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This is the wiki for Open Source Malaria Series 4. Navigate between the various pages using the table of contents on the right.
This is an open source project, so anyone may edit this wiki, but if you do so, please provide a reason for the edit.
For problems/suggestions/discussion for this wiki, create an Issue (tab is above, on this page).
The files (e.g. molecule files and images used on the wiki) are all in this repo (https://github.com/OpenSourceMalaria/Series4/tree/master/Wiki%20Files)
An older (ultra out-of-date) version of the Series 4 wiki is still at http://www.openwetware.org/wiki/OpenSourceMalaria:Triazolopyrazine_(TP)_Series
Aims, Concerns and Current Interest in Series 4
Modification of Core Triazolopyrazine
Modification of Pyrazine Substitution Pattern
Modification of the Triazole Substitution
Pyrazine Side Chain Modifications - Ethers
Pyrazine Side Chain Modifications - Amides
Pyrazine Side Chain Modifications - Reversed Amides
Pyrazine Side Chain Modifications - Others
Biological Data Currently not Incorporated into the Main Wiki Sections
Mechanism of Action: Possible PfATP4 Activity Deduced from Parasite Ion Regulation Assays
Synthesis of the Ether-Linked Series
Synthesis of the Amide-Linked Series
Synthesis of the Reverse Amide- Linked Series
Synthesis of Benzylic Functionalised Ether-Linked Series
Alternative Routes to the Triazolopyrazine Core
Triazolopyrazine telesubstitution
Chirality/Stereogenic Centres in This Series
Other Sources of Compounds Relevant to this Series
Desirable Compounds Not Yet Synthesised