Gametocyte Stage
The original Series 4 briefing document stated the series had "no or weak >>1uM activity against gametocytes" but there are no associated data to support this statement.
As was discussed, a mechanism of action vs. PfATP4 is compatible with activity vs. gametocytes. Representative series members were collected for analysis in a relevant assay and the resulting data showed that weak activity vs male gamete formation was observed.
