licks. There was a slight error in the code which resulted in some very proper licks not being rewarded. Corrected for next experiments.
Block 1: Hit 71% FA 44 % Airpuff 526 129 trials totals
Block 2: Hit 95% FA 64 % Airpuff 864 127 trials totals
Block 3: Hit 25% FA 9 % Airpuff 54 100 trials total - 07/23/2015. tested the lick detector (ok). block 1, 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 1 sec TO.
Block 1: Hit 29% FA 20 %
Block 2: Hit 27% FA 19 % by mistake, the reward delay was sat at 0 sec instead of 0.5 sec. Air puff 126
Block 3: Hit 30 % FA 5 % Air puff 139 We found out NbGO and NbNoGO is miscalculated in the table (overestimated because of the new time out). We corrected.
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07/24/2015. tested the lick detector (ok). block 1, 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 1 sec TO. mouse freaked out in the last 5 min of block 1 and stopped responding after i moved the lick tube further away to help with reducing random licks. fixed after testing lick detector (free rewards). tested lick detector (ok). block 2, same parameters
Block 1: Hit 59% FA 10% air puff 128
Block 2: Hit 60% FA 15% air puff 126 trials 140
Block 3: Hit 73% FA 13% air puff 81 trials 146 -
07/25/2015 tested lick detector (ok). block 1, 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 1 sec TO. Block 1: Hits 60% FA 10% air puff 62 trials 149
Block 2: Hits 93% FA 20% air puff 180 trials 132
Block 3: Hits 87% FA 8% air puff 114 trials 143 -
07/26/2015 blocks : 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 1 sec TO. Mouse got confused in the middle of block 1, as if it expected air puff at all time points. I could see it trying to lick and holding at the same time. Mouse seems to be getting better at licking. Need more time. Block 1: Hits 56 % FA 14 % air puff 99 trials 143
Block 2: Hits 94 % FA 27 % air puff 177 trials 131
Block 3: Hits 94 % FA 18 % air puff 166 trials 134 -
07/27/2015 blocks : 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 1 sec TO. block 2 1 to 3 seconds TO for random licks.
Block 1: Hits 85 % FA 28 % air puff 175 trials 131
Block 2: Hits 82 % FA 17 % air puff 105 trials 118
Block 3: Hits 79 % FA 17 % air puff 106 trials 117 -
07/28/2015 blocks : 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 1 sec TO. block 2, 3 seconds TO for random licks.
Block 1: Hits 96% FA 19 % air puff 69 trials 132
Block 2: Hits 97% FA 7 % air puff 56 trials 138
Block 3: Hits 73% FA 12% air puff 51 trials 140 -
07/29/2015 blocks : 20 min go + nogo, 100% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 3 seconds TO. Block 1: Hits 94 % FA 18 % air puff 85 trials 126 Block 2: Hits 97 % FA 42 % air puff 107 trials 117 Contrast is now 50% Block 3: Hits 60 % FA 21 % air puff 67 trials 133
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07/30/2015 blocks : 20 min go + nogo, 50% contrast, no go punished by air puff and TO, reward delay 0.5. random licks punished by air puff and 3 seconds TO. battery failed so no lick detected initially, replaced circuit battery.
Block 1: Hits 97 % FA 34% air puff 75 trials 129
Block 2: Hits 98 % FA 25% air puff 75 trials 129
Block 3: Hits 33 % FA 20% air puff 34 trials 146 contrast dropped to 25%
Mapping: 0 degrees (bar going top to bottom) and 90 degrees (bar going front to back of the mouse in left eye) Filenames: L347Mapping0deg and L347Mapping90deg Duration 1600 seconds each (102 trials each). Behavioral parameters are in a Mosaic file.
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07/31/2015 check lick detector (ok). full task, 25% contrast. Block 1: Hits 86% FA 36% air puff 67 trials 132
Block 2: Hits 93% FA 34% air puff 88 trials 125
Block 3: Hits 95% FA 20% air puff 68 trials 132 -
08/01/2015 full task, didn't check the lick detector before (but mouse got an air puff soon so it's ok). 25% contrast. Mouse has a lot of air puffs during stimulus presentation
Block 1: Hit 72% FA 32% air puff 75 trials 129
Block 2: Hit 94% FA 45% air puff 98 trials 119
Block 3: Hit 95% FA 34% air puff 90 trials 123 -
08/02/2015 full task
Block 1: Hit 63% FA 29% air puff 98 trials 119
Block 2: Hit 91% FA 34% air puff 131 trials 107
Block 3: Hit 85% FA 35% air puff 101 trials 118 -
08/03/2015 full task - no imaging recorded
Block 1: Hit 98% FA 41% air puff 85 trials 125
Block 2: Hit 93% FA 41% air puff 88 trials 123
Block 3: Hit 96% FA 14% air puff 84 trials 127 -
08/04/2015 full task - with imaging. We had some misadventure with positioning with Sadegh. The mouse got wet a little against the ball. Mouse was initially stressed. Mouse was then-repositioned and we did a short 10 min block, gave it some reward and restarted. Then the mouse performed properly. Block 1: Hit % FA % air puff trials
Block 2: Hit % FA % air puff trials
Block 3: Hit % FA % air puff trials -
08/05/2015 full task - with imaging. Block 1: Hit 98 % FA 46 % air puff 106 trials 125
Block 2: Hit 92 % FA 22 % air puff 76 trials 137
Block 3: Hit 40 % FA 2 % air puff 14 trials 163 -
08/06/2015 full task - with imaging. Block 1: Hit 100 % FA 43 % air puff 113 trials 122
Block 2: Hit 58 % FA 6 % air puff 42 trials 151 Block 3: Hit 3 % FA 0 % air puff 2 trials 168 -
08/07/2015 full task - with imaging. Block 1: Hit 90 % FA 30 % air puff 92 trials 131 Block 2: Hit 96 % FA 15 % air puff 85 trials 134 Block 3: Hit 41 % FA 14 % air puff 27 trials 156
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08/08/2015 full task - with imaging. Block 1: Hit 88 % FA 30 % air puff 71 trials 140
Block 2: Hit 94 % FA 36 % air puff 84 trials 133 Block 3: Hit 3 % FA 1.1 % air puff 6 trials 166 -
Notes
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Weight :
80 % of 25 = 20 g
| Day | Weight pre-water | Weight post-behavior | Weight 1h later | Given water | Weight post-water |
|---|---|---|---|---|---|
| June 30 | 25 g | None | |||
| July 1 | 22 g | 0.8 mL | 22.8 g | ||
| July 2 | 20.9 g | 0.6 mL | 21.6 g | ||
| July 3 | 20.2 g | 0.7 mL | 20.9 g | ||
| July 4 | 19.5 g | 0.7 mL | 20.0 g | ||
| July 5 | 18.9 g | 0.8 mL | 19.7 g | ||
| July 6 | 18.6 g | 0.7 mL | 18.7 g | ||
| July 7 | 18.2 g | 19.3 g | 19.7 g | 0.35 mL | 20.1 g |
| July 8 | 18.9 g | 20.1 g | |||
| July 9 | 19.8 g | 20.6 g | |||
| July 10 | 19.7 g | 20.2 g | |||
| July 11 | 19.3 g | 19.7 g | 19.5 g | 0.5 ml | 20.0 g |
| July 12 | 19 g | 19.8 g | |||
| July 13 | 18.6 g | 19.7 g | |||
| July 14 | 18.4 g | 19.3 g | 19.3 g | 0.7ml | 19.8 g |
| July 15 | 19 g | 19.8 g | |||
| July 16 | 18.5 g | 19.4 g | 0.5 | 19.9 | |
| July 17 | 18.9 g | 19.5 g | |||
| July 18 | 18.3 g | 18.6 g | 18.5 | 1.1 | 19.6 |
| July 19 | 19.2 g | 19.9 g | |||
| July 20 | 19.2 g | 20 g | |||
| July 21 | 19.3 g | g | |||
| July 22 | 19.4 g | 20.3 g | |||
| July 23 | 19.4 g | 20.3 g | |||
| July 24 | 19.6 g | 20.4 g | |||
| July 25 | 19.4 g | 20.8 g | |||
| July 26 | 20.0 g | 21.2 g | |||
| July 27 | g | 21.2 g | |||
| July 28 | 20.4 g | 21.4 g | |||
| July 29 | 20.8 g | 21.5 g | |||
| July 30 | 20.6 g | 21.5 g | |||
| July 31 | 20.6 g | 21.5 g | |||
| August 1 | 20.4 g | 21.4 g | |||
| August 2 | 20.7 g | 21.3 g | |||
| August 3 | 21.2 g | ||||
| August 4 | 20.4 g | 21.2 g | |||
| August 5 | 20.1 g | 20.7 g | |||
| August 6 | 19.5 g | 20.3 g | |||
| August 7 | 19.8 g | 20.7 g | |||
| August 8 | 20 g | 20.7 g | END OF DEPRIV |